Incidental Mutation 'R7710:Vmn2r61'
| ID |
594538 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R7710 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 41916472 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 362
(C362R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166131
AA Change: C362R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: C362R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl1 |
G |
A |
4: 86,150,810 (GRCm39) |
E151K |
|
Het |
| Ap3b1 |
T |
C |
13: 94,587,581 (GRCm39) |
S452P |
probably damaging |
Het |
| Cacna2d4 |
A |
G |
6: 119,251,200 (GRCm39) |
I463V |
probably benign |
Het |
| Calhm4 |
A |
T |
10: 33,920,045 (GRCm39) |
M74K |
possibly damaging |
Het |
| Ccdc142 |
T |
C |
6: 83,078,677 (GRCm39) |
S5P |
probably benign |
Het |
| Cd300ld |
C |
T |
11: 114,875,038 (GRCm39) |
V199M |
probably damaging |
Het |
| Cep162 |
T |
C |
9: 87,114,172 (GRCm39) |
Y300C |
probably damaging |
Het |
| Ces2h |
C |
T |
8: 105,727,497 (GRCm39) |
Q5* |
probably null |
Het |
| Col9a3 |
C |
T |
2: 180,251,158 (GRCm39) |
L310F |
probably damaging |
Het |
| Copa |
A |
G |
1: 171,937,411 (GRCm39) |
D454G |
possibly damaging |
Het |
| Ctnnbip1 |
A |
C |
4: 149,630,277 (GRCm39) |
M29L |
probably benign |
Het |
| Ctnnbl1 |
A |
G |
2: 157,616,491 (GRCm39) |
D64G |
probably benign |
Het |
| Dcxr |
T |
A |
11: 120,617,908 (GRCm39) |
T23S |
probably benign |
Het |
| Dennd1b |
T |
A |
1: 138,990,670 (GRCm39) |
H211Q |
probably damaging |
Het |
| Ercc8 |
G |
A |
13: 108,320,397 (GRCm39) |
A328T |
probably benign |
Het |
| Fam217a |
T |
C |
13: 35,095,111 (GRCm39) |
D216G |
possibly damaging |
Het |
| Fat2 |
T |
A |
11: 55,201,589 (GRCm39) |
Y495F |
probably benign |
Het |
| Fbxw13 |
G |
A |
9: 109,024,968 (GRCm39) |
S15F |
probably damaging |
Het |
| Fras1 |
T |
A |
5: 96,792,962 (GRCm39) |
C964* |
probably null |
Het |
| Fshr |
T |
A |
17: 89,292,683 (GRCm39) |
H665L |
probably benign |
Het |
| Gm10447 |
A |
T |
11: 53,347,437 (GRCm39) |
C31S |
unknown |
Het |
| Gm13272 |
A |
T |
4: 88,698,586 (GRCm39) |
Q167L |
probably benign |
Het |
| Gtpbp2 |
T |
C |
17: 46,478,713 (GRCm39) |
I510T |
possibly damaging |
Het |
| Hps6 |
G |
A |
19: 45,993,007 (GRCm39) |
A315T |
probably benign |
Het |
| Igfbp6 |
A |
C |
15: 102,056,285 (GRCm39) |
T115P |
probably damaging |
Het |
| Ikzf4 |
A |
G |
10: 128,468,610 (GRCm39) |
V623A |
possibly damaging |
Het |
| Il11ra1 |
T |
C |
4: 41,764,846 (GRCm39) |
V100A |
probably benign |
Het |
| Ints1 |
T |
C |
5: 139,756,840 (GRCm39) |
T493A |
probably benign |
Het |
| Itgax |
C |
T |
7: 127,735,028 (GRCm39) |
T453I |
probably benign |
Het |
| Kras |
T |
C |
6: 145,166,354 (GRCm39) |
T183A |
probably benign |
Het |
| Lhcgr |
T |
C |
17: 89,050,210 (GRCm39) |
T439A |
probably damaging |
Het |
| Lrrn4 |
T |
C |
2: 132,721,451 (GRCm39) |
H122R |
probably benign |
Het |
| Muc2 |
A |
T |
7: 141,287,452 (GRCm39) |
R210S |
possibly damaging |
Het |
| Myh7 |
C |
G |
14: 55,226,258 (GRCm39) |
D461H |
probably damaging |
Het |
| Myo18b |
T |
C |
5: 113,022,891 (GRCm39) |
D167G |
unknown |
Het |
| Nedd8 |
G |
A |
14: 55,909,446 (GRCm39) |
|
probably benign |
Het |
| Or5b94 |
A |
C |
19: 12,652,340 (GRCm39) |
Y257S |
probably damaging |
Het |
| Pars2 |
T |
A |
4: 106,511,276 (GRCm39) |
Y353N |
probably damaging |
Het |
| Pbxip1 |
T |
A |
3: 89,355,408 (GRCm39) |
D642E |
probably damaging |
Het |
| Pcdhb10 |
A |
T |
18: 37,546,654 (GRCm39) |
R577* |
probably null |
Het |
| Pcna-ps2 |
T |
A |
19: 9,261,489 (GRCm39) |
Y249* |
probably null |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pla2g6 |
A |
T |
15: 79,171,358 (GRCm39) |
V744E |
probably damaging |
Het |
| Ppfibp1 |
A |
G |
6: 146,897,903 (GRCm39) |
I207V |
probably benign |
Het |
| Prr11 |
T |
C |
11: 86,994,433 (GRCm39) |
D71G |
probably benign |
Het |
| Rnf150 |
A |
C |
8: 83,590,781 (GRCm39) |
Y48S |
probably damaging |
Het |
| Rsf1 |
G |
A |
7: 97,331,041 (GRCm39) |
G1237D |
|
Het |
| Rusc2 |
C |
T |
4: 43,416,119 (GRCm39) |
T475I |
probably benign |
Het |
| Scgb1b20 |
T |
A |
7: 33,072,867 (GRCm39) |
I25N |
probably damaging |
Het |
| Sdr39u1 |
T |
C |
14: 56,137,116 (GRCm39) |
N65S |
probably benign |
Het |
| Sh3gl3 |
T |
C |
7: 81,933,294 (GRCm39) |
V219A |
possibly damaging |
Het |
| Shcbp1 |
A |
G |
8: 4,814,965 (GRCm39) |
F171S |
probably benign |
Het |
| Shq1 |
A |
G |
6: 100,648,006 (GRCm39) |
F6S |
probably damaging |
Het |
| Slc12a4 |
C |
T |
8: 106,672,203 (GRCm39) |
R868H |
possibly damaging |
Het |
| Smg6 |
T |
C |
11: 74,821,445 (GRCm39) |
V572A |
probably benign |
Het |
| Syn3 |
A |
G |
10: 86,243,534 (GRCm39) |
V135A |
probably damaging |
Het |
| Tars3 |
A |
T |
7: 65,314,717 (GRCm39) |
D425V |
probably benign |
Het |
| Tmem253 |
A |
T |
14: 52,254,608 (GRCm39) |
Q21L |
possibly damaging |
Het |
| Trpm3 |
G |
T |
19: 22,896,154 (GRCm39) |
R997L |
probably damaging |
Het |
| Ubr5 |
G |
A |
15: 37,980,076 (GRCm39) |
A2434V |
probably null |
Het |
| Ugt1a9 |
A |
G |
1: 87,998,831 (GRCm39) |
T94A |
probably benign |
Het |
| Vmn1r62 |
A |
G |
7: 5,678,182 (GRCm39) |
|
probably benign |
Het |
| Zfp354c |
TCACACTCGGCACA |
TCACA |
11: 50,706,067 (GRCm39) |
|
probably benign |
Het |
| Zfp94 |
T |
C |
7: 24,003,107 (GRCm39) |
K112E |
probably benign |
Het |
| Zfp954 |
A |
T |
7: 7,120,889 (GRCm39) |
V47E |
probably damaging |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCTTGACCTCTTCATGGG -3'
(R):5'- GGGGAGAATACCATTTCTTCTCC -3'
Sequencing Primer
(F):5'- GACCTCTTCATGGGATGTTGATACAC -3'
(R):5'- GGAGAATACCATTTCTTCTCCATTTG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation