Incidental Mutation 'R7694:Lcn2'
ID 593523
Institutional Source Beutler Lab
Gene Symbol Lcn2
Ensembl Gene ENSMUSG00000026822
Gene Name lipocalin 2
Synonyms 24p3, neu-related lipocalin, NGAL, NRL
MMRRC Submission 045757-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7694 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 32274649-32277751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32278042 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 17 (C17R)
Ref Sequence ENSEMBL: ENSMUSP00000141430 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050785] [ENSMUST00000192241]
AlphaFold P11672
Predicted Effect probably benign
Transcript: ENSMUST00000050785
SMART Domains Protein: ENSMUSP00000053962
Gene: ENSMUSG00000026822

DomainStartEndE-ValueType
Pfam:Lipocalin 48 195 2.2e-27 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000192241
AA Change: C17R
SMART Domains Protein: ENSMUSP00000141430
Gene: ENSMUSG00000026822
AA Change: C17R

DomainStartEndE-ValueType
low complexity region 30 45 N/A INTRINSIC
Pfam:Lipocalin 134 271 5.3e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron and impaired thermogenesis. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afdn T G 17: 14,109,144 (GRCm39) S1571A probably damaging Het
Agbl1 C A 7: 76,348,513 (GRCm39) A870D unknown Het
Alpl C T 4: 137,471,120 (GRCm39) G339R probably damaging Het
Ankrd55 T C 13: 112,504,498 (GRCm39) Y415H probably damaging Het
Cd69 G A 6: 129,247,008 (GRCm39) R111C possibly damaging Het
Cdh26 A T 2: 178,101,896 (GRCm39) T172S probably damaging Het
Cflar T A 1: 58,791,966 (GRCm39) V423E Het
Cgrrf1 A C 14: 47,091,415 (GRCm39) Q313P possibly damaging Het
Chga G A 12: 102,527,606 (GRCm39) A87T probably benign Het
Chrna4 T A 2: 180,660,386 (GRCm39) D102V Het
Cpvl A T 6: 53,909,502 (GRCm39) Y211* probably null Het
Cyp26a1 G A 19: 37,689,512 (GRCm39) D403N possibly damaging Het
Dchs2 T C 3: 83,036,789 (GRCm39) L512P probably damaging Het
Dll3 A C 7: 28,001,170 (GRCm39) M1R probably null Het
Dnah12 A G 14: 26,503,337 (GRCm39) T1564A probably damaging Het
Efhb A G 17: 53,707,836 (GRCm39) S776P probably damaging Het
Eml5 T C 12: 98,758,822 (GRCm39) S1831G probably damaging Het
Fat1 G T 8: 45,441,967 (GRCm39) probably null Het
Fhad1 T C 4: 141,632,375 (GRCm39) K1255E probably benign Het
Fitm2 C T 2: 163,311,892 (GRCm39) C107Y probably damaging Het
Gdpd4 T C 7: 97,621,146 (GRCm39) V153A probably benign Het
Ggnbp2 A G 11: 84,751,539 (GRCm39) V87A possibly damaging Het
Glb1l G T 1: 75,178,436 (GRCm39) A334E probably damaging Het
Gnas T G 2: 174,142,005 (GRCm39) L784R probably damaging Het
Gtf2i C T 5: 134,311,659 (GRCm39) E223K probably damaging Het
H2-M10.5 T C 17: 37,084,641 (GRCm39) Y122H probably damaging Het
Hikeshi G A 7: 89,579,554 (GRCm39) Q6* probably null Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Irak2 A C 6: 113,667,859 (GRCm39) D528A probably damaging Het
Lcp2 G T 11: 34,000,924 (GRCm39) V36L probably benign Het
Lin7c T C 2: 109,726,617 (GRCm39) S89P probably benign Het
Lrrc37a C T 11: 103,395,204 (GRCm39) A74T probably benign Het
Lrrtm3 T A 10: 63,923,818 (GRCm39) M450L probably benign Het
Lsm11 C T 11: 45,824,768 (GRCm39) R253Q probably benign Het
Map9 A T 3: 82,266,290 (GRCm39) probably benign Het
Mmp2 T A 8: 93,558,358 (GRCm39) D142E possibly damaging Het
Nrn1l A T 8: 106,621,430 (GRCm39) T127S probably damaging Het
Or14c46 T C 7: 85,918,983 (GRCm39) T5A probably damaging Het
Pelp1 G A 11: 70,285,585 (GRCm39) T761I probably damaging Het
Pmm2 T A 16: 8,463,254 (GRCm39) V63E probably damaging Het
Ptprb T A 10: 116,208,853 (GRCm39) L1942H probably damaging Het
Ptprk T A 10: 28,465,366 (GRCm39) C1350S possibly damaging Het
Rnf44 A G 13: 54,829,841 (GRCm39) V381A probably damaging Het
Robo3 G A 9: 37,329,816 (GRCm39) P1167S probably benign Het
Ryk A G 9: 102,775,979 (GRCm39) E489G probably damaging Het
Satb2 T A 1: 56,910,683 (GRCm39) I321L probably benign Het
Sh2b1 A T 7: 126,066,929 (GRCm39) V655E probably benign Het
Slc16a12 G A 19: 34,648,035 (GRCm39) T486M probably damaging Het
Slc34a1 G T 13: 55,561,221 (GRCm39) R562L probably benign Het
Slc4a9 A G 18: 36,669,902 (GRCm39) E779G probably damaging Het
Strc C A 2: 121,207,577 (GRCm39) C598F probably damaging Het
Stxbp6 A T 12: 44,948,810 (GRCm39) F100I probably damaging Het
Tap2 A G 17: 34,424,671 (GRCm39) T135A probably benign Het
Tmcc1 G A 6: 116,110,805 (GRCm39) P159S Het
Tmem106b T A 6: 13,078,105 (GRCm39) M100K probably benign Het
Ttn T A 2: 76,578,039 (GRCm39) T24285S probably damaging Het
Vmn1r116 G A 7: 20,606,337 (GRCm39) V53M possibly damaging Het
Zar1 A T 5: 72,738,193 (GRCm39) S70T probably benign Het
Zfp235 C T 7: 23,841,525 (GRCm39) T648M probably benign Het
Zfp937 C T 2: 150,081,268 (GRCm39) H433Y probably damaging Het
Other mutations in Lcn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00935:Lcn2 APN 2 32,277,590 (GRCm39) critical splice donor site probably null
IGL01327:Lcn2 APN 2 32,276,030 (GRCm39) missense possibly damaging 0.62
IGL01913:Lcn2 APN 2 32,277,157 (GRCm39) missense possibly damaging 0.46
IGL02108:Lcn2 APN 2 32,277,617 (GRCm39) missense probably damaging 0.99
IGL02215:Lcn2 APN 2 32,274,877 (GRCm39) makesense probably null
IGL02577:Lcn2 APN 2 32,277,101 (GRCm39) missense probably damaging 0.97
IGL03129:Lcn2 APN 2 32,277,716 (GRCm39) missense possibly damaging 0.70
R0302:Lcn2 UTSW 2 32,274,901 (GRCm39) unclassified probably benign
R1864:Lcn2 UTSW 2 32,275,434 (GRCm39) missense possibly damaging 0.77
R1865:Lcn2 UTSW 2 32,275,434 (GRCm39) missense possibly damaging 0.77
R4093:Lcn2 UTSW 2 32,277,728 (GRCm39) start codon destroyed probably null 1.00
R4621:Lcn2 UTSW 2 32,274,655 (GRCm39) unclassified probably benign
R5236:Lcn2 UTSW 2 32,275,973 (GRCm39) missense probably benign 0.06
R5716:Lcn2 UTSW 2 32,275,825 (GRCm39) missense possibly damaging 0.88
R6785:Lcn2 UTSW 2 32,277,039 (GRCm39) critical splice donor site probably null
R7059:Lcn2 UTSW 2 32,277,608 (GRCm39) missense possibly damaging 0.85
R7514:Lcn2 UTSW 2 32,277,861 (GRCm39) critical splice donor site probably null
R7596:Lcn2 UTSW 2 32,275,721 (GRCm39) missense probably damaging 1.00
R7778:Lcn2 UTSW 2 32,277,927 (GRCm39) missense probably benign
R8913:Lcn2 UTSW 2 32,277,158 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- CGGGGTAGTCCATCCTTTAC -3'
(R):5'- TTCCCCAGACAAGGAAGCTG -3'

Sequencing Primer
(F):5'- GGGGTAGTCCATCCTTTACCAAGTC -3'
(R):5'- AAGCTGCACAGGGTCTGGTG -3'
Posted On 2019-11-12