|Institutional Source||Beutler Lab|
|Gene Name||cysteine rich protein 61|
|Is this an essential gene?||Possibly non essential (E-score: 0.498)|
|Stock #||R7699 (G1)|
|Chromosomal Location||145646976-145649981 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 145648692 bp|
|Amino Acid Change||Glycine to Arginine at position 155 (G155R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000029846 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029846]|
|Predicted Effect||probably damaging
AA Change: G155R
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: G155R
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
PHENOTYPE: Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth. About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cyr61||
(F):5'- TCTATATCCACTTACCAGGAAGCC -3'
(R):5'- GCGGCGAATCTTAACCTTCTC -3'
(F):5'- TTACCAGGAAGCCTCTTCAGTGAG -3'
(R):5'- CGTCTTTGCAGCTCAGTCAGAAG -3'