Incidental Mutation 'R7727:Slit3'
| ID |
595573 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slit3
|
| Ensembl Gene |
ENSMUSG00000056427 |
| Gene Name |
slit guidance ligand 3 |
| Synonyms |
Slit1, b2b2362.1Clo |
| MMRRC Submission |
045783-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.871)
|
| Stock # |
R7727 (G1)
|
| Quality Score |
219.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
35012283-35599334 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 35574871 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 1062
(C1062R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066857
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069837]
|
| AlphaFold |
Q9WVB4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069837
AA Change: C1062R
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000066857
Gene: ENSMUSG00000056427
AA Change: C1062R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
23 |
N/A |
INTRINSIC |
|
LRRNT
|
33 |
65 |
2.12e-8 |
SMART |
|
LRR
|
59 |
83 |
1.37e2 |
SMART |
|
LRR_TYP
|
84 |
107 |
1.12e-3 |
SMART |
|
LRR_TYP
|
108 |
131 |
7.78e-3 |
SMART |
|
LRR_TYP
|
132 |
155 |
5.42e-2 |
SMART |
|
LRR
|
156 |
179 |
5.88e0 |
SMART |
|
LRR
|
180 |
203 |
7.55e-1 |
SMART |
|
LRRCT
|
215 |
264 |
1.33e-6 |
SMART |
|
LRRNT
|
279 |
311 |
6.79e-7 |
SMART |
|
LRR
|
305 |
329 |
1.16e2 |
SMART |
|
LRR
|
330 |
353 |
1.26e1 |
SMART |
|
LRR_TYP
|
354 |
377 |
2.79e-4 |
SMART |
|
LRR
|
378 |
401 |
4.05e-1 |
SMART |
|
LRR
|
402 |
425 |
4.05e-1 |
SMART |
|
LRRCT
|
437 |
486 |
7.75e-8 |
SMART |
|
LRRNT
|
504 |
536 |
1.95e-7 |
SMART |
|
LRR_TYP
|
556 |
579 |
7.49e-5 |
SMART |
|
LRR
|
581 |
603 |
6.41e1 |
SMART |
|
LRR_TYP
|
604 |
627 |
2.53e-2 |
SMART |
|
LRR
|
628 |
651 |
1.76e-1 |
SMART |
|
LRRCT
|
663 |
712 |
2.52e-7 |
SMART |
|
LRRNT
|
724 |
756 |
3e-8 |
SMART |
|
LRR
|
774 |
797 |
2.14e0 |
SMART |
|
LRR_TYP
|
798 |
821 |
2.95e-3 |
SMART |
|
LRR_TYP
|
822 |
845 |
2.43e-4 |
SMART |
|
LRRCT
|
857 |
906 |
1.12e-13 |
SMART |
|
EGF
|
919 |
953 |
6.86e-4 |
SMART |
|
EGF
|
958 |
994 |
8.84e-7 |
SMART |
|
EGF
|
999 |
1032 |
1.13e-4 |
SMART |
|
EGF
|
1037 |
1072 |
2.3e-5 |
SMART |
|
EGF_CA
|
1074 |
1110 |
5.92e-8 |
SMART |
|
EGF
|
1122 |
1155 |
3.79e-6 |
SMART |
|
LamG
|
1178 |
1314 |
3.16e-34 |
SMART |
|
EGF
|
1331 |
1365 |
2.19e-2 |
SMART |
|
EGF
|
1371 |
1403 |
1.13e-4 |
SMART |
|
EGF
|
1411 |
1444 |
5.57e-4 |
SMART |
|
CT
|
1455 |
1523 |
4.56e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.9658 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (69/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts5 |
A |
T |
16: 85,696,854 (GRCm39) |
L101Q |
probably damaging |
Het |
| Arhgap18 |
A |
T |
10: 26,746,007 (GRCm39) |
I293F |
possibly damaging |
Het |
| Atp8b1 |
T |
A |
18: 64,678,346 (GRCm39) |
Q850L |
probably damaging |
Het |
| B4galnt3 |
A |
T |
6: 120,202,148 (GRCm39) |
F118Y |
probably benign |
Het |
| Bcl6 |
A |
G |
16: 23,790,163 (GRCm39) |
|
probably null |
Het |
| Cc2d2b |
T |
A |
19: 40,744,974 (GRCm39) |
L31Q |
probably benign |
Het |
| Cd5l |
G |
T |
3: 87,275,162 (GRCm39) |
E234* |
probably null |
Het |
| Cemip2 |
C |
T |
19: 21,807,321 (GRCm39) |
L917F |
probably benign |
Het |
| Cfap65 |
T |
C |
1: 74,965,784 (GRCm39) |
T409A |
probably benign |
Het |
| Chst5 |
A |
T |
8: 112,617,557 (GRCm39) |
I21N |
probably benign |
Het |
| Cldn20 |
T |
C |
17: 3,583,030 (GRCm39) |
Y68H |
probably benign |
Het |
| Col4a4 |
T |
C |
1: 82,506,514 (GRCm39) |
M269V |
unknown |
Het |
| Dgkh |
A |
G |
14: 78,832,585 (GRCm39) |
|
probably null |
Het |
| Dpp6 |
A |
G |
5: 27,656,242 (GRCm39) |
T166A |
probably benign |
Het |
| Drosha |
A |
G |
15: 12,881,731 (GRCm39) |
D754G |
probably damaging |
Het |
| Epb41l4a |
C |
A |
18: 33,987,326 (GRCm39) |
K350N |
probably damaging |
Het |
| Fsd1 |
T |
G |
17: 56,295,150 (GRCm39) |
D46E |
probably benign |
Het |
| Gabra1 |
T |
C |
11: 42,024,418 (GRCm39) |
D419G |
probably damaging |
Het |
| Golga4 |
T |
A |
9: 118,377,770 (GRCm39) |
D458E |
probably damaging |
Het |
| Grm6 |
C |
A |
11: 50,742,369 (GRCm39) |
A134E |
probably benign |
Het |
| Ikzf1 |
T |
A |
11: 11,698,339 (GRCm39) |
S63R |
probably damaging |
Het |
| Ilvbl |
G |
A |
10: 78,412,500 (GRCm39) |
V74I |
probably benign |
Het |
| Kcng2 |
C |
T |
18: 80,339,305 (GRCm39) |
V328M |
probably benign |
Het |
| Kpna7 |
T |
C |
5: 144,941,855 (GRCm39) |
E145G |
probably benign |
Het |
| Krt81 |
A |
G |
15: 101,357,448 (GRCm39) |
V428A |
probably damaging |
Het |
| Lalba |
T |
C |
15: 98,380,549 (GRCm39) |
M2V |
probably benign |
Het |
| Lrpprc |
T |
C |
17: 85,084,375 (GRCm39) |
S113G |
probably benign |
Het |
| Mboat1 |
A |
C |
13: 30,410,289 (GRCm39) |
M249L |
probably benign |
Het |
| Meltf |
T |
C |
16: 31,702,612 (GRCm39) |
V113A |
probably damaging |
Het |
| Muc16 |
T |
A |
9: 18,571,538 (GRCm39) |
H327L |
unknown |
Het |
| Myh1 |
A |
G |
11: 67,106,748 (GRCm39) |
I1277V |
probably benign |
Het |
| Naf1 |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
8: 67,313,200 (GRCm39) |
|
probably benign |
Het |
| Naga |
C |
A |
15: 82,214,348 (GRCm39) |
V388L |
probably benign |
Het |
| Nfkb1 |
A |
C |
3: 135,291,162 (GRCm39) |
M957R |
possibly damaging |
Het |
| Nol12 |
C |
A |
15: 78,824,793 (GRCm39) |
S157* |
probably null |
Het |
| Or13c25 |
A |
G |
4: 52,911,368 (GRCm39) |
V142A |
possibly damaging |
Het |
| Or5g23 |
A |
G |
2: 85,438,751 (GRCm39) |
F168L |
possibly damaging |
Het |
| Or8u3-ps |
A |
T |
2: 85,952,840 (GRCm39) |
D191V |
possibly damaging |
Het |
| Pcdhga5 |
T |
C |
18: 37,828,098 (GRCm39) |
V182A |
probably benign |
Het |
| Pik3r4 |
A |
G |
9: 105,547,081 (GRCm39) |
E953G |
probably damaging |
Het |
| Piwil2 |
C |
T |
14: 70,631,506 (GRCm39) |
R646Q |
probably damaging |
Het |
| Plxnc1 |
T |
C |
10: 94,779,971 (GRCm39) |
H157R |
probably damaging |
Het |
| Prrg4 |
A |
T |
2: 104,669,723 (GRCm39) |
F131L |
probably benign |
Het |
| Prss3b |
C |
A |
6: 41,010,127 (GRCm39) |
R69L |
probably benign |
Het |
| Rab28 |
A |
G |
5: 41,865,313 (GRCm39) |
S4P |
probably damaging |
Het |
| Ranbp2 |
C |
A |
10: 58,291,260 (GRCm39) |
Q209K |
probably benign |
Het |
| Schip1 |
G |
A |
3: 67,972,317 (GRCm39) |
D15N |
probably benign |
Het |
| Serpina3f |
T |
G |
12: 104,184,477 (GRCm39) |
M207R |
probably benign |
Het |
| Sgsm1 |
A |
T |
5: 113,422,193 (GRCm39) |
M487K |
possibly damaging |
Het |
| Sh3tc2 |
A |
T |
18: 62,122,651 (GRCm39) |
I471F |
probably benign |
Het |
| Slamf1 |
G |
A |
1: 171,602,467 (GRCm39) |
V65I |
possibly damaging |
Het |
| Snapc4 |
T |
G |
2: 26,263,446 (GRCm39) |
K344N |
probably damaging |
Het |
| Sorl1 |
A |
G |
9: 41,895,822 (GRCm39) |
Y1778H |
probably damaging |
Het |
| Spon2 |
G |
A |
5: 33,373,019 (GRCm39) |
R228C |
probably damaging |
Het |
| Sv2c |
A |
G |
13: 96,113,203 (GRCm39) |
I582T |
possibly damaging |
Het |
| Tamm41 |
C |
T |
6: 114,993,139 (GRCm39) |
V205M |
probably damaging |
Het |
| Trpm2 |
T |
C |
10: 77,761,623 (GRCm39) |
D1009G |
probably benign |
Het |
| Trpm6 |
T |
C |
19: 18,831,613 (GRCm39) |
S1493P |
probably damaging |
Het |
| Ttc34 |
G |
A |
4: 154,923,731 (GRCm39) |
V147I |
possibly damaging |
Het |
| Tut7 |
A |
G |
13: 59,947,496 (GRCm39) |
F942L |
probably benign |
Het |
| Uba2 |
C |
T |
7: 33,850,275 (GRCm39) |
A393T |
probably damaging |
Het |
| Ubn2 |
T |
A |
6: 38,440,873 (GRCm39) |
N416K |
probably benign |
Het |
| Uevld |
T |
C |
7: 46,593,553 (GRCm39) |
N233S |
probably benign |
Het |
| Upp2 |
G |
A |
2: 58,664,160 (GRCm39) |
M142I |
possibly damaging |
Het |
| Vps52 |
T |
A |
17: 34,181,108 (GRCm39) |
V450D |
probably benign |
Het |
| Wdr31 |
A |
T |
4: 62,378,873 (GRCm39) |
F118Y |
probably damaging |
Het |
| Zfp110 |
T |
A |
7: 12,582,922 (GRCm39) |
D523E |
possibly damaging |
Het |
| Zfp367 |
A |
T |
13: 64,293,457 (GRCm39) |
V143D |
probably damaging |
Het |
| Zfp950 |
T |
C |
19: 61,108,379 (GRCm39) |
I235V |
probably benign |
Het |
|
| Other mutations in Slit3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00731:Slit3
|
APN |
11 |
35,512,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Slit3
|
APN |
11 |
35,501,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01612:Slit3
|
APN |
11 |
35,591,211 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02145:Slit3
|
APN |
11 |
35,520,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02146:Slit3
|
APN |
11 |
35,125,675 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02430:Slit3
|
APN |
11 |
35,068,601 (GRCm39) |
splice site |
probably null |
|
|
IGL02528:Slit3
|
APN |
11 |
35,469,801 (GRCm39) |
missense |
probably benign |
|
|
IGL02530:Slit3
|
APN |
11 |
35,598,969 (GRCm39) |
makesense |
probably null |
|
|
IGL02640:Slit3
|
APN |
11 |
35,591,172 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02819:Slit3
|
APN |
11 |
35,062,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Slit3
|
APN |
11 |
35,539,874 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03150:Slit3
|
APN |
11 |
35,399,084 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03161:Slit3
|
APN |
11 |
35,591,241 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03336:Slit3
|
APN |
11 |
35,560,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Bloated
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
Quellung
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02988:Slit3
|
UTSW |
11 |
35,598,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4791001:Slit3
|
UTSW |
11 |
35,552,072 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0334:Slit3
|
UTSW |
11 |
35,469,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0385:Slit3
|
UTSW |
11 |
35,591,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0840:Slit3
|
UTSW |
11 |
35,514,263 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Slit3
|
UTSW |
11 |
35,012,462 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1364:Slit3
|
UTSW |
11 |
35,560,934 (GRCm39) |
missense |
probably benign |
|
|
R1476:Slit3
|
UTSW |
11 |
35,577,126 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1508:Slit3
|
UTSW |
11 |
35,461,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Slit3
|
UTSW |
11 |
35,125,733 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1692:Slit3
|
UTSW |
11 |
35,550,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1696:Slit3
|
UTSW |
11 |
35,566,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1727:Slit3
|
UTSW |
11 |
35,520,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Slit3
|
UTSW |
11 |
35,455,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1970:Slit3
|
UTSW |
11 |
35,521,668 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2077:Slit3
|
UTSW |
11 |
35,435,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2126:Slit3
|
UTSW |
11 |
35,579,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Slit3
|
UTSW |
11 |
35,503,088 (GRCm39) |
splice site |
probably null |
|
|
R2162:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R2873:Slit3
|
UTSW |
11 |
35,435,620 (GRCm39) |
nonsense |
probably null |
|
|
R3813:Slit3
|
UTSW |
11 |
35,566,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3831:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3832:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3833:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3839:Slit3
|
UTSW |
11 |
35,399,064 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4152:Slit3
|
UTSW |
11 |
35,589,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4387:Slit3
|
UTSW |
11 |
35,574,875 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4795:Slit3
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4910:Slit3
|
UTSW |
11 |
35,523,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Slit3
|
UTSW |
11 |
35,579,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5106:Slit3
|
UTSW |
11 |
35,503,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5218:Slit3
|
UTSW |
11 |
35,575,002 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Slit3
|
UTSW |
11 |
35,512,975 (GRCm39) |
missense |
probably benign |
|
|
R5354:Slit3
|
UTSW |
11 |
35,566,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Slit3
|
UTSW |
11 |
35,598,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5896:Slit3
|
UTSW |
11 |
35,598,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5933:Slit3
|
UTSW |
11 |
35,520,578 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5963:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Slit3
|
UTSW |
11 |
35,461,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6153:Slit3
|
UTSW |
11 |
35,591,310 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6484:Slit3
|
UTSW |
11 |
35,552,125 (GRCm39) |
missense |
probably benign |
|
|
R6526:Slit3
|
UTSW |
11 |
35,552,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6797:Slit3
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6887:Slit3
|
UTSW |
11 |
35,435,633 (GRCm39) |
splice site |
probably null |
|
|
R7067:Slit3
|
UTSW |
11 |
35,399,057 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7150:Slit3
|
UTSW |
11 |
35,461,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Slit3
|
UTSW |
11 |
35,490,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Slit3
|
UTSW |
11 |
35,501,516 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7418:Slit3
|
UTSW |
11 |
35,577,255 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7545:Slit3
|
UTSW |
11 |
35,591,139 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7820:Slit3
|
UTSW |
11 |
35,591,235 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8177:Slit3
|
UTSW |
11 |
35,469,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Slit3
|
UTSW |
11 |
35,554,903 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8416:Slit3
|
UTSW |
11 |
35,399,062 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8417:Slit3
|
UTSW |
11 |
35,501,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8476:Slit3
|
UTSW |
11 |
35,520,596 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8785:Slit3
|
UTSW |
11 |
35,560,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8955:Slit3
|
UTSW |
11 |
35,589,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9040:Slit3
|
UTSW |
11 |
35,594,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9068:Slit3
|
UTSW |
11 |
35,574,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Slit3
|
UTSW |
11 |
35,012,463 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9266:Slit3
|
UTSW |
11 |
35,598,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9539:Slit3
|
UTSW |
11 |
35,589,155 (GRCm39) |
nonsense |
probably null |
|
|
R9636:Slit3
|
UTSW |
11 |
35,594,088 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0028:Slit3
|
UTSW |
11 |
35,455,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Slit3
|
UTSW |
11 |
35,598,751 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGAGAGCAAAGGCCATGG -3'
(R):5'- CCAACTTCTGCATCGAGCTG -3'
Sequencing Primer
(F):5'- GGCCATGGACCACAAGTG -3'
(R):5'- ATCGAGCTGCCCTGGCTAG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation