Mutagenetix > Incidental Mutation

Incidental Mutation 'R7375:Slc22a26'

596141

Institutional Source

Beutler Lab

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R7375 (G1)

Quality Score

218.009

Status

Validated

Chromosome

Chromosomal Location

7781041-7802667 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 7783144 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably null
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (59/59)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	A	G	5: 8,918,671	I337V	probably benign	Het
Abl2	A	G	1: 156,622,614	D117G	probably damaging	Het
Arhgap5	T	A	12: 52,516,582	L112*	probably null	Het
Brinp3	C	G	1: 146,902,010	L732V	possibly damaging	Het
Cmya5	T	G	13: 93,091,661	K2306N	probably damaging	Het
Col16a1	A	C	4: 130,065,501	K680T	unknown	Het
Col28a1	T	A	6: 7,998,499	T1137S	possibly damaging	Het
Crnn	A	T	3: 93,149,145	T413S	possibly damaging	Het
Csf1	A	G	3: 107,748,179	L512P	possibly damaging	Het
Dlx3	C	A	11: 95,120,635	A105D	possibly damaging	Het
Dnah3	T	G	7: 119,951,677	T161P	probably damaging	Het
Dnah7b	A	G	1: 46,303,634	D3435G	probably damaging	Het
Dpp10	A	G	1: 123,367,795	I541T	probably benign	Het
Efcc1	T	C	6: 87,751,856	V431A	possibly damaging	Het
Enpp5	T	C	17: 44,080,977	I99T	probably benign	Het
Fam192a	G	A	8: 94,583,008	L119F	probably benign	Het
Gm11232	C	T	4: 71,757,346	W59*	probably null	Het
Gm17660	G	T	5: 104,071,257		probably null	Het
Gm8251	A	T	1: 44,060,534	I468N	possibly damaging	Het
Gxylt2	A	T	6: 100,750,422	T166S	probably benign	Het
Herc6	A	T	6: 57,651,806		probably null	Het
Itga2	T	C	13: 114,869,217	I476V	probably benign	Het
Kcnq5	T	C	1: 21,469,486	T403A	possibly damaging	Het
Klhl42	A	G	6: 147,092,040	K170R	probably benign	Het
Klk13	T	C	7: 43,721,158		probably null	Het
Krt32	G	T	11: 100,081,224	R433S	probably benign	Het
Lrp1	G	T	10: 127,539,348	T4461N	probably damaging	Het
Maats1	T	A	16: 38,335,618	H81L	probably damaging	Het
Mapk10	A	T	5: 102,976,390	M256K	probably null	Het
Mogat2	T	C	7: 99,223,698	K93R	probably damaging	Het
Myh1	G	T	11: 67,210,428	V677L	probably damaging	Het
Naip5	T	C	13: 100,219,696	Q1137R	probably benign	Het
Naip5	G	T	13: 100,219,697	Q1137K	not run	Het
Olfr1242	C	T	2: 89,493,692	G207R	possibly damaging	Het
Oog4	G	A	4: 143,438,974	T201M	possibly damaging	Het
Pik3c2a	T	C	7: 116,376,386	T649A	probably damaging	Het
Plec	T	A	15: 76,177,355	H2794L	possibly damaging	Het
Pros1	T	A	16: 62,924,550	N509K	probably damaging	Het
Psme4	T	A	11: 30,772,700		probably null	Het
Ptprf	A	G	4: 118,212,814	V1457A	probably benign	Het
Rad50	A	G	11: 53,652,228		probably null	Het
Rfx5	C	T	3: 94,958,742	P451S	unknown	Het
Sdk1	G	T	5: 141,998,843	V728L	probably benign	Het
Sfxn4	T	C	19: 60,858,674	D57G	probably benign	Het
Slc10a4	A	G	5: 73,012,307	D425G	probably benign	Het
Slc17a5	C	T	9: 78,587,892	A26T	probably benign	Het
Slc22a30	A	G	19: 8,404,691	L72P	probably damaging	Het
Slco6c1	T	C	1: 97,081,421	T447A	possibly damaging	Het
Slco6d1	A	G	1: 98,421,447	N81S	probably damaging	Het
Stard9	T	C	2: 120,665,002		probably null	Het
Tecpr1	T	C	5: 144,208,599	E610G	possibly damaging	Het
Tmem81	G	T	1: 132,507,563	V36L	possibly damaging	Het
Trabd2b	G	T	4: 114,609,997	K474N	probably benign	Het
Tspan33	T	C	6: 29,713,520	F149L	probably benign	Het
Ttn	A	G	2: 76,776,339	Y18076H	probably damaging	Het
Utrn	G	A	10: 12,641,020	R2277C	probably damaging	Het
Vmn2r101	T	A	17: 19,611,390	D549E	probably damaging	Het
Vmn2r107	T	A	17: 20,355,876	I156K	probably benign	Het
Wwc2	T	G	8: 47,863,920	S713R	unknown	Het
Xndc1	C	A	7: 102,081,480		probably null	Het
Zfp810	A	G	9: 22,290,537		probably null	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7782836	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7782975	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7790162	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7790099	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7802184	missense	probably benign	0.15
IGL02502:Slc22a26	APN	19	7790760	critical splice donor site	probably null
IGL02658:Slc22a26	APN	19	7788248	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7791105	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7802101	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7802253	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7788210	critical splice donor site	probably null
R0676:Slc22a26	UTSW	19	7796144	splice site	probably benign
R2156:Slc22a26	UTSW	19	7802115	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7788329	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7790135	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7791054	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7802181	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7786447	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7802286	missense	probably damaging	1.00
R6512:Slc22a26	UTSW	19	7802500	start gained	probably benign
R6724:Slc22a26	UTSW	19	7802361	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7790894	missense	probably damaging	0.97
R7558:Slc22a26	UTSW	19	7785286	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7802587	splice site	probably null
R8772:Slc22a26	UTSW	19	7790112	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7782966	missense	probably damaging	0.97
R8937:Slc22a26	UTSW	19	7791025	splice site	probably benign
R9059:Slc22a26	UTSW	19	7785194	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- CAGAGTACAGCGTGAGGATC -3'
(R):5'- TTAGATTCATACCCAGGAATAGCAG -3'

Sequencing Primer
(F):5'- CAATGACTCCTAATGCTGTTGC -3'
(R):5'- CATACCCAGGAATAGCAGGGTCTTG -3'

Posted On

2019-11-21