Incidental Mutation 'R7740:Trpa1'
ID 596464
Institutional Source Beutler Lab
Gene Symbol Trpa1
Ensembl Gene ENSMUSG00000032769
Gene Name transient receptor potential cation channel, subfamily A, member 1
Synonyms ANKTM1
MMRRC Submission 045796-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R7740 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 14942872-14989086 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 14982625 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 77 (V77A)
Ref Sequence ENSEMBL: ENSMUSP00000043594 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041447]
AlphaFold Q8BLA8
Predicted Effect possibly damaging
Transcript: ENSMUST00000041447
AA Change: V77A

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769
AA Change: V77A

DomainStartEndE-ValueType
ANK 63 94 1.01e2 SMART
ANK 98 127 9.7e-8 SMART
ANK 131 161 1.36e-2 SMART
ANK 165 194 5.45e-2 SMART
ANK 198 226 3.07e2 SMART
ANK 239 268 1.99e-4 SMART
ANK 272 302 1.33e2 SMART
ANK 309 338 4.19e-3 SMART
ANK 342 371 2.34e-1 SMART
ANK 413 442 3.41e-3 SMART
ANK 446 475 5.75e-1 SMART
ANK 482 511 4.1e-6 SMART
ANK 514 543 1.68e-2 SMART
ANK 548 577 4.97e-5 SMART
Blast:ANK 580 609 2e-11 BLAST
Pfam:Ion_trans 736 975 1.8e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik G A 5: 109,885,370 (GRCm39) Q163* probably null Het
Anxa6 T A 11: 54,898,725 (GRCm39) T150S probably damaging Het
Bpifb6 T A 2: 153,744,929 (GRCm39) L45Q probably damaging Het
Brwd1 T C 16: 95,828,568 (GRCm39) D1121G probably damaging Het
C1ql3 A G 2: 13,015,483 (GRCm39) I59T possibly damaging Het
Ccdc80 A G 16: 44,924,888 (GRCm39) H674R possibly damaging Het
Cdhr1 T G 14: 36,811,337 (GRCm39) E258A probably damaging Het
Ces2g T A 8: 105,692,962 (GRCm39) F333L probably damaging Het
Chn2 C T 6: 54,277,156 (GRCm39) T445I probably benign Het
Cpe T C 8: 65,050,562 (GRCm39) D382G possibly damaging Het
Crb1 T A 1: 139,165,428 (GRCm39) I960L probably benign Het
Cyp4a14 A T 4: 115,350,806 (GRCm39) V156D probably damaging Het
Ddx23 A T 15: 98,556,315 (GRCm39) M1K probably null Het
Dnajc7 T C 11: 100,482,387 (GRCm39) I202V probably benign Het
Dsn1 T A 2: 156,839,636 (GRCm39) D255V possibly damaging Het
Dvl3 A T 16: 20,346,000 (GRCm39) probably null Het
Epm2a A G 10: 11,266,684 (GRCm39) D143G possibly damaging Het
Erc1 T A 6: 119,738,149 (GRCm39) M565L probably benign Het
Fancm T C 12: 65,173,321 (GRCm39) C1878R possibly damaging Het
Gapvd1 T C 2: 34,590,834 (GRCm39) E946G probably damaging Het
Gm9195 C T 14: 72,678,113 (GRCm39) R2352K possibly damaging Het
Greb1 C A 12: 16,790,122 (GRCm39) probably benign Het
Haus5 G A 7: 30,362,678 (GRCm39) A44V possibly damaging Het
Herc4 A G 10: 63,105,457 (GRCm39) Y146C probably benign Het
Herc6 T G 6: 57,636,802 (GRCm39) probably null Het
Hivep2 G T 10: 14,003,414 (GRCm39) G4V probably damaging Het
Hsdl2 G T 4: 59,612,724 (GRCm39) G425V probably damaging Het
Igkv1-110 C T 6: 68,247,974 (GRCm39) L28F probably benign Het
Il21r T A 7: 125,231,727 (GRCm39) L385Q possibly damaging Het
Krtap5-1 ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG 7: 141,850,333 (GRCm39) probably benign Het
Krtap5-2 C T 7: 141,728,699 (GRCm39) C149Y unknown Het
Lingo2 T A 4: 35,709,248 (GRCm39) N244I probably damaging Het
Lrrk2 C T 15: 91,651,527 (GRCm39) R1728C probably damaging Het
Macf1 A G 4: 123,578,096 (GRCm39) probably benign Het
Malrd1 G A 2: 15,619,026 (GRCm39) V297I not run Het
Mars1 T A 10: 127,136,444 (GRCm39) E460D probably benign Het
Nr1i3 A G 1: 171,044,396 (GRCm39) I174V probably benign Het
Odf2 C T 2: 29,820,636 (GRCm39) T814M probably damaging Het
Or10q1 T C 19: 13,727,328 (GRCm39) V286A probably benign Het
Or4k1 T C 14: 50,377,803 (GRCm39) M98V probably benign Het
Or4k52 A T 2: 111,610,793 (GRCm39) I43F possibly damaging Het
Pcdhga8 T C 18: 37,860,470 (GRCm39) S509P probably benign Het
Pdzd2 A G 15: 12,374,102 (GRCm39) L2011S probably benign Het
Pole T A 5: 110,478,907 (GRCm39) S1930T probably benign Het
Poteg T A 8: 27,952,052 (GRCm39) probably null Het
Ptprk T A 10: 28,372,920 (GRCm39) C724S probably damaging Het
Rabgap1l T C 1: 160,509,673 (GRCm39) E468G probably benign Het
Rbm12b1 G T 4: 12,145,954 (GRCm39) R642L probably benign Het
Relch T C 1: 105,658,986 (GRCm39) V914A probably damaging Het
S1pr4 A T 10: 81,334,855 (GRCm39) Y206* probably null Het
Sim2 A G 16: 93,915,819 (GRCm39) I261V probably benign Het
Slc22a12 C A 19: 6,587,199 (GRCm39) A448S probably benign Het
Slc4a2 A G 5: 24,636,666 (GRCm39) probably null Het
Slc6a7 T C 18: 61,133,495 (GRCm39) E567G possibly damaging Het
St6gal1 T C 16: 23,139,785 (GRCm39) probably benign Het
Syne3 T C 12: 104,920,546 (GRCm39) K550R probably benign Het
Tekt1 T A 11: 72,250,544 (GRCm39) T51S probably benign Het
Tm9sf4 T A 2: 153,050,663 (GRCm39) V640E probably damaging Het
Tnfsf8 G T 4: 63,752,683 (GRCm39) H127Q possibly damaging Het
Tomm20 A G 8: 127,666,633 (GRCm39) L80S probably damaging Het
Top2a T C 11: 98,884,640 (GRCm39) D1526G probably benign Het
Trmt1l T C 1: 151,316,639 (GRCm39) V200A possibly damaging Het
Vmn2r12 A T 5: 109,239,615 (GRCm39) V316D probably damaging Het
Vmn2r14 A T 5: 109,368,324 (GRCm39) L223M probably benign Het
Zfp2 T C 11: 50,791,605 (GRCm39) H146R probably damaging Het
Zfp52 T C 17: 21,781,252 (GRCm39) S367P probably damaging Het
Other mutations in Trpa1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Trpa1 APN 1 14,961,557 (GRCm39) missense probably damaging 0.97
IGL00937:Trpa1 APN 1 14,950,501 (GRCm39) splice site probably benign
IGL00957:Trpa1 APN 1 14,951,892 (GRCm39) missense probably damaging 0.99
IGL01307:Trpa1 APN 1 14,966,771 (GRCm39) missense probably benign 0.23
IGL01336:Trpa1 APN 1 14,957,104 (GRCm39) splice site probably benign
IGL01408:Trpa1 APN 1 14,959,637 (GRCm39) missense probably benign 0.03
IGL01504:Trpa1 APN 1 14,952,443 (GRCm39) missense possibly damaging 0.79
IGL01543:Trpa1 APN 1 14,970,300 (GRCm39) missense probably damaging 1.00
IGL01609:Trpa1 APN 1 14,982,607 (GRCm39) missense probably damaging 0.99
IGL01895:Trpa1 APN 1 14,957,867 (GRCm39) missense possibly damaging 0.87
IGL02449:Trpa1 APN 1 14,968,381 (GRCm39) missense probably damaging 1.00
IGL02936:Trpa1 APN 1 14,946,193 (GRCm39) splice site probably null
fear-2 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
petrified UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0317:Trpa1 UTSW 1 14,951,856 (GRCm39) missense probably benign 0.03
R0454:Trpa1 UTSW 1 14,955,972 (GRCm39) critical splice donor site probably null
R0828:Trpa1 UTSW 1 14,946,108 (GRCm39) missense probably damaging 1.00
R0944:Trpa1 UTSW 1 14,982,585 (GRCm39) splice site probably null
R0962:Trpa1 UTSW 1 14,968,387 (GRCm39) missense possibly damaging 0.61
R1025:Trpa1 UTSW 1 14,974,407 (GRCm39) missense probably benign 0.01
R1035:Trpa1 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
R1134:Trpa1 UTSW 1 14,951,972 (GRCm39) missense possibly damaging 0.95
R1278:Trpa1 UTSW 1 14,988,947 (GRCm39) critical splice donor site probably null
R1497:Trpa1 UTSW 1 14,956,036 (GRCm39) missense probably benign 0.30
R1617:Trpa1 UTSW 1 14,943,899 (GRCm39) missense probably damaging 1.00
R1800:Trpa1 UTSW 1 14,944,648 (GRCm39) missense probably benign 0.04
R1856:Trpa1 UTSW 1 14,969,612 (GRCm39) nonsense probably null
R1886:Trpa1 UTSW 1 14,959,649 (GRCm39) missense probably benign 0.00
R2004:Trpa1 UTSW 1 14,976,207 (GRCm39) missense possibly damaging 0.83
R2152:Trpa1 UTSW 1 14,969,625 (GRCm39) missense probably damaging 1.00
R2172:Trpa1 UTSW 1 14,951,880 (GRCm39) missense probably benign 0.01
R2198:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign
R2221:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2223:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2307:Trpa1 UTSW 1 14,982,605 (GRCm39) missense probably benign 0.00
R2338:Trpa1 UTSW 1 14,954,469 (GRCm39) missense probably damaging 0.97
R2698:Trpa1 UTSW 1 14,976,222 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2873:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2874:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R3418:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3419:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3796:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R3799:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R4238:Trpa1 UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R4320:Trpa1 UTSW 1 14,944,676 (GRCm39) missense probably benign 0.00
R4591:Trpa1 UTSW 1 14,952,332 (GRCm39) splice site probably null
R4834:Trpa1 UTSW 1 14,966,747 (GRCm39) missense possibly damaging 0.72
R4991:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign 0.00
R4999:Trpa1 UTSW 1 14,946,085 (GRCm39) missense probably benign 0.05
R5038:Trpa1 UTSW 1 14,981,090 (GRCm39) missense probably damaging 1.00
R5055:Trpa1 UTSW 1 14,946,183 (GRCm39) missense probably damaging 1.00
R5158:Trpa1 UTSW 1 14,951,885 (GRCm39) missense probably benign 0.01
R5193:Trpa1 UTSW 1 14,946,141 (GRCm39) missense possibly damaging 0.92
R5558:Trpa1 UTSW 1 14,968,492 (GRCm39) missense probably damaging 1.00
R5578:Trpa1 UTSW 1 14,957,232 (GRCm39) missense probably damaging 1.00
R5680:Trpa1 UTSW 1 14,946,078 (GRCm39) missense probably benign 0.00
R5738:Trpa1 UTSW 1 14,946,174 (GRCm39) missense probably damaging 1.00
R5801:Trpa1 UTSW 1 14,968,302 (GRCm39) missense probably damaging 1.00
R5945:Trpa1 UTSW 1 14,968,359 (GRCm39) missense probably benign 0.03
R6092:Trpa1 UTSW 1 14,959,710 (GRCm39) missense probably damaging 1.00
R6776:Trpa1 UTSW 1 14,982,601 (GRCm39) missense probably benign
R7126:Trpa1 UTSW 1 14,960,648 (GRCm39) missense probably benign 0.00
R7154:Trpa1 UTSW 1 14,952,457 (GRCm39) missense possibly damaging 0.46
R7175:Trpa1 UTSW 1 14,963,431 (GRCm39) missense possibly damaging 0.90
R7258:Trpa1 UTSW 1 14,973,473 (GRCm39) missense probably damaging 1.00
R7358:Trpa1 UTSW 1 14,968,334 (GRCm39) missense probably damaging 1.00
R7412:Trpa1 UTSW 1 14,954,422 (GRCm39) missense probably benign 0.43
R7639:Trpa1 UTSW 1 14,957,137 (GRCm39) missense probably benign 0.00
R7815:Trpa1 UTSW 1 14,974,486 (GRCm39) missense probably benign 0.01
R7854:Trpa1 UTSW 1 14,951,918 (GRCm39) missense probably benign 0.00
R8112:Trpa1 UTSW 1 14,974,490 (GRCm39) missense probably benign
R8217:Trpa1 UTSW 1 14,957,247 (GRCm39) missense probably damaging 0.97
R8711:Trpa1 UTSW 1 14,980,998 (GRCm39) missense probably damaging 1.00
R8834:Trpa1 UTSW 1 14,963,528 (GRCm39) missense possibly damaging 0.60
R8907:Trpa1 UTSW 1 14,963,563 (GRCm39) missense probably damaging 1.00
R8907:Trpa1 UTSW 1 14,959,664 (GRCm39) missense probably benign 0.00
R9058:Trpa1 UTSW 1 14,959,618 (GRCm39) missense probably damaging 1.00
R9135:Trpa1 UTSW 1 14,952,435 (GRCm39) missense probably damaging 1.00
R9261:Trpa1 UTSW 1 14,963,465 (GRCm39) missense probably damaging 1.00
R9266:Trpa1 UTSW 1 14,980,953 (GRCm39) critical splice donor site probably null
R9287:Trpa1 UTSW 1 14,956,040 (GRCm39) nonsense probably null
R9323:Trpa1 UTSW 1 14,968,564 (GRCm39) missense probably benign 0.01
R9379:Trpa1 UTSW 1 14,966,739 (GRCm39) missense possibly damaging 0.64
R9497:Trpa1 UTSW 1 14,989,026 (GRCm39) missense probably benign 0.02
R9616:Trpa1 UTSW 1 14,989,077 (GRCm39) start gained probably benign
R9666:Trpa1 UTSW 1 14,973,455 (GRCm39) missense possibly damaging 0.67
X0028:Trpa1 UTSW 1 14,960,644 (GRCm39) missense probably benign 0.16
Z1176:Trpa1 UTSW 1 14,968,574 (GRCm39) missense probably damaging 1.00
Z1176:Trpa1 UTSW 1 14,961,530 (GRCm39) missense possibly damaging 0.80
Z1176:Trpa1 UTSW 1 14,951,916 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGCCCAGAAATGCTCTTC -3'
(R):5'- GCTGTAAGCATGACTGTAATGAAC -3'

Sequencing Primer
(F):5'- GCCCAGAAATGCTCTTCATATTCAG -3'
(R):5'- TGTTCCTCTAGGTGGACA -3'
Posted On 2019-11-26