Incidental Mutation 'R7737:Zmynd11'
ID 596339
Institutional Source Beutler Lab
Gene Symbol Zmynd11
Ensembl Gene ENSMUSG00000021156
Gene Name zinc finger, MYND domain containing 11
Synonyms 2210402G22Rik
MMRRC Submission 045793-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.668) question?
Stock # R7737 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 9734869-9815366 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 9745175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 248 (T248M)
Ref Sequence ENSEMBL: ENSMUSP00000106266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062658] [ENSMUST00000110633] [ENSMUST00000110634] [ENSMUST00000110635] [ENSMUST00000110636] [ENSMUST00000110637] [ENSMUST00000110638] [ENSMUST00000128658] [ENSMUST00000130151] [ENSMUST00000144642] [ENSMUST00000146059] [ENSMUST00000152725] [ENSMUST00000154994] [ENSMUST00000157035] [ENSMUST00000220996] [ENSMUST00000222475] [ENSMUST00000223421]
AlphaFold Q8R5C8
Predicted Effect probably damaging
Transcript: ENSMUST00000062658
AA Change: T194M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000059767
Gene: ENSMUSG00000021156
AA Change: T194M

DomainStartEndE-ValueType
BROMO 97 203 1.03e-18 SMART
PWWP 224 275 1.96e-21 SMART
low complexity region 318 331 N/A INTRINSIC
low complexity region 351 362 N/A INTRINSIC
coiled coil region 433 473 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110633
AA Change: T208M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106263
Gene: ENSMUSG00000021156
AA Change: T208M

DomainStartEndE-ValueType
PHD 62 106 4.19e-7 SMART
RING 66 105 8.31e-1 SMART
BROMO 111 217 1.03e-18 SMART
PWWP 238 289 1.96e-21 SMART
low complexity region 332 345 N/A INTRINSIC
low complexity region 418 437 N/A INTRINSIC
coiled coil region 503 543 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110634
AA Change: T248M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106264
Gene: ENSMUSG00000021156
AA Change: T248M

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
BROMO 151 257 1.03e-18 SMART
PWWP 278 329 1.96e-21 SMART
low complexity region 372 385 N/A INTRINSIC
low complexity region 405 416 N/A INTRINSIC
coiled coil region 487 527 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110635
AA Change: T217M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106265
Gene: ENSMUSG00000021156
AA Change: T217M

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
BROMO 133 226 3.35e-4 SMART
PWWP 247 298 1.96e-21 SMART
low complexity region 341 354 N/A INTRINSIC
low complexity region 374 385 N/A INTRINSIC
coiled coil region 456 496 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110636
AA Change: T248M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106266
Gene: ENSMUSG00000021156
AA Change: T248M

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
BROMO 151 257 1.03e-18 SMART
PWWP 278 329 1.96e-21 SMART
low complexity region 372 385 N/A INTRINSIC
low complexity region 405 416 N/A INTRINSIC
coiled coil region 487 527 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110637
AA Change: T194M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106267
Gene: ENSMUSG00000021156
AA Change: T194M

DomainStartEndE-ValueType
BROMO 97 203 1.03e-18 SMART
PWWP 224 275 1.96e-21 SMART
low complexity region 318 331 N/A INTRINSIC
low complexity region 351 362 N/A INTRINSIC
coiled coil region 433 473 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110638
AA Change: T194M

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000106268
Gene: ENSMUSG00000021156
AA Change: T194M

DomainStartEndE-ValueType
BROMO 97 203 1.03e-18 SMART
PWWP 224 275 1.96e-21 SMART
low complexity region 318 331 N/A INTRINSIC
low complexity region 404 423 N/A INTRINSIC
coiled coil region 489 529 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128658
SMART Domains Protein: ENSMUSP00000121574
Gene: ENSMUSG00000021156

DomainStartEndE-ValueType
Blast:BROMO 97 149 8e-32 BLAST
PDB:4N4I|A 99 149 6e-29 PDB
Predicted Effect possibly damaging
Transcript: ENSMUST00000130151
AA Change: T263M

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000118964
Gene: ENSMUSG00000021156
AA Change: T263M

DomainStartEndE-ValueType
PHD 117 161 4.19e-7 SMART
RING 121 160 8.31e-1 SMART
BROMO 166 272 1.03e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140180
Predicted Effect probably benign
Transcript: ENSMUST00000144642
SMART Domains Protein: ENSMUSP00000117375
Gene: ENSMUSG00000021156

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146059
SMART Domains Protein: ENSMUSP00000122133
Gene: ENSMUSG00000021156

DomainStartEndE-ValueType
Blast:BROMO 38 81 1e-23 BLAST
PDB:4N4I|A 59 89 2e-13 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000152725
SMART Domains Protein: ENSMUSP00000118002
Gene: ENSMUSG00000021156

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
Blast:BROMO 151 203 8e-31 BLAST
PDB:4N4I|A 153 203 2e-27 PDB
Predicted Effect probably damaging
Transcript: ENSMUST00000154994
AA Change: T248M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116635
Gene: ENSMUSG00000021156
AA Change: T248M

DomainStartEndE-ValueType
PHD 102 146 4.19e-7 SMART
RING 106 145 8.31e-1 SMART
BROMO 151 249 1.59e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000157035
Predicted Effect probably benign
Transcript: ENSMUST00000220996
Predicted Effect probably damaging
Transcript: ENSMUST00000222475
AA Change: T163M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000223421
AA Change: T247M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 A T 8: 114,463,566 (GRCm39) probably null Het
Akap3 T A 6: 126,851,065 (GRCm39) M861K probably damaging Het
Ankrd42 T C 7: 92,254,470 (GRCm39) T380A possibly damaging Het
Arhgef5 A G 6: 43,250,728 (GRCm39) E493G possibly damaging Het
Arvcf G A 16: 18,214,966 (GRCm39) R119Q probably damaging Het
Asmt T C X: 169,110,175 (GRCm39) F228S probably damaging Het
Atp2c2 T A 8: 120,469,134 (GRCm39) V349E probably damaging Het
BC034090 A G 1: 155,117,419 (GRCm39) V233A possibly damaging Het
Brinp3 G T 1: 146,558,332 (GRCm39) K85N probably damaging Het
Ccr6 G A 17: 8,463,926 (GRCm39) probably benign Het
D7Ertd443e A G 7: 133,871,930 (GRCm39) S644P probably damaging Het
Ddb1 C T 19: 10,603,338 (GRCm39) A882V possibly damaging Het
Epha4 C T 1: 77,357,649 (GRCm39) G783D probably damaging Het
Ephb1 T A 9: 101,861,302 (GRCm39) I621F probably damaging Het
Fbxw18 G T 9: 109,530,331 (GRCm39) Y93* probably null Het
Fcgbpl1 T A 7: 27,856,498 (GRCm39) V2095E probably damaging Het
Gak A C 5: 108,764,874 (GRCm39) L84R probably benign Het
Gm5458 A T 14: 19,649,805 (GRCm39) probably null Het
Gpatch3 C G 4: 133,302,407 (GRCm39) Q113E probably benign Het
Gpld1 C A 13: 25,159,709 (GRCm39) L426M probably damaging Het
Ighmbp2 G A 19: 3,324,467 (GRCm39) P234S unknown Het
Itga6 G A 2: 71,652,787 (GRCm39) V217I probably benign Het
Kdm7a A T 6: 39,121,338 (GRCm39) N872K probably benign Het
Klhl14 G T 18: 21,691,191 (GRCm39) Y446* probably null Het
Larp4b T A 13: 9,220,679 (GRCm39) probably null Het
Lct A T 1: 128,226,430 (GRCm39) W1320R probably benign Het
Lrp2 T C 2: 69,326,782 (GRCm39) D1763G possibly damaging Het
Lrrk2 A T 15: 91,699,649 (GRCm39) N2499Y probably damaging Het
Lsg1 T C 16: 30,400,003 (GRCm39) probably null Het
Mettl15 T C 2: 108,967,723 (GRCm39) K188E probably damaging Het
Mfsd4b1 A G 10: 39,879,274 (GRCm39) S208P probably damaging Het
Mlxipl T C 5: 135,164,235 (GRCm39) S793P possibly damaging Het
Ms4a14 G A 19: 11,280,150 (GRCm39) Q803* probably null Het
Mtor A C 4: 148,623,195 (GRCm39) E2015A possibly damaging Het
Myo15b A T 11: 115,778,749 (GRCm39) Y2581F unknown Het
Myo7b A T 18: 32,147,257 (GRCm39) Y95* probably null Het
Nf1 A G 11: 79,436,314 (GRCm39) I1985V probably benign Het
Noxred1 G A 12: 87,268,136 (GRCm39) Q332* probably null Het
Nudt21 A T 8: 94,749,461 (GRCm39) Y202N probably damaging Het
Odad2 A G 18: 7,217,890 (GRCm39) L608P probably damaging Het
Or1j16 A T 2: 36,530,632 (GRCm39) I194F probably benign Het
Pik3c2a A T 7: 115,955,488 (GRCm39) S1176T probably damaging Het
Pramel14 A C 4: 143,718,526 (GRCm39) S306A possibly damaging Het
Qrich2 GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG 11: 116,348,367 (GRCm39) probably benign Het
Rbmxl1 A G 8: 79,232,252 (GRCm39) S364P unknown Het
Rnf24 T A 2: 131,145,416 (GRCm39) K131N probably benign Het
Scai T A 2: 39,013,034 (GRCm39) Q132L probably damaging Het
Sh3tc1 T C 5: 35,881,297 (GRCm39) R49G probably benign Het
Slc12a7 A G 13: 73,936,796 (GRCm39) E152G probably benign Het
Slc22a27 A T 19: 7,874,127 (GRCm39) M316K probably damaging Het
Spag1 G T 15: 36,210,856 (GRCm39) A427S probably benign Het
Speer4a3 AACT A 5: 26,155,849 (GRCm39) probably benign Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Stk16 G T 1: 75,187,995 (GRCm39) C8F probably damaging Het
Syne2 T C 12: 75,989,622 (GRCm39) C1834R probably damaging Het
Tie1 C T 4: 118,336,054 (GRCm39) probably null Het
Timp2 A G 11: 118,194,721 (GRCm39) I156T probably damaging Het
Tmem163 A G 1: 127,419,347 (GRCm39) M286T possibly damaging Het
Tmx4 T A 2: 134,481,588 (GRCm39) M112L probably benign Het
Trank1 G T 9: 111,195,080 (GRCm39) E1035* probably null Het
Trim5 C T 7: 103,928,771 (GRCm39) V57M probably damaging Het
Ubr3 A G 2: 69,821,910 (GRCm39) S1391G probably benign Het
Vmn1r72 A T 7: 11,403,634 (GRCm39) S271R probably damaging Het
Xpo5 G A 17: 46,547,016 (GRCm39) probably null Het
Zfp592 A T 7: 80,674,941 (GRCm39) H635L probably damaging Het
Zfp791 A T 8: 85,838,844 (GRCm39) N62K probably benign Het
Zfp998 A G 13: 66,581,738 (GRCm39) probably null Het
Other mutations in Zmynd11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00573:Zmynd11 APN 13 9,739,262 (GRCm39) missense probably damaging 0.97
IGL00846:Zmynd11 APN 13 9,770,808 (GRCm39) critical splice donor site probably null
IGL01606:Zmynd11 APN 13 9,747,724 (GRCm39) missense probably damaging 1.00
IGL03229:Zmynd11 APN 13 9,739,601 (GRCm39) missense probably damaging 1.00
R1173:Zmynd11 UTSW 13 9,739,585 (GRCm39) missense probably damaging 1.00
R1413:Zmynd11 UTSW 13 9,760,256 (GRCm39) missense probably damaging 1.00
R1813:Zmynd11 UTSW 13 9,739,616 (GRCm39) missense possibly damaging 0.53
R1872:Zmynd11 UTSW 13 9,748,737 (GRCm39) missense possibly damaging 0.88
R2002:Zmynd11 UTSW 13 9,739,514 (GRCm39) splice site probably null
R2991:Zmynd11 UTSW 13 9,745,858 (GRCm39) missense probably damaging 0.99
R4273:Zmynd11 UTSW 13 9,747,726 (GRCm39) missense probably damaging 1.00
R4708:Zmynd11 UTSW 13 9,745,789 (GRCm39) missense probably damaging 0.97
R4718:Zmynd11 UTSW 13 9,739,603 (GRCm39) missense possibly damaging 0.86
R5011:Zmynd11 UTSW 13 9,739,479 (GRCm39) unclassified probably benign
R5151:Zmynd11 UTSW 13 9,740,953 (GRCm39) missense probably damaging 1.00
R5963:Zmynd11 UTSW 13 9,745,931 (GRCm39) intron probably benign
R6648:Zmynd11 UTSW 13 9,763,057 (GRCm39) missense probably benign 0.11
R7002:Zmynd11 UTSW 13 9,744,366 (GRCm39) missense probably damaging 1.00
R7223:Zmynd11 UTSW 13 9,760,198 (GRCm39) missense probably benign 0.09
R7322:Zmynd11 UTSW 13 9,740,445 (GRCm39) missense possibly damaging 0.53
R7462:Zmynd11 UTSW 13 9,748,720 (GRCm39) missense probably benign 0.29
R7500:Zmynd11 UTSW 13 9,785,434 (GRCm39) missense probably benign 0.00
R8181:Zmynd11 UTSW 13 9,739,687 (GRCm39) missense probably benign 0.08
R8331:Zmynd11 UTSW 13 9,745,190 (GRCm39) missense probably benign 0.21
R8853:Zmynd11 UTSW 13 9,740,965 (GRCm39) missense probably damaging 0.99
R9115:Zmynd11 UTSW 13 9,743,495 (GRCm39) missense probably damaging 1.00
R9184:Zmynd11 UTSW 13 9,743,475 (GRCm39) missense probably benign 0.01
R9747:Zmynd11 UTSW 13 9,739,244 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- GAGCAGTGCTTCAAAGTTACTAAAG -3'
(R):5'- CCTGTGCCACCTGAACATTC -3'

Sequencing Primer
(F):5'- GCCATAACATGTTGTTAAGTTTTTCC -3'
(R):5'- TGTGCCACCTGAACATTCTATAAAAC -3'
Posted On 2019-11-26