Mutagenetix > Incidental Mutation

Incidental Mutation 'R7726:Olfr1389'

595507

Institutional Source

Beutler Lab

Gene Symbol

Olfr1389

Ensembl Gene

ENSMUSG00000107573

Gene Name

olfactory receptor 1389

Synonyms

GA_x6K02T2QP88-6004387-6003452, MOR256-1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.247) question?

Stock #

R7726 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

49423067-49432968 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 49430900 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 141 (C141*)

Ref Sequence

ENSEMBL: ENSMUSP00000149032 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000203369] [ENSMUST00000216641] [ENSMUST00000217595]

AlphaFold

Q8VGX0

Predicted Effect

probably null
Transcript: ENSMUST00000203369
AA Change: C141*

SMART Domains

Protein: ENSMUSP00000145461
Gene: ENSMUSG00000107573
AA Change: C141*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	1.9e-49	PFAM
Pfam:7tm_1	41	289	6.6e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216641
AA Change: C141*

Predicted Effect

probably null
Transcript: ENSMUST00000217595
AA Change: C141*

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (65/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931408C20Rik	C	A	1: 26,684,498	A534S	probably benign	Het
A230050P20Rik	T	C	9: 20,873,165	Y182H	possibly damaging	Het
Adam34	T	G	8: 43,651,171	N479T	probably damaging	Het
Add3	C	G	19: 53,239,461	L526V	probably damaging	Het
Alas1	T	C	9: 106,246,951	T3A	probably benign	Het
Arap3	C	T	18: 37,989,467	D579N	probably damaging	Het
Armc6	C	A	8: 70,222,598	D326Y	probably damaging	Het
Atp6v1e2	G	A	17: 86,944,385	T195I	probably damaging	Het
Atrnl1	A	G	19: 57,702,072	E904G	probably damaging	Het
Bhlhe40	T	A	6: 108,662,598	D112E	probably benign	Het
Brf1	T	G	12: 112,964,245	K438T	probably benign	Het
Cabs1	A	T	5: 87,980,286	E265D	probably damaging	Het
Ccdc162	T	A	10: 41,553,075	M1937L	probably benign	Het
Cd55b	A	T	1: 130,411,493	S299R	possibly damaging	Het
Chordc1	A	G	9: 18,302,214	*120W	probably null	Het
Col17a1	C	A	19: 47,655,190		probably null	Het
Cpne8	A	T	15: 90,501,418	I469K	possibly damaging	Het
Crtac1	G	T	19: 42,302,251	S337*	probably null	Het
Cx3cl1	T	C	8: 94,780,239	S291P	probably damaging	Het
Dhx36	G	T	3: 62,488,968	Q423K	probably benign	Het
Eif3h	G	T	15: 51,786,823	Q322K	possibly damaging	Het
Ero1lb	A	G	13: 12,605,833	*494W	probably null	Het
Exph5	G	A	9: 53,373,175	V519I	possibly damaging	Het
Fam184a	C	A	10: 53,633,706	E126*	probably null	Het
Fam208a	C	A	14: 27,447,497	N338K	probably damaging	Het
Fam222b	A	G	11: 78,153,751	D46G	probably damaging	Het
Fbxl6	C	A	15: 76,535,886	R509L	probably damaging	Het
Fgf14	T	C	14: 124,136,244	Y86C	probably damaging	Het
Fras1	A	T	5: 96,712,451	I2119F	probably benign	Het
Gm14085	A	G	2: 122,486,733	E25G	probably damaging	Het
Gpr37	G	A	6: 25,669,117	T576I	possibly damaging	Het
Hnrnpul2	G	T	19: 8,831,280	R702L	possibly damaging	Het
Iqgap1	T	C	7: 80,757,456	N342S	probably benign	Het
Kcnh6	T	C	11: 106,017,575	V339A	probably benign	Het
Klk1b9	A	T	7: 43,978,416	N46I	possibly damaging	Het
Kndc1	C	A	7: 139,939,838	S1703R	possibly damaging	Het
Lyn	C	A	4: 3,756,428	Y306*	probably null	Het
Manba	C	T	3: 135,518,009	T219M	probably benign	Het
Mastl	T	C	2: 23,140,795		probably null	Het
Med15	T	G	16: 17,655,174	M550L	possibly damaging	Het
Men1	G	A	19: 6,337,282		probably null	Het
Mettl11b	A	G	1: 163,703,184	C229R	probably benign	Het
Msh4	C	T	3: 153,866,320		probably null	Het
Myh6	G	T	14: 54,965,365	D32E	probably damaging	Het
Ntn4	A	G	10: 93,733,682	D419G	possibly damaging	Het
Nup155	C	T	15: 8,122,139	P393S	probably damaging	Het
Olfr1415	A	T	1: 92,491,307	F149L	probably benign	Het
Palm2	C	T	4: 57,709,876	P274S	probably damaging	Het
Papss2	A	T	19: 32,634,003		probably null	Het
Pcdhgc3	T	C	18: 37,806,879	V111A	possibly damaging	Het
Pcnx2	C	T	8: 125,850,330	V988I	probably benign	Het
Pom121	C	T	5: 135,378,148	G1178S	probably damaging	Het
Prss33	A	G	17: 23,834,229	C213R	probably damaging	Het
Scap	G	A	9: 110,378,367		probably null	Het
Sirpb1c	T	A	3: 15,848,386	I10F	possibly damaging	Het
Spink5	T	C	18: 43,963,352	L16P	probably damaging	Het
Stk4	T	G	2: 164,110,226	M1R	probably null	Het
Stub1	A	T	17: 25,831,132	Y253*	probably null	Het
Tbce	A	G	13: 14,029,290	V29A	probably damaging	Het
Tchhl1	A	G	3: 93,471,758	R590G	probably benign	Het
Tmem173	C	T	18: 35,735,265	A261T	probably damaging	Het
Ubr4	C	T	4: 139,458,920	P613L	unknown	Het
Vmn2r3	G	T	3: 64,275,518	C253*	probably null	Het
Wfdc8	C	A	2: 164,599,986	E215D	possibly damaging	Het
Zfp874b	T	C	13: 67,473,856	D441G	probably benign	Het
Zscan4d	G	T	7: 11,165,242	P36Q	possibly damaging	Het

Other mutations in Olfr1389

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02377:Olfr1389	APN	11	49431032	missense	probably damaging	1.00
IGL02468:Olfr1389	APN	11	49431114	missense	probably damaging	0.99
IGL02607:Olfr1389	APN	11	49430512	missense	probably damaging	1.00
IGL02721:Olfr1389	APN	11	49430641	nonsense	probably null
IGL02812:Olfr1389	APN	11	49430922	missense	probably damaging	1.00
IGL03086:Olfr1389	APN	11	49430805	missense	probably benign	0.03
IGL03047:Olfr1389	UTSW	11	49430967	missense	probably benign	0.10
PIT4531001:Olfr1389	UTSW	11	49430926	missense	probably benign	0.01
R0413:Olfr1389	UTSW	11	49431385	missense	possibly damaging	0.82
R0598:Olfr1389	UTSW	11	49431403	missense	probably benign	0.00
R0653:Olfr1389	UTSW	11	49431251	nonsense	probably null
R1654:Olfr1389	UTSW	11	49430502	missense	probably benign	0.00
R2321:Olfr1389	UTSW	11	49431280	missense	probably benign	0.00
R4995:Olfr1389	UTSW	11	49430655	missense	probably damaging	1.00
R5670:Olfr1389	UTSW	11	49431208	missense	probably damaging	1.00
R6127:Olfr1389	UTSW	11	49430806	missense	probably damaging	0.97
R6327:Olfr1389	UTSW	11	49431001	missense	probably damaging	1.00
R6935:Olfr1389	UTSW	11	49430998	missense	probably damaging	0.97
R7923:Olfr1389	UTSW	11	49430605	missense	probably benign	0.01
R8960:Olfr1389	UTSW	11	49430716	missense	probably benign	0.19

Predicted Primers

PCR Primer
(F):5'- CTGTGGGTTGGATAGGACCATC -3'
(R):5'- GTCCATAGGAGCCCAGAATC -3'

Sequencing Primer
(F):5'- TTGGATAGGACCATCAGCTATG -3'
(R):5'- GTTCGGGCCACAAACATCTTG -3'

Posted On

2019-11-12