Incidental Mutation 'R7711:Psg22'
ID 594612
Institutional Source Beutler Lab
Gene Symbol Psg22
Ensembl Gene ENSMUSG00000044903
Gene Name pregnancy-specific beta-1-glycoprotein 22
Synonyms cea9
MMRRC Submission 045769-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R7711 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 18452015-18461173 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 18452267 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104121 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051973] [ENSMUST00000108481] [ENSMUST00000208221]
AlphaFold Q810J1
Predicted Effect probably null
Transcript: ENSMUST00000051973
SMART Domains Protein: ENSMUSP00000050633
Gene: ENSMUSG00000044903

DomainStartEndE-ValueType
low complexity region 19 30 N/A INTRINSIC
IG 40 141 7.59e-4 SMART
IG 160 261 1.13e-2 SMART
IG 280 381 3.74e-3 SMART
IGc2 397 461 7.35e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108481
SMART Domains Protein: ENSMUSP00000104121
Gene: ENSMUSG00000044903

DomainStartEndE-ValueType
low complexity region 58 69 N/A INTRINSIC
IG 79 180 7.59e-4 SMART
IG 199 300 1.13e-2 SMART
IG 319 420 3.74e-3 SMART
IGc2 436 500 7.35e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000208221
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik G A 8: 120,886,723 (GRCm39) E342K possibly damaging Het
9430015G10Rik T G 4: 156,203,649 (GRCm39) V34G probably damaging Het
Alkbh3 T C 2: 93,838,437 (GRCm39) S44G probably benign Het
Alpk2 A T 18: 65,439,555 (GRCm39) C613S probably benign Het
Aplp2 G A 9: 31,072,645 (GRCm39) R488C probably damaging Het
Arid1b A G 17: 5,387,095 (GRCm39) N1463S probably benign Het
Atxn2l A T 7: 126,100,441 (GRCm39) L125Q probably damaging Het
Cd3d A G 9: 44,897,634 (GRCm39) K172E probably benign Het
Chd7 T A 4: 8,805,234 (GRCm39) D764E probably benign Het
Col19a1 T C 1: 24,569,089 (GRCm39) I220V unknown Het
Cpq T C 15: 33,497,493 (GRCm39) I411T probably benign Het
Crybg2 C A 4: 133,792,844 (GRCm39) H160N probably benign Het
Cryl1 A T 14: 57,513,013 (GRCm39) C285S probably benign Het
Dapk1 A G 13: 60,909,365 (GRCm39) D1326G probably damaging Het
Dgkh A G 14: 78,962,459 (GRCm39) V24A probably benign Het
Dnajb4 A C 3: 151,892,154 (GRCm39) S226R probably benign Het
Dnm3 A T 1: 161,819,622 (GRCm39) I850N possibly damaging Het
Dtna G T 18: 23,758,253 (GRCm39) probably null Het
Efcab6 G T 15: 83,834,125 (GRCm39) D494E probably benign Het
Fam169a G T 13: 97,263,196 (GRCm39) E550* probably null Het
Fbxw7 A G 3: 84,832,988 (GRCm39) N10S probably benign Het
Flrt2 T C 12: 95,747,528 (GRCm39) F622S probably damaging Het
Gprc5d G A 6: 135,093,355 (GRCm39) T184I possibly damaging Het
Grem2 A G 1: 174,664,693 (GRCm39) V52A probably damaging Het
Gtf3c2 G T 5: 31,327,533 (GRCm39) T310N probably damaging Het
H2-T13 T A 17: 36,394,770 (GRCm39) N51I probably damaging Het
Hyou1 A G 9: 44,295,759 (GRCm39) D338G possibly damaging Het
Ifna6 T C 4: 88,745,971 (GRCm39) S107P probably benign Het
Kif14 G T 1: 136,399,191 (GRCm39) G451C probably benign Het
Kit T A 5: 75,798,019 (GRCm39) F436I probably damaging Het
Lonp2 G A 8: 87,440,636 (GRCm39) C751Y probably damaging Het
Lonrf1 C A 8: 36,716,375 (GRCm39) G87C probably damaging Het
Lrp2 T C 2: 69,309,687 (GRCm39) probably null Het
Lrrc37 G T 11: 103,505,738 (GRCm39) Q2077K probably benign Het
Mkln1 A G 6: 31,469,584 (GRCm39) H598R probably damaging Het
Mmaa T C 8: 79,994,774 (GRCm39) H344R probably benign Het
Myh7 C G 14: 55,226,258 (GRCm39) D461H probably damaging Het
Myh7b T G 2: 155,462,323 (GRCm39) L342R probably damaging Het
Or12e8 A G 2: 87,187,871 (GRCm39) N28D probably benign Het
Or2h2b-ps1 C T 17: 37,480,847 (GRCm39) G129R probably damaging Het
Or4f4-ps1 T A 2: 111,330,497 (GRCm39) I300K probably damaging Het
Or7e178 A T 9: 20,225,319 (GRCm39) V299E possibly damaging Het
Pcsk5 T A 19: 17,416,444 (GRCm39) Y1668F possibly damaging Het
Pfn4 C T 12: 4,824,414 (GRCm39) T47I possibly damaging Het
Pklr T C 3: 89,048,649 (GRCm39) L104P probably damaging Het
Plcxd2 A G 16: 45,800,693 (GRCm39) V177A probably benign Het
Pramel16 T C 4: 143,675,822 (GRCm39) S335G probably benign Het
Prdm10 G T 9: 31,268,528 (GRCm39) A826S probably damaging Het
Prrt4 A G 6: 29,177,455 (GRCm39) S105P probably benign Het
Prss51 T A 14: 64,334,937 (GRCm39) V164E probably damaging Het
Psap T C 10: 60,135,634 (GRCm39) V360A probably damaging Het
Qrfprl A G 6: 65,418,357 (GRCm39) H23R Het
Rad51 A G 2: 118,962,071 (GRCm39) Q206R probably benign Het
Rap1gds1 T C 3: 138,664,874 (GRCm39) K277R probably benign Het
Rassf2 T A 2: 131,847,297 (GRCm39) T103S probably benign Het
Rbm15b T A 9: 106,763,142 (GRCm39) H342L possibly damaging Het
Rsf1 G GACCGCGGCC 7: 97,229,116 (GRCm39) probably benign Het
Scaf8 T C 17: 3,237,909 (GRCm39) F561L probably damaging Het
Scn1a G A 2: 66,134,004 (GRCm39) A130V probably benign Het
Scn7a T C 2: 66,531,221 (GRCm39) E552G probably damaging Het
Slc39a14 T A 14: 70,551,124 (GRCm39) R183W probably damaging Het
Slfn1 A T 11: 83,012,089 (GRCm39) K68N possibly damaging Het
Slx4ip A G 2: 136,909,914 (GRCm39) D303G probably damaging Het
Snx17 T A 5: 31,352,804 (GRCm39) F101Y probably damaging Het
Spata31e3 T G 13: 50,401,131 (GRCm39) R398S probably benign Het
Specc1l C A 10: 75,066,642 (GRCm39) N30K probably benign Het
Spmip2 A G 3: 79,313,167 (GRCm39) I80M probably damaging Het
Tbx19 A G 1: 164,966,768 (GRCm39) S369P probably benign Het
Usp17ld T C 7: 102,899,489 (GRCm39) H481R probably damaging Het
Wnt2 A G 6: 17,990,036 (GRCm39) L287P probably benign Het
Zfhx4 G T 3: 5,462,016 (GRCm39) M1230I probably damaging Het
Zfp1 T C 8: 112,396,794 (GRCm39) C272R not run Het
Zfp458 A G 13: 67,407,664 (GRCm39) S64P possibly damaging Het
Other mutations in Psg22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00797:Psg22 APN 7 18,452,200 (GRCm39) missense probably benign 0.00
IGL00839:Psg22 APN 7 18,456,893 (GRCm39) missense probably benign 0.01
IGL00898:Psg22 APN 7 18,458,392 (GRCm39) missense probably damaging 1.00
IGL02262:Psg22 APN 7 18,458,496 (GRCm39) missense probably damaging 0.98
IGL02678:Psg22 APN 7 18,453,418 (GRCm39) missense probably damaging 0.99
IGL02749:Psg22 APN 7 18,456,944 (GRCm39) missense possibly damaging 0.50
IGL02928:Psg22 APN 7 18,453,458 (GRCm39) missense probably damaging 0.98
IGL02977:Psg22 APN 7 18,453,524 (GRCm39) missense probably benign 0.20
R0470:Psg22 UTSW 7 18,453,589 (GRCm39) missense probably damaging 0.99
R1902:Psg22 UTSW 7 18,458,363 (GRCm39) nonsense probably null
R1935:Psg22 UTSW 7 18,453,635 (GRCm39) missense probably damaging 0.99
R1936:Psg22 UTSW 7 18,453,635 (GRCm39) missense probably damaging 0.99
R2013:Psg22 UTSW 7 18,453,560 (GRCm39) missense possibly damaging 0.93
R2278:Psg22 UTSW 7 18,460,762 (GRCm39) missense possibly damaging 0.80
R4258:Psg22 UTSW 7 18,458,554 (GRCm39) missense probably damaging 1.00
R5029:Psg22 UTSW 7 18,453,662 (GRCm39) missense probably damaging 1.00
R5885:Psg22 UTSW 7 18,452,257 (GRCm39) missense probably damaging 0.98
R6084:Psg22 UTSW 7 18,453,705 (GRCm39) missense probably benign 0.01
R6143:Psg22 UTSW 7 18,456,723 (GRCm39) missense probably benign 0.03
R6209:Psg22 UTSW 7 18,453,599 (GRCm39) missense probably damaging 1.00
R7017:Psg22 UTSW 7 18,458,366 (GRCm39) missense probably benign 0.01
R7337:Psg22 UTSW 7 18,453,499 (GRCm39) missense probably benign 0.20
R7417:Psg22 UTSW 7 18,456,891 (GRCm39) missense probably damaging 1.00
R7460:Psg22 UTSW 7 18,458,329 (GRCm39) missense probably benign 0.03
R7570:Psg22 UTSW 7 18,456,660 (GRCm39) missense possibly damaging 0.95
R7650:Psg22 UTSW 7 18,460,684 (GRCm39) missense possibly damaging 0.66
R7991:Psg22 UTSW 7 18,460,861 (GRCm39) missense probably damaging 1.00
R8001:Psg22 UTSW 7 18,453,671 (GRCm39) missense possibly damaging 0.79
R8003:Psg22 UTSW 7 18,458,350 (GRCm39) missense probably damaging 1.00
R8066:Psg22 UTSW 7 18,452,218 (GRCm39) missense possibly damaging 0.88
R8113:Psg22 UTSW 7 18,456,987 (GRCm39) missense probably benign 0.00
R9136:Psg22 UTSW 7 18,460,811 (GRCm39) missense probably damaging 1.00
R9148:Psg22 UTSW 7 18,460,682 (GRCm39) missense probably benign 0.09
R9152:Psg22 UTSW 7 18,460,646 (GRCm39) missense probably damaging 0.97
R9344:Psg22 UTSW 7 18,460,816 (GRCm39) missense possibly damaging 0.69
R9666:Psg22 UTSW 7 18,458,248 (GRCm39) missense probably benign
R9801:Psg22 UTSW 7 18,456,899 (GRCm39) missense probably benign 0.11
X0064:Psg22 UTSW 7 18,452,106 (GRCm39) missense probably benign 0.01
Z1177:Psg22 UTSW 7 18,453,602 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- AGGATTCTGGGATGTGCTCC -3'
(R):5'- TTTTGAACAGGGACAGCTGAGG -3'

Sequencing Primer
(F):5'- TGTGCTCCTGCCTGAGAGAAAAC -3'
(R):5'- GAGGCTTTTCTTTCCATCCTCAG -3'
Posted On 2019-11-12