Incidental Mutation 'R7695:Or4k48'
ID 593587
Institutional Source Beutler Lab
Gene Symbol Or4k48
Ensembl Gene ENSMUSG00000109487
Gene Name olfactory receptor family 4 subfamily K member 48
Synonyms Olfr1298, GA_x6K02T2Q125-72697413-72696475, MOR248-6
MMRRC Submission 045758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R7695 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111475402-111476340 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111475970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 124 (V124A)
Ref Sequence ENSEMBL: ENSMUSP00000146343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119566] [ENSMUST00000208284]
AlphaFold Q8VGE6
Predicted Effect probably damaging
Transcript: ENSMUST00000119566
AA Change: V124A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000208284
AA Change: V124A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb1 T C 15: 74,415,487 (GRCm39) V689A possibly damaging Het
Casp12 A G 9: 5,353,641 (GRCm39) E225G probably damaging Het
Ccdc39 A G 3: 33,868,668 (GRCm39) L806P probably damaging Het
Ccnd3 T A 17: 47,908,421 (GRCm39) I164N probably damaging Het
Cd209b A G 8: 3,976,005 (GRCm39) V52A probably benign Het
Celsr2 G A 3: 108,310,069 (GRCm39) R1554W probably damaging Het
Cnot1 A T 8: 96,497,260 (GRCm39) I239N probably benign Het
Csmd3 A T 15: 47,683,777 (GRCm39) V948D Het
Dnmt1 C A 9: 20,825,281 (GRCm39) G1061V probably null Het
Dpysl4 A G 7: 138,666,039 (GRCm39) M1V probably null Het
Elp5 T C 11: 69,860,327 (GRCm39) T227A probably benign Het
Exosc1 G A 19: 41,916,519 (GRCm39) H86Y possibly damaging Het
Foxn4 G T 5: 114,394,648 (GRCm39) D426E probably damaging Het
Gabbr2 A G 4: 46,875,687 (GRCm39) L145P probably damaging Het
Gkn3 A G 6: 87,361,422 (GRCm39) Y126H probably damaging Het
Gm16506 A G 14: 43,962,463 (GRCm39) F148S Het
Gm3558 A G 14: 19,121,623 (GRCm39) I76T probably benign Het
Gm49359 A G 13: 62,604,558 (GRCm39) F45S possibly damaging Het
Gpc5 A T 14: 115,330,026 (GRCm39) H63L unknown Het
H2bl1 T C 13: 99,120,766 (GRCm39) T87A probably damaging Het
Hbs1l A T 10: 21,175,116 (GRCm39) D28V possibly damaging Het
Ide G A 19: 37,306,435 (GRCm39) H113Y Het
Igkv3-3 A T 6: 70,664,295 (GRCm39) S46C probably damaging Het
Igsf10 A T 3: 59,233,612 (GRCm39) V1707D probably damaging Het
Kcna5 A T 6: 126,511,174 (GRCm39) V318E probably damaging Het
Kdm3b T C 18: 34,927,612 (GRCm39) F158S possibly damaging Het
Lrrc14b T A 13: 74,511,297 (GRCm39) D261V possibly damaging Het
Lrrc71 T A 3: 87,646,769 (GRCm39) I485F probably damaging Het
Map6 C T 7: 98,985,499 (GRCm39) L671F possibly damaging Het
Mast1 A G 8: 85,647,557 (GRCm39) V560A probably damaging Het
Mfap4 A T 11: 61,376,545 (GRCm39) probably null Het
Myh9 A G 15: 77,650,936 (GRCm39) I1637T probably benign Het
Neo1 A T 9: 58,810,212 (GRCm39) F1080I possibly damaging Het
Or1e17 T A 11: 73,831,720 (GRCm39) V216E possibly damaging Het
Or4x6 A G 2: 89,949,207 (GRCm39) V245A probably benign Het
Or51a25 T C 7: 102,372,866 (GRCm39) H277R probably benign Het
Pax2 A G 19: 44,821,638 (GRCm39) Y318C probably damaging Het
Pcnx4 A T 12: 72,588,350 (GRCm39) M53L probably benign Het
Pkd2l2 T A 18: 34,561,298 (GRCm39) D435E possibly damaging Het
Plec G A 15: 76,068,055 (GRCm39) Q1117* probably null Het
Ppp2r2c T C 5: 37,104,526 (GRCm39) L302P probably damaging Het
Prex2 T C 1: 11,232,497 (GRCm39) F855L probably benign Het
Reg3d A T 6: 78,354,119 (GRCm39) W103R probably benign Het
Rnf216 A C 5: 143,071,659 (GRCm39) H440Q possibly damaging Het
Scn2a A G 2: 65,542,251 (GRCm39) T785A probably damaging Het
Sh3pxd2a T A 19: 47,256,270 (GRCm39) Y844F probably damaging Het
Sp110 G A 1: 85,506,813 (GRCm39) R417C probably benign Het
Spp1 T C 5: 104,583,009 (GRCm39) probably benign Het
Tacc2 T A 7: 130,330,633 (GRCm39) S196T probably benign Het
Thrap3 G A 4: 126,073,891 (GRCm39) S285L probably damaging Het
Ttn T A 2: 76,666,305 (GRCm39) R11584* probably null Het
Ubap2 A G 4: 41,211,740 (GRCm39) S341P probably damaging Het
Upf3a T G 8: 13,848,279 (GRCm39) S358R probably benign Het
Zdbf2 T A 1: 63,346,529 (GRCm39) I1636N possibly damaging Het
Zfp946 C A 17: 22,674,002 (GRCm39) T252N probably benign Het
Other mutations in Or4k48
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01393:Or4k48 APN 2 111,475,601 (GRCm39) missense probably damaging 1.00
IGL01571:Or4k48 APN 2 111,475,725 (GRCm39) missense probably benign 0.00
IGL02605:Or4k48 APN 2 111,475,850 (GRCm39) missense probably benign 0.00
IGL02652:Or4k48 APN 2 111,475,839 (GRCm39) missense probably benign 0.16
IGL02669:Or4k48 APN 2 111,476,236 (GRCm39) nonsense probably null
R0197:Or4k48 UTSW 2 111,476,136 (GRCm39) missense probably benign 0.00
R0701:Or4k48 UTSW 2 111,476,136 (GRCm39) missense probably benign 0.00
R0883:Or4k48 UTSW 2 111,476,136 (GRCm39) missense probably benign 0.00
R1563:Or4k48 UTSW 2 111,476,027 (GRCm39) missense probably damaging 1.00
R1567:Or4k48 UTSW 2 111,476,271 (GRCm39) missense possibly damaging 0.92
R1740:Or4k48 UTSW 2 111,476,214 (GRCm39) missense probably damaging 0.97
R2142:Or4k48 UTSW 2 111,475,566 (GRCm39) missense probably benign 0.04
R3949:Or4k48 UTSW 2 111,475,871 (GRCm39) missense possibly damaging 0.67
R4766:Or4k48 UTSW 2 111,476,226 (GRCm39) missense probably benign
R4924:Or4k48 UTSW 2 111,476,121 (GRCm39) missense possibly damaging 0.87
R7320:Or4k48 UTSW 2 111,476,297 (GRCm39) missense probably benign 0.03
R7961:Or4k48 UTSW 2 111,476,282 (GRCm39) missense probably damaging 0.97
R8549:Or4k48 UTSW 2 111,479,512 (GRCm39) start gained probably benign
R8958:Or4k48 UTSW 2 111,476,070 (GRCm39) missense possibly damaging 0.93
R9444:Or4k48 UTSW 2 111,476,132 (GRCm39) missense probably damaging 1.00
R9744:Or4k48 UTSW 2 111,475,664 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-11-12