|Institutional Source||Beutler Lab|
|Gene Name||transient receptor potential cation channel, subfamily A, member 1|
|Is this an essential gene?||Probably non essential (E-score: 0.163)|
|Stock #||R7740 (G1)|
|Chromosomal Location||14872648-14918862 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 14912401 bp|
|Amino Acid Change||Valine to Alanine at position 77 (V77A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000043594 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041447]|
|Predicted Effect||possibly damaging
AA Change: V77A
PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
AA Change: V77A
|Coding Region Coverage||
|Validation Efficiency||100% (65/65)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trpa1||
(F):5'- GCAGCCCAGAAATGCTCTTC -3'
(R):5'- GCTGTAAGCATGACTGTAATGAAC -3'
(F):5'- GCCCAGAAATGCTCTTCATATTCAG -3'
(R):5'- TGTTCCTCTAGGTGGACA -3'