Incidental Mutation 'R7736:Zfp867'
ID596275
Institutional Source Beutler Lab
Gene Symbol Zfp867
Ensembl Gene ENSMUSG00000054519
Gene Namezinc finger protein 867
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #R7736 (G1)
Quality Score225.009
Status Not validated
Chromosome11
Chromosomal Location59461197-59472474 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 59463190 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 438 (A438T)
Ref Sequence ENSEMBL: ENSMUSP00000050746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045279] [ENSMUST00000057799] [ENSMUST00000108777] [ENSMUST00000147163]
Predicted Effect probably benign
Transcript: ENSMUST00000045279
SMART Domains Protein: ENSMUSP00000043473
Gene: ENSMUSG00000036819

DomainStartEndE-ValueType
low complexity region 19 33 N/A INTRINSIC
Blast:JmjC 34 89 2e-21 BLAST
Blast:JmjC 103 144 1e-18 BLAST
JmjC 147 294 1.56e-13 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000057799
AA Change: A438T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000050746
Gene: ENSMUSG00000054519
AA Change: A438T

DomainStartEndE-ValueType
KRAB 12 70 1.36e-16 SMART
low complexity region 84 90 N/A INTRINSIC
ZnF_C2H2 121 143 4.47e-3 SMART
ZnF_C2H2 149 171 5.59e-4 SMART
ZnF_C2H2 177 199 5.5e-3 SMART
ZnF_C2H2 205 227 5.14e-3 SMART
ZnF_C2H2 233 255 1.2e-3 SMART
ZnF_C2H2 261 283 5.5e-3 SMART
ZnF_C2H2 289 311 1.38e-3 SMART
ZnF_C2H2 317 339 5.42e-2 SMART
ZnF_C2H2 346 368 1.47e-3 SMART
ZnF_C2H2 374 396 7.11e0 SMART
ZnF_C2H2 402 424 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108777
SMART Domains Protein: ENSMUSP00000104407
Gene: ENSMUSG00000036819

DomainStartEndE-ValueType
low complexity region 19 33 N/A INTRINSIC
Blast:JmjC 34 89 3e-21 BLAST
JmjC 147 306 1.84e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000147163
SMART Domains Protein: ENSMUSP00000123531
Gene: ENSMUSG00000036819

DomainStartEndE-ValueType
low complexity region 19 33 N/A INTRINSIC
Blast:JmjC 68 152 8e-38 BLAST
Blast:JmjC 152 190 2e-15 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T G 1: 71,319,964 D561A probably benign Het
Adgrg1 T C 8: 95,005,337 F204S probably benign Het
Apoa2 T C 1: 171,226,172 L72P probably damaging Het
Arhgef10 A T 8: 14,980,583 K987* probably null Het
Arrb1 A G 7: 99,539,774 D9G unknown Het
Asph A G 4: 9,621,930 S192P possibly damaging Het
Bcas1 G A 2: 170,387,164 T309M possibly damaging Het
Bcat2 C T 7: 45,585,193 T166M possibly damaging Het
Bmp5 A T 9: 75,893,790 I401L probably damaging Het
Bpifb9b G A 2: 154,312,105 G261R probably benign Het
Cd53 T A 3: 106,767,936 Y106F probably benign Het
Cdhr3 T A 12: 33,053,520 D366V probably benign Het
Ceacam10 G C 7: 24,781,211 V256L unknown Het
Cilp2 A G 8: 69,881,421 Y976H probably damaging Het
Cklf A G 8: 104,261,555 T107A possibly damaging Het
Dhx16 T A 17: 35,881,676 W167R possibly damaging Het
Dkk2 T G 3: 132,178,014 L225R probably damaging Het
Dmbt1 A T 7: 131,116,896 D1782V unknown Het
Ebag9 A T 15: 44,628,404 D64V probably damaging Het
Eif3j2 T C 18: 43,477,317 N144D possibly damaging Het
Foxk2 A T 11: 121,299,647 Q538L possibly damaging Het
Fpgt T G 3: 155,087,110 I427L probably benign Het
Ganc A T 2: 120,433,814 N416I possibly damaging Het
Gata6 A G 18: 11,084,379 Y556C probably damaging Het
Gga2 A T 7: 121,990,524 V534E probably damaging Het
Gm6904 C T 14: 59,251,145 D68N probably benign Het
Gm7324 T A 14: 43,714,799 S300T possibly damaging Het
Gprc6a A C 10: 51,615,453 N733K possibly damaging Het
Hivep3 C T 4: 120,095,543 T352I possibly damaging Het
Ift88 T G 14: 57,445,664 V266G probably benign Het
Ikbkap T C 4: 56,776,920 T626A possibly damaging Het
Ip6k1 G T 9: 108,045,692 G341V probably damaging Het
Itga3 G T 11: 95,076,203 A45E probably damaging Het
Kctd14 T A 7: 97,457,940 L134Q probably damaging Het
Lats1 C A 10: 7,702,364 N417K probably damaging Het
Lrrc37a T C 11: 103,497,459 H2380R unknown Het
Lrrc4c A G 2: 97,630,360 T444A probably benign Het
M1ap T C 6: 83,005,584 I283T probably benign Het
Mapre2 T C 18: 23,877,955 S207P probably benign Het
Moxd1 T C 10: 24,282,710 F421L probably damaging Het
Nos2 T A 11: 78,922,366 C33* probably null Het
Olfr115 A T 17: 37,610,412 L113H probably damaging Het
Olfr154 T C 2: 85,664,414 T7A probably damaging Het
Olfr345 A T 2: 36,640,185 I49F probably damaging Het
Otud4 T C 8: 79,655,765 I201T possibly damaging Het
Pank4 T C 4: 154,969,747 Y128H probably benign Het
Pitpnm2 A G 5: 124,123,030 V1027A possibly damaging Het
Plcb3 A G 19: 6,969,623 V8A probably benign Het
Por A G 5: 135,731,122 E221G probably damaging Het
Prokr2 A T 2: 132,381,580 L14* probably null Het
Ptgis A G 2: 167,191,971 F459S unknown Het
Ptpru T C 4: 131,788,382 E887G probably damaging Het
Qrich2 GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG 11: 116,457,541 probably benign Het
Slc18a1 A G 8: 69,065,554 probably null Het
Slc27a3 A G 3: 90,389,433 S120P probably benign Het
Slc2a12 T A 10: 22,664,818 Y191N probably damaging Het
Snx29 T A 16: 11,367,724 M57K probably benign Het
Syncrip A G 9: 88,461,668 probably null Het
Taar4 T A 10: 23,960,999 V169E probably damaging Het
Tas1r1 C T 4: 152,032,466 G237D probably benign Het
Tle1 T C 4: 72,199,334 K30E probably damaging Het
Tmem131l A T 3: 83,940,568 L330Q probably damaging Het
Tmem67 A G 4: 12,053,455 F698L probably benign Het
Ttn T A 2: 76,909,230 Q3701L unknown Het
Vmn2r17 G A 5: 109,452,891 R685K probably benign Het
Ylpm1 C A 12: 85,012,983 A321E unknown Het
Zdbf2 T A 1: 63,308,007 Y1848* probably null Het
Zfand2b T A 1: 75,169,532 N61K probably null Het
Zkscan14 G A 5: 145,195,509 T404I probably benign Het
Zrsr1 C T 11: 22,973,510 Q95* probably null Het
Other mutations in Zfp867
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03156:Zfp867 APN 11 59465008 splice site probably benign
IGL03338:Zfp867 APN 11 59464177 nonsense probably null
R0040:Zfp867 UTSW 11 59463865 missense possibly damaging 0.88
R1997:Zfp867 UTSW 11 59463591 missense probably damaging 0.98
R2251:Zfp867 UTSW 11 59465493 nonsense probably null
R4015:Zfp867 UTSW 11 59463694 missense probably damaging 1.00
R4429:Zfp867 UTSW 11 59465037 missense possibly damaging 0.55
R4697:Zfp867 UTSW 11 59463661 missense probably damaging 1.00
R7428:Zfp867 UTSW 11 59463934 missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AAAAGGTCATTTCCAGTGTGCTTTG -3'
(R):5'- AGCTTTCAGTTGTCCCAGTTAC -3'

Sequencing Primer
(F):5'- CCAGTGTGCTTTGTCATTTTTG -3'
(R):5'- CAGTTGTCCCAGTTACATTCGAAAGC -3'
Posted On2019-11-26