Incidental Mutation 'R7693:Or7a37'
ID 593508
Institutional Source Beutler Lab
Gene Symbol Or7a37
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor family 7 subfamily A member 37
Synonyms GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2
MMRRC Submission 045708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R7693 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 78799143-78806446 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78806137 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 218 (Y218F)
Ref Sequence ENSEMBL: ENSMUSP00000038992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably damaging
Transcript: ENSMUST00000039718
AA Change: Y218F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: Y218F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204849
AA Change: Y218F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: Y218F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205193
AA Change: Y218F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: Y218F

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 C A 7: 45,827,968 (GRCm39) S63I probably damaging Het
Adcy10 A G 1: 165,398,340 (GRCm39) E1479G probably benign Het
Alpl C T 4: 137,471,120 (GRCm39) G339R probably damaging Het
Anapc1 A G 2: 128,483,457 (GRCm39) S1213P possibly damaging Het
Aoc3 C A 11: 101,223,338 (GRCm39) H525N probably benign Het
Arhgap33 A T 7: 30,225,537 (GRCm39) probably null Het
Arhgef4 A G 1: 34,763,222 (GRCm39) E826G probably benign Het
Art2a A T 7: 101,204,056 (GRCm39) *161R probably null Het
Azi2 A T 9: 117,876,661 (GRCm39) N59I probably damaging Het
Cdhr5 T C 7: 140,851,691 (GRCm39) T538A probably benign Het
Cilk1 A G 9: 78,065,008 (GRCm39) D306G probably benign Het
Csnk2b C A 17: 35,336,972 (GRCm39) G123C probably null Het
Dnaaf10 T C 11: 17,162,064 (GRCm39) V34A probably benign Het
Dnaja2 G T 8: 86,266,939 (GRCm39) P306Q probably damaging Het
Dusp19 A G 2: 80,447,905 (GRCm39) T60A probably benign Het
Epm2aip1 G A 9: 111,101,443 (GRCm39) G139S probably benign Het
Fer1l4 A G 2: 155,862,351 (GRCm39) F1774S possibly damaging Het
Fxyd3 T A 7: 30,770,598 (GRCm39) R66S probably benign Het
Gjd2 T C 2: 113,842,309 (GRCm39) N56S probably damaging Het
Gmcl1 A G 6: 86,691,239 (GRCm39) I252T probably benign Het
Gnl1 T C 17: 36,299,112 (GRCm39) C517R probably damaging Het
Grin1 T A 2: 25,208,679 (GRCm39) M74L possibly damaging Het
Hinfp A G 9: 44,209,642 (GRCm39) M244T probably damaging Het
Iqca1l T C 5: 24,751,626 (GRCm39) I541V probably benign Het
Kcnma1 T A 14: 23,417,680 (GRCm39) I850F probably damaging Het
Kif13a G T 13: 46,904,089 (GRCm39) T1748N probably benign Het
Lama1 C T 17: 68,124,026 (GRCm39) A2817V Het
Map6 C T 7: 98,985,499 (GRCm39) L671F possibly damaging Het
Neb C T 2: 52,189,581 (GRCm39) A770T probably damaging Het
Noc2l T A 4: 156,324,764 (GRCm39) H280Q probably damaging Het
Ntrk1 T C 3: 87,695,733 (GRCm39) D205G probably benign Het
Or5m5 A T 2: 85,814,979 (GRCm39) Y265F probably damaging Het
Parp9 A G 16: 35,777,282 (GRCm39) S409G possibly damaging Het
Pcnx2 G A 8: 126,613,864 (GRCm39) T529I probably benign Het
Popdc3 A G 10: 45,191,227 (GRCm39) S113G probably benign Het
Rbm8a T C 3: 96,537,624 (GRCm39) I25T probably damaging Het
Rfc4 A G 16: 22,946,163 (GRCm39) W40R probably damaging Het
Rp1 T C 1: 4,417,626 (GRCm39) D1162G probably damaging Het
Slc14a2 G A 18: 78,197,218 (GRCm39) A846V possibly damaging Het
Spx A G 6: 142,360,516 (GRCm39) D56G probably damaging Het
Tanc2 T A 11: 105,814,293 (GRCm39) N1912K probably damaging Het
Tmcc1 T C 6: 116,001,843 (GRCm39) I559V Het
Tnfaip3 A G 10: 18,880,528 (GRCm39) V513A probably benign Het
Ucp3 T C 7: 100,131,799 (GRCm39) F217L probably benign Het
Zc3h11a A T 1: 133,573,475 (GRCm39) M55K probably damaging Het
Zfp316 G A 5: 143,249,167 (GRCm39) T156I unknown Het
Other mutations in Or7a37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Or7a37 APN 10 78,805,940 (GRCm39) missense probably damaging 1.00
IGL02159:Or7a37 APN 10 78,805,735 (GRCm39) missense probably damaging 1.00
R0355:Or7a37 UTSW 10 78,806,267 (GRCm39) missense probably damaging 1.00
R0561:Or7a37 UTSW 10 78,805,729 (GRCm39) nonsense probably null
R1305:Or7a37 UTSW 10 78,805,933 (GRCm39) missense probably benign 0.03
R1921:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R1922:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R2382:Or7a37 UTSW 10 78,805,990 (GRCm39) missense probably damaging 0.99
R2920:Or7a37 UTSW 10 78,805,846 (GRCm39) missense probably damaging 1.00
R4491:Or7a37 UTSW 10 78,806,151 (GRCm39) missense probably damaging 1.00
R5113:Or7a37 UTSW 10 78,806,037 (GRCm39) missense probably benign
R5305:Or7a37 UTSW 10 78,806,390 (GRCm39) missense possibly damaging 0.68
R5744:Or7a37 UTSW 10 78,806,017 (GRCm39) missense probably damaging 1.00
R5861:Or7a37 UTSW 10 78,805,765 (GRCm39) missense probably damaging 1.00
R6197:Or7a37 UTSW 10 78,805,974 (GRCm39) missense probably damaging 1.00
R6314:Or7a37 UTSW 10 78,806,179 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACCAGCTCTGTGGATTTCTG -3'
(R):5'- GACTGAGGCTGTTGCACTTG -3'

Sequencing Primer
(F):5'- GTGTTCTGCATGCCTTATTTCAAAG -3'
(R):5'- GCACTTGTTTGTGACCCATG -3'
Posted On 2019-11-12