Incidental Mutation 'R7692:Olfr1450'
ID 593472
Institutional Source Beutler Lab
Gene Symbol Olfr1450
Ensembl Gene ENSMUSG00000062892
Gene Name olfactory receptor 1450
Synonyms MOR202-33, GA_x6K02T2RE5P-3283121-3284098
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R7692 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 12950258-12956406 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12953642 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 18 (T18A)
Ref Sequence ENSEMBL: ENSMUSP00000150243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082006] [ENSMUST00000213587] [ENSMUST00000213925]
AlphaFold Q8VF19
Predicted Effect possibly damaging
Transcript: ENSMUST00000082006
AA Change: T18A

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000080666
Gene: ENSMUSG00000062892
AA Change: T18A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.5e-6 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213587
AA Change: T18A

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213925
AA Change: T18A

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b G A 8: 43,520,795 T390I probably benign Het
Adgb A G 10: 10,411,712 probably null Het
Ado G T 10: 67,548,435 Y113* probably null Het
Angptl1 A G 1: 156,845,315 E237G probably damaging Het
Arid2 T A 15: 96,356,697 Y141* probably null Het
Clvs1 T C 4: 9,350,739 I183T probably benign Het
Dnah1 T C 14: 31,292,338 K1817E probably benign Het
Eif3e C A 15: 43,263,246 R271L probably damaging Het
Eml6 A G 11: 29,753,085 V1611A probably damaging Het
Enpp3 G T 10: 24,784,841 Y634* probably null Het
Evi5l C T 8: 4,200,886 R394W probably damaging Het
Fcgr3 A C 1: 171,054,092 F156V probably damaging Het
Fmo1 T A 1: 162,833,833 T294S probably benign Het
Gabrb3 A G 7: 57,816,455 Q339R probably damaging Het
Gen1 T A 12: 11,242,166 T606S probably benign Het
Gfod1 T C 13: 43,201,052 Q149R probably benign Het
Golm1 A G 13: 59,640,257 V276A probably benign Het
Hc C A 2: 35,024,149 V849F probably damaging Het
Hectd4 T C 5: 121,321,564 I832T possibly damaging Het
Hspa14 T C 2: 3,496,606 D283G probably damaging Het
Lztfl1 C T 9: 123,712,471 W94* probably null Het
Lzts3 T C 2: 130,635,386 S381G probably benign Het
Mgat2 A G 12: 69,184,670 Y6C probably damaging Het
Mrpl30 T C 1: 37,895,358 I27T probably benign Het
Muc5b A T 7: 141,853,229 T1045S unknown Het
Nlrp4a G A 7: 26,449,265 R99Q probably benign Het
Olfr1510 T C 14: 52,410,488 Y128C probably damaging Het
Phlpp1 T C 1: 106,281,402 L495P probably damaging Het
Pla2g4d T C 2: 120,279,295 D178G possibly damaging Het
Prl5a1 C G 13: 28,150,014 L167V probably damaging Het
Sardh A G 2: 27,197,639 V740A probably benign Het
Sbno1 T G 5: 124,405,646 T277P probably benign Het
Slc2a1 T C 4: 119,136,265 V433A probably damaging Het
Slc4a10 T C 2: 62,303,964 V1008A possibly damaging Het
Smarcal1 T G 1: 72,586,020 S109A probably benign Het
Speg A G 1: 75,401,190 D864G probably benign Het
Steap4 T C 5: 7,976,976 I313T probably benign Het
Tab2 A T 10: 7,911,105 D614E probably damaging Het
Tenm4 A G 7: 96,895,403 K2246E probably damaging Het
Timm23 A G 14: 32,180,563 S208P probably damaging Het
Tmem229a C A 6: 24,955,212 C181F probably benign Het
Ugdh T C 5: 65,417,615 Y356C probably damaging Het
Ugt2a1 A G 5: 87,486,727 L7P probably damaging Het
Uhrf1 A G 17: 56,312,905 D272G possibly damaging Het
Vmn1r206 T A 13: 22,620,657 I127F probably damaging Het
Vmn2r106 T C 17: 20,285,228 Y68C possibly damaging Het
Zfand6 G A 7: 84,633,933 P72L not run Het
Other mutations in Olfr1450
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01978:Olfr1450 APN 19 12954042 missense probably benign 0.00
IGL02378:Olfr1450 APN 19 12954383 missense probably benign 0.01
IGL02405:Olfr1450 APN 19 12954459 missense probably damaging 1.00
IGL02493:Olfr1450 APN 19 12953774 missense probably benign 0.12
IGL02496:Olfr1450 APN 19 12954192 missense possibly damaging 0.86
IGL02866:Olfr1450 APN 19 12954355 missense possibly damaging 0.81
IGL02886:Olfr1450 APN 19 12954518 missense probably benign 0.00
IGL03223:Olfr1450 APN 19 12953904 missense probably benign 0.00
IGL03286:Olfr1450 APN 19 12954168 missense probably benign 0.05
IGL03396:Olfr1450 APN 19 12953820 missense probably damaging 1.00
R0106:Olfr1450 UTSW 19 12954356 missense probably benign 0.10
R0106:Olfr1450 UTSW 19 12954356 missense probably benign 0.10
R0544:Olfr1450 UTSW 19 12953702 missense possibly damaging 0.79
R1660:Olfr1450 UTSW 19 12953691 missense probably damaging 1.00
R2020:Olfr1450 UTSW 19 12954332 missense possibly damaging 0.61
R4292:Olfr1450 UTSW 19 12954156 missense possibly damaging 0.83
R4647:Olfr1450 UTSW 19 12954077 missense probably benign 0.00
R5964:Olfr1450 UTSW 19 12954531 missense probably benign 0.03
R6398:Olfr1450 UTSW 19 12954317 missense probably damaging 1.00
R6681:Olfr1450 UTSW 19 12954459 missense probably damaging 1.00
R7129:Olfr1450 UTSW 19 12954114 missense possibly damaging 0.94
R7399:Olfr1450 UTSW 19 12954447 missense probably damaging 1.00
R7561:Olfr1450 UTSW 19 12954039 missense probably benign 0.00
R8094:Olfr1450 UTSW 19 12954002 missense probably benign 0.00
R8258:Olfr1450 UTSW 19 12954363 missense possibly damaging 0.58
R8259:Olfr1450 UTSW 19 12954363 missense possibly damaging 0.58
R9522:Olfr1450 UTSW 19 12954013 nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTCTGAGCAACTTAAACTCAAACTC -3'
(R):5'- ACTTTTGGAGTCACAGCAGAG -3'

Sequencing Primer
(F):5'- GAGCAACTTAAACTCAAACTCTTTAC -3'
(R):5'- GCAGAGGAATAAACACAGTCTGCC -3'
Posted On 2019-11-12