Mutagenetix > Incidental Mutation

Incidental Mutation 'R7736:Abca12'

596224

Institutional Source

Beutler Lab

Gene Symbol

Abca12

Ensembl Gene

ENSMUSG00000050296

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 12

Synonyms

4833417A11Rik, 4832428G11Rik

MMRRC Submission

045792-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7736 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

71242276-71414910 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 71319964 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 561 (D561A)

Ref Sequence

ENSEMBL: ENSMUSP00000084523 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087268]

AlphaFold

E9Q876

Predicted Effect

probably benign
Transcript: ENSMUST00000087268
AA Change: D561A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000084523
Gene: ENSMUSG00000050296
AA Change: D561A

Domain	Start	End	E-Value	Type
transmembrane domain	24	43	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
Pfam:ABC2_membrane_3	885	1267	2.9e-24	PFAM
AAA	1370	1554	4.2e-10	SMART
low complexity region	1717	1735	N/A	INTRINSIC
Pfam:ABC2_membrane_3	1744	2206	9.6e-35	PFAM
AAA	2282	2467	4.61e-7	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg1	T	C	8: 95,005,337 (GRCm38)	F204S	probably benign	Het
Apoa2	T	C	1: 171,226,172 (GRCm38)	L72P	probably damaging	Het
Arhgef10	A	T	8: 14,980,583 (GRCm38)	K987*	probably null	Het
Arrb1	A	G	7: 99,539,774 (GRCm38)	D9G	unknown	Het
Asph	A	G	4: 9,621,930 (GRCm38)	S192P	possibly damaging	Het
Bcas1	G	A	2: 170,387,164 (GRCm38)	T309M	possibly damaging	Het
Bcat2	C	T	7: 45,585,193 (GRCm38)	T166M	possibly damaging	Het
Bmp5	A	T	9: 75,893,790 (GRCm38)	I401L	probably damaging	Het
Bpifb9b	G	A	2: 154,312,105 (GRCm38)	G261R	probably benign	Het
Cd53	T	A	3: 106,767,936 (GRCm38)	Y106F	probably benign	Het
Cdhr3	T	A	12: 33,053,520 (GRCm38)	D366V	probably benign	Het
Ceacam10	G	C	7: 24,781,211 (GRCm38)	V256L	unknown	Het
Cilp2	A	G	8: 69,881,421 (GRCm38)	Y976H	probably damaging	Het
Cklf	A	G	8: 104,261,555 (GRCm38)	T107A	possibly damaging	Het
Dhx16	T	A	17: 35,881,676 (GRCm38)	W167R	possibly damaging	Het
Dkk2	T	G	3: 132,178,014 (GRCm38)	L225R	probably damaging	Het
Dmbt1	A	T	7: 131,116,896 (GRCm38)	D1782V	unknown	Het
Ebag9	A	T	15: 44,628,404 (GRCm38)	D64V	probably damaging	Het
Eif3j2	T	C	18: 43,477,317 (GRCm38)	N144D	possibly damaging	Het
Foxk2	A	T	11: 121,299,647 (GRCm38)	Q538L	possibly damaging	Het
Fpgt	T	G	3: 155,087,110 (GRCm38)	I427L	probably benign	Het
Ganc	A	T	2: 120,433,814 (GRCm38)	N416I	possibly damaging	Het
Gata6	A	G	18: 11,084,379 (GRCm38)	Y556C	probably damaging	Het
Gga2	A	T	7: 121,990,524 (GRCm38)	V534E	probably damaging	Het
Gm6904	C	T	14: 59,251,145 (GRCm38)	D68N	probably benign	Het
Gm7324	T	A	14: 43,714,799 (GRCm38)	S300T	possibly damaging	Het
Gprc6a	A	C	10: 51,615,453 (GRCm38)	N733K	possibly damaging	Het
Hivep3	C	T	4: 120,095,543 (GRCm38)	T352I	possibly damaging	Het
Ift88	T	G	14: 57,445,664 (GRCm38)	V266G	probably benign	Het
Ikbkap	T	C	4: 56,776,920 (GRCm38)	T626A	possibly damaging	Het
Ip6k1	G	T	9: 108,045,692 (GRCm38)	G341V	probably damaging	Het
Itga3	G	T	11: 95,076,203 (GRCm38)	A45E	probably damaging	Het
Kctd14	T	A	7: 97,457,940 (GRCm38)	L134Q	probably damaging	Het
Lats1	C	A	10: 7,702,364 (GRCm38)	N417K	probably damaging	Het
Lrrc37a	T	C	11: 103,497,459 (GRCm38)	H2380R	unknown	Het
Lrrc4c	A	G	2: 97,630,360 (GRCm38)	T444A	probably benign	Het
M1ap	T	C	6: 83,005,584 (GRCm38)	I283T	probably benign	Het
Mapre2	T	C	18: 23,877,955 (GRCm38)	S207P	probably benign	Het
Moxd1	T	C	10: 24,282,710 (GRCm38)	F421L	probably damaging	Het
Nos2	T	A	11: 78,922,366 (GRCm38)	C33*	probably null	Het
Olfr115	A	T	17: 37,610,412 (GRCm38)	L113H	probably damaging	Het
Olfr154	T	C	2: 85,664,414 (GRCm38)	T7A	probably damaging	Het
Olfr345	A	T	2: 36,640,185 (GRCm38)	I49F	probably damaging	Het
Otud4	T	C	8: 79,655,765 (GRCm38)	I201T	possibly damaging	Het
Pank4	T	C	4: 154,969,747 (GRCm38)	Y128H	probably benign	Het
Pitpnm2	A	G	5: 124,123,030 (GRCm38)	V1027A	possibly damaging	Het
Plcb3	A	G	19: 6,969,623 (GRCm38)	V8A	probably benign	Het
Por	A	G	5: 135,731,122 (GRCm38)	E221G	probably damaging	Het
Prokr2	A	T	2: 132,381,580 (GRCm38)	L14*	probably null	Het
Ptgis	A	G	2: 167,191,971 (GRCm38)	F459S	unknown	Het
Ptpru	T	C	4: 131,788,382 (GRCm38)	E887G	probably damaging	Het
Qrich2	GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG	GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG	11: 116,457,541 (GRCm38)		probably benign	Het
Slc18a1	A	G	8: 69,065,554 (GRCm38)		probably null	Het
Slc27a3	A	G	3: 90,389,433 (GRCm38)	S120P	probably benign	Het
Slc2a12	T	A	10: 22,664,818 (GRCm38)	Y191N	probably damaging	Het
Snx29	T	A	16: 11,367,724 (GRCm38)	M57K	probably benign	Het
Syncrip	A	G	9: 88,461,668 (GRCm38)		probably null	Het
Taar4	T	A	10: 23,960,999 (GRCm38)	V169E	probably damaging	Het
Tas1r1	C	T	4: 152,032,466 (GRCm38)	G237D	probably benign	Het
Tle1	T	C	4: 72,199,334 (GRCm38)	K30E	probably damaging	Het
Tmem131l	A	T	3: 83,940,568 (GRCm38)	L330Q	probably damaging	Het
Tmem67	A	G	4: 12,053,455 (GRCm38)	F698L	probably benign	Het
Ttn	T	A	2: 76,909,230 (GRCm38)	Q3701L	unknown	Het
Vmn2r17	G	A	5: 109,452,891 (GRCm38)	R685K	probably benign	Het
Ylpm1	C	A	12: 85,012,983 (GRCm38)	A321E	unknown	Het
Zdbf2	T	A	1: 63,308,007 (GRCm38)	Y1848*	probably null	Het
Zfand2b	T	A	1: 75,169,532 (GRCm38)	N61K	probably null	Het
Zfp867	C	T	11: 59,463,190 (GRCm38)	A438T	probably damaging	Het
Zkscan14	G	A	5: 145,195,509 (GRCm38)	T404I	probably benign	Het
Zrsr1	C	T	11: 22,973,510 (GRCm38)	Q95*	probably null	Het

Other mutations in Abca12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Abca12	APN	1	71,303,541 (GRCm38)	missense	possibly damaging	0.64
IGL00556:Abca12	APN	1	71,353,757 (GRCm38)	missense	probably benign	0.00
IGL00813:Abca12	APN	1	71,353,762 (GRCm38)	critical splice acceptor site	probably null
IGL00835:Abca12	APN	1	71,302,733 (GRCm38)	missense	probably damaging	1.00
IGL00921:Abca12	APN	1	71,285,729 (GRCm38)	missense	probably damaging	1.00
IGL01011:Abca12	APN	1	71,263,632 (GRCm38)	missense	probably benign	0.02
IGL01066:Abca12	APN	1	71,353,730 (GRCm38)	missense	possibly damaging	0.95
IGL01082:Abca12	APN	1	71,314,114 (GRCm38)	missense	probably damaging	1.00
IGL01310:Abca12	APN	1	71,284,156 (GRCm38)	missense	probably benign	0.00
IGL01360:Abca12	APN	1	71,286,489 (GRCm38)	missense	possibly damaging	0.95
IGL01585:Abca12	APN	1	71,319,886 (GRCm38)	missense	probably benign	0.00
IGL01608:Abca12	APN	1	71,259,442 (GRCm38)	missense	probably damaging	1.00
IGL01687:Abca12	APN	1	71,267,610 (GRCm38)	splice site	probably benign
IGL01700:Abca12	APN	1	71,280,390 (GRCm38)	missense	probably benign
IGL01723:Abca12	APN	1	71,314,168 (GRCm38)	missense	probably benign	0.01
IGL01804:Abca12	APN	1	71,276,183 (GRCm38)	missense	probably benign	0.01
IGL01982:Abca12	APN	1	71,346,698 (GRCm38)	missense	probably benign	0.34
IGL02136:Abca12	APN	1	71,247,142 (GRCm38)	missense	probably damaging	1.00
IGL02172:Abca12	APN	1	71,302,658 (GRCm38)	missense	probably benign	0.09
IGL02222:Abca12	APN	1	71,282,886 (GRCm38)	missense	probably benign	0.40
IGL02266:Abca12	APN	1	71,268,201 (GRCm38)	nonsense	probably null
IGL02449:Abca12	APN	1	71,401,749 (GRCm38)	splice site	probably null
IGL02471:Abca12	APN	1	71,258,198 (GRCm38)	missense	probably benign	0.00
IGL02496:Abca12	APN	1	71,288,553 (GRCm38)	missense	possibly damaging	0.55
IGL02552:Abca12	APN	1	71,294,747 (GRCm38)	missense	probably damaging	0.96
IGL02795:Abca12	APN	1	71,288,748 (GRCm38)	missense	probably damaging	1.00
IGL03000:Abca12	APN	1	71,321,800 (GRCm38)	missense	probably benign	0.01
IGL03031:Abca12	APN	1	71,314,024 (GRCm38)	missense	probably benign	0.00
IGL03131:Abca12	APN	1	71,346,702 (GRCm38)	missense	probably benign
IGL03260:Abca12	APN	1	71,284,099 (GRCm38)	missense	probably damaging	1.00
IGL03324:Abca12	APN	1	71,314,008 (GRCm38)	missense	probably benign
IGL03408:Abca12	APN	1	71,264,795 (GRCm38)	missense	probably damaging	1.00
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0121:Abca12	UTSW	1	71,259,786 (GRCm38)	splice site	probably null
R0172:Abca12	UTSW	1	71,279,402 (GRCm38)	missense	probably damaging	0.99
R0196:Abca12	UTSW	1	71,259,813 (GRCm38)	missense	possibly damaging	0.81
R0400:Abca12	UTSW	1	71,259,776 (GRCm38)	splice site	probably benign
R0466:Abca12	UTSW	1	71,302,663 (GRCm38)	missense	probably damaging	1.00
R0616:Abca12	UTSW	1	71,302,671 (GRCm38)	missense	probably damaging	1.00
R0668:Abca12	UTSW	1	71,263,614 (GRCm38)	missense	probably damaging	1.00
R0928:Abca12	UTSW	1	71,349,174 (GRCm38)	missense	probably benign	0.06
R1036:Abca12	UTSW	1	71,263,410 (GRCm38)	critical splice donor site	probably null
R1086:Abca12	UTSW	1	71,295,061 (GRCm38)	splice site	probably benign
R1300:Abca12	UTSW	1	71,244,808 (GRCm38)	missense	probably damaging	1.00
R1337:Abca12	UTSW	1	71,294,819 (GRCm38)	missense	probably benign	0.03
R1356:Abca12	UTSW	1	71,302,953 (GRCm38)	splice site	probably benign
R1372:Abca12	UTSW	1	71,294,857 (GRCm38)	missense	probably damaging	1.00
R1434:Abca12	UTSW	1	71,309,800 (GRCm38)	missense	probably benign	0.00
R1580:Abca12	UTSW	1	71,265,965 (GRCm38)	missense	possibly damaging	0.65
R1675:Abca12	UTSW	1	71,263,411 (GRCm38)	critical splice donor site	probably null
R1773:Abca12	UTSW	1	71,288,596 (GRCm38)	missense	probably damaging	1.00
R1829:Abca12	UTSW	1	71,295,029 (GRCm38)	missense	probably benign	0.26
R1922:Abca12	UTSW	1	71,319,924 (GRCm38)	missense	probably benign	0.10
R1927:Abca12	UTSW	1	71,244,840 (GRCm38)	missense	probably damaging	1.00
R2115:Abca12	UTSW	1	71,244,771 (GRCm38)	missense	probably benign	0.01
R2146:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2148:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2149:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2150:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2299:Abca12	UTSW	1	71,258,222 (GRCm38)	missense	probably damaging	1.00
R2392:Abca12	UTSW	1	71,258,105 (GRCm38)	missense	probably damaging	1.00
R2571:Abca12	UTSW	1	71,249,885 (GRCm38)	missense	probably benign	0.00
R3077:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3078:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3705:Abca12	UTSW	1	71,285,705 (GRCm38)	missense	probably damaging	1.00
R3800:Abca12	UTSW	1	71,265,887 (GRCm38)	missense	probably damaging	1.00
R3905:Abca12	UTSW	1	71,279,457 (GRCm38)	missense	probably benign	0.02
R3905:Abca12	UTSW	1	71,268,230 (GRCm38)	missense	possibly damaging	0.79
R3962:Abca12	UTSW	1	71,274,515 (GRCm38)	splice site	probably null
R4082:Abca12	UTSW	1	71,267,463 (GRCm38)	missense	possibly damaging	0.64
R4131:Abca12	UTSW	1	71,319,871 (GRCm38)	critical splice donor site	probably null
R4214:Abca12	UTSW	1	71,288,697 (GRCm38)	missense	probably damaging	0.99
R4403:Abca12	UTSW	1	71,267,436 (GRCm38)	missense	probably damaging	1.00
R4524:Abca12	UTSW	1	71,302,917 (GRCm38)	missense	probably benign	0.19
R4615:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4617:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4714:Abca12	UTSW	1	71,321,450 (GRCm38)	missense	probably benign	0.00
R4809:Abca12	UTSW	1	71,278,856 (GRCm38)	missense	probably benign	0.10
R4810:Abca12	UTSW	1	71,303,612 (GRCm38)	missense	probably benign	0.00
R4825:Abca12	UTSW	1	71,302,685 (GRCm38)	missense	possibly damaging	0.70
R4990:Abca12	UTSW	1	71,294,939 (GRCm38)	missense	possibly damaging	0.61
R5013:Abca12	UTSW	1	71,264,767 (GRCm38)	missense	probably damaging	0.99
R5026:Abca12	UTSW	1	71,317,224 (GRCm38)	missense	probably benign	0.04
R5064:Abca12	UTSW	1	71,300,960 (GRCm38)	missense	probably damaging	1.00
R5188:Abca12	UTSW	1	71,291,492 (GRCm38)	missense	probably benign	0.23
R5234:Abca12	UTSW	1	71,263,664 (GRCm38)	missense	probably damaging	0.99
R5267:Abca12	UTSW	1	71,335,774 (GRCm38)	splice site	probably benign
R5302:Abca12	UTSW	1	71,283,952 (GRCm38)	missense	possibly damaging	0.91
R5441:Abca12	UTSW	1	71,295,056 (GRCm38)	missense	probably damaging	1.00
R5451:Abca12	UTSW	1	71,294,917 (GRCm38)	missense	possibly damaging	0.94
R5526:Abca12	UTSW	1	71,292,446 (GRCm38)	missense	probably benign	0.29
R5529:Abca12	UTSW	1	71,264,881 (GRCm38)	missense	probably damaging	1.00
R5615:Abca12	UTSW	1	71,307,059 (GRCm38)	missense	probably damaging	1.00
R5649:Abca12	UTSW	1	71,291,342 (GRCm38)	missense	probably damaging	1.00
R5800:Abca12	UTSW	1	71,321,432 (GRCm38)	missense	possibly damaging	0.78
R5807:Abca12	UTSW	1	71,303,492 (GRCm38)	missense	probably damaging	1.00
R5878:Abca12	UTSW	1	71,346,633 (GRCm38)	missense	possibly damaging	0.79
R5987:Abca12	UTSW	1	71,258,098 (GRCm38)	missense	probably damaging	1.00
R6280:Abca12	UTSW	1	71,272,460 (GRCm38)	missense	probably benign	0.04
R6316:Abca12	UTSW	1	71,313,959 (GRCm38)	missense	probably benign	0.01
R6337:Abca12	UTSW	1	71,295,013 (GRCm38)	missense	probably damaging	1.00
R6383:Abca12	UTSW	1	71,247,184 (GRCm38)	missense	probably benign	0.03
R6564:Abca12	UTSW	1	71,309,850 (GRCm38)	missense	possibly damaging	0.57
R6582:Abca12	UTSW	1	71,258,225 (GRCm38)	missense	probably benign	0.00
R6756:Abca12	UTSW	1	71,259,353 (GRCm38)	splice site	probably null
R6876:Abca12	UTSW	1	71,263,508 (GRCm38)	missense	probably damaging	0.98
R6999:Abca12	UTSW	1	71,317,162 (GRCm38)	nonsense	probably null
R7145:Abca12	UTSW	1	71,307,053 (GRCm38)	missense	possibly damaging	0.92
R7272:Abca12	UTSW	1	71,248,432 (GRCm38)	missense	probably damaging	0.99
R7285:Abca12	UTSW	1	71,349,155 (GRCm38)	nonsense	probably null
R7421:Abca12	UTSW	1	71,247,136 (GRCm38)	nonsense	probably null
R7531:Abca12	UTSW	1	71,247,173 (GRCm38)	missense	probably damaging	0.99
R7592:Abca12	UTSW	1	71,288,677 (GRCm38)	missense	probably benign	0.01
R7687:Abca12	UTSW	1	71,258,182 (GRCm38)	missense	probably benign	0.00
R7690:Abca12	UTSW	1	71,314,154 (GRCm38)	missense	probably benign	0.00
R7709:Abca12	UTSW	1	71,335,728 (GRCm38)	missense	probably benign	0.00
R7754:Abca12	UTSW	1	71,302,887 (GRCm38)	missense	probably benign
R7761:Abca12	UTSW	1	71,330,288 (GRCm38)	missense	probably damaging	1.00
R7808:Abca12	UTSW	1	71,274,634 (GRCm38)	splice site	probably null
R7816:Abca12	UTSW	1	71,292,429 (GRCm38)	missense	probably benign	0.01
R7821:Abca12	UTSW	1	71,259,791 (GRCm38)	missense	probably benign	0.12
R7827:Abca12	UTSW	1	71,414,678 (GRCm38)	start gained	probably benign
R7829:Abca12	UTSW	1	71,292,421 (GRCm38)	missense	probably benign	0.37
R7863:Abca12	UTSW	1	71,293,497 (GRCm38)	missense	probably damaging	0.96
R8053:Abca12	UTSW	1	71,349,169 (GRCm38)	nonsense	probably null
R8093:Abca12	UTSW	1	71,280,393 (GRCm38)	missense	probably benign	0.00
R8120:Abca12	UTSW	1	71,259,381 (GRCm38)	missense	possibly damaging	0.92
R8136:Abca12	UTSW	1	71,248,397 (GRCm38)	missense	probably benign	0.15
R8155:Abca12	UTSW	1	71,291,338 (GRCm38)	missense	probably damaging	1.00
R8189:Abca12	UTSW	1	71,285,726 (GRCm38)	missense	probably damaging	1.00
R8233:Abca12	UTSW	1	71,351,757 (GRCm38)	missense	probably benign	0.00
R8249:Abca12	UTSW	1	71,321,812 (GRCm38)	missense	probably benign	0.00
R8255:Abca12	UTSW	1	71,319,899 (GRCm38)	missense	probably benign	0.13
R8300:Abca12	UTSW	1	71,313,964 (GRCm38)	missense	possibly damaging	0.77
R8339:Abca12	UTSW	1	71,285,672 (GRCm38)	missense	probably damaging	1.00
R8490:Abca12	UTSW	1	71,284,097 (GRCm38)	missense	probably damaging	1.00
R8494:Abca12	UTSW	1	71,288,662 (GRCm38)	missense	probably benign	0.02
R8527:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8542:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8692:Abca12	UTSW	1	71,288,715 (GRCm38)	missense	probably damaging	0.96
R8723:Abca12	UTSW	1	71,321,738 (GRCm38)	missense	probably benign	0.04
R8796:Abca12	UTSW	1	71,258,089 (GRCm38)	critical splice donor site	probably benign
R8911:Abca12	UTSW	1	71,341,531 (GRCm38)	missense	probably benign	0.07
R8913:Abca12	UTSW	1	71,264,813 (GRCm38)	missense	probably damaging	1.00
R8957:Abca12	UTSW	1	71,321,625 (GRCm38)	missense	possibly damaging	0.90
R9000:Abca12	UTSW	1	71,314,036 (GRCm38)	missense	probably damaging	1.00
R9137:Abca12	UTSW	1	71,259,366 (GRCm38)	missense	possibly damaging	0.80
R9228:Abca12	UTSW	1	71,293,440 (GRCm38)	missense	probably damaging	1.00
R9237:Abca12	UTSW	1	71,279,398 (GRCm38)	missense	probably damaging	0.97
R9299:Abca12	UTSW	1	71,319,883 (GRCm38)	missense	possibly damaging	0.48
R9419:Abca12	UTSW	1	71,303,490 (GRCm38)	missense	possibly damaging	0.81
R9492:Abca12	UTSW	1	71,258,221 (GRCm38)	missense	possibly damaging	0.81
R9538:Abca12	UTSW	1	71,341,513 (GRCm38)	missense	probably benign	0.04
R9585:Abca12	UTSW	1	71,303,586 (GRCm38)	missense	probably damaging	1.00
R9658:Abca12	UTSW	1	71,286,475 (GRCm38)	missense	probably damaging	0.97
R9763:Abca12	UTSW	1	71,263,558 (GRCm38)	missense	possibly damaging	0.84
X0013:Abca12	UTSW	1	71,248,433 (GRCm38)	missense	probably damaging	0.99
X0018:Abca12	UTSW	1	71,314,510 (GRCm38)	missense	probably benign
X0063:Abca12	UTSW	1	71,349,064 (GRCm38)	missense	probably benign	0.15
X0065:Abca12	UTSW	1	71,341,461 (GRCm38)	critical splice donor site	probably null
Z1176:Abca12	UTSW	1	71,284,070 (GRCm38)	missense	probably damaging	1.00
Z1177:Abca12	UTSW	1	71,292,531 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,282,811 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,276,082 (GRCm38)	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- CATGCAACTTCCTGGTGTCTTG -3'
(R):5'- GGCAGCATAAGTACAAGTCTAAATC -3'

Sequencing Primer
(F):5'- CTGGTGTCTTGCTGATAAATACC -3'
(R):5'- AGATCTTAAAGATGCAAAGCCTG -3'

Posted On

2019-11-26