Incidental Mutation 'R7734:Vmn2r100'
ID 596088
Institutional Source Beutler Lab
Gene Symbol Vmn2r100
Ensembl Gene ENSMUSG00000091859
Gene Name vomeronasal 2, receptor 100
Synonyms EG627537
MMRRC Submission 045790-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R7734 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 19725073-19752322 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19742296 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 223 (D223E)
Ref Sequence ENSEMBL: ENSMUSP00000128350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166081] [ENSMUST00000231465]
AlphaFold E9QAZ9
Predicted Effect probably benign
Transcript: ENSMUST00000166081
AA Change: D223E

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000128350
Gene: ENSMUSG00000091859
AA Change: D223E

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 83 456 7.4e-41 PFAM
Pfam:NCD3G 510 563 1.9e-21 PFAM
Pfam:7tm_3 594 831 2.6e-51 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231465
AA Change: D223E

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa2 T C 9: 69,398,764 (GRCm39) Y333H probably benign Het
Arid1a A T 4: 133,408,679 (GRCm39) F1558I unknown Het
Aste1 A G 9: 105,274,678 (GRCm39) D306G probably damaging Het
Atp2a2 A G 5: 122,596,590 (GRCm39) V843A possibly damaging Het
Atrip T A 9: 108,894,574 (GRCm39) H451L probably benign Het
Cdc42bpb T C 12: 111,295,664 (GRCm39) D200G probably damaging Het
Ceacam19 A C 7: 19,620,520 (GRCm39) M37R probably benign Het
Cemip G A 7: 83,606,872 (GRCm39) R782* probably null Het
Cpe A T 8: 65,070,654 (GRCm39) I197N probably benign Het
Csmd2 C A 4: 128,445,850 (GRCm39) P3307T Het
Cyp4a12b C A 4: 115,268,937 (GRCm39) Q20K possibly damaging Het
Dcaf1 T C 9: 106,715,878 (GRCm39) Y332H probably damaging Het
Dclk3 A G 9: 111,298,163 (GRCm39) H569R probably damaging Het
Dcp1b A G 6: 119,192,244 (GRCm39) S387G probably benign Het
Ddx24 A G 12: 103,383,819 (GRCm39) M590T possibly damaging Het
Dixdc1 T G 9: 50,613,268 (GRCm39) Q229P probably damaging Het
Dnase1l3 T C 14: 7,977,144 (GRCm38) R181G probably benign Het
Dzip1l A T 9: 99,549,735 (GRCm39) D735V probably damaging Het
Edem3 T C 1: 151,694,336 (GRCm39) S890P probably benign Het
Fuom A G 7: 139,679,455 (GRCm39) L155P unknown Het
Gm6408 C A 5: 146,421,160 (GRCm39) S263* probably null Het
Helz C G 11: 107,576,248 (GRCm39) S1814R unknown Het
Hrc T C 7: 44,986,100 (GRCm39) L417P probably benign Het
Igdcc4 A C 9: 65,039,035 (GRCm39) H894P probably damaging Het
Lgr6 C A 1: 134,930,981 (GRCm39) V296L probably damaging Het
Map3k4 T A 17: 12,482,998 (GRCm39) Y573F probably damaging Het
Mest T C 6: 30,746,299 (GRCm39) Y296H unknown Het
Mettl21a C T 1: 64,647,288 (GRCm39) V90M probably damaging Het
Mfsd4b1 A T 10: 39,883,374 (GRCm39) N25K probably damaging Het
Mmd T A 11: 90,167,579 (GRCm39) F203I probably damaging Het
Myo15a G A 11: 60,401,108 (GRCm39) V3028M probably benign Het
Nlrp1a T A 11: 70,998,826 (GRCm39) N859I unknown Het
Nrcam T C 12: 44,584,034 (GRCm39) L36P possibly damaging Het
Nup107 C A 10: 117,593,917 (GRCm39) E759* probably null Het
Or14a259 A G 7: 86,013,476 (GRCm39) I23T not run Het
Pcdh7 T G 5: 57,876,976 (GRCm39) I177S probably damaging Het
Pde6a T C 18: 61,365,938 (GRCm39) I221T probably benign Het
Ptpn13 A T 5: 103,709,828 (GRCm39) N1497I probably damaging Het
Rmc1 T A 18: 12,322,320 (GRCm39) I591N possibly damaging Het
Rpl4 T A 9: 64,084,661 (GRCm39) H245Q probably benign Het
Rsf1 C CCACGGCGGG 7: 97,229,115 (GRCm39) probably benign Het
Scara5 A G 14: 65,968,600 (GRCm39) D291G possibly damaging Het
Septin14 T A 5: 129,760,583 (GRCm39) I422L probably benign Het
Serpina1e T C 12: 103,917,151 (GRCm39) K173E probably benign Het
Slc5a1 C T 5: 33,318,279 (GRCm39) T644I probably benign Het
Slc6a13 A T 6: 121,314,334 (GRCm39) T590S probably benign Het
Smarca4 C T 9: 21,578,658 (GRCm39) T938I possibly damaging Het
Stxbp1 A T 2: 32,691,832 (GRCm39) D453E probably benign Het
Tcf12 C A 9: 71,829,943 (GRCm39) V173L probably benign Het
Tenm3 A G 8: 49,099,368 (GRCm39) C146R probably damaging Het
Trim11 T C 11: 58,869,180 (GRCm39) C39R probably damaging Het
Trim37 A G 11: 87,068,821 (GRCm39) Y389C probably damaging Het
Ttll8 C T 15: 88,798,368 (GRCm39) G789D probably damaging Het
Tubb2a C T 13: 34,258,776 (GRCm39) S338N probably benign Het
Ulk2 G A 11: 61,744,127 (GRCm39) Q50* probably null Het
Urgcp T C 11: 5,666,406 (GRCm39) D687G probably benign Het
Usp13 C T 3: 32,892,054 (GRCm39) H78Y probably benign Het
Vwc2 G A 11: 11,065,929 (GRCm39) A6T possibly damaging Het
Other mutations in Vmn2r100
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00904:Vmn2r100 APN 17 19,746,262 (GRCm39) missense probably damaging 1.00
IGL00912:Vmn2r100 APN 17 19,751,654 (GRCm39) missense possibly damaging 0.95
IGL01107:Vmn2r100 APN 17 19,741,618 (GRCm39) missense probably damaging 1.00
IGL01517:Vmn2r100 APN 17 19,742,225 (GRCm39) missense probably benign 0.37
IGL01594:Vmn2r100 APN 17 19,751,495 (GRCm39) missense possibly damaging 0.52
IGL01657:Vmn2r100 APN 17 19,746,178 (GRCm39) missense possibly damaging 0.89
IGL01822:Vmn2r100 APN 17 19,725,100 (GRCm39) missense probably null 0.00
IGL02020:Vmn2r100 APN 17 19,725,200 (GRCm39) missense possibly damaging 0.78
IGL02060:Vmn2r100 APN 17 19,741,516 (GRCm39) missense possibly damaging 0.79
IGL02126:Vmn2r100 APN 17 19,741,504 (GRCm39) splice site probably benign
IGL02142:Vmn2r100 APN 17 19,742,583 (GRCm39) missense probably damaging 1.00
IGL02308:Vmn2r100 APN 17 19,741,597 (GRCm39) missense possibly damaging 0.90
IGL02407:Vmn2r100 APN 17 19,741,770 (GRCm39) missense probably damaging 0.98
IGL02469:Vmn2r100 APN 17 19,751,547 (GRCm39) nonsense probably null
IGL03088:Vmn2r100 APN 17 19,742,301 (GRCm39) missense probably benign 0.27
IGL03181:Vmn2r100 APN 17 19,752,207 (GRCm39) missense probably damaging 1.00
IGL03405:Vmn2r100 APN 17 19,752,186 (GRCm39) missense probably damaging 1.00
H8562:Vmn2r100 UTSW 17 19,741,752 (GRCm39) missense possibly damaging 0.87
R0012:Vmn2r100 UTSW 17 19,746,296 (GRCm39) missense probably damaging 0.99
R0012:Vmn2r100 UTSW 17 19,725,136 (GRCm39) missense probably benign
R0044:Vmn2r100 UTSW 17 19,742,441 (GRCm39) missense possibly damaging 0.46
R0109:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0111:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0112:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0149:Vmn2r100 UTSW 17 19,741,509 (GRCm39) critical splice acceptor site probably null
R0355:Vmn2r100 UTSW 17 19,751,582 (GRCm39) missense probably benign 0.00
R0395:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0396:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0453:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0465:Vmn2r100 UTSW 17 19,751,792 (GRCm39) missense probably damaging 0.98
R0477:Vmn2r100 UTSW 17 19,742,776 (GRCm39) missense probably benign 0.00
R0510:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0512:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0514:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0518:Vmn2r100 UTSW 17 19,742,178 (GRCm39) missense probably damaging 1.00
R0521:Vmn2r100 UTSW 17 19,742,178 (GRCm39) missense probably damaging 1.00
R0555:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0608:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0959:Vmn2r100 UTSW 17 19,743,786 (GRCm39) missense possibly damaging 0.95
R1114:Vmn2r100 UTSW 17 19,752,261 (GRCm39) missense probably damaging 1.00
R2027:Vmn2r100 UTSW 17 19,742,334 (GRCm39) missense probably benign 0.02
R2049:Vmn2r100 UTSW 17 19,742,312 (GRCm39) missense probably benign 0.00
R2224:Vmn2r100 UTSW 17 19,742,634 (GRCm39) missense probably benign 0.03
R2226:Vmn2r100 UTSW 17 19,742,634 (GRCm39) missense probably benign 0.03
R3618:Vmn2r100 UTSW 17 19,743,692 (GRCm39) missense probably benign
R3715:Vmn2r100 UTSW 17 19,752,272 (GRCm39) missense probably damaging 0.99
R4120:Vmn2r100 UTSW 17 19,752,215 (GRCm39) missense probably damaging 1.00
R4152:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4153:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4154:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4200:Vmn2r100 UTSW 17 19,742,797 (GRCm39) missense probably benign 0.29
R4632:Vmn2r100 UTSW 17 19,752,216 (GRCm39) missense probably damaging 1.00
R4720:Vmn2r100 UTSW 17 19,742,788 (GRCm39) missense probably benign 0.02
R4761:Vmn2r100 UTSW 17 19,741,630 (GRCm39) missense possibly damaging 0.47
R4831:Vmn2r100 UTSW 17 19,741,672 (GRCm39) missense probably benign 0.28
R4951:Vmn2r100 UTSW 17 19,752,300 (GRCm39) missense probably benign 0.01
R5211:Vmn2r100 UTSW 17 19,746,257 (GRCm39) missense possibly damaging 0.67
R5553:Vmn2r100 UTSW 17 19,725,110 (GRCm39) missense possibly damaging 0.64
R5657:Vmn2r100 UTSW 17 19,725,178 (GRCm39) missense probably benign 0.31
R5883:Vmn2r100 UTSW 17 19,743,786 (GRCm39) missense probably benign
R5912:Vmn2r100 UTSW 17 19,752,071 (GRCm39) missense probably damaging 0.99
R6141:Vmn2r100 UTSW 17 19,742,576 (GRCm39) missense probably benign 0.07
R6146:Vmn2r100 UTSW 17 19,742,522 (GRCm39) missense probably benign 0.04
R6500:Vmn2r100 UTSW 17 19,742,355 (GRCm39) missense probably damaging 1.00
R6575:Vmn2r100 UTSW 17 19,741,671 (GRCm39) missense probably benign 0.12
R6647:Vmn2r100 UTSW 17 19,742,785 (GRCm39) missense probably benign 0.00
R7038:Vmn2r100 UTSW 17 19,725,263 (GRCm39) missense possibly damaging 0.76
R7052:Vmn2r100 UTSW 17 19,751,556 (GRCm39) missense possibly damaging 0.95
R7170:Vmn2r100 UTSW 17 19,752,233 (GRCm39) missense probably benign 0.00
R7209:Vmn2r100 UTSW 17 19,751,576 (GRCm39) missense not run
R7312:Vmn2r100 UTSW 17 19,742,296 (GRCm39) missense probably benign 0.01
R7750:Vmn2r100 UTSW 17 19,742,726 (GRCm39) missense probably benign
R8103:Vmn2r100 UTSW 17 19,751,415 (GRCm39) splice site probably null
R8193:Vmn2r100 UTSW 17 19,725,102 (GRCm39) nonsense probably null
R8267:Vmn2r100 UTSW 17 19,742,752 (GRCm39) nonsense probably null
R8290:Vmn2r100 UTSW 17 19,751,612 (GRCm39) missense probably damaging 0.99
R8531:Vmn2r100 UTSW 17 19,742,459 (GRCm39) missense possibly damaging 0.66
R8786:Vmn2r100 UTSW 17 19,742,838 (GRCm39) missense probably damaging 1.00
R8920:Vmn2r100 UTSW 17 19,741,620 (GRCm39) missense probably damaging 1.00
R8938:Vmn2r100 UTSW 17 19,751,825 (GRCm39) missense probably benign 0.00
R9555:Vmn2r100 UTSW 17 19,743,857 (GRCm39) missense probably benign 0.00
R9572:Vmn2r100 UTSW 17 19,741,513 (GRCm39) missense probably benign 0.00
R9609:Vmn2r100 UTSW 17 19,743,732 (GRCm39) missense probably damaging 1.00
R9618:Vmn2r100 UTSW 17 19,742,583 (GRCm39) missense probably damaging 1.00
X0062:Vmn2r100 UTSW 17 19,751,652 (GRCm39) missense possibly damaging 0.89
Z1176:Vmn2r100 UTSW 17 19,741,792 (GRCm39) missense probably benign 0.00
Z1177:Vmn2r100 UTSW 17 19,725,251 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GACCCATACAATTCAGTCCAGATTTC -3'
(R):5'- ACCTTCTAGAGAATCAATGTCACC -3'

Sequencing Primer
(F):5'- CTATGTAAGTCCTTGGAAATTAGAGG -3'
(R):5'- AAGTCCATGTGGCTGGAA -3'
Posted On 2019-11-12