Incidental Mutation 'R7710:Cep162'
ID 594548
Institutional Source Beutler Lab
Gene Symbol Cep162
Ensembl Gene ENSMUSG00000056919
Gene Name centrosomal protein 162
Synonyms 4922501C03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R7710 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 87071630-87137589 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87114172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 300 (Y300C)
Ref Sequence ENSEMBL: ENSMUSP00000091319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093802]
AlphaFold Q6ZQ06
Predicted Effect probably damaging
Transcript: ENSMUST00000093802
AA Change: Y300C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: Y300C

DomainStartEndE-ValueType
low complexity region 198 208 N/A INTRINSIC
low complexity region 528 539 N/A INTRINSIC
coiled coil region 630 674 N/A INTRINSIC
coiled coil region 695 899 N/A INTRINSIC
coiled coil region 953 1124 N/A INTRINSIC
coiled coil region 1235 1386 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 G A 4: 86,150,810 (GRCm39) E151K Het
Ap3b1 T C 13: 94,587,581 (GRCm39) S452P probably damaging Het
Cacna2d4 A G 6: 119,251,200 (GRCm39) I463V probably benign Het
Calhm4 A T 10: 33,920,045 (GRCm39) M74K possibly damaging Het
Ccdc142 T C 6: 83,078,677 (GRCm39) S5P probably benign Het
Cd300ld C T 11: 114,875,038 (GRCm39) V199M probably damaging Het
Ces2h C T 8: 105,727,497 (GRCm39) Q5* probably null Het
Col9a3 C T 2: 180,251,158 (GRCm39) L310F probably damaging Het
Copa A G 1: 171,937,411 (GRCm39) D454G possibly damaging Het
Ctnnbip1 A C 4: 149,630,277 (GRCm39) M29L probably benign Het
Ctnnbl1 A G 2: 157,616,491 (GRCm39) D64G probably benign Het
Dcxr T A 11: 120,617,908 (GRCm39) T23S probably benign Het
Dennd1b T A 1: 138,990,670 (GRCm39) H211Q probably damaging Het
Ercc8 G A 13: 108,320,397 (GRCm39) A328T probably benign Het
Fam217a T C 13: 35,095,111 (GRCm39) D216G possibly damaging Het
Fat2 T A 11: 55,201,589 (GRCm39) Y495F probably benign Het
Fbxw13 G A 9: 109,024,968 (GRCm39) S15F probably damaging Het
Fras1 T A 5: 96,792,962 (GRCm39) C964* probably null Het
Fshr T A 17: 89,292,683 (GRCm39) H665L probably benign Het
Gm10447 A T 11: 53,347,437 (GRCm39) C31S unknown Het
Gm13272 A T 4: 88,698,586 (GRCm39) Q167L probably benign Het
Gtpbp2 T C 17: 46,478,713 (GRCm39) I510T possibly damaging Het
Hps6 G A 19: 45,993,007 (GRCm39) A315T probably benign Het
Igfbp6 A C 15: 102,056,285 (GRCm39) T115P probably damaging Het
Ikzf4 A G 10: 128,468,610 (GRCm39) V623A possibly damaging Het
Il11ra1 T C 4: 41,764,846 (GRCm39) V100A probably benign Het
Ints1 T C 5: 139,756,840 (GRCm39) T493A probably benign Het
Itgax C T 7: 127,735,028 (GRCm39) T453I probably benign Het
Kras T C 6: 145,166,354 (GRCm39) T183A probably benign Het
Lhcgr T C 17: 89,050,210 (GRCm39) T439A probably damaging Het
Lrrn4 T C 2: 132,721,451 (GRCm39) H122R probably benign Het
Muc2 A T 7: 141,287,452 (GRCm39) R210S possibly damaging Het
Myh7 C G 14: 55,226,258 (GRCm39) D461H probably damaging Het
Myo18b T C 5: 113,022,891 (GRCm39) D167G unknown Het
Nedd8 G A 14: 55,909,446 (GRCm39) probably benign Het
Or5b94 A C 19: 12,652,340 (GRCm39) Y257S probably damaging Het
Pars2 T A 4: 106,511,276 (GRCm39) Y353N probably damaging Het
Pbxip1 T A 3: 89,355,408 (GRCm39) D642E probably damaging Het
Pcdhb10 A T 18: 37,546,654 (GRCm39) R577* probably null Het
Pcna-ps2 T A 19: 9,261,489 (GRCm39) Y249* probably null Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Pla2g6 A T 15: 79,171,358 (GRCm39) V744E probably damaging Het
Ppfibp1 A G 6: 146,897,903 (GRCm39) I207V probably benign Het
Prr11 T C 11: 86,994,433 (GRCm39) D71G probably benign Het
Rnf150 A C 8: 83,590,781 (GRCm39) Y48S probably damaging Het
Rsf1 G A 7: 97,331,041 (GRCm39) G1237D Het
Rusc2 C T 4: 43,416,119 (GRCm39) T475I probably benign Het
Scgb1b20 T A 7: 33,072,867 (GRCm39) I25N probably damaging Het
Sdr39u1 T C 14: 56,137,116 (GRCm39) N65S probably benign Het
Sh3gl3 T C 7: 81,933,294 (GRCm39) V219A possibly damaging Het
Shcbp1 A G 8: 4,814,965 (GRCm39) F171S probably benign Het
Shq1 A G 6: 100,648,006 (GRCm39) F6S probably damaging Het
Slc12a4 C T 8: 106,672,203 (GRCm39) R868H possibly damaging Het
Smg6 T C 11: 74,821,445 (GRCm39) V572A probably benign Het
Syn3 A G 10: 86,243,534 (GRCm39) V135A probably damaging Het
Tars3 A T 7: 65,314,717 (GRCm39) D425V probably benign Het
Tmem253 A T 14: 52,254,608 (GRCm39) Q21L possibly damaging Het
Trpm3 G T 19: 22,896,154 (GRCm39) R997L probably damaging Het
Ubr5 G A 15: 37,980,076 (GRCm39) A2434V probably null Het
Ugt1a9 A G 1: 87,998,831 (GRCm39) T94A probably benign Het
Vmn1r62 A G 7: 5,678,182 (GRCm39) probably benign Het
Vmn2r61 T C 7: 41,916,472 (GRCm39) C362R probably damaging Het
Zfp354c TCACACTCGGCACA TCACA 11: 50,706,067 (GRCm39) probably benign Het
Zfp94 T C 7: 24,003,107 (GRCm39) K112E probably benign Het
Zfp954 A T 7: 7,120,889 (GRCm39) V47E probably damaging Het
Other mutations in Cep162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Cep162 APN 9 87,109,220 (GRCm39) missense probably benign 0.24
IGL00584:Cep162 APN 9 87,103,143 (GRCm39) splice site probably benign
IGL01387:Cep162 APN 9 87,093,864 (GRCm39) missense probably benign 0.08
IGL01862:Cep162 APN 9 87,135,986 (GRCm39) missense possibly damaging 0.90
IGL02304:Cep162 APN 9 87,109,200 (GRCm39) splice site probably benign
IGL02558:Cep162 APN 9 87,107,779 (GRCm39) missense probably benign
IGL02558:Cep162 APN 9 87,107,786 (GRCm39) missense probably benign 0.04
IGL02602:Cep162 APN 9 87,128,206 (GRCm39) missense probably benign 0.19
IGL02636:Cep162 APN 9 87,130,432 (GRCm39) missense possibly damaging 0.90
IGL02680:Cep162 APN 9 87,128,797 (GRCm39) missense possibly damaging 0.64
IGL03195:Cep162 APN 9 87,107,839 (GRCm39) missense probably benign 0.00
circus UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
moscow UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
smiley UTSW 9 87,099,134 (GRCm39) nonsense probably null
PIT4378001:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
PIT4431001:Cep162 UTSW 9 87,126,398 (GRCm39) missense probably benign 0.00
PIT4434001:Cep162 UTSW 9 87,075,701 (GRCm39) missense probably damaging 1.00
R0060:Cep162 UTSW 9 87,119,878 (GRCm39) splice site probably benign
R0218:Cep162 UTSW 9 87,093,862 (GRCm39) missense possibly damaging 0.73
R0366:Cep162 UTSW 9 87,102,537 (GRCm39) missense probably damaging 0.96
R0468:Cep162 UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
R0764:Cep162 UTSW 9 87,083,798 (GRCm39) missense probably damaging 1.00
R1386:Cep162 UTSW 9 87,103,255 (GRCm39) missense probably benign
R1614:Cep162 UTSW 9 87,094,985 (GRCm39) missense probably damaging 1.00
R1633:Cep162 UTSW 9 87,085,736 (GRCm39) missense probably benign 0.23
R1831:Cep162 UTSW 9 87,088,985 (GRCm39) missense probably damaging 1.00
R1847:Cep162 UTSW 9 87,086,133 (GRCm39) missense probably benign 0.06
R1941:Cep162 UTSW 9 87,082,048 (GRCm39) missense probably benign 0.14
R2228:Cep162 UTSW 9 87,126,384 (GRCm39) missense probably benign 0.05
R2256:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2257:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2936:Cep162 UTSW 9 87,109,467 (GRCm39) missense probably benign
R3005:Cep162 UTSW 9 87,114,113 (GRCm39) missense probably benign 0.00
R3508:Cep162 UTSW 9 87,114,030 (GRCm39) critical splice donor site probably null
R3689:Cep162 UTSW 9 87,107,747 (GRCm39) nonsense probably null
R3743:Cep162 UTSW 9 87,099,230 (GRCm39) splice site probably benign
R4118:Cep162 UTSW 9 87,086,229 (GRCm39) missense probably benign 0.30
R4380:Cep162 UTSW 9 87,082,056 (GRCm39) missense probably damaging 0.99
R4450:Cep162 UTSW 9 87,107,861 (GRCm39) missense probably damaging 1.00
R4540:Cep162 UTSW 9 87,094,992 (GRCm39) missense probably damaging 1.00
R4598:Cep162 UTSW 9 87,085,848 (GRCm39) missense possibly damaging 0.95
R4700:Cep162 UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
R4941:Cep162 UTSW 9 87,108,022 (GRCm39) intron probably benign
R5356:Cep162 UTSW 9 87,088,948 (GRCm39) missense probably damaging 1.00
R5468:Cep162 UTSW 9 87,109,290 (GRCm39) missense probably benign 0.00
R5579:Cep162 UTSW 9 87,085,724 (GRCm39) missense probably benign 0.26
R5859:Cep162 UTSW 9 87,086,145 (GRCm39) missense probably damaging 1.00
R6114:Cep162 UTSW 9 87,085,763 (GRCm39) missense probably benign
R6143:Cep162 UTSW 9 87,094,904 (GRCm39) critical splice donor site probably null
R6422:Cep162 UTSW 9 87,114,069 (GRCm39) missense possibly damaging 0.92
R6517:Cep162 UTSW 9 87,104,227 (GRCm39) missense probably damaging 0.99
R6576:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
R6782:Cep162 UTSW 9 87,093,737 (GRCm39) missense probably benign 0.07
R6867:Cep162 UTSW 9 87,099,134 (GRCm39) nonsense probably null
R7293:Cep162 UTSW 9 87,085,836 (GRCm39) missense probably benign 0.01
R7355:Cep162 UTSW 9 87,136,008 (GRCm39) nonsense probably null
R7391:Cep162 UTSW 9 87,130,547 (GRCm39) nonsense probably null
R7426:Cep162 UTSW 9 87,074,819 (GRCm39) missense probably damaging 1.00
R7593:Cep162 UTSW 9 87,086,250 (GRCm39) missense probably benign 0.40
R7841:Cep162 UTSW 9 87,126,369 (GRCm39) missense probably benign 0.00
R7949:Cep162 UTSW 9 87,088,901 (GRCm39) missense probably benign 0.04
R8351:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8451:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8552:Cep162 UTSW 9 87,126,361 (GRCm39) missense probably benign 0.34
R8755:Cep162 UTSW 9 87,114,064 (GRCm39) missense probably benign 0.02
R8762:Cep162 UTSW 9 87,109,314 (GRCm39) missense probably benign 0.00
R9640:Cep162 UTSW 9 87,126,352 (GRCm39) missense probably benign 0.06
X0063:Cep162 UTSW 9 87,104,095 (GRCm39) critical splice donor site probably null
Z1177:Cep162 UTSW 9 87,082,033 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ATCCGTCCACTAAGTCTGTCAG -3'
(R):5'- TATCAGGACCGGTCTCACCTTG -3'

Sequencing Primer
(F):5'- AAGTCTGTCAGCTTTTACCGGAC -3'
(R):5'- CACTCTGATAGCTTACCCAGG -3'
Posted On 2019-11-12