Incidental Mutation 'R7709:Zp2'
ID 594463
Institutional Source Beutler Lab
Gene Symbol Zp2
Ensembl Gene ENSMUSG00000030911
Gene Name zona pellucida glycoprotein 2
Synonyms Zp-2
MMRRC Submission 045768-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R7709 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 119725995-119744514 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 119734998 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 429 (I429N)
Ref Sequence ENSEMBL: ENSMUSP00000033207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033207] [ENSMUST00000207726] [ENSMUST00000208874]
AlphaFold P20239
Predicted Effect probably damaging
Transcript: ENSMUST00000033207
AA Change: I429N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000033207
Gene: ENSMUSG00000030911
AA Change: I429N

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
ZP 364 630 1.06e-86 SMART
low complexity region 655 668 N/A INTRINSIC
transmembrane domain 684 703 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000207726
Predicted Effect probably damaging
Transcript: ENSMUST00000208874
AA Change: I429N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
PHENOTYPE: Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,201,334 (GRCm39) I443T probably damaging Het
2310002L09Rik A G 4: 73,861,091 (GRCm39) C170R possibly damaging Het
4933415A04Rik GTGTGTGTGTATGTGTGTGT GTGTGTGTGT 11: 43,478,237 (GRCm39) probably null Het
A2m A C 6: 121,637,063 (GRCm39) T809P possibly damaging Het
Abca12 T C 1: 71,374,887 (GRCm39) D340G probably benign Het
Abcg8 A T 17: 84,999,919 (GRCm39) D191V probably damaging Het
Acan G T 7: 78,739,356 (GRCm39) V255F probably damaging Het
Ace G A 11: 105,879,663 (GRCm39) V1248I probably benign Het
Adgre1 A T 17: 57,709,519 (GRCm39) Q87L unknown Het
Adgrl1 G A 8: 84,665,617 (GRCm39) V1435M probably benign Het
Ano8 T C 8: 71,934,933 (GRCm39) D423G probably damaging Het
Aox3 T C 1: 58,219,810 (GRCm39) Y1137H probably damaging Het
Arl5a T C 2: 52,295,068 (GRCm39) D114G probably benign Het
B3galt9 T G 2: 34,728,437 (GRCm39) C79G probably damaging Het
Baiap2l2 G T 15: 79,143,911 (GRCm39) N394K probably benign Het
Cap1 A T 4: 122,756,467 (GRCm39) C355S probably damaging Het
Ccdc25 A T 14: 66,077,933 (GRCm39) D22V probably damaging Het
Ceacam2 T C 7: 25,238,076 (GRCm39) D116G probably damaging Het
Clec4b2 A G 6: 123,149,974 (GRCm39) probably benign Het
CN725425 C A 15: 91,124,930 (GRCm39) R157S probably benign Het
Coq8b T C 7: 26,949,962 (GRCm39) I347T probably damaging Het
Ctbp2 C A 7: 132,591,789 (GRCm39) V338L probably benign Het
Cyp2d22 A G 15: 82,258,612 (GRCm39) V83A possibly damaging Het
Daam1 G A 12: 72,024,423 (GRCm39) R797H probably benign Het
Dab1 C A 4: 104,577,756 (GRCm39) S275* probably null Het
Dgkz T C 2: 91,767,404 (GRCm39) E863G probably benign Het
Dhx34 G A 7: 15,946,789 (GRCm39) A515V possibly damaging Het
Dnah14 T C 1: 181,530,049 (GRCm39) probably null Het
Dnmt3b C A 2: 153,514,140 (GRCm39) N384K probably benign Het
Dock5 A G 14: 68,033,454 (GRCm39) Y972H probably benign Het
Etv5 A T 16: 22,231,597 (GRCm39) Y138* probably null Het
Fdps A G 3: 89,008,397 (GRCm39) S4P probably damaging Het
Gart A G 16: 91,419,853 (GRCm39) F885L possibly damaging Het
Gm32687 A T 10: 81,715,328 (GRCm39) H240L probably damaging Het
Gm4553 C T 7: 141,719,384 (GRCm39) G15R unknown Het
Gm572 C T 4: 148,753,408 (GRCm39) T351M probably damaging Het
Gpr3 A T 4: 132,937,748 (GRCm39) L308Q probably damaging Het
Gpsm2 A G 3: 108,609,097 (GRCm39) V174A probably benign Het
Gucy1a1 T C 3: 82,002,096 (GRCm39) H661R unknown Het
Heatr4 A T 12: 84,004,499 (GRCm39) M774K probably damaging Het
Hmgcr A G 13: 96,799,605 (GRCm39) I163T possibly damaging Het
Ift81 C T 5: 122,747,394 (GRCm39) V91M probably damaging Het
Igsf10 G T 3: 59,238,964 (GRCm39) Q406K probably damaging Het
Il10ra A G 9: 45,171,697 (GRCm39) V257A probably benign Het
Ina A T 19: 47,012,082 (GRCm39) K500I Het
Lce1i A T 3: 92,685,066 (GRCm39) C37S unknown Het
Lrrc59 A T 11: 94,525,811 (GRCm39) D133V probably damaging Het
Magi3 A G 3: 103,941,354 (GRCm39) I867T probably damaging Het
Mmaa T A 8: 79,995,830 (GRCm39) R298W probably damaging Het
Mon1a G T 9: 107,777,327 (GRCm39) V77F probably benign Het
Mrc2 A G 11: 105,237,285 (GRCm39) T1030A probably benign Het
Mrps27 T A 13: 99,541,504 (GRCm39) S162T probably benign Het
Mtmr12 T A 15: 12,245,097 (GRCm39) M204K probably damaging Het
Mtus1 A G 8: 41,507,687 (GRCm39) I21T possibly damaging Het
Myh2 T C 11: 67,085,690 (GRCm39) V1844A probably benign Het
Myh7 C G 14: 55,226,258 (GRCm39) D461H probably damaging Het
Nbr1 T G 11: 101,447,067 (GRCm39) F18V probably damaging Het
Npy2r T C 3: 82,447,689 (GRCm39) N362S probably benign Het
Ocln T A 13: 100,676,106 (GRCm39) Y129F probably damaging Het
Or2t1 T C 14: 14,328,384 (GRCm38) I91T probably damaging Het
Or4c10 T C 2: 89,760,225 (GRCm39) I24T probably benign Het
Or8c20 A G 9: 38,260,573 (GRCm39) M59V probably benign Het
Pik3c2b T G 1: 133,007,579 (GRCm39) probably null Het
Prss39 A G 1: 34,541,709 (GRCm39) D262G probably damaging Het
Ptk7 T A 17: 46,882,569 (GRCm39) D886V possibly damaging Het
Ptprg T A 14: 12,226,452 (GRCm38) D1348E probably damaging Het
Rabgap1 T C 2: 37,427,339 (GRCm39) I640T possibly damaging Het
Rogdi A G 16: 4,827,098 (GRCm39) Y303H probably damaging Het
Rps6kb1 A T 11: 86,404,148 (GRCm39) M283K probably damaging Het
Sardh T A 2: 27,131,529 (GRCm39) T188S possibly damaging Het
Sebox A G 11: 78,394,919 (GRCm39) E87G probably damaging Het
Smchd1 A T 17: 71,665,193 (GRCm39) M1830K probably damaging Het
Spata31h1 A C 10: 82,126,366 (GRCm39) S2215A possibly damaging Het
Spink8 G A 9: 109,645,848 (GRCm39) V7I probably benign Het
Src G A 2: 157,299,164 (GRCm39) V54M probably benign Het
Taar2 A G 10: 23,816,621 (GRCm39) I54V probably benign Het
Tpo A T 12: 30,181,859 (GRCm39) V12E possibly damaging Het
Txk T C 5: 72,864,918 (GRCm39) D373G probably damaging Het
Ubr5 G A 15: 37,980,076 (GRCm39) A2434V probably null Het
Vil1 C T 1: 74,465,754 (GRCm39) T515M probably benign Het
Wdr47 G T 3: 108,525,837 (GRCm39) C120F probably damaging Het
Ylpm1 C T 12: 85,059,799 (GRCm39) P335L unknown Het
Zfp148 T A 16: 33,288,545 (GRCm39) I220N probably damaging Het
Zfp992 A T 4: 146,551,622 (GRCm39) K448* probably null Het
Zfp994 T C 17: 22,419,406 (GRCm39) I514M probably benign Het
Other mutations in Zp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Zp2 APN 7 119,732,623 (GRCm39) missense probably benign 0.00
IGL00707:Zp2 APN 7 119,732,636 (GRCm39) missense probably benign 0.03
IGL00916:Zp2 APN 7 119,737,397 (GRCm39) missense probably damaging 1.00
IGL01554:Zp2 APN 7 119,737,548 (GRCm39) missense possibly damaging 0.78
IGL01845:Zp2 APN 7 119,737,414 (GRCm39) missense probably damaging 1.00
IGL02111:Zp2 APN 7 119,731,641 (GRCm39) missense possibly damaging 0.75
IGL02145:Zp2 APN 7 119,739,074 (GRCm39) critical splice acceptor site probably null
IGL02155:Zp2 APN 7 119,743,340 (GRCm39) missense probably benign 0.00
IGL02178:Zp2 APN 7 119,732,973 (GRCm39) missense possibly damaging 0.85
IGL02646:Zp2 APN 7 119,734,564 (GRCm39) missense possibly damaging 0.92
IGL03220:Zp2 APN 7 119,736,450 (GRCm39) missense possibly damaging 0.90
PIT4687001:Zp2 UTSW 7 119,741,102 (GRCm39) missense probably benign 0.00
R0138:Zp2 UTSW 7 119,736,423 (GRCm39) missense probably damaging 0.96
R0197:Zp2 UTSW 7 119,742,799 (GRCm39) splice site probably benign
R0519:Zp2 UTSW 7 119,737,372 (GRCm39) missense probably damaging 1.00
R0573:Zp2 UTSW 7 119,734,693 (GRCm39) splice site probably benign
R0879:Zp2 UTSW 7 119,734,757 (GRCm39) missense probably damaging 1.00
R0883:Zp2 UTSW 7 119,742,799 (GRCm39) splice site probably benign
R1160:Zp2 UTSW 7 119,735,268 (GRCm39) missense probably damaging 1.00
R1235:Zp2 UTSW 7 119,737,566 (GRCm39) missense possibly damaging 0.57
R1753:Zp2 UTSW 7 119,737,328 (GRCm39) missense probably benign
R1883:Zp2 UTSW 7 119,732,624 (GRCm39) missense probably benign 0.02
R1995:Zp2 UTSW 7 119,734,388 (GRCm39) missense probably damaging 0.97
R2196:Zp2 UTSW 7 119,737,529 (GRCm39) missense probably benign
R2850:Zp2 UTSW 7 119,737,529 (GRCm39) missense probably benign
R3715:Zp2 UTSW 7 119,741,057 (GRCm39) missense possibly damaging 0.95
R3931:Zp2 UTSW 7 119,731,580 (GRCm39) intron probably benign
R4082:Zp2 UTSW 7 119,734,475 (GRCm39) missense probably benign 0.01
R4731:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4732:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4733:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4754:Zp2 UTSW 7 119,737,541 (GRCm39) missense probably benign 0.01
R4863:Zp2 UTSW 7 119,734,995 (GRCm39) missense probably damaging 1.00
R5274:Zp2 UTSW 7 119,737,315 (GRCm39) missense possibly damaging 0.92
R5392:Zp2 UTSW 7 119,734,987 (GRCm39) nonsense probably null
R5877:Zp2 UTSW 7 119,732,562 (GRCm39) missense probably null 0.94
R6390:Zp2 UTSW 7 119,740,453 (GRCm39) missense probably benign 0.23
R6404:Zp2 UTSW 7 119,734,765 (GRCm39) missense possibly damaging 0.73
R6546:Zp2 UTSW 7 119,731,748 (GRCm39) missense probably benign 0.00
R6622:Zp2 UTSW 7 119,741,136 (GRCm39) missense probably benign
R6622:Zp2 UTSW 7 119,731,748 (GRCm39) missense probably benign 0.00
R6707:Zp2 UTSW 7 119,733,145 (GRCm39) missense possibly damaging 0.85
R7274:Zp2 UTSW 7 119,731,614 (GRCm39) makesense probably null
R7275:Zp2 UTSW 7 119,734,576 (GRCm39) splice site probably null
R7541:Zp2 UTSW 7 119,735,279 (GRCm39) missense probably damaging 1.00
R7585:Zp2 UTSW 7 119,733,167 (GRCm39) missense probably damaging 1.00
R7742:Zp2 UTSW 7 119,731,731 (GRCm39) missense unknown
R7767:Zp2 UTSW 7 119,736,392 (GRCm39) missense probably benign 0.01
R7771:Zp2 UTSW 7 119,742,865 (GRCm39) missense probably damaging 0.96
R8391:Zp2 UTSW 7 119,726,179 (GRCm39) missense probably benign 0.00
R8872:Zp2 UTSW 7 119,733,025 (GRCm39) missense probably benign 0.14
R8880:Zp2 UTSW 7 119,742,835 (GRCm39) missense possibly damaging 0.80
R9673:Zp2 UTSW 7 119,733,238 (GRCm39) missense probably damaging 1.00
X0017:Zp2 UTSW 7 119,732,608 (GRCm39) missense probably damaging 1.00
X0023:Zp2 UTSW 7 119,732,590 (GRCm39) missense probably damaging 1.00
Z1176:Zp2 UTSW 7 119,734,402 (GRCm39) missense not run
Z1177:Zp2 UTSW 7 119,734,432 (GRCm39) missense probably damaging 1.00
Z1177:Zp2 UTSW 7 119,734,402 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- CCTTTGACATGGGCATTTAGTAGC -3'
(R):5'- GGAAATTCCTCTTGCCAGCC -3'

Sequencing Primer
(F):5'- CATGGGCATTTAGTAGCATACTGTC -3'
(R):5'- GCCAGCCTATTTTCAAGGTGCAG -3'
Posted On 2019-11-12