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|Institutional Source||Beutler Lab|
|Gene Name||serine (or cysteine) peptidase inhibitor, clade A, member 6|
|Is this an essential gene?||Probably non essential (E-score: 0.078)|
|Stock #||R7725 (G1)|
|Chromosomal Location||103646630-103657212 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||A to T at 103648677 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 303 (Y303*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044033 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000044159]|
|Predicted Effect||probably null
AA Change: Y303*
AA Change: Y303*
|Coding Region Coverage||
FUNCTION: This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
PHENOTYPE: Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Serpina6||
(F):5'- TGGGACCTATGGGACCTTTAAC -3'
(R):5'- TCTTGAAAGGGATCATCCAGGG -3'
(F):5'- CCTATGGGACCTTTAACAAATGGG -3'
(R):5'- CCTGTATCCCTAATGAGTGAGTCAG -3'