Mutagenetix > Incidental Mutation

Incidental Mutation 'R7733:Ptpro'

595985

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

045789-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7733 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 137414286 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 801 (C801*)

Ref Sequence

ENSEMBL: ENSMUSP00000076364 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167002] [ENSMUST00000167679] [ENSMUST00000203914]

AlphaFold

E9Q612

Predicted Effect

probably null
Transcript: ENSMUST00000077115
AA Change: C801*

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: C801*

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000167002

SMART Domains

Protein: ENSMUSP00000131764
Gene: ENSMUSG00000030223

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
transmembrane domain	69	91	N/A	INTRINSIC
PTPc	126	386	1.43e-127	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000167679
AA Change: C801*

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: C801*

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000203914

SMART Domains

Protein: ENSMUSP00000144870
Gene: ENSMUSG00000030223

Domain	Start	End	E-Value	Type
signal peptide	1	33	N/A	INTRINSIC
PTPc	98	358	6.1e-130	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.3%

Validation Efficiency

100% (83/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5530400C23Rik	T	A	6: 133,294,277 (GRCm38)	S95T	probably benign	Het
Abca8a	A	G	11: 110,054,587 (GRCm38)	F1070L	probably benign	Het
Acsl3	G	C	1: 78,688,236 (GRCm38)		probably null	Het
Adarb2	T	A	13: 8,752,608 (GRCm38)	S640T	possibly damaging	Het
Adgre5	T	C	8: 83,729,396 (GRCm38)	D257G	probably benign	Het
Adora2b	A	T	11: 62,265,339 (GRCm38)	I205F	possibly damaging	Het
Asb14	A	G	14: 26,912,352 (GRCm38)	M505V	probably benign	Het
Atrnl1	T	C	19: 57,701,988 (GRCm38)	V876A	probably benign	Het
AU040320	A	G	4: 126,835,529 (GRCm38)	N495D	possibly damaging	Het
Bcam	A	T	7: 19,760,388 (GRCm38)	V361E	probably benign	Het
Ccdc7a	T	A	8: 128,993,052 (GRCm38)	E247V	probably damaging	Het
Cd84	T	A	1: 171,840,659 (GRCm38)	M1K	probably null	Het
Cfap43	C	T	19: 47,897,993 (GRCm38)	R61H	possibly damaging	Het
Clec4a1	A	G	6: 122,932,150 (GRCm38)	D159G	possibly damaging	Het
Ctcfl	C	T	2: 173,117,192 (GRCm38)	R247Q	probably benign	Het
Ctdnep1	G	A	11: 69,990,009 (GRCm38)	R236Q	probably damaging	Het
Cwf19l2	A	T	9: 3,450,066 (GRCm38)	H589L	probably benign	Het
Cyp2u1	G	T	3: 131,303,027 (GRCm38)	A34E	probably benign	Het
Cyp4x1	A	G	4: 115,120,194 (GRCm38)	S281P	possibly damaging	Het
Dag1	T	C	9: 108,208,848 (GRCm38)	T365A	probably benign	Het
Dhx57	A	T	17: 80,265,074 (GRCm38)		probably null	Het
Dnajb1	T	G	8: 83,608,377 (GRCm38)	S16A	probably benign	Het
Dsc2	G	C	18: 20,048,316 (GRCm38)	L145V	probably benign	Het
Dsc2	A	T	18: 20,048,315 (GRCm38)	L145Q	probably benign	Het
Eefsec	T	C	6: 88,376,220 (GRCm38)	T156A	possibly damaging	Het
Eif6	T	A	2: 155,823,232 (GRCm38)	D169V	probably benign	Het
Ell3	C	A	2: 121,442,520 (GRCm38)	G3V	possibly damaging	Het
Eprs1	A	T	1: 185,397,161 (GRCm38)	H615L	probably benign	Het
Fbxw10	A	G	11: 62,873,397 (GRCm38)	Y630C	unknown	Het
Fcgbpl1	A	T	7: 28,139,965 (GRCm38)	D401V	probably damaging	Het
G6pc2	C	T	2: 69,220,183 (GRCm38)	Q51*	probably null	Het
Glt8d1	C	T	14: 31,001,978 (GRCm38)		probably benign	Het
Gpr4	T	C	7: 19,222,710 (GRCm38)	Y186H	probably damaging	Het
Grhpr	T	C	4: 44,981,494 (GRCm38)		probably benign	Het
Gsdma3	A	G	11: 98,635,215 (GRCm38)	H264R	probably damaging	Het
Hcfc2	A	G	10: 82,739,179 (GRCm38)	Y224C	probably benign	Het
Helz2	A	G	2: 181,230,355 (GRCm38)	F2608S	possibly damaging	Het
Herc2	C	T	7: 56,188,664 (GRCm38)	T3313M	probably damaging	Het
Hmgcl	A	T	4: 135,960,083 (GRCm38)	H223L	probably benign	Het
Igf2r	A	G	17: 12,739,369 (GRCm38)	V139A	possibly damaging	Het
Iqcn	A	G	8: 70,717,451 (GRCm38)	T1397A	possibly damaging	Het
Kif5a	T	A	10: 127,236,740 (GRCm38)	T727S	probably benign	Het
Kifc1	G	A	17: 33,883,569 (GRCm38)	R357W	probably damaging	Het
Krt81	T	A	15: 101,463,514 (GRCm38)	S62C	probably damaging	Het
Lgi2	T	C	5: 52,538,531 (GRCm38)	N362S	probably benign	Het
Lig1	G	T	7: 13,296,231 (GRCm38)	R378L	possibly damaging	Het
Map3k13	C	T	16: 21,921,686 (GRCm38)	R588C	probably damaging	Het
Mov10l1	T	A	15: 89,024,801 (GRCm38)	F1008L	probably damaging	Het
Nr4a2	A	G	2: 57,112,321 (GRCm38)	V40A	probably benign	Het
Nrde2	A	T	12: 100,144,140 (GRCm38)	C206S	possibly damaging	Het
Or4f14d	C	T	2: 112,130,041 (GRCm38)	V257I	probably benign	Het
Parp1	T	C	1: 180,600,212 (GRCm38)		probably null	Het
Pcdhb12	A	G	18: 37,437,036 (GRCm38)	T412A	probably damaging	Het
Plekhh2	T	A	17: 84,583,524 (GRCm38)	Y839*	probably null	Het
Pnpla6	T	A	8: 3,522,660 (GRCm38)	F316I	probably benign	Het
Prcp	C	T	7: 92,901,298 (GRCm38)	T101M	probably damaging	Het
Prex2	G	T	1: 11,181,959 (GRCm38)	R1076L	probably benign	Het
Prpf40b	T	C	15: 99,308,343 (GRCm38)		probably null	Het
Psd3	T	G	8: 68,120,916 (GRCm38)	K204N	possibly damaging	Het
Ptprt	A	G	2: 161,575,787 (GRCm38)	V923A	probably damaging	Het
Ptprz1	T	A	6: 23,000,384 (GRCm38)	D824E	probably benign	Het
Rasgrf1	A	G	9: 89,981,727 (GRCm38)	D582G	probably benign	Het
Rfc2	T	C	5: 134,593,216 (GRCm38)	L183P	probably damaging	Het
Rnf114	T	C	2: 167,512,518 (GRCm38)	V173A	probably damaging	Het
Scn3a	T	A	2: 65,508,650 (GRCm38)	I562F	probably benign	Het
Setmar	T	C	6: 108,076,127 (GRCm38)	I194T	probably damaging	Het
Sptb	A	T	12: 76,597,921 (GRCm38)		probably null	Het
Sptbn2	C	G	19: 4,749,012 (GRCm38)	R2037G	probably benign	Het
Sptlc3	G	T	2: 139,631,368 (GRCm38)	M512I	possibly damaging	Het
Svep1	C	A	4: 58,049,239 (GRCm38)	A3423S	probably benign	Het
Sycp1	T	C	3: 102,895,962 (GRCm38)	T511A	probably benign	Het
Synm	T	A	7: 67,735,945 (GRCm38)		probably null	Het
Tada1	C	T	1: 166,389,942 (GRCm38)	P216L	probably damaging	Het
Tas2r117	T	A	6: 132,803,175 (GRCm38)	M92K	probably benign	Het
Thoc2l	T	C	5: 104,519,960 (GRCm38)	F783L	possibly damaging	Het
Thsd1	T	C	8: 22,258,721 (GRCm38)	L536P	probably damaging	Het
Timp2	T	G	11: 118,317,529 (GRCm38)		probably null	Het
Trak1	T	A	9: 121,367,225 (GRCm38)	V41D	possibly damaging	Het
Ubqln3	T	A	7: 104,141,076 (GRCm38)	L602F	probably damaging	Het
Vmn2r59	A	G	7: 42,012,019 (GRCm38)	F791L	probably benign	Het
Wbp4	A	G	14: 79,477,040 (GRCm38)		probably null	Het
Zng1	T	C	19: 24,940,794 (GRCm38)	D204G	probably damaging	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0973:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1448:Ptpro	UTSW	6	137,441,116 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4941:Ptpro	UTSW	6	137,392,765 (GRCm38)	missense	probably damaging	1.00
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5033:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7381:Ptpro	UTSW	6	137,399,561 (GRCm38)	missense	possibly damaging	0.93
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TAATGAGGGCTGCTTCCATGG -3'
(R):5'- TTTCAAAGGAAGACTGACTCCATC -3'

Sequencing Primer
(F):5'- GGGGGAGTTTTTCACTATTAACC -3'
(R):5'- CCATTGTGGAGACAGCTA -3'

Posted On

2019-11-12