Incidental Mutation 'R7709:Adgrl1'
| ID |
594469 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl1
|
| Ensembl Gene |
ENSMUSG00000013033 |
| Gene Name |
adhesion G protein-coupled receptor L1 |
| Synonyms |
Lec2, 2900070I05Rik, lectomedin-2, Lphn1 |
| MMRRC Submission |
045768-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7709 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
84626734-84668583 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 84665617 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1435
(V1435M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118452
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045393]
[ENSMUST00000098595]
[ENSMUST00000124355]
[ENSMUST00000131717]
[ENSMUST00000132500]
[ENSMUST00000141158]
[ENSMUST00000152978]
|
| AlphaFold |
Q80TR1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045393
AA Change: V1440M
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000048422
Gene: ENSMUSG00000013033
AA Change: V1440M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
6.6e-23 |
PFAM |
|
OLF
|
142 |
398 |
8.5e-138 |
SMART |
|
low complexity region
|
405 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
470 |
N/A |
INTRINSIC |
|
HormR
|
476 |
541 |
1.4e-23 |
SMART |
|
low complexity region
|
579 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
758 |
N/A |
INTRINSIC |
|
GPS
|
797 |
849 |
3.5e-27 |
SMART |
|
Pfam:7tm_2
|
856 |
1092 |
5.3e-66 |
PFAM |
|
Pfam:Latrophilin
|
1112 |
1470 |
1.7e-177 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098595
|
| SMART Domains |
Protein: ENSMUSP00000096195
Gene: ENSMUSG00000074219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
60 |
72 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124355
|
| SMART Domains |
Protein: ENSMUSP00000116064
Gene: ENSMUSG00000013033
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
1.1e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131018
|
| SMART Domains |
Protein: ENSMUSP00000117720
Gene: ENSMUSG00000013033
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Latrophilin
|
1 |
213 |
9.2e-76 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131717
AA Change: V1264M
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000118579
Gene: ENSMUSG00000013033
AA Change: V1264M
| Domain | Start | End | E-Value | Type |
|---|
|
OLF
|
1 |
222 |
4.51e-103 |
SMART |
|
low complexity region
|
229 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
294 |
N/A |
INTRINSIC |
|
HormR
|
300 |
365 |
2.26e-21 |
SMART |
|
low complexity region
|
403 |
415 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
582 |
N/A |
INTRINSIC |
|
GPS
|
621 |
673 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
680 |
916 |
7.9e-68 |
PFAM |
|
Pfam:Latrophilin
|
936 |
1295 |
2.7e-181 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132500
AA Change: V1480M
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000119100
Gene: ENSMUSG00000013033
AA Change: V1480M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
1.6e-25 |
PFAM |
|
OLF
|
137 |
393 |
1.39e-135 |
SMART |
|
low complexity region
|
400 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
450 |
465 |
N/A |
INTRINSIC |
|
HormR
|
471 |
536 |
2.26e-21 |
SMART |
|
low complexity region
|
574 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
742 |
753 |
N/A |
INTRINSIC |
|
GPS
|
792 |
844 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
851 |
1087 |
3.4e-68 |
PFAM |
|
Pfam:Latrophilin
|
1146 |
1511 |
6.4e-193 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141158
AA Change: V1435M
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000118452
Gene: ENSMUSG00000013033
AA Change: V1435M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
3.4e-25 |
PFAM |
|
OLF
|
137 |
393 |
1.39e-135 |
SMART |
|
low complexity region
|
400 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
450 |
465 |
N/A |
INTRINSIC |
|
HormR
|
471 |
536 |
2.26e-21 |
SMART |
|
low complexity region
|
574 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
742 |
753 |
N/A |
INTRINSIC |
|
GPS
|
792 |
844 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
851 |
1087 |
4.5e-68 |
PFAM |
|
Pfam:Latrophilin
|
1107 |
1466 |
1.1e-180 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152978
AA Change: V1485M
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000115295
Gene: ENSMUSG00000013033
AA Change: V1485M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
2.1e-25 |
PFAM |
|
OLF
|
142 |
398 |
1.39e-135 |
SMART |
|
low complexity region
|
405 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
470 |
N/A |
INTRINSIC |
|
HormR
|
476 |
541 |
2.26e-21 |
SMART |
|
Pfam:GAIN
|
544 |
773 |
4.1e-59 |
PFAM |
|
GPS
|
797 |
849 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
856 |
1092 |
2.3e-69 |
PFAM |
|
Pfam:Latrophilin
|
1112 |
1516 |
7.3e-136 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a targeted null allele at this locus are viable and fertile. Female homozygotes fail adequately to care for their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
G |
3: 124,201,334 (GRCm39) |
I443T |
probably damaging |
Het |
| 2310002L09Rik |
A |
G |
4: 73,861,091 (GRCm39) |
C170R |
possibly damaging |
Het |
| 4933415A04Rik |
GTGTGTGTGTATGTGTGTGT |
GTGTGTGTGT |
11: 43,478,237 (GRCm39) |
|
probably null |
Het |
| A2m |
A |
C |
6: 121,637,063 (GRCm39) |
T809P |
possibly damaging |
Het |
| Abca12 |
T |
C |
1: 71,374,887 (GRCm39) |
D340G |
probably benign |
Het |
| Abcg8 |
A |
T |
17: 84,999,919 (GRCm39) |
D191V |
probably damaging |
Het |
| Acan |
G |
T |
7: 78,739,356 (GRCm39) |
V255F |
probably damaging |
Het |
| Ace |
G |
A |
11: 105,879,663 (GRCm39) |
V1248I |
probably benign |
Het |
| Adgre1 |
A |
T |
17: 57,709,519 (GRCm39) |
Q87L |
unknown |
Het |
| Ano8 |
T |
C |
8: 71,934,933 (GRCm39) |
D423G |
probably damaging |
Het |
| Aox3 |
T |
C |
1: 58,219,810 (GRCm39) |
Y1137H |
probably damaging |
Het |
| Arl5a |
T |
C |
2: 52,295,068 (GRCm39) |
D114G |
probably benign |
Het |
| B3galt9 |
T |
G |
2: 34,728,437 (GRCm39) |
C79G |
probably damaging |
Het |
| Baiap2l2 |
G |
T |
15: 79,143,911 (GRCm39) |
N394K |
probably benign |
Het |
| Cap1 |
A |
T |
4: 122,756,467 (GRCm39) |
C355S |
probably damaging |
Het |
| Ccdc25 |
A |
T |
14: 66,077,933 (GRCm39) |
D22V |
probably damaging |
Het |
| Ceacam2 |
T |
C |
7: 25,238,076 (GRCm39) |
D116G |
probably damaging |
Het |
| Clec4b2 |
A |
G |
6: 123,149,974 (GRCm39) |
|
probably benign |
Het |
| CN725425 |
C |
A |
15: 91,124,930 (GRCm39) |
R157S |
probably benign |
Het |
| Coq8b |
T |
C |
7: 26,949,962 (GRCm39) |
I347T |
probably damaging |
Het |
| Ctbp2 |
C |
A |
7: 132,591,789 (GRCm39) |
V338L |
probably benign |
Het |
| Cyp2d22 |
A |
G |
15: 82,258,612 (GRCm39) |
V83A |
possibly damaging |
Het |
| Daam1 |
G |
A |
12: 72,024,423 (GRCm39) |
R797H |
probably benign |
Het |
| Dab1 |
C |
A |
4: 104,577,756 (GRCm39) |
S275* |
probably null |
Het |
| Dgkz |
T |
C |
2: 91,767,404 (GRCm39) |
E863G |
probably benign |
Het |
| Dhx34 |
G |
A |
7: 15,946,789 (GRCm39) |
A515V |
possibly damaging |
Het |
| Dnah14 |
T |
C |
1: 181,530,049 (GRCm39) |
|
probably null |
Het |
| Dnmt3b |
C |
A |
2: 153,514,140 (GRCm39) |
N384K |
probably benign |
Het |
| Dock5 |
A |
G |
14: 68,033,454 (GRCm39) |
Y972H |
probably benign |
Het |
| Etv5 |
A |
T |
16: 22,231,597 (GRCm39) |
Y138* |
probably null |
Het |
| Fdps |
A |
G |
3: 89,008,397 (GRCm39) |
S4P |
probably damaging |
Het |
| Gart |
A |
G |
16: 91,419,853 (GRCm39) |
F885L |
possibly damaging |
Het |
| Gm32687 |
A |
T |
10: 81,715,328 (GRCm39) |
H240L |
probably damaging |
Het |
| Gm4553 |
C |
T |
7: 141,719,384 (GRCm39) |
G15R |
unknown |
Het |
| Gm572 |
C |
T |
4: 148,753,408 (GRCm39) |
T351M |
probably damaging |
Het |
| Gpr3 |
A |
T |
4: 132,937,748 (GRCm39) |
L308Q |
probably damaging |
Het |
| Gpsm2 |
A |
G |
3: 108,609,097 (GRCm39) |
V174A |
probably benign |
Het |
| Gucy1a1 |
T |
C |
3: 82,002,096 (GRCm39) |
H661R |
unknown |
Het |
| Heatr4 |
A |
T |
12: 84,004,499 (GRCm39) |
M774K |
probably damaging |
Het |
| Hmgcr |
A |
G |
13: 96,799,605 (GRCm39) |
I163T |
possibly damaging |
Het |
| Ift81 |
C |
T |
5: 122,747,394 (GRCm39) |
V91M |
probably damaging |
Het |
| Igsf10 |
G |
T |
3: 59,238,964 (GRCm39) |
Q406K |
probably damaging |
Het |
| Il10ra |
A |
G |
9: 45,171,697 (GRCm39) |
V257A |
probably benign |
Het |
| Ina |
A |
T |
19: 47,012,082 (GRCm39) |
K500I |
|
Het |
| Lce1i |
A |
T |
3: 92,685,066 (GRCm39) |
C37S |
unknown |
Het |
| Lrrc59 |
A |
T |
11: 94,525,811 (GRCm39) |
D133V |
probably damaging |
Het |
| Magi3 |
A |
G |
3: 103,941,354 (GRCm39) |
I867T |
probably damaging |
Het |
| Mmaa |
T |
A |
8: 79,995,830 (GRCm39) |
R298W |
probably damaging |
Het |
| Mon1a |
G |
T |
9: 107,777,327 (GRCm39) |
V77F |
probably benign |
Het |
| Mrc2 |
A |
G |
11: 105,237,285 (GRCm39) |
T1030A |
probably benign |
Het |
| Mrps27 |
T |
A |
13: 99,541,504 (GRCm39) |
S162T |
probably benign |
Het |
| Mtmr12 |
T |
A |
15: 12,245,097 (GRCm39) |
M204K |
probably damaging |
Het |
| Mtus1 |
A |
G |
8: 41,507,687 (GRCm39) |
I21T |
possibly damaging |
Het |
| Myh2 |
T |
C |
11: 67,085,690 (GRCm39) |
V1844A |
probably benign |
Het |
| Myh7 |
C |
G |
14: 55,226,258 (GRCm39) |
D461H |
probably damaging |
Het |
| Nbr1 |
T |
G |
11: 101,447,067 (GRCm39) |
F18V |
probably damaging |
Het |
| Npy2r |
T |
C |
3: 82,447,689 (GRCm39) |
N362S |
probably benign |
Het |
| Ocln |
T |
A |
13: 100,676,106 (GRCm39) |
Y129F |
probably damaging |
Het |
| Or2t1 |
T |
C |
14: 14,328,384 (GRCm38) |
I91T |
probably damaging |
Het |
| Or4c10 |
T |
C |
2: 89,760,225 (GRCm39) |
I24T |
probably benign |
Het |
| Or8c20 |
A |
G |
9: 38,260,573 (GRCm39) |
M59V |
probably benign |
Het |
| Pik3c2b |
T |
G |
1: 133,007,579 (GRCm39) |
|
probably null |
Het |
| Prss39 |
A |
G |
1: 34,541,709 (GRCm39) |
D262G |
probably damaging |
Het |
| Ptk7 |
T |
A |
17: 46,882,569 (GRCm39) |
D886V |
possibly damaging |
Het |
| Ptprg |
T |
A |
14: 12,226,452 (GRCm38) |
D1348E |
probably damaging |
Het |
| Rabgap1 |
T |
C |
2: 37,427,339 (GRCm39) |
I640T |
possibly damaging |
Het |
| Rogdi |
A |
G |
16: 4,827,098 (GRCm39) |
Y303H |
probably damaging |
Het |
| Rps6kb1 |
A |
T |
11: 86,404,148 (GRCm39) |
M283K |
probably damaging |
Het |
| Sardh |
T |
A |
2: 27,131,529 (GRCm39) |
T188S |
possibly damaging |
Het |
| Sebox |
A |
G |
11: 78,394,919 (GRCm39) |
E87G |
probably damaging |
Het |
| Smchd1 |
A |
T |
17: 71,665,193 (GRCm39) |
M1830K |
probably damaging |
Het |
| Spata31h1 |
A |
C |
10: 82,126,366 (GRCm39) |
S2215A |
possibly damaging |
Het |
| Spink8 |
G |
A |
9: 109,645,848 (GRCm39) |
V7I |
probably benign |
Het |
| Src |
G |
A |
2: 157,299,164 (GRCm39) |
V54M |
probably benign |
Het |
| Taar2 |
A |
G |
10: 23,816,621 (GRCm39) |
I54V |
probably benign |
Het |
| Tpo |
A |
T |
12: 30,181,859 (GRCm39) |
V12E |
possibly damaging |
Het |
| Txk |
T |
C |
5: 72,864,918 (GRCm39) |
D373G |
probably damaging |
Het |
| Ubr5 |
G |
A |
15: 37,980,076 (GRCm39) |
A2434V |
probably null |
Het |
| Vil1 |
C |
T |
1: 74,465,754 (GRCm39) |
T515M |
probably benign |
Het |
| Wdr47 |
G |
T |
3: 108,525,837 (GRCm39) |
C120F |
probably damaging |
Het |
| Ylpm1 |
C |
T |
12: 85,059,799 (GRCm39) |
P335L |
unknown |
Het |
| Zfp148 |
T |
A |
16: 33,288,545 (GRCm39) |
I220N |
probably damaging |
Het |
| Zfp992 |
A |
T |
4: 146,551,622 (GRCm39) |
K448* |
probably null |
Het |
| Zfp994 |
T |
C |
17: 22,419,406 (GRCm39) |
I514M |
probably benign |
Het |
| Zp2 |
A |
T |
7: 119,734,998 (GRCm39) |
I429N |
probably damaging |
Het |
|
| Other mutations in Adgrl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Adgrl1
|
APN |
8 |
84,664,332 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01413:Adgrl1
|
APN |
8 |
84,656,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02020:Adgrl1
|
APN |
8 |
84,659,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02422:Adgrl1
|
APN |
8 |
84,664,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Adgrl1
|
APN |
8 |
84,665,143 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03169:Adgrl1
|
APN |
8 |
84,658,624 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03237:Adgrl1
|
APN |
8 |
84,656,312 (GRCm39) |
splice site |
probably null |
|
|
Swiss_rolls
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0375:Adgrl1
|
UTSW |
8 |
84,661,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0505:Adgrl1
|
UTSW |
8 |
84,661,279 (GRCm39) |
splice site |
probably benign |
|
|
R0681:Adgrl1
|
UTSW |
8 |
84,661,279 (GRCm39) |
splice site |
probably benign |
|
|
R0964:Adgrl1
|
UTSW |
8 |
84,661,041 (GRCm39) |
splice site |
probably benign |
|
|
R1182:Adgrl1
|
UTSW |
8 |
84,656,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Adgrl1
|
UTSW |
8 |
84,664,392 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1475:Adgrl1
|
UTSW |
8 |
84,664,979 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1610:Adgrl1
|
UTSW |
8 |
84,659,002 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1778:Adgrl1
|
UTSW |
8 |
84,656,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2089:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2091:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2091:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2300:Adgrl1
|
UTSW |
8 |
84,656,746 (GRCm39) |
nonsense |
probably null |
|
|
R2403:Adgrl1
|
UTSW |
8 |
84,657,870 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2935:Adgrl1
|
UTSW |
8 |
84,661,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3772:Adgrl1
|
UTSW |
8 |
84,649,633 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4191:Adgrl1
|
UTSW |
8 |
84,665,569 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4393:Adgrl1
|
UTSW |
8 |
84,665,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4406:Adgrl1
|
UTSW |
8 |
84,656,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Adgrl1
|
UTSW |
8 |
84,661,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Adgrl1
|
UTSW |
8 |
84,662,202 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4799:Adgrl1
|
UTSW |
8 |
84,662,202 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5214:Adgrl1
|
UTSW |
8 |
84,642,202 (GRCm39) |
splice site |
probably null |
|
|
R5242:Adgrl1
|
UTSW |
8 |
84,657,711 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5409:Adgrl1
|
UTSW |
8 |
84,656,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5522:Adgrl1
|
UTSW |
8 |
84,649,704 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5607:Adgrl1
|
UTSW |
8 |
84,663,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5608:Adgrl1
|
UTSW |
8 |
84,663,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5652:Adgrl1
|
UTSW |
8 |
84,656,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5655:Adgrl1
|
UTSW |
8 |
84,665,230 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5919:Adgrl1
|
UTSW |
8 |
84,659,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Adgrl1
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6033:Adgrl1
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6129:Adgrl1
|
UTSW |
8 |
84,645,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Adgrl1
|
UTSW |
8 |
84,664,316 (GRCm39) |
nonsense |
probably null |
|
|
R7142:Adgrl1
|
UTSW |
8 |
84,663,829 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7181:Adgrl1
|
UTSW |
8 |
84,652,878 (GRCm39) |
splice site |
probably null |
|
|
R7238:Adgrl1
|
UTSW |
8 |
84,665,693 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7547:Adgrl1
|
UTSW |
8 |
84,665,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7741:Adgrl1
|
UTSW |
8 |
84,656,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7852:Adgrl1
|
UTSW |
8 |
84,662,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7866:Adgrl1
|
UTSW |
8 |
84,664,564 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8146:Adgrl1
|
UTSW |
8 |
84,657,618 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8314:Adgrl1
|
UTSW |
8 |
84,665,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Adgrl1
|
UTSW |
8 |
84,665,458 (GRCm39) |
missense |
|
|
|
R8857:Adgrl1
|
UTSW |
8 |
84,657,657 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8979:Adgrl1
|
UTSW |
8 |
84,665,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9204:Adgrl1
|
UTSW |
8 |
84,660,519 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9226:Adgrl1
|
UTSW |
8 |
84,656,426 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9302:Adgrl1
|
UTSW |
8 |
84,656,426 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9695:Adgrl1
|
UTSW |
8 |
84,665,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9785:Adgrl1
|
UTSW |
8 |
84,665,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF007:Adgrl1
|
UTSW |
8 |
84,661,401 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATGAGTCGGAGAGCTGTAC -3'
(R):5'- TGTCTACTAACCCTGGCACCTG -3'
Sequencing Primer
(F):5'- GACTCCCTCTATGCCAGCG -3'
(R):5'- AGGTCATAGTCCCCAAGGG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation