|Institutional Source||Beutler Lab|
|Gene Name||prostaglandin D receptor|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7399 (G1)|
|Chromosomal Location||44851235-44859375 bp(-) (GRCm38)|
|Type of Mutation||splice site (179 bp from exon)|
|DNA Base Change (assembly)||A to T at 44858232 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000093653 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000095959]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||99% (74/75)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display a reduced inflammatory response to airborn allergens and reduced susceptibility to passive cutaneous anaphylaxis induced by IgE antigen challenge due to impaired mast cell degranulation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptgdr||
(F):5'- TGTGCCCTGGTGAGGAAATAG -3'
(R):5'- CTCATGACAGTGCTCTTCACCATG -3'
(F):5'- TAGAGAACTAAGGTCTAGAGCACAC -3'
(R):5'- GACAGTGCTCTTCACCATGTGTTC -3'