Incidental Mutation 'R7692:Or10g1'
ID 593467
Institutional Source Beutler Lab
Gene Symbol Or10g1
Ensembl Gene ENSMUSG00000063106
Gene Name olfactory receptor family 10 subfamily G member 1
Synonyms MOR223-6, GA_x6K02T2RJGY-583652-584608, Olfr1510
MMRRC Submission 045756-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7692 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52647346-52648384 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52647945 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 128 (Y128C)
Ref Sequence ENSEMBL: ENSMUSP00000150294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079459] [ENSMUST00000215928]
AlphaFold E9PZZ6
Predicted Effect probably damaging
Transcript: ENSMUST00000079459
AA Change: Y128C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078424
Gene: ENSMUSG00000063106
AA Change: Y128C

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 8.1e-50 PFAM
Pfam:7tm_1 45 293 1.8e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215928
AA Change: Y128C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b G A 8: 43,973,832 (GRCm39) T390I probably benign Het
Adgb A G 10: 10,287,456 (GRCm39) probably null Het
Ado G T 10: 67,384,265 (GRCm39) Y113* probably null Het
Angptl1 A G 1: 156,672,885 (GRCm39) E237G probably damaging Het
Arid2 T A 15: 96,254,578 (GRCm39) Y141* probably null Het
Clvs1 T C 4: 9,350,739 (GRCm39) I183T probably benign Het
Dnah1 T C 14: 31,014,295 (GRCm39) K1817E probably benign Het
Eif3e C A 15: 43,126,642 (GRCm39) R271L probably damaging Het
Eml6 A G 11: 29,703,085 (GRCm39) V1611A probably damaging Het
Enpp3 G T 10: 24,660,739 (GRCm39) Y634* probably null Het
Evi5l C T 8: 4,250,886 (GRCm39) R394W probably damaging Het
Fcgr3 A C 1: 170,881,661 (GRCm39) F156V probably damaging Het
Fmo1 T A 1: 162,661,402 (GRCm39) T294S probably benign Het
Gabrb3 A G 7: 57,466,203 (GRCm39) Q339R probably damaging Het
Gen1 T A 12: 11,292,167 (GRCm39) T606S probably benign Het
Gfod1 T C 13: 43,354,528 (GRCm39) Q149R probably benign Het
Golm1 A G 13: 59,788,071 (GRCm39) V276A probably benign Het
Hc C A 2: 34,914,161 (GRCm39) V849F probably damaging Het
Hectd4 T C 5: 121,459,627 (GRCm39) I832T possibly damaging Het
Hspa14 T C 2: 3,497,643 (GRCm39) D283G probably damaging Het
Lztfl1 C T 9: 123,541,536 (GRCm39) W94* probably null Het
Lzts3 T C 2: 130,477,306 (GRCm39) S381G probably benign Het
Mgat2 A G 12: 69,231,444 (GRCm39) Y6C probably damaging Het
Mrpl30 T C 1: 37,934,439 (GRCm39) I27T probably benign Het
Muc5b A T 7: 141,406,966 (GRCm39) T1045S unknown Het
Nlrp4a G A 7: 26,148,690 (GRCm39) R99Q probably benign Het
Or5b98 A G 19: 12,931,006 (GRCm39) T18A possibly damaging Het
Phlpp1 T C 1: 106,209,132 (GRCm39) L495P probably damaging Het
Pla2g4d T C 2: 120,109,776 (GRCm39) D178G possibly damaging Het
Prl5a1 C G 13: 28,333,997 (GRCm39) L167V probably damaging Het
Sardh A G 2: 27,087,651 (GRCm39) V740A probably benign Het
Sbno1 T G 5: 124,543,709 (GRCm39) T277P probably benign Het
Slc2a1 T C 4: 118,993,462 (GRCm39) V433A probably damaging Het
Slc4a10 T C 2: 62,134,308 (GRCm39) V1008A possibly damaging Het
Smarcal1 T G 1: 72,625,179 (GRCm39) S109A probably benign Het
Speg A G 1: 75,377,834 (GRCm39) D864G probably benign Het
Steap4 T C 5: 8,026,976 (GRCm39) I313T probably benign Het
Tab2 A T 10: 7,786,869 (GRCm39) D614E probably damaging Het
Tenm4 A G 7: 96,544,610 (GRCm39) K2246E probably damaging Het
Timm23 A G 14: 31,902,520 (GRCm39) S208P probably damaging Het
Tmem229a C A 6: 24,955,211 (GRCm39) C181F probably benign Het
Ugdh T C 5: 65,574,958 (GRCm39) Y356C probably damaging Het
Ugt2a1 A G 5: 87,634,586 (GRCm39) L7P probably damaging Het
Uhrf1 A G 17: 56,619,905 (GRCm39) D272G possibly damaging Het
Vmn1r206 T A 13: 22,804,827 (GRCm39) I127F probably damaging Het
Vmn2r106 T C 17: 20,505,490 (GRCm39) Y68C possibly damaging Het
Zfand6 G A 7: 84,283,141 (GRCm39) P72L not run Het
Other mutations in Or10g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01564:Or10g1 APN 14 52,648,299 (GRCm39) missense probably benign 0.04
IGL02097:Or10g1 APN 14 52,647,511 (GRCm39) missense probably benign
R0282:Or10g1 UTSW 14 52,647,720 (GRCm39) missense possibly damaging 0.94
R1449:Or10g1 UTSW 14 52,648,024 (GRCm39) missense probably damaging 1.00
R2113:Or10g1 UTSW 14 52,647,753 (GRCm39) missense probably damaging 1.00
R2870:Or10g1 UTSW 14 52,648,318 (GRCm39) missense probably benign
R2870:Or10g1 UTSW 14 52,648,318 (GRCm39) missense probably benign
R2872:Or10g1 UTSW 14 52,648,318 (GRCm39) missense probably benign
R2872:Or10g1 UTSW 14 52,648,318 (GRCm39) missense probably benign
R2873:Or10g1 UTSW 14 52,648,318 (GRCm39) missense probably benign
R3409:Or10g1 UTSW 14 52,647,818 (GRCm39) missense possibly damaging 0.64
R3411:Or10g1 UTSW 14 52,647,818 (GRCm39) missense possibly damaging 0.64
R4480:Or10g1 UTSW 14 52,647,765 (GRCm39) missense probably damaging 1.00
R5292:Or10g1 UTSW 14 52,647,902 (GRCm39) missense possibly damaging 0.90
R5297:Or10g1 UTSW 14 52,647,675 (GRCm39) missense probably damaging 1.00
R5441:Or10g1 UTSW 14 52,647,414 (GRCm39) missense probably benign 0.02
R5749:Or10g1 UTSW 14 52,647,961 (GRCm39) missense probably damaging 1.00
R5872:Or10g1 UTSW 14 52,648,225 (GRCm39) missense probably damaging 1.00
R5941:Or10g1 UTSW 14 52,647,525 (GRCm39) missense probably benign 0.01
R7209:Or10g1 UTSW 14 52,647,550 (GRCm39) missense possibly damaging 0.80
R7379:Or10g1 UTSW 14 52,647,718 (GRCm39) missense probably benign 0.08
R7463:Or10g1 UTSW 14 52,648,168 (GRCm39) missense probably benign 0.00
R8894:Or10g1 UTSW 14 52,647,465 (GRCm39) missense probably damaging 1.00
R9286:Or10g1 UTSW 14 52,648,075 (GRCm39) nonsense probably null
R9394:Or10g1 UTSW 14 52,647,570 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCACCAGTTCATTGACAGTCG -3'
(R):5'- TCTCCTTCCTGGACATGTGG -3'

Sequencing Primer
(F):5'- ATTGACAGTCGTATCGGCAC -3'
(R):5'- TGGACATGTGGCTCTCCTCAG -3'
Posted On 2019-11-12