Incidental Mutation 'R0242:Adgrl2'
| ID |
59534 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl2
|
| Ensembl Gene |
ENSMUSG00000028184 |
| Gene Name |
adhesion G protein-coupled receptor L2 |
| Synonyms |
Lec1, Lphn2, Lphh1 |
| MMRRC Submission |
038480-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0242 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
148815583-148990555 bp(-) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to C
at 148839185 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106128]
[ENSMUST00000195988]
[ENSMUST00000196526]
[ENSMUST00000197567]
[ENSMUST00000198779]
[ENSMUST00000199059]
[ENSMUST00000199238]
[ENSMUST00000199750]
[ENSMUST00000200154]
[ENSMUST00000200543]
|
| AlphaFold |
Q8JZZ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106128
AA Change: I758S
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101734
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.3e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
4.6e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
6.4e-181 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000195988
AA Change: I758S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000143444
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.3e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.1e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1189 |
2.2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1184 |
1435 |
5.5e-123 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000196526
AA Change: I741S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000143788
Gene: ENSMUSG00000028184
AA Change: I741S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
8.7e-24 |
PFAM |
|
OLF
|
138 |
394 |
3.4e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
Pfam:GAIN
|
533 |
747 |
1.1e-54 |
PFAM |
|
GPS
|
771 |
823 |
2.2e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
6.5e-68 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1158 |
9.9e-36 |
PFAM |
|
low complexity region
|
1163 |
1173 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197521
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197567
AA Change: I758S
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000143626
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
1.9e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.1e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
6.4e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
2.8e-181 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000197925
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000198779
AA Change: I758S
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000142347
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1084 |
1.8e-66 |
PFAM |
|
Pfam:Latrophilin
|
1104 |
1452 |
7e-174 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199059
AA Change: I758S
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000143150
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.3e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1467 |
7.1e-174 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199238
AA Change: I758S
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000142405
Gene: ENSMUSG00000028184
AA Change: I758S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.4e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1478 |
1.6e-187 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199750
AA Change: I679S
PolyPhen 2
Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000143320
Gene: ENSMUSG00000028184
AA Change: I679S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.1e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
403 |
468 |
1.9e-22 |
SMART |
|
GPS
|
709 |
761 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
769 |
1005 |
1.6e-66 |
PFAM |
|
Pfam:Latrophilin
|
1025 |
1095 |
2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1090 |
1341 |
4.9e-123 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200154
AA Change: I741S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142865
Gene: ENSMUSG00000028184
AA Change: I741S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.2e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1123 |
2.2e-4 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200543
AA Change: I741S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142336
Gene: ENSMUSG00000028184
AA Change: I741S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.2e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.7e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1157 |
2.1e-28 |
PFAM |
|
Pfam:Latrophilin
|
1152 |
1403 |
5.3e-123 |
PFAM |
|
| Meta Mutation Damage Score |
0.9638 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.3%
- 20x: 94.5%
|
| Validation Efficiency |
97% (110/113) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous null mice die prenatally at fetal stages. Heterozygous mice exhibit decreased locomotor activity in an open field test. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
T |
C |
8: 13,551,676 |
D230G |
probably benign |
Het |
| 4930435E12Rik |
C |
T |
16: 38,824,567 |
|
probably benign |
Het |
| Abhd13 |
A |
G |
8: 9,987,561 |
I53V |
probably benign |
Het |
| Aldh16a1 |
G |
A |
7: 45,144,664 |
A596V |
probably damaging |
Het |
| Aldh3b2 |
T |
A |
19: 3,979,414 |
Y262* |
probably null |
Het |
| Ambn |
A |
G |
5: 88,467,972 |
Q420R |
possibly damaging |
Het |
| Ankib1 |
A |
C |
5: 3,700,344 |
|
probably benign |
Het |
| Arhgap9 |
C |
A |
10: 127,329,538 |
H430Q |
probably benign |
Het |
| Arhgef25 |
C |
T |
10: 127,184,064 |
G435E |
probably damaging |
Het |
| Armc12 |
A |
T |
17: 28,532,392 |
D120V |
possibly damaging |
Het |
| Armc4 |
A |
T |
18: 7,211,516 |
V786D |
probably damaging |
Het |
| Asxl3 |
G |
A |
18: 22,516,681 |
E576K |
possibly damaging |
Het |
| Bcdin3d |
T |
C |
15: 99,470,895 |
E141G |
probably benign |
Het |
| Bmpr1b |
G |
A |
3: 141,840,676 |
T483M |
probably damaging |
Het |
| Caprin2 |
C |
T |
6: 148,842,954 |
S991N |
probably damaging |
Het |
| Cd96 |
T |
C |
16: 46,071,766 |
I286M |
possibly damaging |
Het |
| Cdcp1 |
G |
T |
9: 123,180,172 |
F480L |
probably benign |
Het |
| Celf5 |
T |
C |
10: 81,464,409 |
T258A |
probably benign |
Het |
| Cgnl1 |
A |
G |
9: 71,721,657 |
V577A |
probably damaging |
Het |
| Clca3b |
A |
G |
3: 144,841,465 |
S304P |
probably benign |
Het |
| Cmya5 |
A |
T |
13: 93,095,600 |
H993Q |
probably benign |
Het |
| Cnbp |
A |
T |
6: 87,845,764 |
C6S |
probably damaging |
Het |
| Col14a1 |
C |
T |
15: 55,497,511 |
R1605W |
probably damaging |
Het |
| Cops7a |
T |
C |
6: 124,964,854 |
N11S |
probably benign |
Het |
| Coro7 |
T |
C |
16: 4,630,178 |
|
probably benign |
Het |
| Cpvl |
T |
C |
6: 53,932,500 |
H217R |
possibly damaging |
Het |
| Cuedc1 |
T |
C |
11: 88,184,621 |
|
probably benign |
Het |
| Cyp2c66 |
A |
G |
19: 39,141,925 |
Y68C |
probably damaging |
Het |
| Dicer1 |
G |
A |
12: 104,702,451 |
T1324M |
probably benign |
Het |
| Dlgap2 |
A |
G |
8: 14,727,562 |
D268G |
probably benign |
Het |
| Dnm1 |
T |
A |
2: 32,316,989 |
M535L |
possibly damaging |
Het |
| Dock7 |
A |
T |
4: 98,962,280 |
F1575Y |
probably benign |
Het |
| Dpp10 |
T |
A |
1: 123,398,546 |
H403L |
possibly damaging |
Het |
| Dync1h1 |
A |
G |
12: 110,649,851 |
D3112G |
possibly damaging |
Het |
| Eno3 |
A |
G |
11: 70,657,935 |
E21G |
probably null |
Het |
| Fam120b |
T |
A |
17: 15,422,924 |
V655D |
probably damaging |
Het |
| Fam129a |
A |
G |
1: 151,718,216 |
D884G |
probably benign |
Het |
| Fkbp5 |
A |
T |
17: 28,428,452 |
D136E |
probably benign |
Het |
| Gdap1l1 |
T |
A |
2: 163,447,653 |
Y179* |
probably null |
Het |
| Gfer |
A |
G |
17: 24,694,303 |
W192R |
probably damaging |
Het |
| Gm4782 |
A |
G |
6: 50,609,858 |
T408A |
probably benign |
Het |
| Golgb1 |
C |
T |
16: 36,875,630 |
Q164* |
probably null |
Het |
| Gpnmb |
A |
G |
6: 49,047,342 |
N197S |
probably damaging |
Het |
| Gtf2f1 |
G |
A |
17: 57,003,802 |
T414M |
probably benign |
Het |
| Hc |
A |
G |
2: 35,036,154 |
|
probably benign |
Het |
| Hcfc1 |
A |
T |
X: 73,948,429 |
|
probably benign |
Het |
| Helz2 |
C |
T |
2: 181,230,430 |
R2539Q |
probably damaging |
Het |
| Hsd17b12 |
T |
A |
2: 94,157,815 |
I19F |
probably benign |
Het |
| Incenp |
T |
C |
19: 9,893,750 |
T172A |
unknown |
Het |
| Jmy |
A |
G |
13: 93,441,618 |
Y681H |
probably benign |
Het |
| Kbtbd11 |
A |
G |
8: 15,027,508 |
T36A |
probably benign |
Het |
| Kcnh4 |
T |
C |
11: 100,755,699 |
D267G |
probably damaging |
Het |
| Krt34 |
C |
T |
11: 100,041,331 |
E56K |
probably damaging |
Het |
| Krt40 |
T |
A |
11: 99,538,742 |
E335D |
probably damaging |
Het |
| Krt86 |
T |
A |
15: 101,476,573 |
Y282* |
probably null |
Het |
| Lgi3 |
C |
T |
14: 70,534,815 |
R267* |
probably null |
Het |
| Lnpk |
A |
G |
2: 74,537,289 |
|
probably benign |
Het |
| Lrp1b |
T |
A |
2: 40,998,183 |
H2355L |
probably benign |
Het |
| Lrrc8e |
G |
A |
8: 4,235,401 |
R542H |
probably benign |
Het |
| Mia2 |
T |
C |
12: 59,108,856 |
Y452H |
probably damaging |
Het |
| Mmachc |
C |
T |
4: 116,704,541 |
R132Q |
probably damaging |
Het |
| Mtbp |
T |
A |
15: 55,577,486 |
N356K |
possibly damaging |
Het |
| Mum1 |
T |
C |
10: 80,234,258 |
S354P |
probably benign |
Het |
| Myo5b |
A |
G |
18: 74,661,716 |
H552R |
possibly damaging |
Het |
| Noxred1 |
A |
G |
12: 87,226,979 |
V96A |
probably benign |
Het |
| Nr1d2 |
T |
A |
14: 18,211,933 |
D390V |
possibly damaging |
Het |
| Oas1e |
A |
T |
5: 120,791,774 |
|
probably benign |
Het |
| Olfr398 |
T |
C |
11: 73,983,712 |
S299G |
probably benign |
Het |
| Olfr786 |
T |
A |
10: 129,437,348 |
Y179N |
probably damaging |
Het |
| Otog |
G |
T |
7: 46,267,381 |
C914F |
probably damaging |
Het |
| Pank2 |
G |
T |
2: 131,280,197 |
C214F |
probably damaging |
Het |
| Pcdhb1 |
T |
A |
18: 37,266,735 |
S580T |
probably benign |
Het |
| Pdia3 |
T |
C |
2: 121,414,111 |
S2P |
probably damaging |
Het |
| Peli1 |
G |
T |
11: 21,142,602 |
R83L |
probably damaging |
Het |
| Pla2g3 |
T |
A |
11: 3,491,935 |
C366* |
probably null |
Het |
| Pon3 |
T |
A |
6: 5,240,860 |
D107V |
probably benign |
Het |
| Ppip5k2 |
A |
G |
1: 97,741,091 |
C532R |
probably damaging |
Het |
| Prph |
A |
T |
15: 99,055,727 |
D174V |
probably damaging |
Het |
| Psd3 |
A |
G |
8: 67,758,086 |
M270T |
probably damaging |
Het |
| Pum3 |
A |
G |
19: 27,422,755 |
|
probably benign |
Het |
| Pus1 |
A |
T |
5: 110,779,798 |
H30Q |
probably benign |
Het |
| Rab7 |
A |
T |
6: 88,005,132 |
V87E |
probably damaging |
Het |
| Rbm5 |
A |
T |
9: 107,751,708 |
|
probably benign |
Het |
| Reln |
A |
G |
5: 21,942,597 |
|
probably null |
Het |
| S1pr3 |
A |
G |
13: 51,418,902 |
T40A |
probably benign |
Het |
| Sdk1 |
T |
A |
5: 142,143,922 |
|
probably benign |
Het |
| Senp7 |
T |
A |
16: 56,179,521 |
I853N |
probably damaging |
Het |
| Serpinb6c |
T |
A |
13: 33,899,247 |
|
probably benign |
Het |
| Shroom1 |
T |
G |
11: 53,465,485 |
|
probably null |
Het |
| Slc24a3 |
T |
C |
2: 145,606,664 |
I376T |
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,468,667 |
I375T |
possibly damaging |
Het |
| Slc4a9 |
T |
C |
18: 36,533,680 |
F527S |
probably damaging |
Het |
| Slc4a9 |
T |
A |
18: 36,541,233 |
I924N |
probably damaging |
Het |
| Slx4 |
T |
A |
16: 3,986,952 |
E666V |
probably damaging |
Het |
| Snrnp27 |
G |
A |
6: 86,675,593 |
|
probably benign |
Het |
| Sorcs1 |
C |
T |
19: 50,228,221 |
G640E |
probably damaging |
Het |
| Sptan1 |
A |
T |
2: 30,018,401 |
M1725L |
probably benign |
Het |
| Sync |
G |
A |
4: 129,293,721 |
R182K |
probably damaging |
Het |
| Syne2 |
G |
A |
12: 76,098,034 |
G1586S |
probably damaging |
Het |
| Sytl1 |
G |
T |
4: 133,253,457 |
T522K |
probably damaging |
Het |
| Tex2 |
T |
A |
11: 106,519,955 |
K414* |
probably null |
Het |
| Thegl |
G |
T |
5: 77,016,305 |
E52* |
probably null |
Het |
| Thsd7a |
G |
A |
6: 12,503,916 |
T413I |
probably benign |
Het |
| Tm9sf1 |
C |
T |
14: 55,637,935 |
A451T |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,826,152 |
|
probably benign |
Het |
| Uba2 |
T |
C |
7: 34,154,629 |
I140V |
possibly damaging |
Het |
| Ushbp1 |
C |
A |
8: 71,390,118 |
G361* |
probably null |
Het |
| Wbp2nl |
C |
T |
15: 82,313,787 |
A175V |
probably benign |
Het |
| Zc3h12d |
A |
G |
10: 7,862,566 |
E212G |
probably damaging |
Het |
| Zc3h7b |
T |
C |
15: 81,768,830 |
|
probably benign |
Het |
|
| Other mutations in Adgrl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Adgrl2
|
APN |
3 |
148,865,608 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00572:Adgrl2
|
APN |
3 |
148,826,498 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01624:Adgrl2
|
APN |
3 |
148,836,527 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01796:Adgrl2
|
APN |
3 |
148,858,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02380:Adgrl2
|
APN |
3 |
148,828,489 (GRCm38) |
nonsense |
probably null |
|
|
IGL02468:Adgrl2
|
APN |
3 |
148,890,480 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02708:Adgrl2
|
APN |
3 |
148,826,525 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02869:Adgrl2
|
APN |
3 |
148,890,605 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03248:Adgrl2
|
APN |
3 |
148,817,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03343:Adgrl2
|
APN |
3 |
148,859,380 (GRCm38) |
missense |
probably damaging |
0.98 |
|
P0157:Adgrl2
|
UTSW |
3 |
148,859,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4382001:Adgrl2
|
UTSW |
3 |
148,817,298 (GRCm38) |
missense |
|
|
|
PIT4544001:Adgrl2
|
UTSW |
3 |
148,890,521 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0165:Adgrl2
|
UTSW |
3 |
148,852,863 (GRCm38) |
splice site |
probably benign |
|
|
R0242:Adgrl2
|
UTSW |
3 |
148,839,185 (GRCm38) |
splice site |
probably null |
|
|
R0344:Adgrl2
|
UTSW |
3 |
148,865,595 (GRCm38) |
splice site |
probably null |
|
|
R0488:Adgrl2
|
UTSW |
3 |
148,846,905 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0542:Adgrl2
|
UTSW |
3 |
148,859,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0630:Adgrl2
|
UTSW |
3 |
148,839,244 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0674:Adgrl2
|
UTSW |
3 |
148,837,679 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1401:Adgrl2
|
UTSW |
3 |
148,822,981 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1543:Adgrl2
|
UTSW |
3 |
148,859,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1575:Adgrl2
|
UTSW |
3 |
148,852,762 (GRCm38) |
missense |
probably benign |
0.17 |
|
R1645:Adgrl2
|
UTSW |
3 |
148,865,608 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1780:Adgrl2
|
UTSW |
3 |
148,852,593 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1992:Adgrl2
|
UTSW |
3 |
148,817,244 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R2014:Adgrl2
|
UTSW |
3 |
148,826,475 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2130:Adgrl2
|
UTSW |
3 |
148,890,488 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2131:Adgrl2
|
UTSW |
3 |
148,890,488 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2400:Adgrl2
|
UTSW |
3 |
148,851,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2997:Adgrl2
|
UTSW |
3 |
148,817,649 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3161:Adgrl2
|
UTSW |
3 |
148,817,551 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3416:Adgrl2
|
UTSW |
3 |
148,859,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3417:Adgrl2
|
UTSW |
3 |
148,859,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3551:Adgrl2
|
UTSW |
3 |
148,858,963 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3760:Adgrl2
|
UTSW |
3 |
148,817,235 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4355:Adgrl2
|
UTSW |
3 |
148,839,152 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4850:Adgrl2
|
UTSW |
3 |
148,859,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4911:Adgrl2
|
UTSW |
3 |
148,890,463 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4945:Adgrl2
|
UTSW |
3 |
148,823,036 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5313:Adgrl2
|
UTSW |
3 |
148,823,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5339:Adgrl2
|
UTSW |
3 |
148,817,844 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5540:Adgrl2
|
UTSW |
3 |
148,837,562 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5583:Adgrl2
|
UTSW |
3 |
148,859,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5890:Adgrl2
|
UTSW |
3 |
148,859,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6170:Adgrl2
|
UTSW |
3 |
148,823,009 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6197:Adgrl2
|
UTSW |
3 |
148,858,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6284:Adgrl2
|
UTSW |
3 |
148,826,507 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6877:Adgrl2
|
UTSW |
3 |
148,817,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7048:Adgrl2
|
UTSW |
3 |
148,846,929 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7205:Adgrl2
|
UTSW |
3 |
148,858,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7326:Adgrl2
|
UTSW |
3 |
148,846,870 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7348:Adgrl2
|
UTSW |
3 |
148,817,766 (GRCm38) |
missense |
|
|
|
R7382:Adgrl2
|
UTSW |
3 |
148,817,283 (GRCm38) |
missense |
|
|
|
R7486:Adgrl2
|
UTSW |
3 |
148,817,694 (GRCm38) |
missense |
|
|
|
R7498:Adgrl2
|
UTSW |
3 |
148,859,216 (GRCm38) |
nonsense |
probably null |
|
|
R7644:Adgrl2
|
UTSW |
3 |
148,839,153 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7690:Adgrl2
|
UTSW |
3 |
148,817,298 (GRCm38) |
missense |
|
|
|
R7742:Adgrl2
|
UTSW |
3 |
148,836,428 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7745:Adgrl2
|
UTSW |
3 |
148,836,458 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8291:Adgrl2
|
UTSW |
3 |
148,850,918 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R8326:Adgrl2
|
UTSW |
3 |
148,827,554 (GRCm38) |
missense |
|
|
|
R8343:Adgrl2
|
UTSW |
3 |
148,846,906 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8344:Adgrl2
|
UTSW |
3 |
148,859,525 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8487:Adgrl2
|
UTSW |
3 |
148,859,486 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8748:Adgrl2
|
UTSW |
3 |
148,826,390 (GRCm38) |
missense |
|
|
|
R8769:Adgrl2
|
UTSW |
3 |
148,817,281 (GRCm38) |
missense |
|
|
|
R8804:Adgrl2
|
UTSW |
3 |
148,847,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8911:Adgrl2
|
UTSW |
3 |
148,852,527 (GRCm38) |
intron |
probably benign |
|
|
R8943:Adgrl2
|
UTSW |
3 |
148,828,483 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8977:Adgrl2
|
UTSW |
3 |
148,954,587 (GRCm38) |
missense |
probably null |
|
|
R9030:Adgrl2
|
UTSW |
3 |
148,839,125 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R9105:Adgrl2
|
UTSW |
3 |
148,837,653 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9427:Adgrl2
|
UTSW |
3 |
148,820,432 (GRCm38) |
missense |
|
|
|
R9471:Adgrl2
|
UTSW |
3 |
148,852,729 (GRCm38) |
missense |
probably benign |
|
|
R9646:Adgrl2
|
UTSW |
3 |
148,839,290 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9742:Adgrl2
|
UTSW |
3 |
148,836,350 (GRCm38) |
critical splice donor site |
probably null |
|
|
RF007:Adgrl2
|
UTSW |
3 |
148,839,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0009:Adgrl2
|
UTSW |
3 |
148,852,654 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0019:Adgrl2
|
UTSW |
3 |
148,865,594 (GRCm38) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAACTTGTGTCTCTGACCCAGCCC -3'
(R):5'- TCTTTCATCCCGAGCAATGGTGTG -3'
Sequencing Primer
(F):5'- AGGTCTTCTCCCACCCAGG -3'
(R):5'- AGCAATGGTGTGGTGAGTCC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation