Incidental Mutation 'R7727:Zfp950'
ID 595604
Institutional Source Beutler Lab
Gene Symbol Zfp950
Ensembl Gene ENSMUSG00000074733
Gene Name zinc finger protein 950
Synonyms BC029127
MMRRC Submission 045783-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R7727 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 61053840-61140840 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 61119941 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 235 (I235V)
Ref Sequence ENSEMBL: ENSMUSP00000146243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122927] [ENSMUST00000127117] [ENSMUST00000127290] [ENSMUST00000143264] [ENSMUST00000178819] [ENSMUST00000180544] [ENSMUST00000205712] [ENSMUST00000205854]
AlphaFold A0A0U1RQ46
Predicted Effect probably benign
Transcript: ENSMUST00000122927
Predicted Effect probably benign
Transcript: ENSMUST00000127117
Predicted Effect probably benign
Transcript: ENSMUST00000127290
Predicted Effect probably benign
Transcript: ENSMUST00000143264
Predicted Effect probably benign
Transcript: ENSMUST00000178819
Predicted Effect probably benign
Transcript: ENSMUST00000180544
AA Change: I235V

PolyPhen 2 Score 0.330 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000205712
Predicted Effect probably benign
Transcript: ENSMUST00000205854
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (69/69)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele exhibit some postnatal lethality, altered craniofacial structures, kidney defects, embryonic hemorrhaging and cell migration defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts5 A T 16: 85,899,966 (GRCm38) L101Q probably damaging Het
Arhgap18 A T 10: 26,870,011 (GRCm38) I293F possibly damaging Het
Atp8b1 T A 18: 64,545,275 (GRCm38) Q850L probably damaging Het
B4galnt3 A T 6: 120,225,187 (GRCm38) F118Y probably benign Het
Bcl6 A G 16: 23,971,413 (GRCm38) probably null Het
Cc2d2b T A 19: 40,756,530 (GRCm38) L31Q probably benign Het
Cd5l G T 3: 87,367,855 (GRCm38) E234* probably null Het
Cemip2 C T 19: 21,829,957 (GRCm38) L917F probably benign Het
Cfap65 T C 1: 74,926,625 (GRCm38) T409A probably benign Het
Chst5 A T 8: 111,890,925 (GRCm38) I21N probably benign Het
Cldn20 T C 17: 3,532,755 (GRCm38) Y68H probably benign Het
Col4a4 T C 1: 82,528,793 (GRCm38) M269V unknown Het
Dgkh A G 14: 78,595,145 (GRCm38) probably null Het
Dpp6 A G 5: 27,451,244 (GRCm38) T166A probably benign Het
Drosha A G 15: 12,881,645 (GRCm38) D754G probably damaging Het
Epb41l4a C A 18: 33,854,273 (GRCm38) K350N probably damaging Het
Fsd1 T G 17: 55,988,150 (GRCm38) D46E probably benign Het
Gabra1 T C 11: 42,133,591 (GRCm38) D419G probably damaging Het
Golga4 T A 9: 118,548,702 (GRCm38) D458E probably damaging Het
Grm6 C A 11: 50,851,542 (GRCm38) A134E probably benign Het
Ikzf1 T A 11: 11,748,339 (GRCm38) S63R probably damaging Het
Ilvbl G A 10: 78,576,666 (GRCm38) V74I probably benign Het
Kcng2 C T 18: 80,296,090 (GRCm38) V328M probably benign Het
Kpna7 T C 5: 145,005,045 (GRCm38) E145G probably benign Het
Krt81 A G 15: 101,459,567 (GRCm38) V428A probably damaging Het
Lalba T C 15: 98,482,668 (GRCm38) M2V probably benign Het
Lrpprc T C 17: 84,776,947 (GRCm38) S113G probably benign Het
Mboat1 A C 13: 30,226,306 (GRCm38) M249L probably benign Het
Meltf T C 16: 31,883,794 (GRCm38) V113A probably damaging Het
Muc16 T A 9: 18,660,242 (GRCm38) H327L unknown Het
Myh1 A G 11: 67,215,922 (GRCm38) I1277V probably benign Het
Naga C A 15: 82,330,147 (GRCm38) V388L probably benign Het
Nfkb1 A C 3: 135,585,401 (GRCm38) M957R possibly damaging Het
Nol12 C A 15: 78,940,593 (GRCm38) S157* probably null Het
Or13c25 A G 4: 52,911,368 (GRCm38) V142A possibly damaging Het
Or5g23 A G 2: 85,608,407 (GRCm38) F168L possibly damaging Het
Or8u3-ps A T 2: 86,122,496 (GRCm38) D191V possibly damaging Het
Pcdhga5 T C 18: 37,695,045 (GRCm38) V182A probably benign Het
Pik3r4 A G 9: 105,669,882 (GRCm38) E953G probably damaging Het
Piwil2 C T 14: 70,394,057 (GRCm38) R646Q probably damaging Het
Plxnc1 T C 10: 94,944,109 (GRCm38) H157R probably damaging Het
Prrg4 A T 2: 104,839,378 (GRCm38) F131L probably benign Het
Prss3b C A 6: 41,033,193 (GRCm38) R69L probably benign Het
Rab28 A G 5: 41,707,970 (GRCm38) S4P probably damaging Het
Ranbp2 C A 10: 58,455,438 (GRCm38) Q209K probably benign Het
Schip1 G A 3: 68,064,984 (GRCm38) D15N probably benign Het
Serpina3f T G 12: 104,218,218 (GRCm38) M207R probably benign Het
Sgsm1 A T 5: 113,274,327 (GRCm38) M487K possibly damaging Het
Sh3tc2 A T 18: 61,989,580 (GRCm38) I471F probably benign Het
Slamf1 G A 1: 171,774,899 (GRCm38) V65I possibly damaging Het
Slit3 T C 11: 35,684,044 (GRCm38) C1062R probably damaging Het
Snapc4 T G 2: 26,373,434 (GRCm38) K344N probably damaging Het
Sorl1 A G 9: 41,984,526 (GRCm38) Y1778H probably damaging Het
Spon2 G A 5: 33,215,675 (GRCm38) R228C probably damaging Het
Sv2c A G 13: 95,976,695 (GRCm38) I582T possibly damaging Het
Tamm41 C T 6: 115,016,178 (GRCm38) V205M probably damaging Het
Trpm2 T C 10: 77,925,789 (GRCm38) D1009G probably benign Het
Trpm6 T C 19: 18,854,249 (GRCm38) S1493P probably damaging Het
Ttc34 G A 4: 154,839,274 (GRCm38) V147I possibly damaging Het
Tut7 A G 13: 59,799,682 (GRCm38) F942L probably benign Het
Uba2 C T 7: 34,150,850 (GRCm38) A393T probably damaging Het
Ubn2 T A 6: 38,463,938 (GRCm38) N416K probably benign Het
Uevld T C 7: 46,943,805 (GRCm38) N233S probably benign Het
Upp2 G A 2: 58,774,148 (GRCm38) M142I possibly damaging Het
Vps52 T A 17: 33,962,134 (GRCm38) V450D probably benign Het
Wdr31 A T 4: 62,460,636 (GRCm38) F118Y probably damaging Het
Zfp110 T A 7: 12,848,995 (GRCm38) D523E possibly damaging Het
Zfp367 A T 13: 64,145,643 (GRCm38) V143D probably damaging Het
Other mutations in Zfp950
AlleleSourceChrCoordTypePredicted EffectPPH Score
BB005:Zfp950 UTSW 19 61,119,500 (GRCm38) missense probably damaging 1.00
R1892:Zfp950 UTSW 19 61,119,111 (GRCm38) missense probably benign 0.05
R3442:Zfp950 UTSW 19 61,118,732 (GRCm38) nonsense probably null
R6062:Zfp950 UTSW 19 61,120,425 (GRCm38) missense possibly damaging 0.89
R7231:Zfp950 UTSW 19 61,119,212 (GRCm38) missense probably benign 0.28
R7285:Zfp950 UTSW 19 61,119,112 (GRCm38) missense probably benign 0.02
R7399:Zfp950 UTSW 19 61,119,155 (GRCm38) missense probably damaging 1.00
R7744:Zfp950 UTSW 19 61,127,572 (GRCm38) splice site probably null
R7811:Zfp950 UTSW 19 61,119,915 (GRCm38) nonsense probably null
R7928:Zfp950 UTSW 19 61,119,500 (GRCm38) missense probably damaging 1.00
R8857:Zfp950 UTSW 19 61,127,563 (GRCm38) missense probably benign 0.14
R9143:Zfp950 UTSW 19 61,120,340 (GRCm38) missense probably benign 0.26
R9711:Zfp950 UTSW 19 61,127,562 (GRCm38) missense probably damaging 0.96
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-11-12