Incidental Mutation 'R7715:Vmn2r11'
ID |
594840 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r11
|
Ensembl Gene |
ENSMUSG00000091450 |
Gene Name |
vomeronasal 2, receptor 11 |
Synonyms |
EG384219 |
MMRRC Submission |
045773-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R7715 (G1)
|
Quality Score |
145.008 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 109195307 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 673
(V673A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
AlphaFold |
E9Q4X4 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000164875
AA Change: V673A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000133218 Gene: ENSMUSG00000091450 AA Change: V673A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
Validation Efficiency |
99% (67/68) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 69 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700019A02Rik |
A |
G |
1: 53,221,659 (GRCm39) |
F57L |
probably benign |
Het |
Agl |
C |
T |
3: 116,551,905 (GRCm39) |
R563Q |
|
Het |
Ahctf1 |
A |
G |
1: 179,598,413 (GRCm39) |
M919T |
probably benign |
Het |
Ano4 |
A |
T |
10: 88,831,173 (GRCm39) |
N483K |
probably damaging |
Het |
Armt1 |
A |
G |
10: 4,400,751 (GRCm39) |
K166R |
probably benign |
Het |
Asgr2 |
T |
C |
11: 69,987,721 (GRCm39) |
V73A |
probably benign |
Het |
Atp6v0a2 |
A |
C |
5: 124,791,262 (GRCm39) |
T564P |
probably damaging |
Het |
B3gntl1 |
T |
C |
11: 121,530,622 (GRCm39) |
T150A |
possibly damaging |
Het |
Bach1 |
A |
G |
16: 87,516,859 (GRCm39) |
I467V |
possibly damaging |
Het |
Bicd1 |
A |
G |
6: 149,414,471 (GRCm39) |
K395E |
probably benign |
Het |
Cadps |
G |
A |
14: 12,457,762 (GRCm38) |
P1040S |
probably benign |
Het |
Calcoco2 |
TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC |
TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC |
11: 95,990,862 (GRCm39) |
|
probably null |
Het |
Canx |
A |
G |
11: 50,201,631 (GRCm39) |
S80P |
probably benign |
Het |
Ccdc149 |
T |
A |
5: 52,561,533 (GRCm39) |
|
probably null |
Het |
Cd34 |
A |
T |
1: 194,631,624 (GRCm39) |
N87Y |
probably damaging |
Het |
Cdh11 |
T |
A |
8: 103,391,346 (GRCm39) |
I297F |
possibly damaging |
Het |
Cfap251 |
A |
G |
5: 123,400,197 (GRCm39) |
N439D |
probably damaging |
Het |
Cip2a |
A |
T |
16: 48,834,347 (GRCm39) |
Q643L |
probably damaging |
Het |
Col14a1 |
A |
G |
15: 55,351,379 (GRCm39) |
I1569V |
unknown |
Het |
Cxcr4 |
C |
T |
1: 128,517,479 (GRCm39) |
V61M |
probably damaging |
Het |
Cyp20a1 |
G |
A |
1: 60,411,764 (GRCm39) |
V271M |
probably benign |
Het |
Cyp2b23 |
T |
C |
7: 26,381,120 (GRCm39) |
Y79C |
probably benign |
Het |
Daam1 |
A |
G |
12: 72,035,675 (GRCm39) |
K957E |
probably benign |
Het |
Dip2c |
A |
G |
13: 9,664,427 (GRCm39) |
K947E |
probably damaging |
Het |
Efcab12 |
T |
C |
6: 115,800,504 (GRCm39) |
K173R |
possibly damaging |
Het |
Emc1 |
C |
T |
4: 139,098,934 (GRCm39) |
R806C |
probably damaging |
Het |
Epg5 |
G |
A |
18: 78,011,801 (GRCm39) |
R816Q |
probably damaging |
Het |
Faf1 |
G |
T |
4: 109,568,011 (GRCm39) |
D24Y |
probably damaging |
Het |
Fchsd1 |
A |
T |
18: 38,099,695 (GRCm39) |
|
probably null |
Het |
Foxp1 |
T |
C |
6: 98,922,621 (GRCm39) |
T404A |
unknown |
Het |
Fra10ac1 |
T |
C |
19: 38,178,286 (GRCm39) |
E299G |
probably damaging |
Het |
Gon4l |
A |
G |
3: 88,815,313 (GRCm39) |
T1959A |
probably benign |
Het |
Gpam |
A |
C |
19: 55,077,353 (GRCm39) |
V146G |
probably benign |
Het |
Hephl1 |
T |
A |
9: 14,972,081 (GRCm39) |
D953V |
probably benign |
Het |
Kcnc2 |
G |
T |
10: 112,107,845 (GRCm39) |
E79* |
probably null |
Het |
Kcnj12 |
T |
A |
11: 60,957,778 (GRCm39) |
|
probably null |
Het |
Llgl2 |
A |
T |
11: 115,740,554 (GRCm39) |
T417S |
probably benign |
Het |
Lrrc17 |
A |
T |
5: 21,766,078 (GRCm39) |
N187Y |
probably damaging |
Het |
Macc1 |
C |
T |
12: 119,409,991 (GRCm39) |
A253V |
possibly damaging |
Het |
Mark1 |
A |
G |
1: 184,639,431 (GRCm39) |
S529P |
probably damaging |
Het |
Mfsd6l |
T |
C |
11: 68,448,376 (GRCm39) |
L409P |
probably damaging |
Het |
Nek1 |
A |
G |
8: 61,459,794 (GRCm39) |
E34G |
probably damaging |
Het |
Nlrp3 |
T |
A |
11: 59,433,829 (GRCm39) |
|
probably null |
Het |
Obsl1 |
A |
T |
1: 75,478,680 (GRCm39) |
V686D |
probably damaging |
Het |
Or2l5 |
C |
T |
16: 19,333,480 (GRCm39) |
R302K |
probably benign |
Het |
Or55b10 |
T |
A |
7: 102,143,668 (GRCm39) |
M105L |
possibly damaging |
Het |
Or7h8 |
G |
A |
9: 20,123,731 (GRCm39) |
G29R |
probably damaging |
Het |
Or7h8 |
G |
A |
9: 20,123,732 (GRCm39) |
G29E |
probably benign |
Het |
Or8c15 |
T |
A |
9: 38,120,775 (GRCm39) |
M140K |
probably benign |
Het |
Or8g18 |
A |
T |
9: 39,149,174 (GRCm39) |
L182H |
probably damaging |
Het |
Ostm1 |
G |
A |
10: 42,559,183 (GRCm39) |
G148R |
probably benign |
Het |
Oxsr1 |
A |
G |
9: 119,071,822 (GRCm39) |
S470P |
probably damaging |
Het |
Pacs1 |
C |
T |
19: 5,191,709 (GRCm39) |
M709I |
probably benign |
Het |
Pan2 |
A |
G |
10: 128,153,592 (GRCm39) |
M963V |
probably benign |
Het |
Pds5a |
A |
G |
5: 65,795,904 (GRCm39) |
L662P |
possibly damaging |
Het |
Rsf1 |
GGCGGCGGC |
GGCGGCGGCCGCGGCGGC |
7: 97,229,119 (GRCm39) |
|
probably benign |
Het |
Sh2b2 |
T |
C |
5: 136,247,889 (GRCm39) |
N554S |
probably benign |
Het |
Sh3gl2 |
T |
A |
4: 85,317,077 (GRCm39) |
|
probably null |
Het |
Slc24a4 |
A |
G |
12: 102,185,219 (GRCm39) |
M93V |
possibly damaging |
Het |
Sohlh1 |
A |
G |
2: 25,734,640 (GRCm39) |
S218P |
possibly damaging |
Het |
Spast |
T |
A |
17: 74,675,921 (GRCm39) |
N321K |
probably benign |
Het |
Srcap |
T |
G |
7: 127,148,460 (GRCm39) |
I1936S |
probably damaging |
Het |
Themis |
G |
A |
10: 28,739,305 (GRCm39) |
V592I |
probably benign |
Het |
Tnfrsf1a |
C |
T |
6: 125,338,377 (GRCm39) |
T296I |
possibly damaging |
Het |
Ttk |
A |
G |
9: 83,747,206 (GRCm39) |
T682A |
probably benign |
Het |
Virma |
C |
T |
4: 11,549,682 (GRCm39) |
R1807W |
probably damaging |
Het |
Virma |
A |
G |
4: 11,513,016 (GRCm39) |
|
probably null |
Het |
Vmn2r101 |
T |
A |
17: 19,832,177 (GRCm39) |
D724E |
probably damaging |
Het |
Wbp4 |
C |
T |
14: 79,703,734 (GRCm39) |
S271N |
probably benign |
Het |
|
Other mutations in Vmn2r11 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
Predicted Primers |
PCR Primer
(F):5'- GAGATGTTACCAACCAGATTCCAC -3'
(R):5'- ATAGCTCTAGGATGCATGGCC -3'
Sequencing Primer
(F):5'- CAGATTCCACAGAAAACAAGTTGG -3'
(R):5'- CTAGGATGCATGGCCCTGTTC -3'
|
Posted On |
2019-11-12 |