Incidental Mutation 'R7737:Ccr6'
ID 596346
Institutional Source Beutler Lab
Gene Symbol Ccr6
Ensembl Gene ENSMUSG00000040899
Gene Name chemokine (C-C motif) receptor 6
Synonyms Cmkbr6
MMRRC Submission 045793-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7737 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 8236043-8257141 bp(+) (GRCm38)
Type of Mutation start gained
DNA Base Change (assembly) G to A at 8245094 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097418] [ENSMUST00000164411] [ENSMUST00000166348] [ENSMUST00000167956] [ENSMUST00000177568] [ENSMUST00000180103] [ENSMUST00000231340] [ENSMUST00000231545]
AlphaFold O54689
Predicted Effect probably benign
Transcript: ENSMUST00000097418
SMART Domains Protein: ENSMUSP00000095029
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 6.5e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164411
SMART Domains Protein: ENSMUSP00000131153
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 6.5e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166348
SMART Domains Protein: ENSMUSP00000128559
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 6.5e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000167956
SMART Domains Protein: ENSMUSP00000128529
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 6.5e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177568
SMART Domains Protein: ENSMUSP00000137249
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 8.9e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000180103
SMART Domains Protein: ENSMUSP00000135945
Gene: ENSMUSG00000040899

Pfam:7tm_1 55 308 6.5e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231340
Predicted Effect probably benign
Transcript: ENSMUST00000231545
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410141K09Rik A G 13: 66,433,677 (GRCm38) probably null Het
9530053A07Rik T A 7: 28,157,073 (GRCm38) V2095E probably damaging Het
Adamts18 A T 8: 113,736,934 (GRCm38) probably null Het
Akap3 T A 6: 126,874,102 (GRCm38) M861K probably damaging Het
Ankrd42 T C 7: 92,605,262 (GRCm38) T380A possibly damaging Het
Arhgef5 A G 6: 43,273,794 (GRCm38) E493G possibly damaging Het
Armc4 A G 18: 7,217,890 (GRCm38) L608P probably damaging Het
Arvcf G A 16: 18,397,101 (GRCm38) R119Q probably damaging Het
Asmt T C X: 170,676,440 (GRCm38) F228S probably damaging Het
Atp2c2 T A 8: 119,742,395 (GRCm38) V349E probably damaging Het
BC034090 A G 1: 155,241,673 (GRCm38) V233A possibly damaging Het
Brinp3 G T 1: 146,682,594 (GRCm38) K85N probably damaging Het
D7Ertd443e A G 7: 134,270,201 (GRCm38) S644P probably damaging Het
Ddb1 C T 19: 10,625,974 (GRCm38) A882V possibly damaging Het
Epha4 C T 1: 77,381,012 (GRCm38) G783D probably damaging Het
Ephb1 T A 9: 101,984,103 (GRCm38) I621F probably damaging Het
Fbxw18 G T 9: 109,701,263 (GRCm38) Y93* probably null Het
Gak A C 5: 108,617,008 (GRCm38) L84R probably benign Het
Gm21671 AACT A 5: 25,950,851 (GRCm38) probably benign Het
Gm5458 A T 14: 19,599,737 (GRCm38) probably null Het
Gpatch3 C G 4: 133,575,096 (GRCm38) Q113E probably benign Het
Gpld1 C A 13: 24,975,726 (GRCm38) L426M probably damaging Het
Ighmbp2 G A 19: 3,274,467 (GRCm38) P234S unknown Het
Itga6 G A 2: 71,822,443 (GRCm38) V217I probably benign Het
Kdm7a A T 6: 39,144,404 (GRCm38) N872K probably benign Het
Klhl14 G T 18: 21,558,134 (GRCm38) Y446* probably null Het
Larp4b T A 13: 9,170,643 (GRCm38) probably null Het
Lct A T 1: 128,298,693 (GRCm38) W1320R probably benign Het
Lrp2 T C 2: 69,496,438 (GRCm38) D1763G possibly damaging Het
Lrrk2 A T 15: 91,815,446 (GRCm38) N2499Y probably damaging Het
Lsg1 T C 16: 30,581,185 (GRCm38) probably null Het
Mettl15 T C 2: 109,137,378 (GRCm38) K188E probably damaging Het
Mfsd4b1 A G 10: 40,003,278 (GRCm38) S208P probably damaging Het
Mlxipl T C 5: 135,135,381 (GRCm38) S793P possibly damaging Het
Ms4a14 G A 19: 11,302,786 (GRCm38) Q803* probably null Het
Mtor A C 4: 148,538,738 (GRCm38) E2015A possibly damaging Het
Myo15b A T 11: 115,887,923 (GRCm38) Y2581F unknown Het
Myo7b A T 18: 32,014,204 (GRCm38) Y95* probably null Het
Nf1 A G 11: 79,545,488 (GRCm38) I1985V probably benign Het
Noxred1 G A 12: 87,221,362 (GRCm38) Q332* probably null Het
Nudt21 A T 8: 94,022,833 (GRCm38) Y202N probably damaging Het
Olfr345 A T 2: 36,640,620 (GRCm38) I194F probably benign Het
Pik3c2a A T 7: 116,356,253 (GRCm38) S1176T probably damaging Het
Pramef17 A C 4: 143,991,956 (GRCm38) S306A possibly damaging Het
Rbmxl1 A G 8: 78,505,623 (GRCm38) S364P unknown Het
Rnf24 T A 2: 131,303,496 (GRCm38) K131N probably benign Het
Scai T A 2: 39,123,022 (GRCm38) Q132L probably damaging Het
Sh3tc1 T C 5: 35,723,953 (GRCm38) R49G probably benign Het
Slc12a7 A G 13: 73,788,677 (GRCm38) E152G probably benign Het
Slc22a27 A T 19: 7,896,762 (GRCm38) M316K probably damaging Het
Spag1 G T 15: 36,210,710 (GRCm38) A427S probably benign Het
Stk16 G T 1: 75,211,351 (GRCm38) C8F probably damaging Het
Syne2 T C 12: 75,942,848 (GRCm38) C1834R probably damaging Het
Tie1 C T 4: 118,478,857 (GRCm38) probably null Het
Timp2 A G 11: 118,303,895 (GRCm38) I156T probably damaging Het
Tmem163 A G 1: 127,491,610 (GRCm38) M286T possibly damaging Het
Tmx4 T A 2: 134,639,668 (GRCm38) M112L probably benign Het
Trank1 G T 9: 111,366,012 (GRCm38) E1035* probably null Het
Trim5 C T 7: 104,279,564 (GRCm38) V57M probably damaging Het
Ubr3 A G 2: 69,991,566 (GRCm38) S1391G probably benign Het
Vmn1r72 A T 7: 11,669,707 (GRCm38) S271R probably damaging Het
Xpo5 G A 17: 46,236,090 (GRCm38) probably null Het
Zfp592 A T 7: 81,025,193 (GRCm38) H635L probably damaging Het
Zfp791 A T 8: 85,112,215 (GRCm38) N62K probably benign Het
Zmynd11 G A 13: 9,695,139 (GRCm38) T248M probably damaging Het
Other mutations in Ccr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00927:Ccr6 APN 17 8,255,993 (GRCm38) missense probably benign 0.07
IGL02227:Ccr6 APN 17 8,256,452 (GRCm38) missense probably damaging 1.00
IGL02339:Ccr6 APN 17 8,256,253 (GRCm38) missense probably benign 0.01
E0374:Ccr6 UTSW 17 8,256,452 (GRCm38) missense probably damaging 1.00
R0021:Ccr6 UTSW 17 8,256,766 (GRCm38) missense possibly damaging 0.46
R0976:Ccr6 UTSW 17 8,256,422 (GRCm38) missense probably damaging 1.00
R0980:Ccr6 UTSW 17 8,256,014 (GRCm38) missense probably benign 0.00
R1141:Ccr6 UTSW 17 8,256,002 (GRCm38) missense probably damaging 1.00
R1674:Ccr6 UTSW 17 8,256,217 (GRCm38) missense probably damaging 0.99
R2117:Ccr6 UTSW 17 8,256,082 (GRCm38) missense possibly damaging 0.75
R2176:Ccr6 UTSW 17 8,256,241 (GRCm38) missense probably damaging 0.99
R4736:Ccr6 UTSW 17 8,256,064 (GRCm38) nonsense probably null
R5050:Ccr6 UTSW 17 8,256,104 (GRCm38) missense probably damaging 1.00
R5786:Ccr6 UTSW 17 8,256,412 (GRCm38) missense probably damaging 0.99
R6138:Ccr6 UTSW 17 8,256,382 (GRCm38) missense probably damaging 1.00
R6856:Ccr6 UTSW 17 8,256,049 (GRCm38) missense probably benign 0.08
R6950:Ccr6 UTSW 17 8,257,066 (GRCm38) makesense probably null
R7102:Ccr6 UTSW 17 8,256,187 (GRCm38) missense probably benign 0.15
R7206:Ccr6 UTSW 17 8,256,949 (GRCm38) missense probably benign
R7223:Ccr6 UTSW 17 8,256,140 (GRCm38) missense probably damaging 1.00
R7323:Ccr6 UTSW 17 8,256,779 (GRCm38) missense possibly damaging 0.88
R7974:Ccr6 UTSW 17 8,256,224 (GRCm38) missense probably damaging 1.00
R8145:Ccr6 UTSW 17 8,256,113 (GRCm38) missense probably benign 0.16
R8699:Ccr6 UTSW 17 8,256,566 (GRCm38) missense probably benign 0.20
R8738:Ccr6 UTSW 17 8,256,562 (GRCm38) missense probably damaging 0.98
R8983:Ccr6 UTSW 17 8,256,046 (GRCm38) missense probably damaging 1.00
R9242:Ccr6 UTSW 17 8,256,133 (GRCm38) missense probably benign 0.01
R9689:Ccr6 UTSW 17 8,256,989 (GRCm38) missense possibly damaging 0.87
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-11-26