Incidental Mutation 'R7718:Tmem132c'
ID 595030
Institutional Source Beutler Lab
Gene Symbol Tmem132c
Ensembl Gene ENSMUSG00000034324
Gene Name transmembrane protein 132C
Synonyms 2810482M11Rik, 4632425D07Rik
MMRRC Submission 045775-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R7718 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 127318890-127642854 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 127640504 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 892 (T892S)
Ref Sequence ENSEMBL: ENSMUSP00000113090 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119026]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000119026
AA Change: T892S

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000113090
Gene: ENSMUSG00000034324
AA Change: T892S

DomainStartEndE-ValueType
low complexity region 14 21 N/A INTRINSIC
Pfam:TMEM132D_N 58 187 1.2e-54 PFAM
Pfam:TMEM132 444 787 4.5e-143 PFAM
Pfam:TMEM132D_C 892 980 2.4e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145748
SMART Domains Protein: ENSMUSP00000121783
Gene: ENSMUSG00000034324

DomainStartEndE-ValueType
Pfam:TMEM132 1 112 6.2e-31 PFAM
Meta Mutation Damage Score 0.2195 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (77/78)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A T 5: 138,646,122 (GRCm39) H669L possibly damaging Het
Abcb1a A T 5: 8,765,788 (GRCm39) N700I probably damaging Het
Abcc6 T C 7: 45,626,816 (GRCm39) K1414E possibly damaging Het
Adcy5 T C 16: 35,100,785 (GRCm39) V779A probably benign Het
Agap2 A G 10: 126,915,734 (GRCm39) S82G possibly damaging Het
Aldh1l1 A G 6: 90,575,305 (GRCm39) N864S probably damaging Het
Ang2 A T 14: 51,433,217 (GRCm39) V55E probably benign Het
Ank2 A G 3: 126,758,662 (GRCm39) M179T possibly damaging Het
Atrnl1 T A 19: 57,728,615 (GRCm39) C1090* probably null Het
Atxn1l A G 8: 110,459,866 (GRCm39) L132P probably damaging Het
Bptf A G 11: 106,972,282 (GRCm39) V862A possibly damaging Het
Capn11 C A 17: 45,954,707 (GRCm39) K143N probably damaging Het
Card6 A G 15: 5,129,269 (GRCm39) V709A possibly damaging Het
Cavin4 C T 4: 48,671,984 (GRCm39) A143V probably benign Het
Cntn5 A G 9: 9,984,133 (GRCm39) I160T probably benign Het
Cyp2c40 T A 19: 39,755,782 (GRCm39) N511Y probably benign Het
Dsc2 A T 18: 20,174,835 (GRCm39) I480N probably damaging Het
Elf2 G T 3: 51,173,385 (GRCm39) probably benign Het
Enoph1 T C 5: 100,210,019 (GRCm39) V133A possibly damaging Het
Ezh2 A T 6: 47,531,125 (GRCm39) D186E probably benign Het
Fcgbpl1 T C 7: 27,846,626 (GRCm39) F1106S probably damaging Het
Gfra1 T C 19: 58,441,889 (GRCm39) D14G possibly damaging Het
Gmip C T 8: 70,270,383 (GRCm39) R698W probably damaging Het
Grk4 A G 5: 34,852,160 (GRCm39) N135D probably benign Het
Hspb6 A G 7: 30,253,772 (GRCm39) D95G probably benign Het
Htatip2 T G 7: 49,420,632 (GRCm39) H159Q possibly damaging Het
Igfn1 T C 1: 135,896,774 (GRCm39) E1264G probably benign Het
Insyn2b T C 11: 34,352,539 (GRCm39) S194P probably benign Het
Katnb1 T A 8: 95,821,836 (GRCm39) V223E possibly damaging Het
Klra6 AGG AG 6: 129,990,315 (GRCm39) probably null Het
Masp2 C T 4: 148,687,204 (GRCm39) R29C probably damaging Het
Mcm3 A T 1: 20,887,498 (GRCm39) C123* probably null Het
Mdn1 T C 4: 32,718,420 (GRCm39) V2225A probably damaging Het
Me1 A G 9: 86,561,953 (GRCm39) L44S probably damaging Het
Mlxip A G 5: 123,583,577 (GRCm39) N380S probably benign Het
Muc21 T C 17: 35,933,728 (GRCm39) T153A unknown Het
Myh14 C T 7: 44,310,464 (GRCm39) V140I probably damaging Het
Myocd A T 11: 65,109,452 (GRCm39) D106E probably damaging Het
Oat T C 7: 132,159,988 (GRCm39) I411V probably benign Het
Or2d2 A T 7: 106,727,925 (GRCm39) V225D probably damaging Het
Or5p59 T C 7: 107,702,855 (GRCm39) V113A probably benign Het
Or8k38 A G 2: 86,488,373 (GRCm39) V143A probably benign Het
Orc2 A T 1: 58,519,476 (GRCm39) H246Q possibly damaging Het
Pank4 A G 4: 155,059,100 (GRCm39) E411G probably damaging Het
Patl2 A T 2: 121,957,255 (GRCm39) probably null Het
Pcdhb15 A G 18: 37,608,216 (GRCm39) N483D probably damaging Het
Pcdhb20 A G 18: 37,638,704 (GRCm39) D410G probably damaging Het
Pdcl2 A G 5: 76,465,846 (GRCm39) C125R probably damaging Het
Peli3 C G 19: 4,984,584 (GRCm39) probably null Het
Pkd1 A G 17: 24,805,474 (GRCm39) D3313G probably benign Het
Plec A C 15: 76,061,639 (GRCm39) M2766R probably damaging Het
Ppargc1a C T 5: 51,655,504 (GRCm39) V99M probably damaging Het
Prr35 T A 17: 26,165,998 (GRCm39) R430* probably null Het
Psg19 G A 7: 18,526,368 (GRCm39) A374V probably benign Het
Psmd7 A T 8: 108,313,261 (GRCm39) F54L possibly damaging Het
Ptbp2 C T 3: 119,514,637 (GRCm39) G397R probably null Het
Ranbp3 A G 17: 57,003,718 (GRCm39) D39G probably damaging Het
Rcor3 T C 1: 191,786,021 (GRCm39) T406A probably benign Het
Rhbdl2 T A 4: 123,718,712 (GRCm39) I222K probably damaging Het
Ripk2 T C 4: 16,151,968 (GRCm39) N197S possibly damaging Het
Rpia A T 6: 70,743,602 (GRCm39) M283K probably damaging Het
Rps6kc1 T C 1: 190,604,022 (GRCm39) D200G probably benign Het
Sipa1l1 A T 12: 82,389,271 (GRCm39) K499M probably damaging Het
Slc5a4b A G 10: 75,906,407 (GRCm39) L404P probably damaging Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Spmip4 G A 6: 50,566,078 (GRCm39) probably null Het
St7 A C 6: 17,854,998 (GRCm39) T312P probably damaging Het
Strbp T C 2: 37,515,294 (GRCm39) E244G probably damaging Het
Tbc1d8 T G 1: 39,416,061 (GRCm39) T871P probably benign Het
Tcp1 T A 17: 13,141,049 (GRCm39) I286N probably damaging Het
Tead3 C A 17: 28,552,491 (GRCm39) V327F probably damaging Het
Trmt2a T C 16: 18,068,487 (GRCm39) S65P probably benign Het
Ubp1 A G 9: 113,802,597 (GRCm39) N479S possibly damaging Het
Ubtfl1 A T 9: 18,320,527 (GRCm39) L18F possibly damaging Het
Uevld T G 7: 46,587,804 (GRCm39) M299L probably benign Het
Unc13b T A 4: 43,173,854 (GRCm39) Y1561N unknown Het
Ylpm1 A G 12: 85,075,896 (GRCm39) K874E probably damaging Het
Zbtb37 G A 1: 160,859,802 (GRCm39) R168W possibly damaging Het
Other mutations in Tmem132c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00869:Tmem132c APN 5 127,640,306 (GRCm39) missense possibly damaging 0.95
IGL00985:Tmem132c APN 5 127,581,930 (GRCm39) missense probably damaging 0.99
IGL01599:Tmem132c APN 5 127,436,616 (GRCm39) splice site probably benign
IGL01750:Tmem132c APN 5 127,540,023 (GRCm39) missense possibly damaging 0.91
IGL01893:Tmem132c APN 5 127,540,093 (GRCm39) missense possibly damaging 0.51
IGL02143:Tmem132c APN 5 127,640,466 (GRCm39) missense probably benign 0.03
IGL02164:Tmem132c APN 5 127,613,441 (GRCm39) missense probably damaging 1.00
IGL02252:Tmem132c APN 5 127,539,991 (GRCm39) missense possibly damaging 0.91
IGL02527:Tmem132c APN 5 127,436,675 (GRCm39) missense possibly damaging 0.95
IGL02584:Tmem132c APN 5 127,582,063 (GRCm39) missense probably damaging 1.00
IGL02878:Tmem132c APN 5 127,640,154 (GRCm39) missense probably damaging 0.99
IGL03065:Tmem132c APN 5 127,640,688 (GRCm39) missense probably damaging 1.00
IGL03120:Tmem132c APN 5 127,640,448 (GRCm39) missense probably benign 0.06
IGL03380:Tmem132c APN 5 127,613,506 (GRCm39) missense probably benign 0.00
IGL03387:Tmem132c APN 5 127,640,784 (GRCm39) missense probably benign 0.00
R0106:Tmem132c UTSW 5 127,631,733 (GRCm39) missense possibly damaging 0.94
R0106:Tmem132c UTSW 5 127,631,733 (GRCm39) missense possibly damaging 0.94
R0415:Tmem132c UTSW 5 127,640,769 (GRCm39) missense probably damaging 1.00
R0607:Tmem132c UTSW 5 127,640,617 (GRCm39) nonsense probably null
R1413:Tmem132c UTSW 5 127,640,631 (GRCm39) missense probably damaging 1.00
R1531:Tmem132c UTSW 5 127,436,955 (GRCm39) missense probably damaging 1.00
R1648:Tmem132c UTSW 5 127,540,120 (GRCm39) splice site probably benign
R2148:Tmem132c UTSW 5 127,540,026 (GRCm39) missense probably damaging 1.00
R2149:Tmem132c UTSW 5 127,540,026 (GRCm39) missense probably damaging 1.00
R2259:Tmem132c UTSW 5 127,581,988 (GRCm39) missense probably benign 0.01
R3853:Tmem132c UTSW 5 127,436,933 (GRCm39) missense probably benign 0.00
R4204:Tmem132c UTSW 5 127,640,829 (GRCm39) missense possibly damaging 0.73
R4543:Tmem132c UTSW 5 127,582,041 (GRCm39) missense probably benign 0.00
R4701:Tmem132c UTSW 5 127,641,560 (GRCm39) unclassified probably benign
R5017:Tmem132c UTSW 5 127,640,414 (GRCm39) missense probably benign 0.13
R5037:Tmem132c UTSW 5 127,630,199 (GRCm39) missense probably benign 0.42
R5327:Tmem132c UTSW 5 127,640,816 (GRCm39) missense possibly damaging 0.50
R5423:Tmem132c UTSW 5 127,640,907 (GRCm39) missense probably benign 0.02
R5548:Tmem132c UTSW 5 127,628,587 (GRCm39) nonsense probably null
R6425:Tmem132c UTSW 5 127,630,329 (GRCm39) missense possibly damaging 0.95
R6717:Tmem132c UTSW 5 127,641,093 (GRCm39) missense possibly damaging 0.93
R6899:Tmem132c UTSW 5 127,628,744 (GRCm39) missense probably damaging 1.00
R7007:Tmem132c UTSW 5 127,436,679 (GRCm39) missense probably damaging 1.00
R7297:Tmem132c UTSW 5 127,437,281 (GRCm39) missense probably benign 0.06
R7326:Tmem132c UTSW 5 127,641,123 (GRCm39) missense possibly damaging 0.51
R7386:Tmem132c UTSW 5 127,640,990 (GRCm39) missense probably benign 0.16
R7504:Tmem132c UTSW 5 127,631,696 (GRCm39) missense probably damaging 1.00
R7640:Tmem132c UTSW 5 127,640,070 (GRCm39) missense probably damaging 1.00
R7762:Tmem132c UTSW 5 127,631,760 (GRCm39) missense possibly damaging 0.90
R7818:Tmem132c UTSW 5 127,641,152 (GRCm39) makesense probably null
R8117:Tmem132c UTSW 5 127,437,176 (GRCm39) missense probably benign 0.22
R8425:Tmem132c UTSW 5 127,641,421 (GRCm39) missense
R8749:Tmem132c UTSW 5 127,437,003 (GRCm39) missense possibly damaging 0.75
R8771:Tmem132c UTSW 5 127,437,192 (GRCm39) missense probably benign 0.00
R8798:Tmem132c UTSW 5 127,437,217 (GRCm39) nonsense probably null
R9372:Tmem132c UTSW 5 127,640,145 (GRCm39) missense probably damaging 1.00
X0067:Tmem132c UTSW 5 127,613,471 (GRCm39) missense possibly damaging 0.79
Z1088:Tmem132c UTSW 5 127,581,985 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- TCAAGAACCATGCCAGTGAC -3'
(R):5'- TTGTGCCTGTACTTGAAGGC -3'

Sequencing Primer
(F):5'- TGACCGTCGGCAGAAGATTC -3'
(R):5'- CCTGTACTTGAAGGCAAAGGTG -3'
Posted On 2019-11-12