Incidental Mutation 'R0067:Gps2'
| ID |
59653 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gps2
|
| Ensembl Gene |
ENSMUSG00000023170 |
| Gene Name |
G protein pathway suppressor 2 |
| Synonyms |
|
| MMRRC Submission |
038358-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.891)
|
| Stock # |
R0067 (G1)
|
| Quality Score |
184 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
69804714-69807417 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 69805607 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 42
(Q42*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112062
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043419]
[ENSMUST00000057884]
[ENSMUST00000061837]
[ENSMUST00000070996]
[ENSMUST00000071026]
[ENSMUST00000072581]
[ENSMUST00000108607]
[ENSMUST00000116358]
[ENSMUST00000134581]
[ENSMUST00000108608]
[ENSMUST00000108611]
[ENSMUST00000108617]
[ENSMUST00000108609]
[ENSMUST00000108610]
[ENSMUST00000133203]
[ENSMUST00000108612]
[ENSMUST00000152589]
[ENSMUST00000108613]
[ENSMUST00000177476]
[ENSMUST00000177138]
[ENSMUST00000153652]
[ENSMUST00000164359]
|
| AlphaFold |
Q921N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043419
|
| SMART Domains |
Protein: ENSMUSP00000047008
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
eIF-5a
|
83 |
150 |
2.43e-29 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000057884
AA Change: Q42*
|
| SMART Domains |
Protein: ENSMUSP00000054072
Gene: ENSMUSG00000023170
AA Change: Q42*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:G_path_suppress
|
5 |
294 |
6.1e-93 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061837
|
| SMART Domains |
Protein: ENSMUSP00000053235
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
913 |
1043 |
2.27e-17 |
SMART |
|
low complexity region
|
1108 |
1117 |
N/A |
INTRINSIC |
|
NEUZ
|
1130 |
1250 |
4.93e-6 |
SMART |
|
low complexity region
|
1453 |
1464 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1483 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070996
|
| SMART Domains |
Protein: ENSMUSP00000067077
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071026
|
| SMART Domains |
Protein: ENSMUSP00000068651
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000072581
AA Change: Q42*
|
| SMART Domains |
Protein: ENSMUSP00000072389
Gene: ENSMUSG00000023170
AA Change: Q42*
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108607
|
| SMART Domains |
Protein: ENSMUSP00000104247
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000116358
AA Change: Q42*
|
| SMART Domains |
Protein: ENSMUSP00000112062
Gene: ENSMUSG00000023170
AA Change: Q42*
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143861
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124596
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134581
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108608
|
| SMART Domains |
Protein: ENSMUSP00000104248
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108611
|
| SMART Domains |
Protein: ENSMUSP00000104251
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108617
|
| SMART Domains |
Protein: ENSMUSP00000104257
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
3.5e-31 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
2.5e-54 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
2e-48 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
2.6e-41 |
SMART |
|
NEUZ
|
891 |
1021 |
7.6e-20 |
SMART |
|
low complexity region
|
1086 |
1095 |
N/A |
INTRINSIC |
|
NEUZ
|
1108 |
1228 |
1.7e-8 |
SMART |
|
low complexity region
|
1431 |
1442 |
N/A |
INTRINSIC |
|
low complexity region
|
1452 |
1461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108609
|
| SMART Domains |
Protein: ENSMUSP00000104249
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108610
|
| SMART Domains |
Protein: ENSMUSP00000104250
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133203
|
| SMART Domains |
Protein: ENSMUSP00000117917
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
60 |
185 |
7.22e-52 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
NEUZ
|
263 |
387 |
6.15e-46 |
SMART |
|
low complexity region
|
429 |
443 |
N/A |
INTRINSIC |
|
NEUZ
|
459 |
583 |
7.81e-39 |
SMART |
|
NEUZ
|
656 |
786 |
2.27e-17 |
SMART |
|
low complexity region
|
851 |
860 |
N/A |
INTRINSIC |
|
Pfam:Neuralized
|
875 |
942 |
6.5e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108612
|
| SMART Domains |
Protein: ENSMUSP00000104252
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132183
|
| SMART Domains |
Protein: ENSMUSP00000118868
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
161 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152589
|
| SMART Domains |
Protein: ENSMUSP00000123402
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
2e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
149 |
6.9e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108613
|
| SMART Domains |
Protein: ENSMUSP00000104253
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175761
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177476
|
| SMART Domains |
Protein: ENSMUSP00000135185
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
911 |
1041 |
2.27e-17 |
SMART |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
NEUZ
|
1128 |
1248 |
4.93e-6 |
SMART |
|
low complexity region
|
1451 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1481 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177138
|
| SMART Domains |
Protein: ENSMUSP00000135277
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
7.22e-52 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
6.15e-46 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
7.81e-39 |
SMART |
|
NEUZ
|
889 |
1019 |
2.27e-17 |
SMART |
|
low complexity region
|
1084 |
1093 |
N/A |
INTRINSIC |
|
NEUZ
|
1106 |
1226 |
4.93e-6 |
SMART |
|
low complexity region
|
1429 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1450 |
1459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153652
|
| SMART Domains |
Protein: ENSMUSP00000137459
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:eIF-5a
|
5 |
72 |
1.7e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164359
|
| SMART Domains |
Protein: ENSMUSP00000132717
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Meta Mutation Damage Score |
0.9712 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.3%
|
| Validation Efficiency |
97% (63/65) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Gene trapped(1)
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actn4 |
C |
T |
7: 28,610,995 (GRCm39) |
V248M |
possibly damaging |
Het |
| Adamts9 |
T |
A |
6: 92,867,148 (GRCm39) |
K79N |
probably damaging |
Het |
| AW209491 |
A |
T |
13: 14,812,328 (GRCm39) |
I394F |
probably benign |
Het |
| Cacna1d |
A |
T |
14: 29,796,967 (GRCm39) |
|
probably benign |
Het |
| Cacna1i |
A |
T |
15: 80,265,373 (GRCm39) |
I1542F |
probably damaging |
Het |
| Cep97 |
A |
T |
16: 55,735,924 (GRCm39) |
N291K |
possibly damaging |
Het |
| Clasp2 |
A |
T |
9: 113,689,209 (GRCm39) |
|
probably benign |
Het |
| Coq8b |
T |
C |
7: 26,932,906 (GRCm39) |
L5P |
possibly damaging |
Het |
| Dennd1c |
T |
C |
17: 57,382,465 (GRCm39) |
Q67R |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,040,313 (GRCm39) |
V119A |
possibly damaging |
Het |
| Eml1 |
A |
G |
12: 108,429,786 (GRCm39) |
D23G |
possibly damaging |
Het |
| Eva1c |
A |
T |
16: 90,663,305 (GRCm39) |
D13V |
possibly damaging |
Het |
| Fam151b |
T |
C |
13: 92,610,504 (GRCm39) |
K95R |
probably benign |
Het |
| Glo1 |
A |
T |
17: 30,813,245 (GRCm39) |
|
probably null |
Het |
| Gm11360 |
T |
A |
13: 28,140,214 (GRCm39) |
M26K |
probably benign |
Het |
| Gypa |
A |
G |
8: 81,229,710 (GRCm39) |
H102R |
possibly damaging |
Het |
| Hdac4 |
G |
A |
1: 91,957,706 (GRCm39) |
H103Y |
probably damaging |
Het |
| Hivep1 |
T |
A |
13: 42,312,132 (GRCm39) |
D1457E |
probably benign |
Het |
| Hunk |
A |
G |
16: 90,244,200 (GRCm39) |
D110G |
probably damaging |
Het |
| L3mbtl1 |
A |
G |
2: 162,790,748 (GRCm39) |
K225E |
probably damaging |
Het |
| Limch1 |
A |
G |
5: 67,131,965 (GRCm39) |
S143G |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,369,041 (GRCm39) |
K342E |
possibly damaging |
Het |
| Mc5r |
T |
A |
18: 68,472,637 (GRCm39) |
M332K |
probably damaging |
Het |
| Memo1 |
A |
G |
17: 74,532,453 (GRCm39) |
V185A |
probably damaging |
Het |
| Mtrex |
C |
T |
13: 113,023,396 (GRCm39) |
V727I |
probably benign |
Het |
| Myf6 |
A |
T |
10: 107,329,340 (GRCm39) |
|
probably null |
Het |
| Myh14 |
G |
A |
7: 44,272,551 (GRCm39) |
T1418I |
probably benign |
Het |
| Pbk |
G |
A |
14: 66,052,675 (GRCm39) |
V173I |
possibly damaging |
Het |
| Plekha5 |
C |
T |
6: 140,470,629 (GRCm39) |
T90I |
probably damaging |
Het |
| Ptbp2 |
T |
C |
3: 119,514,290 (GRCm39) |
T478A |
probably benign |
Het |
| Rasgrp1 |
C |
A |
2: 117,125,301 (GRCm39) |
R246S |
probably damaging |
Het |
| Rflnb |
A |
T |
11: 75,912,987 (GRCm39) |
S134T |
possibly damaging |
Het |
| Rnf214 |
A |
G |
9: 45,778,796 (GRCm39) |
|
probably null |
Het |
| Rps6ka5 |
T |
A |
12: 100,582,342 (GRCm39) |
I177F |
probably damaging |
Het |
| Rtn2 |
T |
A |
7: 19,028,396 (GRCm39) |
|
probably benign |
Het |
| Satb1 |
T |
C |
17: 52,111,364 (GRCm39) |
T165A |
probably damaging |
Het |
| Scamp1 |
T |
C |
13: 94,340,658 (GRCm39) |
Y237C |
probably damaging |
Het |
| Skint10 |
A |
T |
4: 112,568,753 (GRCm39) |
F321L |
probably benign |
Het |
| Slc36a2 |
A |
G |
11: 55,053,466 (GRCm39) |
|
probably benign |
Het |
| Slc8a1 |
A |
G |
17: 81,745,188 (GRCm39) |
V672A |
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,987,364 (GRCm39) |
L781H |
probably damaging |
Het |
| Sp140l2 |
T |
A |
1: 85,247,773 (GRCm39) |
N5Y |
probably benign |
Het |
| Spats2 |
C |
A |
15: 99,110,168 (GRCm39) |
P522T |
possibly damaging |
Het |
| Stkld1 |
A |
T |
2: 26,839,352 (GRCm39) |
E339D |
probably benign |
Het |
| Tbc1d9 |
A |
G |
8: 83,960,872 (GRCm39) |
T241A |
probably damaging |
Het |
| Ticrr |
A |
T |
7: 79,327,158 (GRCm39) |
D622V |
probably damaging |
Het |
| Tie1 |
A |
G |
4: 118,333,477 (GRCm39) |
|
probably benign |
Het |
| Trak1 |
G |
C |
9: 121,301,973 (GRCm39) |
V910L |
probably damaging |
Het |
| Trmt1l |
T |
C |
1: 151,324,131 (GRCm39) |
V326A |
probably benign |
Het |
| Tshr |
A |
G |
12: 91,472,057 (GRCm39) |
T136A |
probably damaging |
Het |
| Ube3c |
A |
G |
5: 29,803,936 (GRCm39) |
T180A |
possibly damaging |
Het |
| Unc13a |
A |
C |
8: 72,087,302 (GRCm39) |
F1482V |
probably damaging |
Het |
| Unc79 |
A |
G |
12: 103,025,777 (GRCm39) |
E388G |
probably damaging |
Het |
| Ush2a |
A |
T |
1: 188,697,043 (GRCm39) |
D5167V |
probably damaging |
Het |
| Vmn2r93 |
A |
T |
17: 18,546,672 (GRCm39) |
H848L |
probably benign |
Het |
| Wdfy4 |
G |
A |
14: 32,884,708 (GRCm39) |
R65C |
probably null |
Het |
| Zcchc9 |
T |
C |
13: 91,945,368 (GRCm39) |
I72V |
probably benign |
Het |
| Zfc3h1 |
G |
T |
10: 115,259,379 (GRCm39) |
L1650F |
possibly damaging |
Het |
| Zzz3 |
A |
G |
3: 152,134,040 (GRCm39) |
D366G |
possibly damaging |
Het |
|
| Other mutations in Gps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0067:Gps2
|
UTSW |
11 |
69,805,607 (GRCm39) |
nonsense |
probably null |
|
|
R1086:Gps2
|
UTSW |
11 |
69,806,050 (GRCm39) |
unclassified |
probably benign |
|
|
R1109:Gps2
|
UTSW |
11 |
69,806,507 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1938:Gps2
|
UTSW |
11 |
69,806,195 (GRCm39) |
missense |
probably benign |
|
|
R1964:Gps2
|
UTSW |
11 |
69,807,246 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2355:Gps2
|
UTSW |
11 |
69,806,207 (GRCm39) |
frame shift |
probably null |
|
|
R3773:Gps2
|
UTSW |
11 |
69,806,927 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4765:Gps2
|
UTSW |
11 |
69,807,187 (GRCm39) |
unclassified |
probably benign |
|
|
R4811:Gps2
|
UTSW |
11 |
69,806,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5119:Gps2
|
UTSW |
11 |
69,805,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5183:Gps2
|
UTSW |
11 |
69,806,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5218:Gps2
|
UTSW |
11 |
69,807,121 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5965:Gps2
|
UTSW |
11 |
69,805,620 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7172:Gps2
|
UTSW |
11 |
69,807,262 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7562:Gps2
|
UTSW |
11 |
69,807,308 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7854:Gps2
|
UTSW |
11 |
69,806,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8524:Gps2
|
UTSW |
11 |
69,805,832 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8713:Gps2
|
UTSW |
11 |
69,806,180 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1186:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1187:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1188:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1189:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1190:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1191:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1192:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACCTAATGAAGCCAAGTTCTCCC -3'
(R):5'- CACCTGTGCCACTGCACAATTTTAC -3'
Sequencing Primer
(F):5'- CTCCCTGTGGCTGTGATG -3'
(R):5'- AGAAAAGCTGGTGCTTCTCC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation