Incidental Mutation 'R7715:Vmn2r101'
ID 594884
Institutional Source Beutler Lab
Gene Symbol Vmn2r101
Ensembl Gene ENSMUSG00000094892
Gene Name vomeronasal 2, receptor 101
Synonyms EG627576
MMRRC Submission 045773-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R7715 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 19797493-19832579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19832177 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 724 (D724E)
Ref Sequence ENSEMBL: ENSMUSP00000131583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171914]
AlphaFold E9PZS9
Predicted Effect probably damaging
Transcript: ENSMUST00000171914
AA Change: D724E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: D724E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 466 1.6e-36 PFAM
Pfam:NCD3G 509 562 6.4e-22 PFAM
Pfam:7tm_3 595 830 1.4e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 99% (67/68)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A G 1: 53,221,659 (GRCm39) F57L probably benign Het
Agl C T 3: 116,551,905 (GRCm39) R563Q Het
Ahctf1 A G 1: 179,598,413 (GRCm39) M919T probably benign Het
Ano4 A T 10: 88,831,173 (GRCm39) N483K probably damaging Het
Armt1 A G 10: 4,400,751 (GRCm39) K166R probably benign Het
Asgr2 T C 11: 69,987,721 (GRCm39) V73A probably benign Het
Atp6v0a2 A C 5: 124,791,262 (GRCm39) T564P probably damaging Het
B3gntl1 T C 11: 121,530,622 (GRCm39) T150A possibly damaging Het
Bach1 A G 16: 87,516,859 (GRCm39) I467V possibly damaging Het
Bicd1 A G 6: 149,414,471 (GRCm39) K395E probably benign Het
Cadps G A 14: 12,457,762 (GRCm38) P1040S probably benign Het
Calcoco2 TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,862 (GRCm39) probably null Het
Canx A G 11: 50,201,631 (GRCm39) S80P probably benign Het
Ccdc149 T A 5: 52,561,533 (GRCm39) probably null Het
Cd34 A T 1: 194,631,624 (GRCm39) N87Y probably damaging Het
Cdh11 T A 8: 103,391,346 (GRCm39) I297F possibly damaging Het
Cfap251 A G 5: 123,400,197 (GRCm39) N439D probably damaging Het
Cip2a A T 16: 48,834,347 (GRCm39) Q643L probably damaging Het
Col14a1 A G 15: 55,351,379 (GRCm39) I1569V unknown Het
Cxcr4 C T 1: 128,517,479 (GRCm39) V61M probably damaging Het
Cyp20a1 G A 1: 60,411,764 (GRCm39) V271M probably benign Het
Cyp2b23 T C 7: 26,381,120 (GRCm39) Y79C probably benign Het
Daam1 A G 12: 72,035,675 (GRCm39) K957E probably benign Het
Dip2c A G 13: 9,664,427 (GRCm39) K947E probably damaging Het
Efcab12 T C 6: 115,800,504 (GRCm39) K173R possibly damaging Het
Emc1 C T 4: 139,098,934 (GRCm39) R806C probably damaging Het
Epg5 G A 18: 78,011,801 (GRCm39) R816Q probably damaging Het
Faf1 G T 4: 109,568,011 (GRCm39) D24Y probably damaging Het
Fchsd1 A T 18: 38,099,695 (GRCm39) probably null Het
Foxp1 T C 6: 98,922,621 (GRCm39) T404A unknown Het
Fra10ac1 T C 19: 38,178,286 (GRCm39) E299G probably damaging Het
Gon4l A G 3: 88,815,313 (GRCm39) T1959A probably benign Het
Gpam A C 19: 55,077,353 (GRCm39) V146G probably benign Het
Hephl1 T A 9: 14,972,081 (GRCm39) D953V probably benign Het
Kcnc2 G T 10: 112,107,845 (GRCm39) E79* probably null Het
Kcnj12 T A 11: 60,957,778 (GRCm39) probably null Het
Llgl2 A T 11: 115,740,554 (GRCm39) T417S probably benign Het
Lrrc17 A T 5: 21,766,078 (GRCm39) N187Y probably damaging Het
Macc1 C T 12: 119,409,991 (GRCm39) A253V possibly damaging Het
Mark1 A G 1: 184,639,431 (GRCm39) S529P probably damaging Het
Mfsd6l T C 11: 68,448,376 (GRCm39) L409P probably damaging Het
Nek1 A G 8: 61,459,794 (GRCm39) E34G probably damaging Het
Nlrp3 T A 11: 59,433,829 (GRCm39) probably null Het
Obsl1 A T 1: 75,478,680 (GRCm39) V686D probably damaging Het
Or2l5 C T 16: 19,333,480 (GRCm39) R302K probably benign Het
Or55b10 T A 7: 102,143,668 (GRCm39) M105L possibly damaging Het
Or7h8 G A 9: 20,123,731 (GRCm39) G29R probably damaging Het
Or7h8 G A 9: 20,123,732 (GRCm39) G29E probably benign Het
Or8c15 T A 9: 38,120,775 (GRCm39) M140K probably benign Het
Or8g18 A T 9: 39,149,174 (GRCm39) L182H probably damaging Het
Ostm1 G A 10: 42,559,183 (GRCm39) G148R probably benign Het
Oxsr1 A G 9: 119,071,822 (GRCm39) S470P probably damaging Het
Pacs1 C T 19: 5,191,709 (GRCm39) M709I probably benign Het
Pan2 A G 10: 128,153,592 (GRCm39) M963V probably benign Het
Pds5a A G 5: 65,795,904 (GRCm39) L662P possibly damaging Het
Rsf1 GGCGGCGGC GGCGGCGGCCGCGGCGGC 7: 97,229,119 (GRCm39) probably benign Het
Sh2b2 T C 5: 136,247,889 (GRCm39) N554S probably benign Het
Sh3gl2 T A 4: 85,317,077 (GRCm39) probably null Het
Slc24a4 A G 12: 102,185,219 (GRCm39) M93V possibly damaging Het
Sohlh1 A G 2: 25,734,640 (GRCm39) S218P possibly damaging Het
Spast T A 17: 74,675,921 (GRCm39) N321K probably benign Het
Srcap T G 7: 127,148,460 (GRCm39) I1936S probably damaging Het
Themis G A 10: 28,739,305 (GRCm39) V592I probably benign Het
Tnfrsf1a C T 6: 125,338,377 (GRCm39) T296I possibly damaging Het
Ttk A G 9: 83,747,206 (GRCm39) T682A probably benign Het
Virma C T 4: 11,549,682 (GRCm39) R1807W probably damaging Het
Virma A G 4: 11,513,016 (GRCm39) probably null Het
Vmn2r11 A G 5: 109,195,307 (GRCm39) V673A probably damaging Het
Wbp4 C T 14: 79,703,734 (GRCm39) S271N probably benign Het
Other mutations in Vmn2r101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Vmn2r101 APN 17 19,809,936 (GRCm39) missense probably damaging 0.99
IGL02125:Vmn2r101 APN 17 19,809,963 (GRCm39) missense possibly damaging 0.95
IGL02300:Vmn2r101 APN 17 19,832,199 (GRCm39) missense probably damaging 1.00
IGL02682:Vmn2r101 APN 17 19,832,507 (GRCm39) missense possibly damaging 0.82
IGL02825:Vmn2r101 APN 17 19,810,132 (GRCm39) missense probably benign 0.00
IGL02862:Vmn2r101 APN 17 19,831,867 (GRCm39) missense probably damaging 1.00
IGL02943:Vmn2r101 APN 17 19,831,666 (GRCm39) missense probably damaging 0.99
R0371:Vmn2r101 UTSW 17 19,810,394 (GRCm39) missense probably benign 0.07
R0462:Vmn2r101 UTSW 17 19,810,431 (GRCm39) missense probably benign 0.04
R0492:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R0654:Vmn2r101 UTSW 17 19,810,373 (GRCm39) missense probably benign 0.01
R1120:Vmn2r101 UTSW 17 19,797,723 (GRCm39) splice site probably benign
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1676:Vmn2r101 UTSW 17 19,832,184 (GRCm39) missense probably benign 0.00
R2023:Vmn2r101 UTSW 17 19,810,368 (GRCm39) nonsense probably null
R2149:Vmn2r101 UTSW 17 19,809,225 (GRCm39) missense probably benign 0.00
R2350:Vmn2r101 UTSW 17 19,810,045 (GRCm39) missense probably benign 0.01
R2760:Vmn2r101 UTSW 17 19,809,901 (GRCm39) missense probably benign 0.14
R3085:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3086:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3719:Vmn2r101 UTSW 17 19,809,811 (GRCm39) missense possibly damaging 0.50
R3771:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R3773:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R4225:Vmn2r101 UTSW 17 19,831,951 (GRCm39) missense probably damaging 1.00
R4248:Vmn2r101 UTSW 17 19,809,376 (GRCm39) missense probably damaging 1.00
R4290:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4291:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4293:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r101 UTSW 17 19,810,423 (GRCm39) missense probably damaging 1.00
R4721:Vmn2r101 UTSW 17 19,832,287 (GRCm39) missense probably damaging 0.99
R4829:Vmn2r101 UTSW 17 19,832,229 (GRCm39) missense probably benign 0.03
R5022:Vmn2r101 UTSW 17 19,831,649 (GRCm39) critical splice acceptor site probably null
R5110:Vmn2r101 UTSW 17 19,831,897 (GRCm39) missense possibly damaging 0.92
R5244:Vmn2r101 UTSW 17 19,831,788 (GRCm39) missense probably damaging 1.00
R5397:Vmn2r101 UTSW 17 19,809,104 (GRCm39) missense probably damaging 1.00
R5875:Vmn2r101 UTSW 17 19,809,092 (GRCm39) missense probably damaging 0.99
R5944:Vmn2r101 UTSW 17 19,809,769 (GRCm39) missense probably benign 0.00
R6216:Vmn2r101 UTSW 17 19,811,267 (GRCm39) missense probably benign 0.00
R6334:Vmn2r101 UTSW 17 19,810,112 (GRCm39) missense possibly damaging 0.83
R6512:Vmn2r101 UTSW 17 19,809,146 (GRCm39) missense probably damaging 1.00
R6607:Vmn2r101 UTSW 17 19,832,296 (GRCm39) missense probably damaging 1.00
R6965:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R7101:Vmn2r101 UTSW 17 19,809,350 (GRCm39) missense probably null 0.14
R7183:Vmn2r101 UTSW 17 19,832,440 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r101 UTSW 17 19,832,059 (GRCm39) missense probably benign 0.38
R7375:Vmn2r101 UTSW 17 19,831,652 (GRCm39) missense probably damaging 1.00
R7574:Vmn2r101 UTSW 17 19,831,899 (GRCm39) missense possibly damaging 0.91
R7575:Vmn2r101 UTSW 17 19,831,654 (GRCm39) missense probably benign 0.01
R7592:Vmn2r101 UTSW 17 19,811,443 (GRCm39) splice site probably null
R7626:Vmn2r101 UTSW 17 19,832,192 (GRCm39) nonsense probably null
R7730:Vmn2r101 UTSW 17 19,831,950 (GRCm39) missense possibly damaging 0.81
R8078:Vmn2r101 UTSW 17 19,810,507 (GRCm39) missense probably benign 0.07
R8228:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R8283:Vmn2r101 UTSW 17 19,832,253 (GRCm39) missense probably damaging 1.00
R8712:Vmn2r101 UTSW 17 19,811,397 (GRCm39) missense probably benign 0.24
R8765:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R9091:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9092:Vmn2r101 UTSW 17 19,809,807 (GRCm39) missense probably benign 0.07
R9113:Vmn2r101 UTSW 17 19,811,288 (GRCm39) missense possibly damaging 0.56
R9158:Vmn2r101 UTSW 17 19,809,161 (GRCm39) missense probably benign 0.00
R9168:Vmn2r101 UTSW 17 19,809,138 (GRCm39) missense probably damaging 1.00
R9235:Vmn2r101 UTSW 17 19,810,238 (GRCm39) missense probably damaging 0.99
R9270:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9290:Vmn2r101 UTSW 17 19,811,395 (GRCm39) missense probably benign 0.05
R9296:Vmn2r101 UTSW 17 19,810,047 (GRCm39) missense probably damaging 0.98
R9602:Vmn2r101 UTSW 17 19,831,780 (GRCm39) nonsense probably null
R9706:Vmn2r101 UTSW 17 19,809,925 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r101 UTSW 17 19,809,237 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- TTGCTACTGTGTTGGCCAAAG -3'
(R):5'- CCCTTTAGTGCTGTGGAAGAC -3'

Sequencing Primer
(F):5'- GCTACTGTGTTGGCCAAAGCTATTAC -3'
(R):5'- GTGAGCCAGACACAGAAGAACAC -3'
Posted On 2019-11-12