Incidental Mutation 'R7689:Zfp39'
ID 593285
Institutional Source Beutler Lab
Gene Symbol Zfp39
Ensembl Gene ENSMUSG00000037001
Gene Name zinc finger protein 39
Synonyms Zfp-39, CTfin33
MMRRC Submission 045753-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.152) question?
Stock # R7689 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58778979-58795051 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58781469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 431 (H431R)
Ref Sequence ENSEMBL: ENSMUSP00000099764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102703]
AlphaFold Q02525
Predicted Effect probably damaging
Transcript: ENSMUST00000102703
AA Change: H431R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099764
Gene: ENSMUSG00000037001
AA Change: H431R

DomainStartEndE-ValueType
KRAB 59 119 8.23e-34 SMART
low complexity region 171 180 N/A INTRINSIC
ZnF_C2H2 298 320 9.58e-3 SMART
ZnF_C2H2 326 347 2.2e2 SMART
ZnF_C2H2 353 373 1.18e2 SMART
ZnF_C2H2 409 431 8.34e-3 SMART
ZnF_C2H2 437 459 7.26e-3 SMART
ZnF_C2H2 465 487 1.53e-1 SMART
ZnF_C2H2 493 515 9.08e-4 SMART
ZnF_C2H2 521 543 2.61e-4 SMART
ZnF_C2H2 549 571 1.12e-3 SMART
ZnF_C2H2 577 599 4.94e-5 SMART
ZnF_C2H2 605 627 5.14e-3 SMART
ZnF_C2H2 633 655 1.38e-3 SMART
ZnF_C2H2 661 683 6.78e-3 SMART
ZnF_C2H2 689 711 5.14e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik T A 4: 148,029,440 (GRCm39) F470Y probably damaging Het
Adra1a T C 14: 66,875,250 (GRCm39) L75P probably damaging Het
Agap1 T C 1: 89,762,188 (GRCm39) S560P probably damaging Het
Ahcyl T C 16: 45,974,970 (GRCm39) T136A probably benign Het
Arrdc4 T A 7: 68,391,623 (GRCm39) I215L probably damaging Het
Atad3a C T 4: 155,840,610 (GRCm39) A97T probably damaging Het
Bcas3 A T 11: 85,386,713 (GRCm39) T383S probably benign Het
C2cd5 G A 6: 142,995,951 (GRCm39) R379* probably null Het
Cacna1e G T 1: 154,274,549 (GRCm39) H2138N probably benign Het
Card14 A T 11: 119,216,328 (GRCm39) D303V possibly damaging Het
Ccdc202 T C 14: 96,119,252 (GRCm39) V3A probably benign Het
Cfhr1 T C 1: 139,475,478 (GRCm39) Y331C unknown Het
Chp1 G A 2: 119,415,146 (GRCm39) D183N probably benign Het
Cntn2 T C 1: 132,443,882 (GRCm39) T966A probably benign Het
Cpne9 T G 6: 113,266,965 (GRCm39) C133G probably damaging Het
Cspg4b A G 13: 113,515,948 (GRCm39) T121A Het
Cul7 C T 17: 46,963,747 (GRCm39) Q275* probably null Het
Cyp11b1 T C 15: 74,710,897 (GRCm39) D221G probably benign Het
Dmxl1 T A 18: 49,979,685 (GRCm39) F107I probably benign Het
Dnhd1 A G 7: 105,363,170 (GRCm39) I3911V probably benign Het
Eif1ad16 A G 12: 87,985,259 (GRCm39) Y95H probably damaging Het
Eloa T C 4: 135,736,595 (GRCm39) H551R probably benign Het
Fam171b T A 2: 83,709,732 (GRCm39) V468D probably benign Het
Fat2 A G 11: 55,200,666 (GRCm39) W803R probably damaging Het
Fbxo43 T C 15: 36,163,201 (GRCm39) D2G probably benign Het
Fbxo8 A G 8: 57,041,120 (GRCm39) T179A probably benign Het
Gdap1 A G 1: 17,231,623 (GRCm39) T323A probably damaging Het
Gm136 T C 4: 34,743,875 (GRCm39) N323S probably null Het
Gm6899 A T 11: 26,543,819 (GRCm39) T129S unknown Het
Gnb3 A T 6: 124,814,183 (GRCm39) C166S possibly damaging Het
Gpr61 A G 3: 108,057,966 (GRCm39) F232L probably damaging Het
Gpx8 T C 13: 113,179,711 (GRCm39) M197V probably benign Het
Gse1 G T 8: 121,295,217 (GRCm39) R446L unknown Het
Itch A T 2: 155,054,987 (GRCm39) T764S probably benign Het
Itch A G 2: 155,051,922 (GRCm39) K614E probably damaging Het
Itpkb T G 1: 180,241,544 (GRCm39) M738R probably damaging Het
Jph1 T A 1: 17,074,192 (GRCm39) K609* probably null Het
Kcns1 G A 2: 164,010,241 (GRCm39) R173C probably damaging Het
Larp4b C T 13: 9,186,834 (GRCm39) S54L probably damaging Het
Lonrf1 G T 8: 36,715,918 (GRCm39) S239* probably null Het
Lyst T G 13: 13,857,808 (GRCm39) probably null Het
Mccc1 T A 3: 36,015,132 (GRCm39) R663* probably null Het
Mcm3 A G 1: 20,876,997 (GRCm39) V646A probably benign Het
Mdn1 T C 4: 32,739,912 (GRCm39) L3722P probably damaging Het
Mmp27 T G 9: 7,579,002 (GRCm39) D392E probably damaging Het
Ms4a14 A G 19: 11,279,906 (GRCm39) I884T probably benign Het
Muc4 C T 16: 32,574,439 (GRCm39) T963I probably benign Het
Muc6 G C 7: 141,217,659 (GRCm39) P2338R probably damaging Het
Mucl3 C A 17: 35,948,969 (GRCm39) S210I possibly damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Ndrg2 C T 14: 52,147,812 (GRCm39) A102T possibly damaging Het
Nhsl3 T C 4: 129,117,566 (GRCm39) N411S probably benign Het
Nos1 A G 5: 118,035,792 (GRCm39) D431G probably damaging Het
Oog4 CAA CA 4: 143,164,022 (GRCm39) probably null Het
Otog T C 7: 45,901,480 (GRCm39) L393P probably damaging Het
Plcl1 A G 1: 55,736,627 (GRCm39) N656S probably damaging Het
Pole3 C A 4: 62,443,060 (GRCm39) V27F probably damaging Het
Prrt4 T A 6: 29,177,140 (GRCm39) I210F probably damaging Het
Ptpn18 G A 1: 34,512,445 (GRCm39) D417N possibly damaging Het
Rbpms A T 8: 34,354,387 (GRCm39) S53T possibly damaging Het
Rgs7 C A 1: 174,949,296 (GRCm39) V203L probably benign Het
Riok1 A T 13: 38,229,263 (GRCm39) D150V probably damaging Het
Rrp1b T C 17: 32,274,900 (GRCm39) L335P probably benign Het
Rsph6a T G 7: 18,801,962 (GRCm39) I592S possibly damaging Het
Skor1 C T 9: 63,052,661 (GRCm39) G436D probably damaging Het
Slc17a8 T C 10: 89,433,319 (GRCm39) T51A possibly damaging Het
Slc22a8 T C 19: 8,585,248 (GRCm39) S266P probably damaging Het
Socs2 A G 10: 95,250,845 (GRCm39) probably benign Het
Tas2r106 A G 6: 131,655,668 (GRCm39) I61T possibly damaging Het
Tfap2a T C 13: 40,882,051 (GRCm39) N77D probably damaging Het
Tmem236 T A 2: 14,197,076 (GRCm39) L88Q probably damaging Het
Ttc41 A G 10: 86,595,088 (GRCm39) E954G probably damaging Het
Vmn1r34 G T 6: 66,613,994 (GRCm39) S248* probably null Het
Wipf1 T C 2: 73,262,789 (GRCm39) R483G probably damaging Het
Zfhx4 A G 3: 5,476,946 (GRCm39) N3187S probably benign Het
Zfp202 C A 9: 40,121,829 (GRCm39) P309T probably benign Het
Zfp658 T A 7: 43,224,102 (GRCm39) H792Q probably benign Het
Other mutations in Zfp39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp39 APN 11 58,783,885 (GRCm39) splice site probably benign
IGL01597:Zfp39 APN 11 58,782,369 (GRCm39) missense probably damaging 0.96
IGL02055:Zfp39 APN 11 58,782,156 (GRCm39) missense probably benign
IGL02456:Zfp39 APN 11 58,793,626 (GRCm39) nonsense probably null
IGL02873:Zfp39 APN 11 58,781,848 (GRCm39) missense probably benign 0.12
H8562:Zfp39 UTSW 11 58,791,512 (GRCm39) missense probably damaging 1.00
R0462:Zfp39 UTSW 11 58,781,232 (GRCm39) missense probably benign 0.03
R0513:Zfp39 UTSW 11 58,780,813 (GRCm39) missense probably benign 0.09
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1401:Zfp39 UTSW 11 58,781,149 (GRCm39) missense probably benign 0.01
R1797:Zfp39 UTSW 11 58,791,486 (GRCm39) missense probably damaging 0.96
R2146:Zfp39 UTSW 11 58,781,158 (GRCm39) missense probably benign 0.05
R3903:Zfp39 UTSW 11 58,781,001 (GRCm39) missense probably benign 0.44
R4303:Zfp39 UTSW 11 58,780,843 (GRCm39) missense probably damaging 1.00
R4706:Zfp39 UTSW 11 58,793,633 (GRCm39) missense probably benign 0.41
R4957:Zfp39 UTSW 11 58,782,057 (GRCm39) missense possibly damaging 0.63
R5092:Zfp39 UTSW 11 58,782,028 (GRCm39) missense possibly damaging 0.71
R5158:Zfp39 UTSW 11 58,780,671 (GRCm39) missense possibly damaging 0.81
R5292:Zfp39 UTSW 11 58,791,415 (GRCm39) missense probably damaging 0.97
R5697:Zfp39 UTSW 11 58,780,661 (GRCm39) missense probably benign 0.08
R5906:Zfp39 UTSW 11 58,793,717 (GRCm39) missense probably benign
R5925:Zfp39 UTSW 11 58,782,099 (GRCm39) missense possibly damaging 0.94
R6174:Zfp39 UTSW 11 58,782,213 (GRCm39) missense probably benign 0.01
R6177:Zfp39 UTSW 11 58,781,887 (GRCm39) missense probably benign 0.27
R6968:Zfp39 UTSW 11 58,782,306 (GRCm39) missense probably benign 0.00
R7045:Zfp39 UTSW 11 58,781,269 (GRCm39) missense unknown
R7139:Zfp39 UTSW 11 58,781,385 (GRCm39) missense probably damaging 1.00
R7421:Zfp39 UTSW 11 58,780,933 (GRCm39) missense probably damaging 1.00
R7493:Zfp39 UTSW 11 58,781,869 (GRCm39) missense possibly damaging 0.82
R8061:Zfp39 UTSW 11 58,793,573 (GRCm39) missense probably benign
R8136:Zfp39 UTSW 11 58,782,228 (GRCm39) missense probably damaging 0.99
R8955:Zfp39 UTSW 11 58,780,946 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1186:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1186:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1186:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1186:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1186:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1186:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1186:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1187:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1187:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1187:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1187:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1187:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1187:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1187:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1187:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1188:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1188:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1188:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1188:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1188:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1188:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1188:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1188:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1189:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1189:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1189:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1189:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1189:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1189:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1189:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1189:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1189:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1190:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1190:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1190:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1190:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1190:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1190:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1190:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1190:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1190:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1190:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1191:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1191:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1191:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1191:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1191:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1191:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1191:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1191:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1192:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1192:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1192:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1192:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1192:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1192:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1192:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1192:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1192:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1192:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGAGGACTTATGGAGGAAGGTTT -3'
(R):5'- AGTCCCCAGAGAAGCCCG -3'

Sequencing Primer
(F):5'- GACTGCCGGTGAAAAGTTTTCCC -3'
(R):5'- AAGCCCGACTCTGGGAAGTTTATC -3'
Posted On 2019-11-12