Incidental Mutation 'R7734:Ulk2'
ID 596074
Institutional Source Beutler Lab
Gene Symbol Ulk2
Ensembl Gene ENSMUSG00000004798
Gene Name unc-51 like kinase 2
Synonyms A830085I22Rik, Unc51.2
MMRRC Submission 045790-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.219) question?
Stock # R7734 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 61666475-61745899 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 61744127 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 50 (Q50*)
Ref Sequence ENSEMBL: ENSMUSP00000004920 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004920]
AlphaFold Q9QY01
Predicted Effect probably null
Transcript: ENSMUST00000004920
AA Change: Q50*
SMART Domains Protein: ENSMUSP00000004920
Gene: ENSMUSG00000004798
AA Change: Q50*

DomainStartEndE-ValueType
S_TKc 9 271 1.1e-93 SMART
low complexity region 274 309 N/A INTRINSIC
Blast:S_TKc 310 413 9e-28 BLAST
Blast:S_TKc 433 738 1e-29 BLAST
low complexity region 751 766 N/A INTRINSIC
low complexity region 771 791 N/A INTRINSIC
Pfam:DUF3543 821 1032 1.8e-31 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous mutation of this gene results in an increased anxiety-like response in males. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa2 T C 9: 69,398,764 (GRCm39) Y333H probably benign Het
Arid1a A T 4: 133,408,679 (GRCm39) F1558I unknown Het
Aste1 A G 9: 105,274,678 (GRCm39) D306G probably damaging Het
Atp2a2 A G 5: 122,596,590 (GRCm39) V843A possibly damaging Het
Atrip T A 9: 108,894,574 (GRCm39) H451L probably benign Het
Cdc42bpb T C 12: 111,295,664 (GRCm39) D200G probably damaging Het
Ceacam19 A C 7: 19,620,520 (GRCm39) M37R probably benign Het
Cemip G A 7: 83,606,872 (GRCm39) R782* probably null Het
Cpe A T 8: 65,070,654 (GRCm39) I197N probably benign Het
Csmd2 C A 4: 128,445,850 (GRCm39) P3307T Het
Cyp4a12b C A 4: 115,268,937 (GRCm39) Q20K possibly damaging Het
Dcaf1 T C 9: 106,715,878 (GRCm39) Y332H probably damaging Het
Dclk3 A G 9: 111,298,163 (GRCm39) H569R probably damaging Het
Dcp1b A G 6: 119,192,244 (GRCm39) S387G probably benign Het
Ddx24 A G 12: 103,383,819 (GRCm39) M590T possibly damaging Het
Dixdc1 T G 9: 50,613,268 (GRCm39) Q229P probably damaging Het
Dnase1l3 T C 14: 7,977,144 (GRCm38) R181G probably benign Het
Dzip1l A T 9: 99,549,735 (GRCm39) D735V probably damaging Het
Edem3 T C 1: 151,694,336 (GRCm39) S890P probably benign Het
Fuom A G 7: 139,679,455 (GRCm39) L155P unknown Het
Gm6408 C A 5: 146,421,160 (GRCm39) S263* probably null Het
Helz C G 11: 107,576,248 (GRCm39) S1814R unknown Het
Hrc T C 7: 44,986,100 (GRCm39) L417P probably benign Het
Igdcc4 A C 9: 65,039,035 (GRCm39) H894P probably damaging Het
Lgr6 C A 1: 134,930,981 (GRCm39) V296L probably damaging Het
Map3k4 T A 17: 12,482,998 (GRCm39) Y573F probably damaging Het
Mest T C 6: 30,746,299 (GRCm39) Y296H unknown Het
Mettl21a C T 1: 64,647,288 (GRCm39) V90M probably damaging Het
Mfsd4b1 A T 10: 39,883,374 (GRCm39) N25K probably damaging Het
Mmd T A 11: 90,167,579 (GRCm39) F203I probably damaging Het
Myo15a G A 11: 60,401,108 (GRCm39) V3028M probably benign Het
Nlrp1a T A 11: 70,998,826 (GRCm39) N859I unknown Het
Nrcam T C 12: 44,584,034 (GRCm39) L36P possibly damaging Het
Nup107 C A 10: 117,593,917 (GRCm39) E759* probably null Het
Or14a259 A G 7: 86,013,476 (GRCm39) I23T not run Het
Pcdh7 T G 5: 57,876,976 (GRCm39) I177S probably damaging Het
Pde6a T C 18: 61,365,938 (GRCm39) I221T probably benign Het
Ptpn13 A T 5: 103,709,828 (GRCm39) N1497I probably damaging Het
Rmc1 T A 18: 12,322,320 (GRCm39) I591N possibly damaging Het
Rpl4 T A 9: 64,084,661 (GRCm39) H245Q probably benign Het
Rsf1 C CCACGGCGGG 7: 97,229,115 (GRCm39) probably benign Het
Scara5 A G 14: 65,968,600 (GRCm39) D291G possibly damaging Het
Septin14 T A 5: 129,760,583 (GRCm39) I422L probably benign Het
Serpina1e T C 12: 103,917,151 (GRCm39) K173E probably benign Het
Slc5a1 C T 5: 33,318,279 (GRCm39) T644I probably benign Het
Slc6a13 A T 6: 121,314,334 (GRCm39) T590S probably benign Het
Smarca4 C T 9: 21,578,658 (GRCm39) T938I possibly damaging Het
Stxbp1 A T 2: 32,691,832 (GRCm39) D453E probably benign Het
Tcf12 C A 9: 71,829,943 (GRCm39) V173L probably benign Het
Tenm3 A G 8: 49,099,368 (GRCm39) C146R probably damaging Het
Trim11 T C 11: 58,869,180 (GRCm39) C39R probably damaging Het
Trim37 A G 11: 87,068,821 (GRCm39) Y389C probably damaging Het
Ttll8 C T 15: 88,798,368 (GRCm39) G789D probably damaging Het
Tubb2a C T 13: 34,258,776 (GRCm39) S338N probably benign Het
Urgcp T C 11: 5,666,406 (GRCm39) D687G probably benign Het
Usp13 C T 3: 32,892,054 (GRCm39) H78Y probably benign Het
Vmn2r100 T A 17: 19,742,296 (GRCm39) D223E probably benign Het
Vwc2 G A 11: 11,065,929 (GRCm39) A6T possibly damaging Het
Other mutations in Ulk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01599:Ulk2 APN 11 61,682,262 (GRCm39) nonsense probably null
IGL02044:Ulk2 APN 11 61,672,465 (GRCm39) missense probably damaging 1.00
IGL02185:Ulk2 APN 11 61,672,886 (GRCm39) missense probably damaging 1.00
IGL03036:Ulk2 APN 11 61,725,660 (GRCm39) missense probably damaging 1.00
BB007:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB009:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
BB017:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB019:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R0207:Ulk2 UTSW 11 61,668,611 (GRCm39) missense probably benign 0.42
R0362:Ulk2 UTSW 11 61,678,412 (GRCm39) missense probably benign
R0657:Ulk2 UTSW 11 61,698,880 (GRCm39) splice site probably benign
R1076:Ulk2 UTSW 11 61,710,135 (GRCm39) missense probably damaging 1.00
R1144:Ulk2 UTSW 11 61,690,886 (GRCm39) missense possibly damaging 0.80
R1573:Ulk2 UTSW 11 61,670,581 (GRCm39) missense probably damaging 1.00
R1583:Ulk2 UTSW 11 61,674,371 (GRCm39) missense possibly damaging 0.95
R1619:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R1757:Ulk2 UTSW 11 61,732,165 (GRCm39) splice site probably benign
R1845:Ulk2 UTSW 11 61,703,564 (GRCm39) missense probably benign 0.04
R1883:Ulk2 UTSW 11 61,721,438 (GRCm39) missense probably damaging 1.00
R1966:Ulk2 UTSW 11 61,710,297 (GRCm39) splice site probably null
R2177:Ulk2 UTSW 11 61,682,335 (GRCm39) missense probably benign 0.01
R2416:Ulk2 UTSW 11 61,672,865 (GRCm39) missense probably damaging 1.00
R2509:Ulk2 UTSW 11 61,678,340 (GRCm39) missense probably benign 0.00
R2847:Ulk2 UTSW 11 61,715,555 (GRCm39) critical splice acceptor site probably null
R4736:Ulk2 UTSW 11 61,724,261 (GRCm39) missense probably damaging 1.00
R4997:Ulk2 UTSW 11 61,689,982 (GRCm39) missense probably benign 0.00
R5081:Ulk2 UTSW 11 61,694,488 (GRCm39) missense probably damaging 1.00
R5190:Ulk2 UTSW 11 61,672,537 (GRCm39) missense probably benign
R5346:Ulk2 UTSW 11 61,725,740 (GRCm39) missense probably damaging 1.00
R5348:Ulk2 UTSW 11 61,674,439 (GRCm39) missense probably benign
R5520:Ulk2 UTSW 11 61,698,970 (GRCm39) missense probably damaging 1.00
R5954:Ulk2 UTSW 11 61,694,622 (GRCm39) splice site probably benign
R6153:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R6223:Ulk2 UTSW 11 61,678,330 (GRCm39) nonsense probably null
R7204:Ulk2 UTSW 11 61,674,457 (GRCm39) missense probably benign 0.11
R7205:Ulk2 UTSW 11 61,725,657 (GRCm39) missense possibly damaging 0.84
R7259:Ulk2 UTSW 11 61,672,909 (GRCm39) missense probably damaging 1.00
R7353:Ulk2 UTSW 11 61,710,174 (GRCm39) missense probably damaging 1.00
R7797:Ulk2 UTSW 11 61,672,928 (GRCm39) missense probably benign 0.06
R7808:Ulk2 UTSW 11 61,745,378 (GRCm39) missense probably damaging 1.00
R7930:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
R7932:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R8882:Ulk2 UTSW 11 61,698,887 (GRCm39) critical splice donor site probably null
R8909:Ulk2 UTSW 11 61,690,380 (GRCm39) missense probably benign
R9704:Ulk2 UTSW 11 61,716,694 (GRCm39) missense probably damaging 1.00
X0028:Ulk2 UTSW 11 61,690,394 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATTGGGCACTGTACTCGTG -3'
(R):5'- TGACTAGTGCTGTAGGACATTGC -3'

Sequencing Primer
(F):5'- TTTTCTAGCACTCCAGAGGCAGAG -3'
(R):5'- AGATTTGAGGTCTTTGCCATGTTTCC -3'
Posted On 2019-11-12