Mutagenetix > Incidental Mutation

Incidental Mutation 'R7733:Ptprz1'

595979

Institutional Source

Beutler Lab

Gene Symbol

Ptprz1

Ensembl Gene

ENSMUSG00000068748

Gene Name

protein tyrosine phosphatase receptor type Z, polypeptide 1

Synonyms

DSD-1-PG, phosphacan, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz, PTPbeta

MMRRC Submission

045789-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.715) question?

Stock #

R7733 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22875501-23052915 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23000383 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 824 (D824E)

Ref Sequence

ENSEMBL: ENSMUSP00000088056 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090568] [ENSMUST00000202102] [ENSMUST00000202579]

AlphaFold

B9EKR1

Predicted Effect

probably benign
Transcript: ENSMUST00000090568
AA Change: D824E

PolyPhen 2 Score 0.315 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000088056
Gene: ENSMUSG00000068748
AA Change: D824E

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Carb_anhydrase	38	300	5.12e-99	SMART
FN3	312	397	5.53e-4	SMART
low complexity region	588	609	N/A	INTRINSIC
low complexity region	825	837	N/A	INTRINSIC
low complexity region	1417	1441	N/A	INTRINSIC
low complexity region	1485	1495	N/A	INTRINSIC
Blast:PTPc	1497	1573	1e-12	BLAST
low complexity region	1606	1620	N/A	INTRINSIC
transmembrane domain	1637	1659	N/A	INTRINSIC
low complexity region	1679	1693	N/A	INTRINSIC
PTPc	1720	1991	2.8e-130	SMART
PTPc	2019	2281	1.65e-77	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000202102

SMART Domains

Protein: ENSMUSP00000143902
Gene: ENSMUSG00000068748

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Carb_anhydrase	38	300	5.12e-99	SMART
FN3	312	397	5.53e-4	SMART
low complexity region	588	609	N/A	INTRINSIC
transmembrane domain	788	810	N/A	INTRINSIC
low complexity region	830	844	N/A	INTRINSIC
PTPc	871	1142	2.8e-130	SMART
PTPc	1170	1432	1.65e-77	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000202579
AA Change: D824E

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000144605
Gene: ENSMUSG00000068748
AA Change: D824E

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Carb_anhydrase	38	300	4e-103	SMART
FN3	312	397	2.8e-6	SMART
low complexity region	588	609	N/A	INTRINSIC
low complexity region	825	837	N/A	INTRINSIC
low complexity region	1417	1441	N/A	INTRINSIC
low complexity region	1485	1495	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.3%

Validation Efficiency

100% (83/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5530400C23Rik	T	A	6: 133,271,240 (GRCm39)	S95T	probably benign	Het
Abca8a	A	G	11: 109,945,413 (GRCm39)	F1070L	probably benign	Het
Acsl3	G	C	1: 78,665,953 (GRCm39)		probably null	Het
Adarb2	T	A	13: 8,802,644 (GRCm39)	S640T	possibly damaging	Het
Adgre5	T	C	8: 84,456,025 (GRCm39)	D257G	probably benign	Het
Adora2b	A	T	11: 62,156,165 (GRCm39)	I205F	possibly damaging	Het
Asb14	A	G	14: 26,634,309 (GRCm39)	M505V	probably benign	Het
Atrnl1	T	C	19: 57,690,420 (GRCm39)	V876A	probably benign	Het
AU040320	A	G	4: 126,729,322 (GRCm39)	N495D	possibly damaging	Het
Bcam	A	T	7: 19,494,313 (GRCm39)	V361E	probably benign	Het
Ccdc7a	T	A	8: 129,719,533 (GRCm39)	E247V	probably damaging	Het
Cd84	T	A	1: 171,668,226 (GRCm39)	M1K	probably null	Het
Cfap43	C	T	19: 47,886,432 (GRCm39)	R61H	possibly damaging	Het
Clec4a1	A	G	6: 122,909,109 (GRCm39)	D159G	possibly damaging	Het
Ctcfl	C	T	2: 172,958,985 (GRCm39)	R247Q	probably benign	Het
Ctdnep1	G	A	11: 69,880,835 (GRCm39)	R236Q	probably damaging	Het
Cwf19l2	A	T	9: 3,450,066 (GRCm39)	H589L	probably benign	Het
Cyp2u1	G	T	3: 131,096,676 (GRCm39)	A34E	probably benign	Het
Cyp4x1	A	G	4: 114,977,391 (GRCm39)	S281P	possibly damaging	Het
Dag1	T	C	9: 108,086,047 (GRCm39)	T365A	probably benign	Het
Dhx57	A	T	17: 80,572,503 (GRCm39)		probably null	Het
Dnajb1	T	G	8: 84,335,006 (GRCm39)	S16A	probably benign	Het
Dsc2	A	T	18: 20,181,372 (GRCm39)	L145Q	probably benign	Het
Dsc2	G	C	18: 20,181,373 (GRCm39)	L145V	probably benign	Het
Eefsec	T	C	6: 88,353,202 (GRCm39)	T156A	possibly damaging	Het
Eif6	T	A	2: 155,665,152 (GRCm39)	D169V	probably benign	Het
Ell3	C	A	2: 121,273,001 (GRCm39)	G3V	possibly damaging	Het
Eprs1	A	T	1: 185,129,358 (GRCm39)	H615L	probably benign	Het
Fbxw10	A	G	11: 62,764,223 (GRCm39)	Y630C	unknown	Het
Fcgbpl1	A	T	7: 27,839,390 (GRCm39)	D401V	probably damaging	Het
G6pc2	C	T	2: 69,050,527 (GRCm39)	Q51*	probably null	Het
Glt8d1	C	T	14: 30,723,935 (GRCm39)		probably benign	Het
Gpr4	T	C	7: 18,956,635 (GRCm39)	Y186H	probably damaging	Het
Grhpr	T	C	4: 44,981,494 (GRCm39)		probably benign	Het
Gsdma3	A	G	11: 98,526,041 (GRCm39)	H264R	probably damaging	Het
Hcfc2	A	G	10: 82,575,013 (GRCm39)	Y224C	probably benign	Het
Helz2	A	G	2: 180,872,148 (GRCm39)	F2608S	possibly damaging	Het
Herc2	C	T	7: 55,838,412 (GRCm39)	T3313M	probably damaging	Het
Hmgcl	A	T	4: 135,687,394 (GRCm39)	H223L	probably benign	Het
Igf2r	A	G	17: 12,958,256 (GRCm39)	V139A	possibly damaging	Het
Iqcn	A	G	8: 71,170,100 (GRCm39)	T1397A	possibly damaging	Het
Kif5a	T	A	10: 127,072,609 (GRCm39)	T727S	probably benign	Het
Kifc1	G	A	17: 34,102,543 (GRCm39)	R357W	probably damaging	Het
Krt81	T	A	15: 101,361,395 (GRCm39)	S62C	probably damaging	Het
Lgi2	T	C	5: 52,695,873 (GRCm39)	N362S	probably benign	Het
Lig1	G	T	7: 13,030,157 (GRCm39)	R378L	possibly damaging	Het
Map3k13	C	T	16: 21,740,436 (GRCm39)	R588C	probably damaging	Het
Mov10l1	T	A	15: 88,909,004 (GRCm39)	F1008L	probably damaging	Het
Nr4a2	A	G	2: 57,002,333 (GRCm39)	V40A	probably benign	Het
Nrde2	A	T	12: 100,110,399 (GRCm39)	C206S	possibly damaging	Het
Or4f14d	C	T	2: 111,960,386 (GRCm39)	V257I	probably benign	Het
Parp1	T	C	1: 180,427,777 (GRCm39)		probably null	Het
Pcdhb12	A	G	18: 37,570,089 (GRCm39)	T412A	probably damaging	Het
Plekhh2	T	A	17: 84,890,952 (GRCm39)	Y839*	probably null	Het
Pnpla6	T	A	8: 3,572,660 (GRCm39)	F316I	probably benign	Het
Prcp	C	T	7: 92,550,506 (GRCm39)	T101M	probably damaging	Het
Prex2	G	T	1: 11,252,183 (GRCm39)	R1076L	probably benign	Het
Prpf40b	T	C	15: 99,206,224 (GRCm39)		probably null	Het
Psd3	T	G	8: 68,573,568 (GRCm39)	K204N	possibly damaging	Het
Ptpro	C	A	6: 137,391,284 (GRCm39)	C801*	probably null	Het
Ptprt	A	G	2: 161,417,707 (GRCm39)	V923A	probably damaging	Het
Rasgrf1	A	G	9: 89,863,780 (GRCm39)	D582G	probably benign	Het
Rfc2	T	C	5: 134,622,070 (GRCm39)	L183P	probably damaging	Het
Rnf114	T	C	2: 167,354,438 (GRCm39)	V173A	probably damaging	Het
Scn3a	T	A	2: 65,338,994 (GRCm39)	I562F	probably benign	Het
Setmar	T	C	6: 108,053,088 (GRCm39)	I194T	probably damaging	Het
Sptb	A	T	12: 76,644,695 (GRCm39)		probably null	Het
Sptbn2	C	G	19: 4,799,040 (GRCm39)	R2037G	probably benign	Het
Sptlc3	G	T	2: 139,473,288 (GRCm39)	M512I	possibly damaging	Het
Svep1	C	A	4: 58,049,239 (GRCm39)	A3423S	probably benign	Het
Sycp1	T	C	3: 102,803,278 (GRCm39)	T511A	probably benign	Het
Synm	T	A	7: 67,385,693 (GRCm39)		probably null	Het
Tada1	C	T	1: 166,217,511 (GRCm39)	P216L	probably damaging	Het
Tas2r117	T	A	6: 132,780,138 (GRCm39)	M92K	probably benign	Het
Thoc2l	T	C	5: 104,667,826 (GRCm39)	F783L	possibly damaging	Het
Thsd1	T	C	8: 22,748,737 (GRCm39)	L536P	probably damaging	Het
Timp2	T	G	11: 118,208,355 (GRCm39)		probably null	Het
Trak1	T	A	9: 121,196,291 (GRCm39)	V41D	possibly damaging	Het
Ubqln3	T	A	7: 103,790,283 (GRCm39)	L602F	probably damaging	Het
Vmn2r59	A	G	7: 41,661,443 (GRCm39)	F791L	probably benign	Het
Wbp4	A	G	14: 79,714,480 (GRCm39)		probably null	Het
Zng1	T	C	19: 24,918,158 (GRCm39)	D204G	probably damaging	Het

Other mutations in Ptprz1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00486:Ptprz1	APN	6	22,973,053 (GRCm39)	missense	probably damaging	1.00
IGL00773:Ptprz1	APN	6	23,002,628 (GRCm39)	missense	probably benign	0.41
IGL01458:Ptprz1	APN	6	22,972,843 (GRCm39)	missense	probably damaging	0.99
IGL01481:Ptprz1	APN	6	22,999,979 (GRCm39)	missense	probably benign	0.05
IGL01501:Ptprz1	APN	6	22,973,081 (GRCm39)	missense	probably damaging	1.00
IGL01601:Ptprz1	APN	6	23,000,437 (GRCm39)	missense	probably damaging	0.99
IGL01882:Ptprz1	APN	6	23,000,463 (GRCm39)	missense	probably damaging	1.00
IGL02058:Ptprz1	APN	6	23,002,502 (GRCm39)	missense	probably benign	0.00
IGL02089:Ptprz1	APN	6	23,033,447 (GRCm39)	missense	probably damaging	1.00
IGL02136:Ptprz1	APN	6	22,972,821 (GRCm39)	missense	probably damaging	1.00
IGL02215:Ptprz1	APN	6	22,965,181 (GRCm39)	missense	possibly damaging	0.91
IGL02220:Ptprz1	APN	6	23,042,742 (GRCm39)	splice site	probably benign
IGL02556:Ptprz1	APN	6	22,972,844 (GRCm39)	missense	probably benign	0.01
IGL02601:Ptprz1	APN	6	23,000,686 (GRCm39)	missense	probably benign	0.11
IGL02620:Ptprz1	APN	6	22,959,739 (GRCm39)	missense	probably damaging	1.00
IGL02666:Ptprz1	APN	6	23,001,209 (GRCm39)	missense	probably benign	0.00
IGL02718:Ptprz1	APN	6	23,001,348 (GRCm39)	missense	possibly damaging	0.77
IGL02792:Ptprz1	APN	6	22,959,722 (GRCm39)	missense	probably damaging	1.00
IGL02894:Ptprz1	APN	6	23,035,148 (GRCm39)	missense	probably damaging	1.00
IGL02952:Ptprz1	APN	6	23,036,925 (GRCm39)	missense	probably damaging	1.00
IGL03003:Ptprz1	APN	6	23,002,582 (GRCm39)	missense	probably damaging	0.98
IGL03060:Ptprz1	APN	6	22,972,834 (GRCm39)	missense	probably damaging	1.00
IGL03170:Ptprz1	APN	6	22,959,766 (GRCm39)	missense	probably benign	0.00
IGL03246:Ptprz1	APN	6	22,986,159 (GRCm39)	missense	probably damaging	0.99
IGL03349:Ptprz1	APN	6	23,000,331 (GRCm39)	missense	probably damaging	1.00
IGL03365:Ptprz1	APN	6	23,030,581 (GRCm39)	splice site	probably benign
Elevator	UTSW	6	23,030,661 (GRCm39)	missense	probably benign	0.03
escalator	UTSW	6	22,986,187 (GRCm39)	missense	probably damaging	1.00
R0044:Ptprz1	UTSW	6	23,007,402 (GRCm39)	missense	probably damaging	1.00
R0054:Ptprz1	UTSW	6	22,986,195 (GRCm39)	missense	probably damaging	1.00
R0054:Ptprz1	UTSW	6	22,986,195 (GRCm39)	missense	probably damaging	1.00
R0107:Ptprz1	UTSW	6	23,000,569 (GRCm39)	missense	probably damaging	0.98
R0278:Ptprz1	UTSW	6	23,000,816 (GRCm39)	missense	probably benign	0.31
R0345:Ptprz1	UTSW	6	23,016,164 (GRCm39)	missense	probably damaging	1.00
R0359:Ptprz1	UTSW	6	22,973,175 (GRCm39)	splice site	probably benign
R0743:Ptprz1	UTSW	6	23,044,366 (GRCm39)	nonsense	probably null
R1014:Ptprz1	UTSW	6	23,000,643 (GRCm39)	missense	probably damaging	1.00
R1016:Ptprz1	UTSW	6	23,000,973 (GRCm39)	missense	probably damaging	1.00
R1106:Ptprz1	UTSW	6	22,965,748 (GRCm39)	missense	probably damaging	0.99
R1391:Ptprz1	UTSW	6	23,001,728 (GRCm39)	missense	probably benign	0.33
R1424:Ptprz1	UTSW	6	23,000,382 (GRCm39)	missense	probably benign	0.00
R1445:Ptprz1	UTSW	6	23,050,473 (GRCm39)	missense	probably damaging	1.00
R1496:Ptprz1	UTSW	6	23,049,523 (GRCm39)	splice site	probably benign
R1544:Ptprz1	UTSW	6	23,000,747 (GRCm39)	missense	possibly damaging	0.63
R1626:Ptprz1	UTSW	6	23,001,573 (GRCm39)	missense	probably benign
R1641:Ptprz1	UTSW	6	23,049,605 (GRCm39)	missense	probably damaging	1.00
R1757:Ptprz1	UTSW	6	23,044,319 (GRCm39)	missense	probably damaging	1.00
R1812:Ptprz1	UTSW	6	22,959,711 (GRCm39)	missense	probably benign	0.07
R1917:Ptprz1	UTSW	6	23,035,039 (GRCm39)	splice site	probably benign
R1930:Ptprz1	UTSW	6	23,007,354 (GRCm39)	missense	probably damaging	1.00
R1931:Ptprz1	UTSW	6	23,007,354 (GRCm39)	missense	probably damaging	1.00
R1974:Ptprz1	UTSW	6	22,986,310 (GRCm39)	missense	probably damaging	1.00
R1992:Ptprz1	UTSW	6	22,959,747 (GRCm39)	missense	probably benign	0.24
R1997:Ptprz1	UTSW	6	23,050,496 (GRCm39)	missense	probably damaging	0.99
R2002:Ptprz1	UTSW	6	23,027,833 (GRCm39)	nonsense	probably null
R2012:Ptprz1	UTSW	6	23,001,026 (GRCm39)	missense	probably benign	0.03
R2059:Ptprz1	UTSW	6	22,986,322 (GRCm39)	splice site	probably benign
R2061:Ptprz1	UTSW	6	23,049,674 (GRCm39)	critical splice donor site	probably null
R2064:Ptprz1	UTSW	6	23,050,388 (GRCm39)	splice site	probably benign
R2067:Ptprz1	UTSW	6	23,050,388 (GRCm39)	splice site	probably benign
R2108:Ptprz1	UTSW	6	23,033,476 (GRCm39)	missense	probably damaging	0.99
R2152:Ptprz1	UTSW	6	23,030,670 (GRCm39)	missense	probably damaging	0.99
R2166:Ptprz1	UTSW	6	23,045,632 (GRCm39)	missense	possibly damaging	0.90
R2183:Ptprz1	UTSW	6	23,002,284 (GRCm39)	missense	probably benign
R2202:Ptprz1	UTSW	6	23,000,649 (GRCm39)	missense	possibly damaging	0.63
R2238:Ptprz1	UTSW	6	22,987,376 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprz1	UTSW	6	23,000,990 (GRCm39)	missense	probably damaging	1.00
R3027:Ptprz1	UTSW	6	23,016,196 (GRCm39)	missense	possibly damaging	0.89
R3861:Ptprz1	UTSW	6	23,036,894 (GRCm39)	missense	probably damaging	0.98
R4012:Ptprz1	UTSW	6	23,002,584 (GRCm39)	missense	probably damaging	0.99
R4020:Ptprz1	UTSW	6	22,959,623 (GRCm39)	splice site	probably benign
R4158:Ptprz1	UTSW	6	23,022,204 (GRCm39)	missense	possibly damaging	0.73
R4158:Ptprz1	UTSW	6	23,001,683 (GRCm39)	nonsense	probably null
R4159:Ptprz1	UTSW	6	23,001,683 (GRCm39)	nonsense	probably null
R4160:Ptprz1	UTSW	6	23,022,204 (GRCm39)	missense	possibly damaging	0.73
R4606:Ptprz1	UTSW	6	23,001,486 (GRCm39)	missense	possibly damaging	0.80
R4621:Ptprz1	UTSW	6	23,001,453 (GRCm39)	missense	possibly damaging	0.68
R4640:Ptprz1	UTSW	6	22,972,797 (GRCm39)	missense	probably damaging	1.00
R4731:Ptprz1	UTSW	6	23,002,609 (GRCm39)	missense	probably benign	0.06
R4732:Ptprz1	UTSW	6	23,002,609 (GRCm39)	missense	probably benign	0.06
R4733:Ptprz1	UTSW	6	23,002,609 (GRCm39)	missense	probably benign	0.06
R4803:Ptprz1	UTSW	6	23,001,545 (GRCm39)	missense	probably benign	0.00
R4890:Ptprz1	UTSW	6	23,024,957 (GRCm39)	missense	probably damaging	1.00
R5035:Ptprz1	UTSW	6	23,016,214 (GRCm39)	missense	probably benign	0.06
R5052:Ptprz1	UTSW	6	23,045,625 (GRCm39)	missense	probably damaging	1.00
R5106:Ptprz1	UTSW	6	23,000,027 (GRCm39)	missense	probably benign	0.04
R5248:Ptprz1	UTSW	6	23,001,900 (GRCm39)	missense	probably benign	0.11
R5292:Ptprz1	UTSW	6	23,002,581 (GRCm39)	missense	probably benign	0.31
R5373:Ptprz1	UTSW	6	23,007,354 (GRCm39)	missense	probably damaging	1.00
R5374:Ptprz1	UTSW	6	23,007,354 (GRCm39)	missense	probably damaging	1.00
R5378:Ptprz1	UTSW	6	23,007,401 (GRCm39)	missense	probably damaging	1.00
R5408:Ptprz1	UTSW	6	23,002,599 (GRCm39)	missense	probably damaging	1.00
R5479:Ptprz1	UTSW	6	23,001,665 (GRCm39)	missense	probably benign
R5524:Ptprz1	UTSW	6	22,986,317 (GRCm39)	splice site	probably null
R5527:Ptprz1	UTSW	6	23,000,052 (GRCm39)	missense	possibly damaging	0.66
R5557:Ptprz1	UTSW	6	23,001,000 (GRCm39)	missense	probably benign	0.04
R5654:Ptprz1	UTSW	6	22,986,133 (GRCm39)	missense	probably damaging	1.00
R5655:Ptprz1	UTSW	6	22,999,772 (GRCm39)	missense	probably benign	0.00
R5658:Ptprz1	UTSW	6	23,016,188 (GRCm39)	missense	probably damaging	1.00
R5663:Ptprz1	UTSW	6	23,035,142 (GRCm39)	missense	probably damaging	1.00
R5765:Ptprz1	UTSW	6	23,000,235 (GRCm39)	missense	probably damaging	1.00
R5822:Ptprz1	UTSW	6	23,001,444 (GRCm39)	missense	probably benign	0.01
R5837:Ptprz1	UTSW	6	23,001,417 (GRCm39)	missense	probably benign	0.00
R6108:Ptprz1	UTSW	6	23,045,658 (GRCm39)	missense	probably damaging	1.00
R6199:Ptprz1	UTSW	6	23,002,470 (GRCm39)	missense	probably benign	0.01
R6245:Ptprz1	UTSW	6	23,051,989 (GRCm39)	missense	probably damaging	1.00
R6257:Ptprz1	UTSW	6	22,959,639 (GRCm39)	missense	probably damaging	1.00
R6488:Ptprz1	UTSW	6	23,001,516 (GRCm39)	nonsense	probably null
R6606:Ptprz1	UTSW	6	23,002,500 (GRCm39)	missense	probably benign	0.27
R6612:Ptprz1	UTSW	6	23,052,081 (GRCm39)	missense	probably damaging	1.00
R6824:Ptprz1	UTSW	6	23,002,130 (GRCm39)	missense	probably benign	0.05
R6834:Ptprz1	UTSW	6	22,999,632 (GRCm39)	missense	probably benign	0.38
R6836:Ptprz1	UTSW	6	23,030,664 (GRCm39)	nonsense	probably null
R6991:Ptprz1	UTSW	6	23,002,686 (GRCm39)	missense	probably benign	0.00
R7044:Ptprz1	UTSW	6	23,044,345 (GRCm39)	missense	probably damaging	1.00
R7048:Ptprz1	UTSW	6	22,961,622 (GRCm39)	missense	probably benign	0.18
R7225:Ptprz1	UTSW	6	23,000,928 (GRCm39)	missense	possibly damaging	0.61
R7284:Ptprz1	UTSW	6	23,000,097 (GRCm39)	missense	probably damaging	1.00
R7360:Ptprz1	UTSW	6	23,000,906 (GRCm39)	missense	probably damaging	1.00
R7501:Ptprz1	UTSW	6	23,001,746 (GRCm39)	nonsense	probably null
R7515:Ptprz1	UTSW	6	23,022,266 (GRCm39)	missense	probably damaging	1.00
R7538:Ptprz1	UTSW	6	22,999,895 (GRCm39)	missense	possibly damaging	0.81
R7567:Ptprz1	UTSW	6	22,959,779 (GRCm39)	missense	probably damaging	0.97
R7599:Ptprz1	UTSW	6	23,002,518 (GRCm39)	missense	not run
R7611:Ptprz1	UTSW	6	23,001,219 (GRCm39)	missense	probably benign
R7685:Ptprz1	UTSW	6	23,024,977 (GRCm39)	missense	probably damaging	1.00
R7707:Ptprz1	UTSW	6	23,002,295 (GRCm39)	missense	probably benign	0.00
R7786:Ptprz1	UTSW	6	23,036,992 (GRCm39)	missense	probably damaging	1.00
R7868:Ptprz1	UTSW	6	23,000,963 (GRCm39)	missense	not run
R7882:Ptprz1	UTSW	6	23,002,256 (GRCm39)	missense	probably benign	0.13
R7968:Ptprz1	UTSW	6	22,959,675 (GRCm39)	missense	probably damaging	0.98
R8024:Ptprz1	UTSW	6	23,042,750 (GRCm39)	missense	probably damaging	1.00
R8157:Ptprz1	UTSW	6	23,002,539 (GRCm39)	missense	probably damaging	1.00
R8159:Ptprz1	UTSW	6	23,001,662 (GRCm39)	missense	probably benign
R8354:Ptprz1	UTSW	6	22,999,614 (GRCm39)	missense	probably damaging	0.99
R8496:Ptprz1	UTSW	6	22,972,797 (GRCm39)	missense	probably damaging	0.96
R8757:Ptprz1	UTSW	6	22,972,716 (GRCm39)	missense	possibly damaging	0.74
R8767:Ptprz1	UTSW	6	22,986,187 (GRCm39)	missense	probably damaging	1.00
R8783:Ptprz1	UTSW	6	23,002,026 (GRCm39)	missense	probably benign	0.00
R8811:Ptprz1	UTSW	6	23,030,661 (GRCm39)	missense	probably benign	0.03
R8817:Ptprz1	UTSW	6	23,007,371 (GRCm39)	missense	probably damaging	1.00
R8822:Ptprz1	UTSW	6	23,002,588 (GRCm39)	missense	probably damaging	0.98
R8874:Ptprz1	UTSW	6	23,042,747 (GRCm39)	missense
R9009:Ptprz1	UTSW	6	23,001,653 (GRCm39)	missense	possibly damaging	0.94
R9126:Ptprz1	UTSW	6	23,002,334 (GRCm39)	nonsense	probably null
R9201:Ptprz1	UTSW	6	22,972,869 (GRCm39)	critical splice donor site	probably null
R9210:Ptprz1	UTSW	6	23,050,493 (GRCm39)	missense	probably damaging	0.99
R9212:Ptprz1	UTSW	6	23,050,493 (GRCm39)	missense	probably damaging	0.99
R9229:Ptprz1	UTSW	6	22,986,283 (GRCm39)	missense	probably null	0.03
R9279:Ptprz1	UTSW	6	23,002,444 (GRCm39)	missense	probably benign
R9336:Ptprz1	UTSW	6	23,000,855 (GRCm39)	missense	probably benign	0.01
R9372:Ptprz1	UTSW	6	23,045,706 (GRCm39)	missense	probably damaging	1.00
R9577:Ptprz1	UTSW	6	23,002,202 (GRCm39)	missense	probably damaging	1.00
R9594:Ptprz1	UTSW	6	23,025,026 (GRCm39)	missense	probably damaging	0.98
R9632:Ptprz1	UTSW	6	23,007,292 (GRCm39)	missense	probably damaging	1.00
R9636:Ptprz1	UTSW	6	22,999,994 (GRCm39)	missense	probably benign
R9657:Ptprz1	UTSW	6	23,042,377 (GRCm39)	missense	possibly damaging	0.92
R9694:Ptprz1	UTSW	6	22,959,694 (GRCm39)	missense	probably damaging	1.00
R9716:Ptprz1	UTSW	6	22,959,650 (GRCm39)	missense	probably damaging	1.00
R9794:Ptprz1	UTSW	6	23,000,204 (GRCm39)	missense	probably benign	0.00
Z1176:Ptprz1	UTSW	6	23,051,994 (GRCm39)	missense	probably damaging	0.99
Z1177:Ptprz1	UTSW	6	23,052,023 (GRCm39)	missense	probably damaging	1.00
Z1177:Ptprz1	UTSW	6	22,999,839 (GRCm39)	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- TCAACATCCTCCATTCGCAG -3'
(R):5'- AACAAGGCTGGGTTCTAACAG -3'

Sequencing Primer
(F):5'- CGACTCAACCAGTATACAATGGTGAG -3'
(R):5'- TGGGTTCTAACAGCAAATCACC -3'

Posted On

2019-11-12