|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase 2, regulatory subunit B, gamma|
|Synonyms||6330548O06Rik, IMYPNO1, PR52|
|Is this an essential gene?||Possibly essential (E-score: 0.504)|
|Stock #||R7695 (G1)|
|Chromosomal Location||36868513-36955078 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 36947182 bp|
|Amino Acid Change||Leucine to Proline at position 302 (L302P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031003 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031003]|
|Predicted Effect||probably damaging
AA Change: L302P
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: L302P
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppp2r2c||
(F):5'- ACAGATGAATACAGCCAGCTCTG -3'
(R):5'- CAAAGGCTCTCTGCAGTTTCATC -3'
(F):5'- CCAGCTCTGGTTCTGACTGG -3'
(R):5'- GCAGTTTCATCTACACTGCAAC -3'