Incidental Mutation 'R7718:Atrnl1'
ID 595080
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
MMRRC Submission 045775-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.182) question?
Stock # R7718 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 57599466-58121775 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 57728615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 1090 (C1090*)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably null
Transcript: ENSMUST00000077282
AA Change: C1090*
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: C1090*

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (77/78)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik A T 5: 138,646,122 (GRCm39) H669L possibly damaging Het
Abcb1a A T 5: 8,765,788 (GRCm39) N700I probably damaging Het
Abcc6 T C 7: 45,626,816 (GRCm39) K1414E possibly damaging Het
Adcy5 T C 16: 35,100,785 (GRCm39) V779A probably benign Het
Agap2 A G 10: 126,915,734 (GRCm39) S82G possibly damaging Het
Aldh1l1 A G 6: 90,575,305 (GRCm39) N864S probably damaging Het
Ang2 A T 14: 51,433,217 (GRCm39) V55E probably benign Het
Ank2 A G 3: 126,758,662 (GRCm39) M179T possibly damaging Het
Atxn1l A G 8: 110,459,866 (GRCm39) L132P probably damaging Het
Bptf A G 11: 106,972,282 (GRCm39) V862A possibly damaging Het
Capn11 C A 17: 45,954,707 (GRCm39) K143N probably damaging Het
Card6 A G 15: 5,129,269 (GRCm39) V709A possibly damaging Het
Cavin4 C T 4: 48,671,984 (GRCm39) A143V probably benign Het
Cntn5 A G 9: 9,984,133 (GRCm39) I160T probably benign Het
Cyp2c40 T A 19: 39,755,782 (GRCm39) N511Y probably benign Het
Dsc2 A T 18: 20,174,835 (GRCm39) I480N probably damaging Het
Elf2 G T 3: 51,173,385 (GRCm39) probably benign Het
Enoph1 T C 5: 100,210,019 (GRCm39) V133A possibly damaging Het
Ezh2 A T 6: 47,531,125 (GRCm39) D186E probably benign Het
Fcgbpl1 T C 7: 27,846,626 (GRCm39) F1106S probably damaging Het
Gfra1 T C 19: 58,441,889 (GRCm39) D14G possibly damaging Het
Gmip C T 8: 70,270,383 (GRCm39) R698W probably damaging Het
Grk4 A G 5: 34,852,160 (GRCm39) N135D probably benign Het
Hspb6 A G 7: 30,253,772 (GRCm39) D95G probably benign Het
Htatip2 T G 7: 49,420,632 (GRCm39) H159Q possibly damaging Het
Igfn1 T C 1: 135,896,774 (GRCm39) E1264G probably benign Het
Insyn2b T C 11: 34,352,539 (GRCm39) S194P probably benign Het
Katnb1 T A 8: 95,821,836 (GRCm39) V223E possibly damaging Het
Klra6 AGG AG 6: 129,990,315 (GRCm39) probably null Het
Masp2 C T 4: 148,687,204 (GRCm39) R29C probably damaging Het
Mcm3 A T 1: 20,887,498 (GRCm39) C123* probably null Het
Mdn1 T C 4: 32,718,420 (GRCm39) V2225A probably damaging Het
Me1 A G 9: 86,561,953 (GRCm39) L44S probably damaging Het
Mlxip A G 5: 123,583,577 (GRCm39) N380S probably benign Het
Muc21 T C 17: 35,933,728 (GRCm39) T153A unknown Het
Myh14 C T 7: 44,310,464 (GRCm39) V140I probably damaging Het
Myocd A T 11: 65,109,452 (GRCm39) D106E probably damaging Het
Oat T C 7: 132,159,988 (GRCm39) I411V probably benign Het
Or2d2 A T 7: 106,727,925 (GRCm39) V225D probably damaging Het
Or5p59 T C 7: 107,702,855 (GRCm39) V113A probably benign Het
Or8k38 A G 2: 86,488,373 (GRCm39) V143A probably benign Het
Orc2 A T 1: 58,519,476 (GRCm39) H246Q possibly damaging Het
Pank4 A G 4: 155,059,100 (GRCm39) E411G probably damaging Het
Patl2 A T 2: 121,957,255 (GRCm39) probably null Het
Pcdhb15 A G 18: 37,608,216 (GRCm39) N483D probably damaging Het
Pcdhb20 A G 18: 37,638,704 (GRCm39) D410G probably damaging Het
Pdcl2 A G 5: 76,465,846 (GRCm39) C125R probably damaging Het
Peli3 C G 19: 4,984,584 (GRCm39) probably null Het
Pkd1 A G 17: 24,805,474 (GRCm39) D3313G probably benign Het
Plec A C 15: 76,061,639 (GRCm39) M2766R probably damaging Het
Ppargc1a C T 5: 51,655,504 (GRCm39) V99M probably damaging Het
Prr35 T A 17: 26,165,998 (GRCm39) R430* probably null Het
Psg19 G A 7: 18,526,368 (GRCm39) A374V probably benign Het
Psmd7 A T 8: 108,313,261 (GRCm39) F54L possibly damaging Het
Ptbp2 C T 3: 119,514,637 (GRCm39) G397R probably null Het
Ranbp3 A G 17: 57,003,718 (GRCm39) D39G probably damaging Het
Rcor3 T C 1: 191,786,021 (GRCm39) T406A probably benign Het
Rhbdl2 T A 4: 123,718,712 (GRCm39) I222K probably damaging Het
Ripk2 T C 4: 16,151,968 (GRCm39) N197S possibly damaging Het
Rpia A T 6: 70,743,602 (GRCm39) M283K probably damaging Het
Rps6kc1 T C 1: 190,604,022 (GRCm39) D200G probably benign Het
Sipa1l1 A T 12: 82,389,271 (GRCm39) K499M probably damaging Het
Slc5a4b A G 10: 75,906,407 (GRCm39) L404P probably damaging Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Spmip4 G A 6: 50,566,078 (GRCm39) probably null Het
St7 A C 6: 17,854,998 (GRCm39) T312P probably damaging Het
Strbp T C 2: 37,515,294 (GRCm39) E244G probably damaging Het
Tbc1d8 T G 1: 39,416,061 (GRCm39) T871P probably benign Het
Tcp1 T A 17: 13,141,049 (GRCm39) I286N probably damaging Het
Tead3 C A 17: 28,552,491 (GRCm39) V327F probably damaging Het
Tmem132c A T 5: 127,640,504 (GRCm39) T892S probably benign Het
Trmt2a T C 16: 18,068,487 (GRCm39) S65P probably benign Het
Ubp1 A G 9: 113,802,597 (GRCm39) N479S possibly damaging Het
Ubtfl1 A T 9: 18,320,527 (GRCm39) L18F possibly damaging Het
Uevld T G 7: 46,587,804 (GRCm39) M299L probably benign Het
Unc13b T A 4: 43,173,854 (GRCm39) Y1561N unknown Het
Ylpm1 A G 12: 85,075,896 (GRCm39) K874E probably damaging Het
Zbtb37 G A 1: 160,859,802 (GRCm39) R168W possibly damaging Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,680,249 (GRCm39) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,661,697 (GRCm39) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,690,585 (GRCm39) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,119,536 (GRCm39) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,688,144 (GRCm39) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,641,380 (GRCm39) missense probably benign
IGL01971:Atrnl1 APN 19 57,741,715 (GRCm39) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,680,195 (GRCm39) splice site probably benign
IGL02580:Atrnl1 APN 19 57,703,008 (GRCm39) splice site probably benign
IGL02649:Atrnl1 APN 19 57,638,873 (GRCm39) splice site probably benign
IGL02676:Atrnl1 APN 19 57,680,316 (GRCm39) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,641,359 (GRCm39) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,630,973 (GRCm39) missense probably benign 0.02
Magnetogorsk UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
polar UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
PIT4812001:Atrnl1 UTSW 19 57,720,055 (GRCm39) missense probably benign 0.08
R0109:Atrnl1 UTSW 19 57,743,949 (GRCm39) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,741,720 (GRCm39) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,661,608 (GRCm39) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,643,293 (GRCm39) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R1183:Atrnl1 UTSW 19 57,638,725 (GRCm39) missense probably damaging 0.97
R1213:Atrnl1 UTSW 19 57,626,894 (GRCm39) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,675,169 (GRCm39) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,703,134 (GRCm39) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,680,281 (GRCm39) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,744,048 (GRCm39) nonsense probably null
R2130:Atrnl1 UTSW 19 57,643,426 (GRCm39) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,645,546 (GRCm39) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,924,084 (GRCm39) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4785:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,030,793 (GRCm39) missense probably benign
R5172:Atrnl1 UTSW 19 57,673,945 (GRCm39) nonsense probably null
R5226:Atrnl1 UTSW 19 57,638,767 (GRCm39) missense probably benign
R5289:Atrnl1 UTSW 19 57,645,514 (GRCm39) missense probably damaging 1.00
R5372:Atrnl1 UTSW 19 57,743,968 (GRCm39) missense probably benign
R5737:Atrnl1 UTSW 19 57,766,320 (GRCm39) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,741,718 (GRCm39) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,618,724 (GRCm39) nonsense probably null
R6169:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,630,910 (GRCm39) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,626,942 (GRCm39) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,638,764 (GRCm39) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,643,393 (GRCm39) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,030,800 (GRCm39) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,626,882 (GRCm39) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,680,289 (GRCm39) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,030,784 (GRCm39) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,924,038 (GRCm39) nonsense probably null
R7289:Atrnl1 UTSW 19 57,638,846 (GRCm39) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,630,856 (GRCm39) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,924,078 (GRCm39) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,743,956 (GRCm39) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,684,744 (GRCm39) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,643,278 (GRCm39) missense probably benign
R7567:Atrnl1 UTSW 19 57,687,955 (GRCm39) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,703,119 (GRCm39) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7656:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7721:Atrnl1 UTSW 19 57,684,763 (GRCm39) missense probably benign 0.00
R7726:Atrnl1 UTSW 19 57,690,504 (GRCm39) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,688,103 (GRCm39) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,670,878 (GRCm39) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,645,660 (GRCm39) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,766,359 (GRCm39) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,643,420 (GRCm39) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,617,551 (GRCm39) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,618,695 (GRCm39) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,599,786 (GRCm39) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,630,905 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTCCTGGATACGGCCTTTTCAC -3'
(R):5'- CTTAGCAACAGATGTGGAAGTG -3'

Sequencing Primer
(F):5'- GGGTTTCTGCAGTCAGTTA -3'
(R):5'- GGCTGGCCTTGAACTCAGAAATC -3'
Posted On 2019-11-12