Incidental Mutation 'R0241:Bicra'
ID 59482
Institutional Source Beutler Lab
Gene Symbol Bicra
Ensembl Gene ENSMUSG00000070808
Gene Name BRD4 interacting chromatin remodeling complex associated protein
Synonyms Gltscr1
MMRRC Submission 038479-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R0241 (G1)
Quality Score 184
Status Validated
Chromosome 7
Chromosomal Location 15704597-15781846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 15709070 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1188 (M1188K)
Ref Sequence ENSEMBL: ENSMUSP00000148012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]
AlphaFold F8VPZ9
Predicted Effect probably damaging
Transcript: ENSMUST00000094821
AA Change: M1188K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: M1188K

DomainStartEndE-ValueType
low complexity region 86 96 N/A INTRINSIC
low complexity region 140 155 N/A INTRINSIC
internal_repeat_1 156 298 1.03e-6 PROSPERO
low complexity region 308 323 N/A INTRINSIC
low complexity region 427 443 N/A INTRINSIC
internal_repeat_1 479 614 1.03e-6 PROSPERO
low complexity region 619 638 N/A INTRINSIC
low complexity region 642 676 N/A INTRINSIC
low complexity region 719 732 N/A INTRINSIC
low complexity region 756 782 N/A INTRINSIC
low complexity region 790 819 N/A INTRINSIC
low complexity region 827 843 N/A INTRINSIC
low complexity region 852 906 N/A INTRINSIC
low complexity region 940 950 N/A INTRINSIC
low complexity region 987 1006 N/A INTRINSIC
Pfam:GLTSCR1 1094 1202 4.6e-43 PFAM
low complexity region 1232 1251 N/A INTRINSIC
low complexity region 1275 1294 N/A INTRINSIC
low complexity region 1349 1371 N/A INTRINSIC
low complexity region 1460 1473 N/A INTRINSIC
low complexity region 1535 1555 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209251
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210035
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210713
Predicted Effect probably damaging
Transcript: ENSMUST00000210781
AA Change: M1188K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Meta Mutation Damage Score 0.1229 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 99% (72/73)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck2 T A 6: 39,560,752 (GRCm39) V380E probably benign Het
Anapc1 A T 2: 128,470,549 (GRCm39) M1527K possibly damaging Het
Arfgef3 T A 10: 18,474,962 (GRCm39) I1575F probably damaging Het
Atp4a G T 7: 30,416,560 (GRCm39) G446C probably benign Het
Brd7 G A 8: 89,072,478 (GRCm39) R331W probably benign Het
Cactin A G 10: 81,158,486 (GRCm39) T151A probably benign Het
Cadps G A 14: 12,376,675 (GRCm38) T1274M probably damaging Het
Catsper3 T C 13: 55,952,667 (GRCm39) M175T probably damaging Het
Chd5 A G 4: 152,450,589 (GRCm39) D605G probably damaging Het
Chst12 G A 5: 140,510,054 (GRCm39) R227H possibly damaging Het
Cic T A 7: 24,986,565 (GRCm39) S1299T probably damaging Het
Cic C A 7: 24,986,566 (GRCm39) S1299Y probably damaging Het
Cimap1d C T 10: 79,480,564 (GRCm39) probably null Het
Cobl A T 11: 12,204,524 (GRCm39) V644E probably benign Het
Ddx31 A G 2: 28,738,303 (GRCm39) T155A probably damaging Het
Dnah3 T C 7: 119,521,953 (GRCm39) Q4069R probably damaging Het
Dnah8 T C 17: 30,984,653 (GRCm39) I3117T probably damaging Het
Doc2b A G 11: 75,663,387 (GRCm39) V355A probably damaging Het
Dock10 A T 1: 80,556,340 (GRCm39) S578T probably benign Het
Duox1 T C 2: 122,163,878 (GRCm39) probably benign Het
Epb41l5 T C 1: 119,495,509 (GRCm39) probably null Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Fcer2a A G 8: 3,738,796 (GRCm39) probably null Het
Fmnl1 G A 11: 103,072,996 (GRCm39) probably null Het
Fry A T 5: 150,183,811 (GRCm39) probably benign Het
Git2 T C 5: 114,871,290 (GRCm39) E208G probably damaging Het
Hs6st3 T C 14: 119,376,232 (GRCm39) F136L probably benign Het
Hydin G A 8: 111,124,655 (GRCm39) V555I probably benign Het
Kcns1 A T 2: 164,010,300 (GRCm39) I153N probably damaging Het
Kmt2b A G 7: 30,276,494 (GRCm39) L1726S probably damaging Het
Loxl3 A G 6: 83,027,114 (GRCm39) D615G probably damaging Het
Negr1 T A 3: 156,914,036 (GRCm39) probably benign Het
Nfasc C A 1: 132,564,731 (GRCm39) A70S probably benign Het
Or4d1 T A 11: 87,804,860 (GRCm39) N291Y probably damaging Het
Or4p21 A T 2: 88,276,889 (GRCm39) M131K possibly damaging Het
Or52n4 A G 7: 104,294,450 (GRCm39) M41T probably benign Het
Or5g29 A G 2: 85,421,154 (GRCm39) K90R probably benign Het
Otud7a T C 7: 63,346,992 (GRCm39) probably benign Het
Pacs2 T C 12: 113,032,890 (GRCm39) probably benign Het
Pde7b A G 10: 20,311,962 (GRCm39) C239R probably damaging Het
Pdzd2 A T 15: 12,368,027 (GRCm39) L2654Q probably damaging Het
Pgap1 T C 1: 54,575,110 (GRCm39) probably null Het
Proz T A 8: 13,115,356 (GRCm39) M124K probably benign Het
Raet1d A G 10: 22,247,328 (GRCm39) T135A probably benign Het
Rapgef1 A G 2: 29,592,682 (GRCm39) N558S possibly damaging Het
Rpl7 C G 1: 16,173,446 (GRCm39) G101A possibly damaging Het
Sec14l1 G A 11: 117,037,924 (GRCm39) probably benign Het
Sfi1 CCTCTC CCTCTCTC 11: 3,127,419 (GRCm39) probably benign Het
Simc1 G T 13: 54,698,338 (GRCm39) L1319F probably damaging Het
Sspo A G 6: 48,438,429 (GRCm39) E1499G possibly damaging Het
Tango6 C T 8: 107,473,993 (GRCm39) probably benign Het
Tas2r118 T C 6: 23,969,338 (GRCm39) Y241C probably damaging Het
Tbck A G 3: 132,430,636 (GRCm39) E344G probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Thop1 T A 10: 80,916,079 (GRCm39) probably benign Het
Tmbim7 A T 5: 3,716,866 (GRCm39) Y66F probably benign Het
Tmc8 C T 11: 117,677,207 (GRCm39) probably benign Het
Tnfrsf19 A G 14: 61,211,041 (GRCm39) S216P possibly damaging Het
Trappc2l A G 8: 123,341,132 (GRCm39) probably benign Het
Trim67 A G 8: 125,549,929 (GRCm39) R520G probably damaging Het
Ubp1 T A 9: 113,795,655 (GRCm39) probably null Het
Vil1 T C 1: 74,465,853 (GRCm39) L548P probably damaging Het
Wdr3 A G 3: 100,052,973 (GRCm39) V593A probably damaging Het
Wdr5 A G 2: 27,423,025 (GRCm39) Y243C probably damaging Het
Zan T C 5: 137,420,084 (GRCm39) T2858A unknown Het
Zbtb37 A T 1: 160,847,939 (GRCm39) V356E probably benign Het
Zfp36 C T 7: 28,077,759 (GRCm39) V50I probably damaging Het
Zfp563 A T 17: 33,323,659 (GRCm39) S85C possibly damaging Het
Other mutations in Bicra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Bicra APN 7 15,730,502 (GRCm39) missense possibly damaging 0.70
IGL01521:Bicra APN 7 15,723,113 (GRCm39) missense probably benign 0.18
IGL01690:Bicra APN 7 15,721,678 (GRCm39) missense probably benign 0.09
IGL01721:Bicra APN 7 15,722,624 (GRCm39) missense probably benign
IGL01994:Bicra APN 7 15,706,741 (GRCm39) missense possibly damaging 0.46
IGL02084:Bicra APN 7 15,721,663 (GRCm39) missense probably benign 0.09
IGL02312:Bicra APN 7 15,727,066 (GRCm39) missense possibly damaging 0.85
IGL02686:Bicra APN 7 15,721,840 (GRCm39) missense probably benign 0.02
IGL02727:Bicra APN 7 15,713,390 (GRCm39) missense possibly damaging 0.95
IGL03031:Bicra APN 7 15,709,726 (GRCm39) missense probably benign 0.16
R0003:Bicra UTSW 7 15,705,812 (GRCm39) missense probably benign
R0025:Bicra UTSW 7 15,721,436 (GRCm39) missense possibly damaging 0.53
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0417:Bicra UTSW 7 15,706,247 (GRCm39) missense probably damaging 1.00
R0437:Bicra UTSW 7 15,722,687 (GRCm39) missense possibly damaging 0.73
R0547:Bicra UTSW 7 15,706,173 (GRCm39) missense probably damaging 1.00
R0688:Bicra UTSW 7 15,723,247 (GRCm39) missense probably damaging 1.00
R0855:Bicra UTSW 7 15,705,929 (GRCm39) missense probably damaging 1.00
R1448:Bicra UTSW 7 15,722,284 (GRCm39) missense possibly damaging 0.86
R1637:Bicra UTSW 7 15,706,614 (GRCm39) missense probably benign 0.19
R1899:Bicra UTSW 7 15,721,676 (GRCm39) missense possibly damaging 0.53
R2035:Bicra UTSW 7 15,730,338 (GRCm39) missense possibly damaging 0.53
R2247:Bicra UTSW 7 15,723,159 (GRCm39) missense probably benign 0.33
R2471:Bicra UTSW 7 15,706,257 (GRCm39) missense probably benign 0.04
R2484:Bicra UTSW 7 15,722,605 (GRCm39) missense possibly damaging 0.96
R3437:Bicra UTSW 7 15,723,223 (GRCm39) missense possibly damaging 0.85
R3551:Bicra UTSW 7 15,713,658 (GRCm39) missense probably benign 0.33
R4816:Bicra UTSW 7 15,722,831 (GRCm39) missense possibly damaging 0.53
R4901:Bicra UTSW 7 15,721,526 (GRCm39) missense possibly damaging 0.53
R5035:Bicra UTSW 7 15,713,349 (GRCm39) missense possibly damaging 0.90
R5078:Bicra UTSW 7 15,709,382 (GRCm39) missense probably damaging 1.00
R5094:Bicra UTSW 7 15,709,296 (GRCm39) missense probably damaging 1.00
R5195:Bicra UTSW 7 15,713,878 (GRCm39) missense possibly damaging 0.93
R5496:Bicra UTSW 7 15,721,766 (GRCm39) missense probably benign 0.33
R5780:Bicra UTSW 7 15,713,679 (GRCm39) missense possibly damaging 0.96
R6541:Bicra UTSW 7 15,713,054 (GRCm39) missense probably benign 0.00
R6560:Bicra UTSW 7 15,723,119 (GRCm39) missense possibly damaging 0.53
R6575:Bicra UTSW 7 15,713,056 (GRCm39) missense probably benign 0.25
R6854:Bicra UTSW 7 15,722,687 (GRCm39) missense probably benign 0.18
R6967:Bicra UTSW 7 15,706,130 (GRCm39) missense probably damaging 0.97
R7283:Bicra UTSW 7 15,706,425 (GRCm39) missense probably damaging 1.00
R7454:Bicra UTSW 7 15,706,059 (GRCm39) missense probably benign 0.30
R7462:Bicra UTSW 7 15,713,060 (GRCm39) missense possibly damaging 0.84
R7488:Bicra UTSW 7 15,723,367 (GRCm39) critical splice acceptor site probably null
R7506:Bicra UTSW 7 15,722,138 (GRCm39) missense possibly damaging 0.96
R7534:Bicra UTSW 7 15,705,860 (GRCm39) missense probably damaging 0.98
R7915:Bicra UTSW 7 15,722,447 (GRCm39) missense probably benign
R8063:Bicra UTSW 7 15,712,969 (GRCm39) missense probably benign
R8147:Bicra UTSW 7 15,722,395 (GRCm39) missense possibly damaging 0.93
R8699:Bicra UTSW 7 15,723,113 (GRCm39) missense probably benign 0.18
R8784:Bicra UTSW 7 15,705,875 (GRCm39) missense probably damaging 1.00
R8859:Bicra UTSW 7 15,721,737 (GRCm39) missense possibly damaging 0.73
R8971:Bicra UTSW 7 15,721,481 (GRCm39) missense probably benign 0.08
R9487:Bicra UTSW 7 15,705,717 (GRCm39) missense probably damaging 0.99
R9614:Bicra UTSW 7 15,705,880 (GRCm39) missense probably damaging 1.00
R9721:Bicra UTSW 7 15,713,101 (GRCm39) missense probably damaging 1.00
R9777:Bicra UTSW 7 15,705,987 (GRCm39) missense probably benign 0.09
X0064:Bicra UTSW 7 15,709,700 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGGCGGAAAAGCTCTTCATTTTAG -3'
(R):5'- CCCAGGCCATGCTCAATAAATATCGG -3'

Sequencing Primer
(F):5'- accaggctggactcaaac -3'
(R):5'- GCTCAATAAATATCGGCTTTTGC -3'
Posted On 2013-07-11