Incidental Mutation 'R7729:Or8g18'
ID 595716
Institutional Source Beutler Lab
Gene Symbol Or8g18
Ensembl Gene ENSMUSG00000096109
Gene Name olfactory receptor family 8 subfamily G member 18
Synonyms MOR171-41P, Olfr1537-ps1, Olfr144, GA_x6K02T2PVTD-32935684-32934749, MOR171-32P, K4, MOR171-32P, Olfr1537
MMRRC Submission 045785-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R7729 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39148783-39149727 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 39149546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 58 (P58L)
Ref Sequence ENSEMBL: ENSMUSP00000149992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073248] [ENSMUST00000213472]
AlphaFold P34983
Predicted Effect probably benign
Transcript: ENSMUST00000073248
AA Change: P61L

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000072979
Gene: ENSMUSG00000096109
AA Change: P61L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.4e-51 PFAM
Pfam:7tm_1 44 293 1.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213472
AA Change: P58L

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810024B03Rik T G 2: 127,028,710 (GRCm39) D163A possibly damaging Het
Abce1 A T 8: 80,414,537 (GRCm39) I454N probably damaging Het
Acaca A G 11: 84,262,339 (GRCm39) I1980M probably damaging Het
Adgrb2 C T 4: 129,885,917 (GRCm39) T19M probably benign Het
Agmo T A 12: 37,464,974 (GRCm39) S417T probably benign Het
Akap8l T C 17: 32,552,068 (GRCm39) E403G probably damaging Het
Art5 C T 7: 101,747,711 (GRCm39) A23T possibly damaging Het
Atg9a T C 1: 75,161,204 (GRCm39) T681A probably benign Het
Atp11b A G 3: 35,832,256 (GRCm39) Q37R probably damaging Het
Atp2a2 T C 5: 122,629,829 (GRCm39) E80G probably benign Het
AW551984 G A 9: 39,511,071 (GRCm39) P172L possibly damaging Het
Bace1 C T 9: 45,769,743 (GRCm39) R296C probably damaging Het
Ccser1 T A 6: 61,288,840 (GRCm39) H334Q probably benign Het
Chtf18 C T 17: 25,942,491 (GRCm39) R449H probably damaging Het
Cit A G 5: 116,122,881 (GRCm39) H1384R possibly damaging Het
Cltc A G 11: 86,612,474 (GRCm39) I524T probably benign Het
Dctn1 T A 6: 83,160,042 (GRCm39) I94N probably damaging Het
Dnhd1 A T 7: 105,354,472 (GRCm39) D3078V probably damaging Het
Dock7 G A 4: 98,943,683 (GRCm39) P520S Het
Epb41l4a C A 18: 33,987,326 (GRCm39) K350N probably damaging Het
Eprs1 T A 1: 185,145,366 (GRCm39) Y1130N probably damaging Het
Fcgrt T C 7: 44,744,797 (GRCm39) T224A probably damaging Het
Flt1 T A 5: 147,637,177 (GRCm39) T39S probably benign Het
Fxyd1 T C 7: 30,752,896 (GRCm39) Y33C probably damaging Het
Gab2 T A 7: 96,950,633 (GRCm39) V442E probably damaging Het
Ganab A G 19: 8,892,076 (GRCm39) D800G probably benign Het
Gata4 C A 14: 63,478,186 (GRCm39) A138S probably benign Het
Golga4 A G 9: 118,385,131 (GRCm39) H751R possibly damaging Het
H1f6 A G 13: 23,880,455 (GRCm39) R203G possibly damaging Het
Htra4 A G 8: 25,527,093 (GRCm39) V234A possibly damaging Het
Igkv4-74 A T 6: 69,161,954 (GRCm39) Y72N probably damaging Het
Iqsec3 T C 6: 121,360,940 (GRCm39) K973E probably damaging Het
Khdc1b C A 1: 21,455,065 (GRCm39) T108K probably benign Het
Krtap5-1 ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG 7: 141,850,333 (GRCm39) probably benign Het
Kyat3 A G 3: 142,432,066 (GRCm39) probably null Het
Lrba T A 3: 86,225,474 (GRCm39) V666E probably damaging Het
Mettl25 T A 10: 105,601,871 (GRCm39) Y528F probably benign Het
Mms19 A T 19: 41,940,904 (GRCm39) Y619* probably null Het
Nlrp12 A C 7: 3,277,020 (GRCm39) probably null Het
Nol10 C T 12: 17,474,676 (GRCm39) L623F possibly damaging Het
Oas1g A G 5: 121,024,063 (GRCm39) F82S probably damaging Het
Or1j8 T G 2: 36,191,772 (GRCm39) S74A probably benign Het
Or5k3 C T 16: 58,969,570 (GRCm39) A119V probably damaging Het
Oxr1 G A 15: 41,686,863 (GRCm39) E582K probably damaging Het
Pdia3 A G 2: 121,262,838 (GRCm39) D268G possibly damaging Het
Pramel13 T C 4: 144,119,434 (GRCm39) S378G probably damaging Het
Rcor3 A G 1: 191,786,078 (GRCm39) Y387H probably damaging Het
Rigi T A 4: 40,206,034 (GRCm39) I853F possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,118 (GRCm39) probably benign Het
Rsl1 T C 13: 67,330,284 (GRCm39) L244P possibly damaging Het
Scn5a G T 9: 119,324,606 (GRCm39) N1407K probably damaging Het
Sdcbp C T 4: 6,378,985 (GRCm39) A24V probably benign Het
Slc22a8 A G 19: 8,571,323 (GRCm39) Y18C possibly damaging Het
Slc35d1 C T 4: 103,072,044 (GRCm39) R7H probably damaging Het
Slco6d1 A T 1: 98,425,248 (GRCm39) T599S probably damaging Het
Spata31d1e C T 13: 59,889,437 (GRCm39) M794I not run Het
St18 T A 1: 6,872,761 (GRCm39) H165Q probably benign Het
Sub1 C T 15: 11,986,589 (GRCm39) R86K probably damaging Het
Tectb G A 19: 55,181,104 (GRCm39) V148M Het
Tgfb2 C A 1: 186,362,954 (GRCm39) G290V possibly damaging Het
Tgm7 T C 2: 120,924,191 (GRCm39) H577R probably benign Het
Tle2 T C 10: 81,422,981 (GRCm39) S460P probably damaging Het
Tmem221 C A 8: 72,011,446 (GRCm39) R3L possibly damaging Het
Tnfrsf19 C A 14: 61,212,183 (GRCm39) V156L possibly damaging Het
Trav6-5 A G 14: 53,728,964 (GRCm39) K75E probably benign Het
Trip10 G A 17: 57,569,442 (GRCm39) G488S probably damaging Het
Usp34 A C 11: 23,399,268 (GRCm39) K2419T Het
Vps13d T C 4: 144,801,622 (GRCm39) Q3532R Het
Vps4a A T 8: 107,767,529 (GRCm39) I163L probably damaging Het
Wrn T C 8: 33,814,454 (GRCm39) H330R probably benign Het
Xpr1 T C 1: 155,188,618 (GRCm39) I341V probably benign Het
Zfyve9 T C 4: 108,548,973 (GRCm39) E105G probably benign Het
Other mutations in Or8g18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00981:Or8g18 APN 9 39,148,901 (GRCm39) missense probably benign 0.25
IGL01691:Or8g18 APN 9 39,149,315 (GRCm39) missense probably benign 0.00
IGL02606:Or8g18 APN 9 39,149,490 (GRCm39) missense probably damaging 0.98
IGL02656:Or8g18 APN 9 39,149,456 (GRCm39) missense probably benign 0.13
R0133:Or8g18 UTSW 9 39,149,307 (GRCm39) missense probably benign 0.00
R0548:Or8g18 UTSW 9 39,149,667 (GRCm39) missense probably benign 0.13
R0558:Or8g18 UTSW 9 39,149,496 (GRCm39) missense probably damaging 0.96
R0616:Or8g18 UTSW 9 39,148,946 (GRCm39) missense probably benign 0.00
R0626:Or8g18 UTSW 9 39,149,162 (GRCm39) missense possibly damaging 0.52
R0826:Or8g18 UTSW 9 39,149,725 (GRCm39) start codon destroyed probably null 0.00
R0839:Or8g18 UTSW 9 39,149,146 (GRCm39) missense possibly damaging 0.51
R1074:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1224:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1226:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1252:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1256:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1355:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1356:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1416:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1499:Or8g18 UTSW 9 39,149,547 (GRCm39) missense probably benign 0.39
R1658:Or8g18 UTSW 9 39,149,255 (GRCm39) missense probably benign 0.03
R1815:Or8g18 UTSW 9 39,149,286 (GRCm39) missense probably benign 0.01
R2198:Or8g18 UTSW 9 39,149,048 (GRCm39) missense possibly damaging 0.48
R4178:Or8g18 UTSW 9 39,149,375 (GRCm39) nonsense probably null
R5112:Or8g18 UTSW 9 39,149,717 (GRCm39) start codon destroyed probably null 0.94
R6251:Or8g18 UTSW 9 39,149,514 (GRCm39) missense possibly damaging 0.94
R6850:Or8g18 UTSW 9 39,149,271 (GRCm39) missense probably benign 0.01
R7032:Or8g18 UTSW 9 39,148,983 (GRCm39) missense possibly damaging 0.73
R7573:Or8g18 UTSW 9 39,148,977 (GRCm39) missense probably benign 0.42
R7715:Or8g18 UTSW 9 39,149,174 (GRCm39) missense probably damaging 1.00
R7722:Or8g18 UTSW 9 39,148,885 (GRCm39) nonsense probably null
R8710:Or8g18 UTSW 9 39,149,306 (GRCm39) missense probably benign 0.00
R9513:Or8g18 UTSW 9 39,149,625 (GRCm39) missense probably benign 0.05
R9515:Or8g18 UTSW 9 39,149,625 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TAGCAACATATCGGTCATAGGCC -3'
(R):5'- TCTCCTTTAGATTTGAATGGAGGAC -3'

Sequencing Primer
(F):5'- CATATCGGTCATAGGCCATTGCAG -3'
(R):5'- CTTTAGATTTGAATGGAGGACATGGC -3'
Posted On 2019-11-12