Incidental Mutation 'R7738:Or55b4'
ID 596372
Institutional Source Beutler Lab
Gene Symbol Or55b4
Ensembl Gene ENSMUSG00000043925
Gene Name olfactory receptor family 55 subfamily B member 4
Synonyms Olfr544, MOR42-3, GA_x6K02T2PBJ9-5206624-5205620
MMRRC Submission 045794-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R7738 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102133321-102137514 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 102133818 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 170 (V170F)
Ref Sequence ENSEMBL: ENSMUSP00000051280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051201] [ENSMUST00000219647]
AlphaFold E9PX47
Predicted Effect probably damaging
Transcript: ENSMUST00000051201
AA Change: V170F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000051280
Gene: ENSMUSG00000043925
AA Change: V170F

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.2e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.3e-8 PFAM
Pfam:7tm_1 45 296 2.4e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219647
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkal1 T A 1: 6,459,728 (GRCm39) D101E probably benign Het
Ank2 C T 3: 126,741,271 (GRCm39) A1538T Het
Arhgap21 A G 2: 20,854,290 (GRCm39) S1701P probably damaging Het
Arhgap21 A G 2: 20,855,169 (GRCm39) Y1408H probably damaging Het
Armc3 A T 2: 19,293,761 (GRCm39) L517F probably damaging Het
Cep57l1 T A 10: 41,616,842 (GRCm39) E148D probably damaging Het
Clstn1 A C 4: 149,719,811 (GRCm39) Q452P probably damaging Het
Csmd1 C A 8: 16,151,004 (GRCm39) R1437L probably damaging Het
Dcbld1 C T 10: 52,188,922 (GRCm39) T249I possibly damaging Het
Dsp A G 13: 38,369,151 (GRCm39) E749G probably damaging Het
Enox1 A C 14: 77,815,220 (GRCm39) N126T probably damaging Het
Fgfr1 T A 8: 26,048,201 (GRCm39) L99Q probably damaging Het
Fscn3 G A 6: 28,434,445 (GRCm39) R340Q probably benign Het
Glrb C T 3: 80,767,491 (GRCm39) C243Y probably damaging Het
Gpld1 A T 13: 25,146,305 (GRCm39) Y183F probably damaging Het
Has2 T C 15: 56,531,108 (GRCm39) K536E possibly damaging Het
Igtp A G 11: 58,097,906 (GRCm39) E359G probably benign Het
Kat14 A G 2: 144,236,162 (GRCm39) D509G probably damaging Het
Kbtbd2 C A 6: 56,756,722 (GRCm39) S338I possibly damaging Het
Mpdz A G 4: 81,253,986 (GRCm39) S1049P probably benign Het
Ncoa3 C T 2: 165,891,987 (GRCm39) A121V probably damaging Het
Nfatc4 A G 14: 56,069,414 (GRCm39) T647A possibly damaging Het
Nip7 T C 8: 107,783,997 (GRCm39) F79S probably damaging Het
Nrxn3 A C 12: 88,817,074 (GRCm39) E251D possibly damaging Het
Olig2 T C 16: 91,024,048 (GRCm39) I254T unknown Het
Or5ac16 G A 16: 59,022,318 (GRCm39) A157V probably benign Het
Ostf1 A T 19: 18,562,065 (GRCm39) L177* probably null Het
Pabpc2 A T 18: 39,907,319 (GRCm39) I195F possibly damaging Het
Pacs1 A T 19: 5,202,378 (GRCm39) M404K probably benign Het
Pcdh1 A G 18: 38,330,529 (GRCm39) S964P probably benign Het
Pcdhb3 T A 18: 37,436,012 (GRCm39) N659K probably benign Het
Pla2g6 A T 15: 79,181,633 (GRCm39) Y537* probably null Het
Plekhn1 G A 4: 156,316,691 (GRCm39) T330M probably damaging Het
Proc G A 18: 32,260,532 (GRCm39) R198* probably null Het
Rfx8 G T 1: 39,722,091 (GRCm39) T298K probably damaging Het
S1pr4 A C 10: 81,334,341 (GRCm39) S378A probably benign Het
Saxo5 T C 8: 3,533,525 (GRCm39) F277S probably damaging Het
Slfn2 T A 11: 82,960,799 (GRCm39) F259L probably damaging Het
Snx14 T C 9: 88,289,527 (GRCm39) T242A probably benign Het
Sptbn2 A G 19: 4,774,153 (GRCm39) N68S probably damaging Het
Tmem44 A T 16: 30,362,228 (GRCm39) S201T probably benign Het
Ttc3 A T 16: 94,188,241 (GRCm39) I177L probably benign Het
Vmn1r177 T C 7: 23,565,559 (GRCm39) T106A probably damaging Het
Vmn1r28 T C 6: 58,243,039 (GRCm39) M294T probably benign Het
Zfp518b G A 5: 38,829,530 (GRCm39) T825I probably benign Het
Zfp729b A T 13: 67,740,194 (GRCm39) N690K probably benign Het
Other mutations in Or55b4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Or55b4 APN 7 102,133,685 (GRCm39) missense probably damaging 1.00
IGL01380:Or55b4 APN 7 102,133,592 (GRCm39) missense probably damaging 1.00
IGL01594:Or55b4 APN 7 102,134,254 (GRCm39) missense probably benign
R0732:Or55b4 UTSW 7 102,133,650 (GRCm39) missense probably benign 0.15
R1061:Or55b4 UTSW 7 102,133,321 (GRCm39) makesense probably null
R1387:Or55b4 UTSW 7 102,133,911 (GRCm39) missense probably benign 0.01
R2760:Or55b4 UTSW 7 102,133,583 (GRCm39) missense probably damaging 1.00
R5151:Or55b4 UTSW 7 102,134,192 (GRCm39) missense probably benign 0.00
R5916:Or55b4 UTSW 7 102,133,586 (GRCm39) missense probably damaging 1.00
R6084:Or55b4 UTSW 7 102,133,596 (GRCm39) missense probably damaging 1.00
R7069:Or55b4 UTSW 7 102,133,979 (GRCm39) missense possibly damaging 0.85
R7195:Or55b4 UTSW 7 102,133,574 (GRCm39) missense probably damaging 1.00
R8299:Or55b4 UTSW 7 102,133,409 (GRCm39) missense probably benign 0.01
R8433:Or55b4 UTSW 7 102,133,991 (GRCm39) missense probably benign 0.00
R9063:Or55b4 UTSW 7 102,133,931 (GRCm39) missense probably damaging 0.98
R9396:Or55b4 UTSW 7 102,134,180 (GRCm39) missense possibly damaging 0.95
R9698:Or55b4 UTSW 7 102,133,377 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GATCCTGAAGGCAGCATGGATG -3'
(R):5'- TCGATGCTTGGGACAGATGTTC -3'

Sequencing Primer
(F):5'- CATGGATGATGCGGGAGTAG -3'
(R):5'- ACTTCCTTATTGTCTTTGACTGCAAC -3'
Posted On 2019-11-26