Incidental Mutation 'R7703:Pcdhgb7'
ID 594156
Institutional Source Beutler Lab
Gene Symbol Pcdhgb7
Ensembl Gene ENSMUSG00000104063
Gene Name protocadherin gamma subfamily B, 7
Synonyms
MMRRC Submission 045764-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R7703 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 37884672-37974923 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37885321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 164 (M164L)
Ref Sequence ENSEMBL: ENSMUSP00000141997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003599] [ENSMUST00000061279] [ENSMUST00000066149] [ENSMUST00000073447] [ENSMUST00000091935] [ENSMUST00000115661] [ENSMUST00000194928] [ENSMUST00000192511] [ENSMUST00000192535] [ENSMUST00000192931] [ENSMUST00000193404] [ENSMUST00000193414] [ENSMUST00000193869] [ENSMUST00000194190] [ENSMUST00000194418] [ENSMUST00000194544] [ENSMUST00000195112] [ENSMUST00000195363] [ENSMUST00000195823]
AlphaFold Q91XX3
Predicted Effect probably benign
Transcript: ENSMUST00000003599
SMART Domains Protein: ENSMUSP00000003599
Gene: ENSMUSG00000103088

DomainStartEndE-ValueType
CA 47 131 8.06e-6 SMART
CA 155 240 2.29e-19 SMART
CA 264 345 3.36e-26 SMART
CA 369 450 4.94e-24 SMART
CA 474 560 7.6e-25 SMART
CA 591 672 9.18e-10 SMART
Pfam:Cadherin_C_2 687 768 3.5e-20 PFAM
Pfam:Cadherin_tail 807 930 8.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000061279
SMART Domains Protein: ENSMUSP00000058362
Gene: ENSMUSG00000102742

DomainStartEndE-ValueType
CA 45 131 3.23e-2 SMART
CA 155 240 2.22e-17 SMART
CA 264 345 3.36e-26 SMART
CA 369 450 7.09e-25 SMART
CA 474 560 3.55e-25 SMART
CA 591 669 2.53e-12 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 914 933 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000066149
SMART Domains Protein: ENSMUSP00000067728
Gene: ENSMUSG00000103897

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
CA 31 131 4.84e-2 SMART
CA 155 240 1.48e-22 SMART
CA 264 345 1.14e-23 SMART
CA 369 450 9.44e-21 SMART
CA 474 560 1.03e-26 SMART
CA 591 669 3.64e-13 SMART
Pfam:Cadherin_C_2 688 772 3e-25 PFAM
Pfam:Cadherin_tail 809 932 8.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000073447
SMART Domains Protein: ENSMUSP00000073150
Gene: ENSMUSG00000104346

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 42 128 2.15e-2 SMART
CA 152 237 4.8e-13 SMART
CA 261 342 9.36e-25 SMART
CA 366 447 6.62e-25 SMART
CA 471 557 6.72e-26 SMART
CA 588 666 2.15e-15 SMART
Pfam:Cadherin_C_2 685 768 4.8e-24 PFAM
Pfam:Cadherin_tail 805 928 8.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091935
SMART Domains Protein: ENSMUSP00000089555
Gene: ENSMUSG00000102440

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
CA 32 132 8.37e-3 SMART
CA 156 241 5.51e-22 SMART
CA 265 346 8.27e-26 SMART
CA 370 451 1.4e-23 SMART
CA 475 561 2.97e-27 SMART
CA 592 670 1.18e-12 SMART
Pfam:Cadherin_C_2 688 772 3.9e-24 PFAM
Pfam:Cadherin_tail 809 932 8.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115661
SMART Domains Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458

DomainStartEndE-ValueType
CA 20 131 5.3e-2 SMART
CA 155 240 1.51e-19 SMART
CA 264 348 7.6e-25 SMART
CA 372 453 1.42e-24 SMART
CA 477 563 1.42e-24 SMART
CA 594 674 4.12e-12 SMART
low complexity region 706 721 N/A INTRINSIC
Pfam:Cadherin_tail 796 930 3.9e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000194928
AA Change: M164L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000141997
Gene: ENSMUSG00000104063
AA Change: M164L

DomainStartEndE-ValueType
CA 47 131 2.48e-6 SMART
CA 155 240 1.57e-17 SMART
CA 264 343 1.29e-27 SMART
CA 367 448 9.14e-28 SMART
CA 472 558 1.24e-24 SMART
CA 589 670 3.73e-10 SMART
transmembrane domain 689 711 N/A INTRINSIC
low complexity region 716 721 N/A INTRINSIC
low complexity region 910 929 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192511
SMART Domains Protein: ENSMUSP00000141704
Gene: ENSMUSG00000103472

DomainStartEndE-ValueType
CA 47 133 1.57e-2 SMART
CA 157 242 3.24e-19 SMART
CA 266 347 3.21e-23 SMART
CA 371 452 9.08e-23 SMART
CA 476 562 1.32e-24 SMART
CA 593 671 3.5e-15 SMART
transmembrane domain 694 716 N/A INTRINSIC
low complexity region 916 935 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192535
SMART Domains Protein: ENSMUSP00000142010
Gene: ENSMUSG00000103749

DomainStartEndE-ValueType
low complexity region 17 25 N/A INTRINSIC
CA 56 131 8e-3 SMART
CA 155 240 2.49e-20 SMART
CA 264 341 4.97e-29 SMART
CA 365 446 1.09e-25 SMART
CA 470 556 1.75e-24 SMART
CA 587 668 9.18e-10 SMART
transmembrane domain 687 709 N/A INTRINSIC
low complexity region 907 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192931
SMART Domains Protein: ENSMUSP00000141348
Gene: ENSMUSG00000103037

DomainStartEndE-ValueType
CA 36 119 8e-3 SMART
CA 143 228 1.34e-20 SMART
CA 252 333 1.52e-24 SMART
CA 357 438 9.22e-24 SMART
CA 462 548 1.24e-24 SMART
CA 579 660 1.3e-9 SMART
transmembrane domain 679 701 N/A INTRINSIC
low complexity region 899 918 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193404
SMART Domains Protein: ENSMUSP00000141359
Gene: ENSMUSG00000102222

DomainStartEndE-ValueType
CA 43 129 2.76e-2 SMART
CA 153 238 1.16e-20 SMART
CA 262 343 1.25e-25 SMART
CA 367 448 4.75e-26 SMART
CA 472 558 3.69e-23 SMART
CA 589 667 3.84e-12 SMART
transmembrane domain 690 712 N/A INTRINSIC
low complexity region 911 930 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193414
SMART Domains Protein: ENSMUSP00000141893
Gene: ENSMUSG00000103567

DomainStartEndE-ValueType
CA 45 131 2.45e-1 SMART
CA 155 240 1.05e-18 SMART
CA 264 345 6.52e-24 SMART
CA 369 450 5.99e-23 SMART
CA 474 560 6.99e-24 SMART
CA 591 669 5.31e-15 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 913 932 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193869
SMART Domains Protein: ENSMUSP00000141482
Gene: ENSMUSG00000103332

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
CA 45 131 1.64e-2 SMART
CA 155 240 6.42e-23 SMART
CA 264 345 1.76e-20 SMART
CA 369 450 2.27e-23 SMART
CA 474 560 1.5e-23 SMART
CA 591 669 1.17e-16 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 912 931 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193984
Predicted Effect probably benign
Transcript: ENSMUST00000194190
SMART Domains Protein: ENSMUSP00000142062
Gene: ENSMUSG00000103144

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
CA 31 131 3.16e-2 SMART
CA 155 240 5.39e-16 SMART
CA 264 345 6.72e-26 SMART
CA 369 450 1.32e-24 SMART
CA 474 560 4.17e-22 SMART
CA 591 669 4.48e-13 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 912 931 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194418
SMART Domains Protein: ENSMUSP00000142140
Gene: ENSMUSG00000103677

DomainStartEndE-ValueType
CA 44 130 1.64e-2 SMART
CA 154 239 3.93e-18 SMART
CA 263 344 5.22e-23 SMART
CA 368 449 5.02e-25 SMART
CA 473 559 2.07e-26 SMART
CA 590 668 6.84e-18 SMART
transmembrane domain 690 712 N/A INTRINSIC
low complexity region 911 930 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194544
SMART Domains Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836

DomainStartEndE-ValueType
Blast:CA 18 66 5e-20 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000195112
SMART Domains Protein: ENSMUSP00000141449
Gene: ENSMUSG00000102748

DomainStartEndE-ValueType
CA 24 130 8.18e-3 SMART
CA 154 239 1.39e-18 SMART
CA 263 344 7.91e-23 SMART
CA 368 449 2.27e-23 SMART
CA 473 559 1.24e-24 SMART
CA 590 671 1.3e-9 SMART
transmembrane domain 690 712 N/A INTRINSIC
low complexity region 909 928 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195363
SMART Domains Protein: ENSMUSP00000142227
Gene: ENSMUSG00000103585

DomainStartEndE-ValueType
low complexity region 17 25 N/A INTRINSIC
CA 56 131 1.47e-2 SMART
CA 155 240 1.23e-19 SMART
CA 264 343 5.54e-27 SMART
CA 367 448 5.09e-26 SMART
CA 472 558 1.98e-23 SMART
CA 589 670 1.3e-9 SMART
transmembrane domain 689 711 N/A INTRINSIC
low complexity region 893 912 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195823
SMART Domains Protein: ENSMUSP00000141803
Gene: ENSMUSG00000103793

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
CA 45 131 2.41e-2 SMART
CA 155 240 5.77e-16 SMART
CA 264 345 1.1e-21 SMART
CA 369 450 2.75e-22 SMART
low complexity region 453 462 N/A INTRINSIC
CA 474 560 9.22e-24 SMART
CA 591 669 2.4e-13 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 913 932 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810065E05Rik T C 11: 58,316,593 (GRCm39) I191T probably damaging Het
2310003L06Rik T C 5: 88,120,671 (GRCm39) L476P possibly damaging Het
Aasdh T C 5: 77,035,924 (GRCm39) D387G probably damaging Het
Ahsa2 T A 11: 23,440,415 (GRCm39) T327S probably benign Het
Ap3d1 A T 10: 80,553,678 (GRCm39) V523E probably damaging Het
Baz2b C A 2: 59,747,769 (GRCm39) R1298L probably damaging Het
Cacna2d3 T C 14: 28,765,503 (GRCm39) T802A possibly damaging Het
Cdh23 G T 10: 60,173,043 (GRCm39) T1714K probably damaging Het
Chrna3 A T 9: 54,923,408 (GRCm39) D133E probably benign Het
Cnot1 C T 8: 96,486,726 (GRCm39) probably null Het
Col16a1 A T 4: 129,990,295 (GRCm39) N1396Y unknown Het
Cox11 A G 11: 90,529,245 (GRCm39) N77S probably benign Het
Ctsf T G 19: 4,906,567 (GRCm39) F165V probably damaging Het
Cytip A G 2: 58,037,920 (GRCm39) V148A probably damaging Het
Diaph1 T C 18: 38,023,862 (GRCm39) I659V unknown Het
Dmxl2 A T 9: 54,368,370 (GRCm39) M26K probably benign Het
Erp44 T A 4: 48,196,904 (GRCm39) I340F probably benign Het
Fam186a A G 15: 99,852,678 (GRCm39) M180T unknown Het
Frem2 C T 3: 53,429,589 (GRCm39) V2793I probably benign Het
Gm19410 A G 8: 36,266,539 (GRCm39) E1064G probably damaging Het
Gria4 T C 9: 4,503,588 (GRCm39) I343V probably benign Het
Grsf1 T A 5: 88,819,150 (GRCm39) N228Y probably damaging Het
H3c13 C A 3: 96,176,309 (GRCm39) Y100* probably null Het
Ighv1-18 A T 12: 114,646,381 (GRCm39) N74K probably benign Het
Kcnh6 A T 11: 105,914,703 (GRCm39) T703S probably benign Het
Lrp1b T A 2: 41,000,798 (GRCm39) D2256V Het
Lrrc63 T C 14: 75,360,447 (GRCm39) T352A possibly damaging Het
Lztfl1 T C 9: 123,531,194 (GRCm39) E258G probably damaging Het
Mcph1 T C 8: 18,721,122 (GRCm39) I650T possibly damaging Het
Mep1a T C 17: 43,788,997 (GRCm39) D606G possibly damaging Het
Muc16 T C 9: 18,516,578 (GRCm39) I313M Het
Myh7b A G 2: 155,462,356 (GRCm39) Y353C probably null Het
Nfatc1 A G 18: 80,725,504 (GRCm39) L420P probably damaging Het
Olfml1 A G 7: 107,170,392 (GRCm39) E93G probably damaging Het
Or6b1 A T 6: 42,814,938 (GRCm39) E41V probably damaging Het
Or8c11 A G 9: 38,289,357 (GRCm39) H54R probably benign Het
Pax1 A T 2: 147,208,034 (GRCm39) N214I probably damaging Het
Pcdhb17 C A 18: 37,619,801 (GRCm39) H530Q probably benign Het
Pcolce T C 5: 137,603,474 (GRCm39) N453S probably benign Het
Prr36 T C 8: 4,262,982 (GRCm39) T895A probably benign Het
Ptprq C T 10: 107,480,007 (GRCm39) V1088I probably benign Het
Rab5a T A 17: 53,807,485 (GRCm39) F174I probably damaging Het
Rapgef4 A G 2: 72,010,315 (GRCm39) D291G probably benign Het
Rbm25 A T 12: 83,721,864 (GRCm39) K683N possibly damaging Het
Rbpj T C 5: 53,803,240 (GRCm39) I156T probably damaging Het
Rgsl1 A G 1: 153,669,610 (GRCm39) S259P possibly damaging Het
Ring1 T C 17: 34,242,109 (GRCm39) D100G probably damaging Het
Ryr3 A T 2: 112,690,110 (GRCm39) D1166E probably damaging Het
Sacs A G 14: 61,443,539 (GRCm39) K1862E possibly damaging Het
Scamp5 A G 9: 57,354,465 (GRCm39) I63T possibly damaging Het
Septin14 C T 5: 129,763,092 (GRCm39) A334T possibly damaging Het
Sh3rf2 A T 18: 42,289,201 (GRCm39) Q706L probably benign Het
Skap2 A T 6: 51,884,934 (GRCm39) H242Q probably benign Het
Spmap2l T C 5: 77,164,444 (GRCm39) I149T probably benign Het
Tfpt A G 7: 3,623,744 (GRCm39) probably null Het
Thg1l T G 11: 45,846,120 (GRCm39) D58A probably damaging Het
Thyn1 A G 9: 26,918,143 (GRCm39) E177G probably benign Het
Tmem151b C T 17: 45,856,724 (GRCm39) A239T probably damaging Het
Ttc21a T C 9: 119,788,095 (GRCm39) V840A probably benign Het
Usp32 A T 11: 84,968,153 (GRCm39) V170E probably damaging Het
Vmn2r29 A G 7: 7,234,864 (GRCm39) V674A probably benign Het
Vwa8 A G 14: 79,263,513 (GRCm39) N781S probably damaging Het
Zbtb7c C A 18: 76,270,433 (GRCm39) Q174K probably benign Het
Zeb1 T C 18: 5,766,917 (GRCm39) I476T probably benign Het
Zfp91 A T 19: 12,754,241 (GRCm39) D282E probably benign Het
Other mutations in Pcdhgb7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03134:Pcdhgb7 UTSW 18 37,884,935 (GRCm39) missense probably damaging 1.00
R3820:Pcdhgb7 UTSW 18 37,885,286 (GRCm39) missense possibly damaging 0.79
R3821:Pcdhgb7 UTSW 18 37,885,286 (GRCm39) missense possibly damaging 0.79
R4014:Pcdhgb7 UTSW 18 37,885,416 (GRCm39) missense probably benign 0.01
R4223:Pcdhgb7 UTSW 18 37,886,856 (GRCm39) missense probably benign 0.06
R4224:Pcdhgb7 UTSW 18 37,886,856 (GRCm39) missense probably benign 0.06
R4225:Pcdhgb7 UTSW 18 37,886,856 (GRCm39) missense probably benign 0.06
R4366:Pcdhgb7 UTSW 18 37,887,125 (GRCm39) missense possibly damaging 0.62
R4622:Pcdhgb7 UTSW 18 37,886,183 (GRCm39) missense probably benign 0.00
R5117:Pcdhgb7 UTSW 18 37,885,939 (GRCm39) missense probably damaging 0.99
R5226:Pcdhgb7 UTSW 18 37,885,577 (GRCm39) missense probably benign 0.32
R5253:Pcdhgb7 UTSW 18 37,886,150 (GRCm39) missense possibly damaging 0.82
R5317:Pcdhgb7 UTSW 18 37,885,887 (GRCm39) missense probably benign 0.01
R6183:Pcdhgb7 UTSW 18 37,885,315 (GRCm39) missense probably damaging 0.97
R6497:Pcdhgb7 UTSW 18 37,886,906 (GRCm39) missense probably damaging 1.00
R6590:Pcdhgb7 UTSW 18 37,886,050 (GRCm39) missense probably benign 0.00
R6690:Pcdhgb7 UTSW 18 37,886,050 (GRCm39) missense probably benign 0.00
R7022:Pcdhgb7 UTSW 18 37,886,086 (GRCm39) missense probably damaging 0.98
R8473:Pcdhgb7 UTSW 18 37,886,852 (GRCm39) missense probably benign 0.00
R8859:Pcdhgb7 UTSW 18 37,886,349 (GRCm39) missense possibly damaging 0.69
R8873:Pcdhgb7 UTSW 18 37,886,575 (GRCm39) missense possibly damaging 0.90
R8970:Pcdhgb7 UTSW 18 37,885,631 (GRCm39) missense probably benign 0.00
R8995:Pcdhgb7 UTSW 18 37,885,230 (GRCm39) missense probably damaging 1.00
R9280:Pcdhgb7 UTSW 18 37,886,585 (GRCm39) missense probably damaging 1.00
R9370:Pcdhgb7 UTSW 18 37,884,937 (GRCm39) missense possibly damaging 0.93
R9439:Pcdhgb7 UTSW 18 37,884,917 (GRCm39) missense probably benign 0.06
R9523:Pcdhgb7 UTSW 18 37,886,636 (GRCm39) missense probably damaging 1.00
R9803:Pcdhgb7 UTSW 18 37,885,088 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTGGAAGCTGTGCTAGAAAAC -3'
(R):5'- CGGTTATCATTGGCGTCCAC -3'

Sequencing Primer
(F):5'- GATCACGCTCCTCAATTTC -3'
(R):5'- TTCGGAGCTGAGTAGTACCAGTAC -3'
Posted On 2019-11-12