Incidental Mutation 'R7701:Or2z9'
ID 594003
Institutional Source Beutler Lab
Gene Symbol Or2z9
Ensembl Gene ENSMUSG00000061561
Gene Name olfactory receptor family 2 subfamily Z member 9
Synonyms MOR282-1, GA_x6K02T2NUPS-231686-232630, Olfr373, MOR282-2
MMRRC Submission 045762-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.187) question?
Stock # R7701 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 72853606-72854550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 72854030 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 142 (L142Q)
Ref Sequence ENSEMBL: ENSMUSP00000149853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074540] [ENSMUST00000213940] [ENSMUST00000215198]
AlphaFold E9Q4J3
Predicted Effect probably damaging
Transcript: ENSMUST00000074540
AA Change: L142Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000074128
Gene: ENSMUSG00000061561
AA Change: L142Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 253 6.5e-8 PFAM
Pfam:7tm_1 41 290 4.9e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213940
AA Change: L142Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000215198
AA Change: L142Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.1526 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930470P17Rik T C 2: 170,443,225 (GRCm39) probably benign Het
4932414N04Rik G A 2: 68,561,548 (GRCm39) V292M possibly damaging Het
Actn1 A T 12: 80,221,328 (GRCm39) V575E possibly damaging Het
Arhgef1 T C 7: 24,612,003 (GRCm39) S129P probably benign Het
Aup1 T C 6: 83,032,908 (GRCm39) V214A probably benign Het
Bbs10 A G 10: 111,135,874 (GRCm39) E329G probably damaging Het
Brinp2 A G 1: 158,094,030 (GRCm39) probably null Het
Ccdc3 A G 2: 5,142,868 (GRCm39) T42A possibly damaging Het
Cd276 T C 9: 58,442,810 (GRCm39) N215S probably benign Het
Col24a1 T A 3: 145,020,772 (GRCm39) M381K probably benign Het
Col24a1 A G 3: 145,072,656 (GRCm39) probably null Het
Col6a4 A C 9: 105,960,087 (GRCm39) F19V probably benign Het
Crybg1 G T 10: 43,865,139 (GRCm39) A1446E probably benign Het
Dach1 C T 14: 98,140,670 (GRCm39) R496K probably damaging Het
Dchs2 A G 3: 83,253,513 (GRCm39) T2308A possibly damaging Het
Duxf1 A G 10: 58,058,885 (GRCm39) V623A possibly damaging Het
Dync1h1 G A 12: 110,585,080 (GRCm39) D828N probably damaging Het
Eif2a A T 3: 58,459,991 (GRCm39) H462L possibly damaging Het
Flot2 A G 11: 77,928,942 (GRCm39) probably null Het
Gas2 T G 7: 51,643,101 (GRCm39) Y263* probably null Het
Gm5111 A G 6: 48,567,027 (GRCm39) I81V unknown Het
Iqcm A G 8: 76,281,539 (GRCm39) I7M probably benign Het
Kank1 G A 19: 25,389,129 (GRCm39) probably null Het
Lnx2 A T 5: 146,961,333 (GRCm39) V533E probably damaging Het
Mapk8ip3 G T 17: 25,120,378 (GRCm39) P904T possibly damaging Het
Mcm5 C A 8: 75,850,551 (GRCm39) H596N probably benign Het
Miip A T 4: 147,947,371 (GRCm39) V237E probably null Het
Mob3a G A 10: 80,525,768 (GRCm39) A181V probably damaging Het
Mrpl38 G A 11: 116,026,104 (GRCm39) R99W probably benign Het
Naa25 A G 5: 121,564,042 (GRCm39) T486A probably benign Het
Or5b102 A G 19: 13,041,445 (GRCm39) I223M probably damaging Het
Or8g4 A G 9: 39,662,597 (GRCm39) Y305C probably benign Het
Pcdha8 A T 18: 37,126,864 (GRCm39) N449Y probably damaging Het
Pcdhb6 A T 18: 37,467,562 (GRCm39) D161V probably damaging Het
Pdlim3 A G 8: 46,361,576 (GRCm39) D134G probably benign Het
Phpt1 A G 2: 25,464,799 (GRCm39) V18A probably benign Het
Prg4 T C 1: 150,333,293 (GRCm39) K177E possibly damaging Het
Psmb1 A G 17: 15,697,509 (GRCm39) F202S probably benign Het
Rab14 A G 2: 35,073,427 (GRCm39) F150L Het
Rgs14 A G 13: 55,527,138 (GRCm39) D169G probably damaging Het
Rreb1 C T 13: 38,114,092 (GRCm39) L484F possibly damaging Het
Rsph14 A T 10: 74,793,608 (GRCm39) Y264* probably null Het
Scly T C 1: 91,236,030 (GRCm39) I152T Het
Ska1 A T 18: 74,335,714 (GRCm39) H85Q probably damaging Het
Slc35b3 T C 13: 39,128,611 (GRCm39) M159V probably benign Het
Smok2b A G 17: 13,453,767 (GRCm39) probably benign Het
Spock1 G A 13: 57,735,472 (GRCm39) Q103* probably null Het
Topbp1 T C 9: 103,210,184 (GRCm39) V914A probably damaging Het
Tspan3 A T 9: 56,054,803 (GRCm39) Y41* probably null Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Ttn T G 2: 76,560,028 (GRCm39) I29458L possibly damaging Het
Tubgcp3 A G 8: 12,705,974 (GRCm39) S183P probably benign Het
Zfat C A 15: 68,052,757 (GRCm39) E346* probably null Het
Zfp341 T A 2: 154,476,000 (GRCm39) probably null Het
Zfp54 A G 17: 21,654,357 (GRCm39) T284A probably benign Het
Other mutations in Or2z9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Or2z9 APN 8 72,854,356 (GRCm39) missense probably damaging 1.00
IGL02440:Or2z9 APN 8 72,854,374 (GRCm39) missense probably damaging 1.00
IGL03403:Or2z9 APN 8 72,854,341 (GRCm39) missense probably benign 0.00
R1099:Or2z9 UTSW 8 72,854,503 (GRCm39) missense probably benign 0.00
R1418:Or2z9 UTSW 8 72,854,231 (GRCm39) missense probably damaging 1.00
R1452:Or2z9 UTSW 8 72,854,020 (GRCm39) nonsense probably null
R1621:Or2z9 UTSW 8 72,853,973 (GRCm39) missense probably damaging 1.00
R2021:Or2z9 UTSW 8 72,853,930 (GRCm39) missense possibly damaging 0.90
R4230:Or2z9 UTSW 8 72,854,188 (GRCm39) missense probably damaging 1.00
R4290:Or2z9 UTSW 8 72,853,612 (GRCm39) missense probably benign
R5035:Or2z9 UTSW 8 72,853,922 (GRCm39) missense probably damaging 1.00
R6884:Or2z9 UTSW 8 72,854,345 (GRCm39) missense probably benign 0.26
R6909:Or2z9 UTSW 8 72,854,372 (GRCm39) missense possibly damaging 0.95
R7233:Or2z9 UTSW 8 72,853,900 (GRCm39) missense probably benign
R7304:Or2z9 UTSW 8 72,854,190 (GRCm39) nonsense probably null
R7312:Or2z9 UTSW 8 72,853,793 (GRCm39) missense probably damaging 1.00
R8789:Or2z9 UTSW 8 72,854,135 (GRCm39) missense probably damaging 1.00
Z1088:Or2z9 UTSW 8 72,854,361 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTACCATCCCCAAAGTGGTGG -3'
(R):5'- GTAGCAGTAAGATCAGCACCC -3'

Sequencing Primer
(F):5'- CCAAAGTGGTGGCTGAGTTCC -3'
(R):5'- GATCAGCACCCCAGAGATGG -3'
Posted On 2019-11-12