Incidental Mutation 'R7721:Atrnl1'
ID 595253
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
MMRRC Submission 045777-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.182) question?
Stock # R7721 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 57599466-58121775 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 57684763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 796 (D796E)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably benign
Transcript: ENSMUST00000077282
AA Change: D796E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: D796E

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 98% (51/52)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T C 5: 121,784,929 (GRCm39) probably null Het
Adamtsl3 T G 7: 82,255,728 (GRCm39) M1580R possibly damaging Het
Alg9 T C 9: 50,687,942 (GRCm39) I78T probably damaging Het
Ankmy2 G T 12: 36,207,143 (GRCm39) probably benign Het
Ankrd11 G T 8: 123,621,498 (GRCm39) L785M probably damaging Het
C1s2 A G 6: 124,607,017 (GRCm39) V277A possibly damaging Het
Ccdc121rt3 A G 5: 112,503,383 (GRCm39) I107T probably benign Het
Cldn15 A G 5: 136,997,015 (GRCm39) M19V probably benign Het
Cldn23 T G 8: 36,293,417 (GRCm39) S24R possibly damaging Het
Cnr1 T A 4: 33,944,416 (GRCm39) I268N probably damaging Het
Csf2ra A T 19: 61,215,024 (GRCm39) W147R probably damaging Het
Ctsb G T 14: 63,370,765 (GRCm39) probably benign Het
D430041D05Rik A G 2: 104,088,874 (GRCm39) M34T probably benign Het
Dmtf1 T C 5: 9,176,564 (GRCm39) I463V probably damaging Het
Dnah7a T A 1: 53,670,842 (GRCm39) D470V probably benign Het
Dtx4 A G 19: 12,459,500 (GRCm39) S435P probably benign Het
Ear2 T A 14: 44,340,495 (GRCm39) M51K probably damaging Het
Efcab3 T A 11: 104,615,366 (GRCm39) L711* probably null Het
Elmo1 T A 13: 20,464,973 (GRCm39) probably null Het
Faf1 T A 4: 109,593,794 (GRCm39) I124N probably damaging Het
Gkap1 A C 13: 58,384,799 (GRCm39) probably null Het
Glipr2 T C 4: 43,957,770 (GRCm39) S4P probably benign Het
Gm38119 A T 3: 92,645,337 (GRCm39) C86S unknown Het
Gpr171 T G 3: 59,005,320 (GRCm39) I152L probably benign Het
Hes7 T A 11: 69,012,352 (GRCm39) T9S unknown Het
Homer3 T C 8: 70,743,662 (GRCm39) V180A probably benign Het
Irx1 T A 13: 72,108,176 (GRCm39) M169L probably benign Het
Kap A G 6: 133,828,690 (GRCm39) probably null Het
Mgat5b A G 11: 116,857,627 (GRCm39) M2V Het
Mob4 C T 1: 55,187,479 (GRCm39) Q76* probably null Het
Or10w3 T A 19: 13,704,207 (GRCm39) I194N possibly damaging Het
Or8b47 A T 9: 38,435,013 (GRCm39) probably null Het
Or8g26 A G 9: 39,096,056 (GRCm39) D191G probably benign Het
Pate14 C T 9: 36,549,159 (GRCm39) G34R possibly damaging Het
Pcdha9 A T 18: 37,132,689 (GRCm39) Q586L probably benign Het
Pgk2 T A 17: 40,518,409 (GRCm39) I340F probably benign Het
Prex1 G A 2: 166,419,810 (GRCm39) Q1289* probably null Het
Prr22 A G 17: 57,078,819 (GRCm39) D324G possibly damaging Het
Rab2b A T 14: 52,501,217 (GRCm39) S201T probably benign Het
Rdh1 T A 10: 127,596,121 (GRCm39) probably null Het
Rhbdl1 G T 17: 26,055,123 (GRCm39) N82K probably benign Het
Rspo1 C A 4: 124,885,210 (GRCm39) Q29K possibly damaging Het
Rtp3 A T 9: 110,814,948 (GRCm39) Y472* probably null Het
Senp5 T A 16: 31,809,252 (GRCm39) M1L unknown Het
Slfn4 A T 11: 83,078,389 (GRCm39) probably null Het
Stab1 A G 14: 30,863,413 (GRCm39) V2091A possibly damaging Het
Stk32c A G 7: 138,768,069 (GRCm39) S71P possibly damaging Het
Tpr A G 1: 150,320,180 (GRCm39) T2243A probably benign Het
Tubgcp6 A T 15: 88,985,604 (GRCm39) N1544K probably damaging Het
Uqcc1 T C 2: 155,700,066 (GRCm39) N202S probably benign Het
Vmn2r18 C T 5: 151,510,158 (GRCm39) E72K possibly damaging Het
Zfp654 C A 16: 64,606,570 (GRCm39) C3F probably damaging Het
Zfp804b T C 5: 6,821,263 (GRCm39) E600G possibly damaging Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,680,249 (GRCm39) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,661,697 (GRCm39) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,690,585 (GRCm39) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,119,536 (GRCm39) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,688,144 (GRCm39) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,641,380 (GRCm39) missense probably benign
IGL01971:Atrnl1 APN 19 57,741,715 (GRCm39) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,680,195 (GRCm39) splice site probably benign
IGL02580:Atrnl1 APN 19 57,703,008 (GRCm39) splice site probably benign
IGL02649:Atrnl1 APN 19 57,638,873 (GRCm39) splice site probably benign
IGL02676:Atrnl1 APN 19 57,680,316 (GRCm39) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,641,359 (GRCm39) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,630,973 (GRCm39) missense probably benign 0.02
Magnetogorsk UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
polar UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
PIT4812001:Atrnl1 UTSW 19 57,720,055 (GRCm39) missense probably benign 0.08
R0109:Atrnl1 UTSW 19 57,743,949 (GRCm39) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,741,720 (GRCm39) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,661,608 (GRCm39) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,643,293 (GRCm39) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R1183:Atrnl1 UTSW 19 57,638,725 (GRCm39) missense probably damaging 0.97
R1213:Atrnl1 UTSW 19 57,626,894 (GRCm39) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,675,169 (GRCm39) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,703,134 (GRCm39) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,680,281 (GRCm39) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,744,048 (GRCm39) nonsense probably null
R2130:Atrnl1 UTSW 19 57,643,426 (GRCm39) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,645,546 (GRCm39) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,924,084 (GRCm39) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4785:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,030,793 (GRCm39) missense probably benign
R5172:Atrnl1 UTSW 19 57,673,945 (GRCm39) nonsense probably null
R5226:Atrnl1 UTSW 19 57,638,767 (GRCm39) missense probably benign
R5289:Atrnl1 UTSW 19 57,645,514 (GRCm39) missense probably damaging 1.00
R5372:Atrnl1 UTSW 19 57,743,968 (GRCm39) missense probably benign
R5737:Atrnl1 UTSW 19 57,766,320 (GRCm39) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,741,718 (GRCm39) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,618,724 (GRCm39) nonsense probably null
R6169:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,630,910 (GRCm39) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,626,942 (GRCm39) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,638,764 (GRCm39) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,643,393 (GRCm39) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,030,800 (GRCm39) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,626,882 (GRCm39) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,680,289 (GRCm39) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,030,784 (GRCm39) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,924,038 (GRCm39) nonsense probably null
R7289:Atrnl1 UTSW 19 57,638,846 (GRCm39) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,630,856 (GRCm39) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,924,078 (GRCm39) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,743,956 (GRCm39) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,684,744 (GRCm39) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,643,278 (GRCm39) missense probably benign
R7567:Atrnl1 UTSW 19 57,687,955 (GRCm39) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,703,119 (GRCm39) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7656:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7718:Atrnl1 UTSW 19 57,728,615 (GRCm39) nonsense probably null
R7726:Atrnl1 UTSW 19 57,690,504 (GRCm39) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,688,103 (GRCm39) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,670,878 (GRCm39) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,645,660 (GRCm39) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,766,359 (GRCm39) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,643,420 (GRCm39) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,617,551 (GRCm39) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,618,695 (GRCm39) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,599,786 (GRCm39) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,630,905 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTCCTAATCCTTGTTTGGCATG -3'
(R):5'- GGCTACCAAGTGCACTAATGG -3'

Sequencing Primer
(F):5'- CCTTGTTTGGCATGTTGAGAAAATG -3'
(R):5'- CACAGATGATGGATCACC -3'
Posted On 2019-11-12