Mutagenetix > Incidental Mutation

Incidental Mutation 'R0032:Vmn2r57'

59405

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r57

Ensembl Gene

ENSMUSG00000066537

Gene Name

vomeronasal 2, receptor 57

Synonyms

EG269902

MMRRC Submission

038326-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R0032 (G1) of strain 731

Quality Score

173

Status

Validated

Chromosome

Chromosomal Location

41399732-41448641 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 41399733 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000125817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]

AlphaFold

L7N269

Predicted Effect

probably benign
Transcript: ENSMUST00000094532

Predicted Effect

probably null
Transcript: ENSMUST00000165029

SMART Domains

Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.4e-44	PFAM
Pfam:NCD3G	514	567	2.7e-23	PFAM
Pfam:7tm_3	600	835	1.8e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170929

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.4%
20x: 94.8%

Validation Efficiency

100% (89/89)

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss3	T	A	10: 107,123,295 (GRCm38)	T97S	probably benign	Het
Adcy1	T	C	11: 7,144,729 (GRCm38)	S552P	possibly damaging	Het
Arrb1	T	C	7: 99,582,265 (GRCm38)	F9L	probably damaging	Het
Auts2	G	C	5: 131,440,093 (GRCm38)	D571E	probably damaging	Het
C2cd3	T	A	7: 100,444,445 (GRCm38)		probably benign	Het
Ccbe1	T	G	18: 66,291,652 (GRCm38)	T35P	possibly damaging	Het
Cct6b	G	T	11: 82,753,643 (GRCm38)	T202K	possibly damaging	Het
Cd86	A	T	16: 36,620,873 (GRCm38)	S77R	probably damaging	Het
Cdk5rap3	A	T	11: 96,908,753 (GRCm38)	L412Q	possibly damaging	Het
Cdsn	G	A	17: 35,555,555 (GRCm38)	G327D	probably damaging	Het
Cfap54	C	T	10: 92,932,697 (GRCm38)	R188H	probably benign	Het
Clca3a2	T	A	3: 144,816,733 (GRCm38)	I176F	probably benign	Het
Cop1	T	C	1: 159,325,036 (GRCm38)		probably null	Het
Cpne8	T	A	15: 90,569,568 (GRCm38)		probably benign	Het
Ctsg	T	A	14: 56,101,739 (GRCm38)	I21F	probably damaging	Het
Cyp2j9	T	G	4: 96,568,806 (GRCm38)	N476T	possibly damaging	Het
Dcaf4	G	A	12: 83,535,988 (GRCm38)		probably benign	Het
Dennd4c	T	C	4: 86,828,150 (GRCm38)		probably null	Het
Des	A	G	1: 75,362,166 (GRCm38)	E195G	possibly damaging	Het
Dicer1	A	T	12: 104,704,798 (GRCm38)	L995*	probably null	Het
Dnah10	A	G	5: 124,800,891 (GRCm38)	K2623R	possibly damaging	Het
Dnajc21	G	T	15: 10,461,877 (GRCm38)	T146K	probably benign	Het
Dnmbp	A	C	19: 43,902,719 (GRCm38)	L203R	probably damaging	Het
Eif4g1	C	T	16: 20,685,898 (GRCm38)	S829F	probably damaging	Het
Enkur	T	C	2: 21,189,304 (GRCm38)	I153V	probably benign	Het
Epb41l3	G	T	17: 69,210,384 (GRCm38)		probably null	Het
Erf	T	C	7: 25,245,075 (GRCm38)	Y277C	possibly damaging	Het
Fstl5	T	A	3: 76,648,435 (GRCm38)		probably benign	Het
Fuk	G	A	8: 110,892,103 (GRCm38)	T341M	possibly damaging	Het
Galnt16	T	C	12: 80,592,469 (GRCm38)	V419A	probably damaging	Het
Gm10226	A	G	17: 21,692,056 (GRCm38)	D66G	possibly damaging	Het
Gm15821	T	A	17: 34,212,225 (GRCm38)		probably benign	Het
Grm3	A	G	5: 9,511,452 (GRCm38)		probably null	Het
Il11ra1	A	G	4: 41,768,187 (GRCm38)	E366G	probably damaging	Het
Impdh2	A	G	9: 108,561,661 (GRCm38)	D71G	probably damaging	Het
Ipo11	A	C	13: 106,834,463 (GRCm38)		probably benign	Het
Ipo8	A	G	6: 148,810,711 (GRCm38)	C261R	probably damaging	Het
Iqsec3	T	C	6: 121,473,130 (GRCm38)	D145G	possibly damaging	Het
Itga11	T	C	9: 62,774,095 (GRCm38)	F998L	probably benign	Het
Junb	T	C	8: 84,977,786 (GRCm38)	H215R	probably benign	Het
Kcnh4	C	T	11: 100,746,932 (GRCm38)	G633E	probably benign	Het
Kcnn3	CGCAGCAGCAGCAGCAGCAGCAG	CGCAGCAGCAGCAGCAGCAG	3: 89,520,665 (GRCm38)		probably benign	Het
Krt73	T	C	15: 101,794,052 (GRCm38)	S459G	probably benign	Het
Krt74	T	A	15: 101,761,452 (GRCm38)		noncoding transcript	Het
Meis3	C	A	7: 16,182,285 (GRCm38)		probably benign	Het
Mlh3	A	G	12: 85,245,749 (GRCm38)		probably benign	Het
Mroh2a	GT	GTT	1: 88,256,166 (GRCm38)		probably null	Het
Naip6	C	T	13: 100,303,237 (GRCm38)	E341K	probably benign	Het
Nbeal2	G	T	9: 110,637,868 (GRCm38)		probably benign	Het
Nfx1	T	A	4: 41,015,321 (GRCm38)	V842E	probably benign	Het
Olfr118	T	A	17: 37,672,487 (GRCm38)	W155R	probably damaging	Het
Olfr800	T	A	10: 129,660,400 (GRCm38)	V198D	probably benign	Het
Olfr891	A	G	9: 38,180,608 (GRCm38)	C72R	probably damaging	Het
Oma1	T	A	4: 103,366,012 (GRCm38)	S465T	possibly damaging	Het
Opa1	A	T	16: 29,615,069 (GRCm38)	H574L	probably damaging	Het
Otog	G	A	7: 46,304,231 (GRCm38)	V2638M	probably damaging	Het
Otog	T	A	7: 46,288,213 (GRCm38)	L1782*	probably null	Het
Pcsk5	T	C	19: 17,564,815 (GRCm38)	N804S	possibly damaging	Het
Pde4a	C	A	9: 21,201,432 (GRCm38)		probably benign	Het
Pilra	T	A	5: 137,831,265 (GRCm38)	D179V	probably damaging	Het
Piwil1	G	A	5: 128,743,280 (GRCm38)	S247N	probably benign	Het
Ppp2r1a	G	A	17: 20,945,584 (GRCm38)		probably benign	Het
Prss58	T	G	6: 40,895,699 (GRCm38)	T158P	probably benign	Het
Setmar	T	A	6: 108,076,416 (GRCm38)	C290*	probably null	Het
Slc35e3	T	C	10: 117,744,932 (GRCm38)	M156V	probably benign	Het
Slc4a5	T	A	6: 83,273,157 (GRCm38)	I509N	probably damaging	Het
Slit2	G	A	5: 48,256,856 (GRCm38)	R938Q	probably damaging	Het
Snrpn	A	G	7: 59,985,082 (GRCm38)	Y168H	probably damaging	Het
Sycn	C	T	7: 28,541,292 (GRCm38)	A128V	possibly damaging	Het
Synm	C	A	7: 67,733,927 (GRCm38)	R1329M	possibly damaging	Het
Syt8	T	C	7: 142,439,189 (GRCm38)	V152A	probably benign	Het
Tcp10a	T	C	17: 7,336,907 (GRCm38)	M247T	probably benign	Het
Tjp2	A	G	19: 24,108,695 (GRCm38)	L821S	probably damaging	Het
Tppp2	G	T	14: 51,919,409 (GRCm38)	R81L	possibly damaging	Het
Trim34b	A	G	7: 104,336,577 (GRCm38)	D473G	possibly damaging	Het
Trpc3	A	G	3: 36,644,256 (GRCm38)	I618T	probably damaging	Het
Trpm5	A	T	7: 143,085,241 (GRCm38)	D264E	probably damaging	Het
Tuba8	A	T	6: 121,225,904 (GRCm38)	D392V	probably benign	Het
Vmn1r50	C	A	6: 90,107,800 (GRCm38)	P176T	probably damaging	Het
Vmn1r76	T	C	7: 11,931,267 (GRCm38)	I7V	probably benign	Het
Vmn2r26	T	A	6: 124,039,899 (GRCm38)	W441R	possibly damaging	Het
Zc3h4	T	A	7: 16,434,640 (GRCm38)	D891E	unknown	Het
Zfp120	A	T	2: 150,117,592 (GRCm38)	V270E	possibly damaging	Het
Znhit1	G	C	5: 136,985,047 (GRCm38)	R8G	possibly damaging	Het

Other mutations in Vmn2r57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Vmn2r57	APN	7	41,428,785 (GRCm38)	missense	probably benign
IGL01108:Vmn2r57	APN	7	41,427,584 (GRCm38)	missense	probably benign	0.01
IGL01112:Vmn2r57	APN	7	41,425,043 (GRCm38)	missense	probably damaging	1.00
IGL01516:Vmn2r57	APN	7	41,399,946 (GRCm38)	missense	probably damaging	1.00
IGL01880:Vmn2r57	APN	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
IGL02117:Vmn2r57	APN	7	41,400,450 (GRCm38)	missense	probably benign	0.00
IGL02500:Vmn2r57	APN	7	41,428,226 (GRCm38)	missense	probably benign
IGL02801:Vmn2r57	APN	7	41,448,632 (GRCm38)	missense	probably benign	0.13
IGL02993:Vmn2r57	APN	7	41,428,074 (GRCm38)	missense	probably benign	0.04
IGL02996:Vmn2r57	APN	7	41,399,741 (GRCm38)	missense	probably benign	0.02
R0008:Vmn2r57	UTSW	7	41,400,652 (GRCm38)	missense	probably damaging	1.00
R0305:Vmn2r57	UTSW	7	41,427,543 (GRCm38)	missense	probably benign	0.00
R0469:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0510:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0847:Vmn2r57	UTSW	7	41,428,801 (GRCm38)	missense	probably benign	0.00
R1025:Vmn2r57	UTSW	7	41,427,804 (GRCm38)	missense	probably benign	0.24
R1081:Vmn2r57	UTSW	7	41,428,211 (GRCm38)	missense	possibly damaging	0.47
R1479:Vmn2r57	UTSW	7	41,427,830 (GRCm38)	missense	possibly damaging	0.45
R1579:Vmn2r57	UTSW	7	41,400,124 (GRCm38)	missense	probably benign	0.38
R1764:Vmn2r57	UTSW	7	41,400,643 (GRCm38)	missense	probably damaging	1.00
R1848:Vmn2r57	UTSW	7	41,428,107 (GRCm38)	missense	probably damaging	1.00
R2006:Vmn2r57	UTSW	7	41,448,577 (GRCm38)	missense	probably benign	0.00
R2197:Vmn2r57	UTSW	7	41,428,825 (GRCm38)	critical splice acceptor site	probably null
R2242:Vmn2r57	UTSW	7	41,428,074 (GRCm38)	missense	probably benign	0.00
R2394:Vmn2r57	UTSW	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
R3937:Vmn2r57	UTSW	7	41,428,130 (GRCm38)	missense	probably damaging	0.97
R4193:Vmn2r57	UTSW	7	41,428,239 (GRCm38)	missense	probably benign
R4423:Vmn2r57	UTSW	7	41,426,640 (GRCm38)	missense	probably damaging	1.00
R4865:Vmn2r57	UTSW	7	41,400,468 (GRCm38)	missense	probably damaging	1.00
R4947:Vmn2r57	UTSW	7	41,400,495 (GRCm38)	missense	probably damaging	1.00
R5042:Vmn2r57	UTSW	7	41,428,662 (GRCm38)	missense	probably benign	0.06
R5084:Vmn2r57	UTSW	7	41,426,550 (GRCm38)	critical splice donor site	probably null
R5177:Vmn2r57	UTSW	7	41,400,240 (GRCm38)	missense	probably benign	0.31
R5192:Vmn2r57	UTSW	7	41,427,939 (GRCm38)	missense	probably damaging	0.96
R5289:Vmn2r57	UTSW	7	41,399,974 (GRCm38)	missense	probably damaging	0.99
R5745:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R6051:Vmn2r57	UTSW	7	41,448,472 (GRCm38)	missense	probably benign	0.00
R6155:Vmn2r57	UTSW	7	41,428,690 (GRCm38)	missense	probably benign	0.14
R6248:Vmn2r57	UTSW	7	41,399,860 (GRCm38)	missense	probably benign
R6381:Vmn2r57	UTSW	7	41,428,818 (GRCm38)	missense	probably benign	0.08
R7019:Vmn2r57	UTSW	7	41,428,665 (GRCm38)	missense	probably damaging	1.00
R7126:Vmn2r57	UTSW	7	41,399,794 (GRCm38)	missense	possibly damaging	0.93
R7146:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R7215:Vmn2r57	UTSW	7	41,400,286 (GRCm38)	missense	probably benign	0.00
R7432:Vmn2r57	UTSW	7	41,426,724 (GRCm38)	missense	probably benign	0.01
R7633:Vmn2r57	UTSW	7	41,425,089 (GRCm38)	missense	possibly damaging	0.76
R7811:Vmn2r57	UTSW	7	41,425,015 (GRCm38)	nonsense	probably null
R8025:Vmn2r57	UTSW	7	41,426,759 (GRCm38)	missense	probably benign	0.00
R8332:Vmn2r57	UTSW	7	41,400,253 (GRCm38)	missense	probably benign	0.01
R8345:Vmn2r57	UTSW	7	41,427,544 (GRCm38)	missense	possibly damaging	0.81
R8360:Vmn2r57	UTSW	7	41,400,216 (GRCm38)	missense	probably damaging	1.00
R8738:Vmn2r57	UTSW	7	41,427,596 (GRCm38)	missense	probably benign	0.00
R8758:Vmn2r57	UTSW	7	41,428,739 (GRCm38)	missense	probably damaging	1.00
R8955:Vmn2r57	UTSW	7	41,400,147 (GRCm38)	missense	possibly damaging	0.64
R8985:Vmn2r57	UTSW	7	41,399,835 (GRCm38)	missense	probably benign
R9108:Vmn2r57	UTSW	7	41,428,768 (GRCm38)	missense	possibly damaging	0.87
R9160:Vmn2r57	UTSW	7	41,426,735 (GRCm38)	missense	possibly damaging	0.48
R9354:Vmn2r57	UTSW	7	41,400,239 (GRCm38)	missense	probably benign	0.01
R9566:Vmn2r57	UTSW	7	41,427,665 (GRCm38)	missense	probably benign	0.32
R9633:Vmn2r57	UTSW	7	41,426,582 (GRCm38)	missense	probably benign	0.00
X0026:Vmn2r57	UTSW	7	41,428,561 (GRCm38)	missense	possibly damaging	0.91
X0026:Vmn2r57	UTSW	7	41,428,125 (GRCm38)	missense	probably benign	0.03
X0065:Vmn2r57	UTSW	7	41,427,971 (GRCm38)	missense	probably benign	0.09
Z1176:Vmn2r57	UTSW	7	41,400,498 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGTTACATAAAGGGGATGCTTGGGGAA -3'
(R):5'- GGGAAGGTCATGGTGGCTATGGA -3'

Sequencing Primer
(F):5'- agaggagggagggtggg -3'
(R):5'- TGGCTATGGAAGTCTTCTCTATC -3'

Posted On

2013-07-11