Incidental Mutation 'R7725:Or2y10'
ID 595455
Institutional Source Beutler Lab
Gene Symbol Or2y10
Ensembl Gene ENSMUSG00000107645
Gene Name olfactory receptor family 2 subfamily Y member 10
Synonyms GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380
MMRRC Submission 045781-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.209) question?
Stock # R7725 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 49454750-49455685 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49455359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 204 (I204L)
Ref Sequence ENSEMBL: ENSMUSP00000151039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204300] [ENSMUST00000215360]
AlphaFold Q7TQT5
Predicted Effect probably benign
Transcript: ENSMUST00000204300
AA Change: I204L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000145428
Gene: ENSMUSG00000107645
AA Change: I204L

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.4e-47 PFAM
Pfam:7tm_1 41 289 9.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215360
AA Change: I204L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.3%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa2 A T 9: 69,387,410 (GRCm39) K6N unknown Het
Arhgap20 T A 9: 51,743,050 (GRCm39) M296K possibly damaging Het
Bdh1 G A 16: 31,256,910 (GRCm39) V20I not run Het
Bop1 A G 15: 76,339,583 (GRCm39) I254T probably benign Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Cct4 A G 11: 22,940,814 (GRCm39) K21E probably benign Het
Cercam G A 2: 29,762,574 (GRCm39) probably null Het
Clip2 A T 5: 134,546,853 (GRCm39) Y238* probably null Het
Col19a1 A T 1: 24,309,525 (GRCm39) S1043T possibly damaging Het
Ctcf A G 8: 106,390,468 (GRCm39) Y25C probably damaging Het
Dennd4c C T 4: 86,704,330 (GRCm39) R282C probably benign Het
Eef1g T A 19: 8,955,427 (GRCm39) H425Q probably benign Het
Fam131b C T 6: 42,295,476 (GRCm39) A234T probably benign Het
Fam184a C A 10: 53,509,802 (GRCm39) E126* probably null Het
Fam187b A G 7: 30,677,139 (GRCm39) D216G possibly damaging Het
Gabra1 A T 11: 42,026,270 (GRCm39) Y341N possibly damaging Het
Glb1l3 T A 9: 26,739,659 (GRCm39) probably null Het
Gm3667 T A 14: 18,271,599 (GRCm39) Q52L probably damaging Het
Gpr179 C T 11: 97,242,118 (GRCm39) R242H probably damaging Het
Gulo T C 14: 66,245,522 (GRCm39) Y24C probably damaging Het
Hectd4 A T 5: 121,358,680 (GRCm39) E49V unknown Het
Htra4 A G 8: 25,527,169 (GRCm39) S209P possibly damaging Het
Lmntd1 A G 6: 145,489,196 (GRCm39) S22P probably benign Het
Lypd8l A T 11: 58,499,325 (GRCm39) N164K probably benign Het
Med12l A G 3: 59,163,413 (GRCm39) K1347E probably damaging Het
Mrc1 C A 2: 14,284,788 (GRCm39) D592E probably benign Het
Muc15 A G 2: 110,562,143 (GRCm39) D193G probably damaging Het
Ncor2 A G 5: 125,100,630 (GRCm39) V1316A Het
Odad1 T A 7: 45,597,835 (GRCm39) S582T probably damaging Het
Or2t43 A G 11: 58,457,593 (GRCm39) Y193H probably damaging Het
Or5t16 T C 2: 86,819,323 (GRCm39) I66V probably benign Het
Serpina6 A T 12: 103,614,936 (GRCm39) Y303* probably null Het
Shld2 T G 14: 33,990,661 (GRCm39) T82P possibly damaging Het
Shroom3 T C 5: 93,089,512 (GRCm39) L754P probably benign Het
Skint5 C A 4: 113,685,099 (GRCm39) L539F unknown Het
St3gal4 C A 9: 34,964,375 (GRCm39) R209L possibly damaging Het
Tex14 A C 11: 87,385,868 (GRCm39) T243P probably damaging Het
Ttc12 T A 9: 49,351,602 (GRCm39) M632L probably benign Het
Ttn T C 2: 76,738,116 (GRCm39) E4187G unknown Het
Txk G A 5: 72,864,900 (GRCm39) A379V probably damaging Het
Wdr43 A G 17: 71,923,338 (GRCm39) Y28C probably benign Het
Zfp1005 A G 2: 150,110,468 (GRCm39) Y386C unknown Het
Zfp40 A G 17: 23,397,251 (GRCm39) V82A probably benign Het
Zfp994 A T 17: 22,419,091 (GRCm39) N619K probably benign Het
Other mutations in Or2y10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or2y10 APN 11 49,454,747 (GRCm39) utr 5 prime probably benign
IGL01354:Or2y10 APN 11 49,455,024 (GRCm39) missense probably damaging 0.99
R0183:Or2y10 UTSW 11 49,455,675 (GRCm39) missense probably benign 0.14
R0849:Or2y10 UTSW 11 49,455,129 (GRCm39) missense probably damaging 0.99
R3855:Or2y10 UTSW 11 49,454,918 (GRCm39) missense probably damaging 0.98
R3904:Or2y10 UTSW 11 49,455,585 (GRCm39) missense possibly damaging 0.50
R4598:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R4599:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R5089:Or2y10 UTSW 11 49,455,240 (GRCm39) missense possibly damaging 0.94
R6029:Or2y10 UTSW 11 49,455,428 (GRCm39) missense possibly damaging 0.94
R6551:Or2y10 UTSW 11 49,454,816 (GRCm39) missense probably benign
R6953:Or2y10 UTSW 11 49,455,117 (GRCm39) missense probably damaging 1.00
R7223:Or2y10 UTSW 11 49,454,925 (GRCm39) missense probably damaging 0.99
R7343:Or2y10 UTSW 11 49,455,329 (GRCm39) missense possibly damaging 0.91
R7762:Or2y10 UTSW 11 49,455,588 (GRCm39) missense possibly damaging 0.76
R8881:Or2y10 UTSW 11 49,455,209 (GRCm39) missense probably benign 0.01
R9361:Or2y10 UTSW 11 49,455,303 (GRCm39) missense probably damaging 0.99
R9380:Or2y10 UTSW 11 49,454,904 (GRCm39) missense possibly damaging 0.91
R9421:Or2y10 UTSW 11 49,455,201 (GRCm39) missense probably benign 0.03
R9733:Or2y10 UTSW 11 49,454,961 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGCACCCTGTTCTCTGCAG -3'
(R):5'- TCCTTCTCAGAATACCTGTGGAC -3'

Sequencing Primer
(F):5'- CCTGTTCTCTGCAGAGCATTGG -3'
(R):5'- ACAGGTTGGAGGTATGTGGAGATG -3'
Posted On 2019-11-12