Incidental Mutation 'R7743:Apc2'
| ID |
596676 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
045799-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R7743 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 80140749 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 201
(M201I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100996
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020349]
[ENSMUST00000105359]
[ENSMUST00000138909]
[ENSMUST00000140828]
[ENSMUST00000154212]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000020349
AA Change: M177I
PolyPhen 2
Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: M177I
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105359
AA Change: M201I
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: M201I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138909
|
| SMART Domains |
Protein: ENSMUSP00000116795
Gene: ENSMUSG00000020135
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
21 |
72 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140828
|
| SMART Domains |
Protein: ENSMUSP00000121324
Gene: ENSMUSG00000020135
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
43 |
94 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154212
|
| SMART Domains |
Protein: ENSMUSP00000118171
Gene: ENSMUSG00000020135
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
6 |
57 |
7e-21 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
97% (77/79) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,774,516 (GRCm39) |
E1235G |
probably damaging |
Het |
| Abtb3 |
A |
T |
10: 85,460,813 (GRCm39) |
I569F |
possibly damaging |
Het |
| Adam6a |
A |
G |
12: 113,508,152 (GRCm39) |
D175G |
probably benign |
Het |
| Adgrf4 |
A |
T |
17: 42,983,453 (GRCm39) |
C76* |
probably null |
Het |
| Agbl3 |
C |
T |
6: 34,823,765 (GRCm39) |
T815I |
probably damaging |
Het |
| Ahnak2 |
A |
G |
12: 112,748,383 (GRCm39) |
V488A |
not run |
Het |
| Akip1 |
T |
A |
7: 109,311,035 (GRCm39) |
S192T |
probably benign |
Het |
| Arel1 |
G |
T |
12: 84,987,043 (GRCm39) |
N124K |
probably damaging |
Het |
| Atp10a |
A |
T |
7: 58,453,457 (GRCm39) |
H845L |
probably damaging |
Het |
| Atp2a2 |
A |
G |
5: 122,599,634 (GRCm39) |
Y586H |
probably benign |
Het |
| BC051019 |
A |
G |
7: 109,315,266 (GRCm39) |
Y330H |
probably damaging |
Het |
| Ccng2 |
C |
G |
5: 93,421,202 (GRCm39) |
S237R |
probably benign |
Het |
| Chek2 |
T |
G |
5: 110,987,916 (GRCm39) |
|
probably null |
Het |
| Cldn14 |
A |
G |
16: 93,716,615 (GRCm39) |
L77S |
probably damaging |
Het |
| Cox15 |
T |
C |
19: 43,728,380 (GRCm39) |
K298E |
possibly damaging |
Het |
| Cpt1b |
G |
T |
15: 89,305,607 (GRCm39) |
D369E |
probably benign |
Het |
| Cpxm1 |
T |
C |
2: 130,235,342 (GRCm39) |
N550S |
probably benign |
Het |
| Csdc2 |
A |
G |
15: 81,833,399 (GRCm39) |
E132G |
possibly damaging |
Het |
| Cyb5d2 |
A |
T |
11: 72,669,702 (GRCm39) |
C219S |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,367,278 (GRCm39) |
T480A |
probably benign |
Het |
| Fndc1 |
G |
A |
17: 7,983,969 (GRCm39) |
T1319I |
unknown |
Het |
| Gm5773 |
T |
G |
3: 93,680,565 (GRCm39) |
V79G |
probably damaging |
Het |
| Hsf2 |
G |
A |
10: 57,387,431 (GRCm39) |
|
probably null |
Het |
| Itgb2l |
T |
C |
16: 96,238,608 (GRCm39) |
T64A |
probably damaging |
Het |
| Kifc5b |
T |
C |
17: 27,143,176 (GRCm39) |
V316A |
probably damaging |
Het |
| Ktn1 |
A |
G |
14: 47,907,750 (GRCm39) |
D279G |
probably damaging |
Het |
| Lonrf1 |
T |
C |
8: 36,716,206 (GRCm39) |
E143G |
possibly damaging |
Het |
| Mroh9 |
C |
T |
1: 162,852,122 (GRCm39) |
E856K |
probably benign |
Het |
| Muc16 |
T |
C |
9: 18,568,773 (GRCm39) |
T1249A |
unknown |
Het |
| Myh6 |
G |
A |
14: 55,194,607 (GRCm39) |
R721W |
probably damaging |
Het |
| Myo6 |
A |
T |
9: 80,183,611 (GRCm39) |
I669F |
unknown |
Het |
| N4bp2 |
A |
G |
5: 65,965,802 (GRCm39) |
T1284A |
probably damaging |
Het |
| Npr3 |
A |
G |
15: 11,905,724 (GRCm39) |
M1T |
probably null |
Het |
| Obscn |
C |
T |
11: 58,990,603 (GRCm39) |
V1657M |
probably damaging |
Het |
| Olfr908 |
A |
G |
9: 38,427,624 (GRCm39) |
T99A |
possibly damaging |
Het |
| Or52a20 |
A |
G |
7: 103,366,560 (GRCm39) |
E253G |
possibly damaging |
Het |
| Or52p2 |
A |
T |
7: 102,237,638 (GRCm39) |
F104Y |
probably benign |
Het |
| Otud6b |
C |
A |
4: 14,818,389 (GRCm39) |
A171S |
possibly damaging |
Het |
| Pdcd2l |
A |
C |
7: 33,892,256 (GRCm39) |
D204E |
probably benign |
Het |
| Pdia2 |
T |
C |
17: 26,417,842 (GRCm39) |
S56G |
probably benign |
Het |
| Plcxd1 |
G |
A |
5: 110,250,369 (GRCm39) |
E237K |
possibly damaging |
Het |
| Plekha5 |
A |
T |
6: 140,501,712 (GRCm39) |
R633S |
probably damaging |
Het |
| Pnpla6 |
T |
C |
8: 3,586,594 (GRCm39) |
F937L |
possibly damaging |
Het |
| Pth2 |
A |
T |
7: 44,830,733 (GRCm39) |
M6L |
probably benign |
Het |
| Ptprd |
T |
A |
4: 76,004,326 (GRCm39) |
K143I |
probably damaging |
Het |
| Rhbdf2 |
T |
C |
11: 116,492,427 (GRCm39) |
D487G |
probably benign |
Het |
| Rhbdf2 |
A |
T |
11: 116,494,775 (GRCm39) |
D300E |
probably benign |
Het |
| Rock2 |
G |
A |
12: 17,026,048 (GRCm39) |
V1265I |
probably damaging |
Het |
| Rsf1 |
CGGC |
CGGCGGCGGAGGC |
7: 97,229,139 (GRCm39) |
|
probably benign |
Het |
| Rtn4 |
T |
A |
11: 29,683,790 (GRCm39) |
Y1027* |
probably null |
Het |
| Rxfp3 |
A |
G |
15: 11,037,216 (GRCm39) |
L52P |
probably damaging |
Het |
| Sel1l3 |
A |
G |
5: 53,293,227 (GRCm39) |
Y830H |
probably benign |
Het |
| Serpinb3d |
C |
T |
1: 107,007,088 (GRCm39) |
V207I |
probably damaging |
Het |
| Sipa1l2 |
T |
C |
8: 126,190,972 (GRCm39) |
E1006G |
probably damaging |
Het |
| Slc22a19 |
C |
T |
19: 7,661,201 (GRCm39) |
M324I |
possibly damaging |
Het |
| Slc37a1 |
T |
A |
17: 31,535,159 (GRCm39) |
F106I |
probably damaging |
Het |
| Snx14 |
A |
T |
9: 88,280,402 (GRCm39) |
S518T |
probably benign |
Het |
| Sp2 |
T |
C |
11: 96,851,935 (GRCm39) |
T330A |
probably damaging |
Het |
| Spata13 |
A |
T |
14: 60,993,698 (GRCm39) |
H1050L |
probably damaging |
Het |
| Sptssa |
A |
C |
12: 54,703,201 (GRCm39) |
V23G |
possibly damaging |
Het |
| Syt3 |
A |
T |
7: 44,042,091 (GRCm39) |
I317F |
probably damaging |
Het |
| Tars1 |
A |
C |
15: 11,399,458 (GRCm39) |
|
probably null |
Het |
| Tead3 |
T |
A |
17: 28,551,801 (GRCm39) |
T431S |
probably benign |
Het |
| Tiam2 |
G |
A |
17: 3,568,431 (GRCm39) |
E1526K |
possibly damaging |
Het |
| Tnni3 |
G |
A |
7: 4,524,891 (GRCm39) |
P12L |
probably benign |
Het |
| Topaz1 |
A |
G |
9: 122,614,201 (GRCm39) |
H1207R |
probably benign |
Het |
| Trdn |
G |
T |
10: 33,133,058 (GRCm39) |
E107* |
probably null |
Het |
| Trp63 |
A |
G |
16: 25,701,375 (GRCm39) |
N483S |
probably benign |
Het |
| Trpm4 |
A |
G |
7: 44,957,762 (GRCm39) |
S1009P |
probably benign |
Het |
| Trpm6 |
T |
C |
19: 18,804,772 (GRCm39) |
V908A |
probably benign |
Het |
| Tsen34 |
A |
T |
7: 3,697,601 (GRCm39) |
M25L |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,781,827 (GRCm39) |
E1073G |
unknown |
Het |
| Uaca |
A |
T |
9: 60,783,677 (GRCm39) |
I1380F |
probably damaging |
Het |
| Ubr3 |
A |
G |
2: 69,774,793 (GRCm39) |
T539A |
probably benign |
Het |
| Ugt1a5 |
T |
A |
1: 88,094,117 (GRCm39) |
M115K |
probably benign |
Het |
| Unc45b |
A |
T |
11: 82,813,726 (GRCm39) |
I378F |
probably damaging |
Het |
| Unk |
G |
A |
11: 115,940,262 (GRCm39) |
R205Q |
possibly damaging |
Het |
| Ush2a |
T |
A |
1: 188,542,376 (GRCm39) |
L3314Q |
probably benign |
Het |
| Vezt |
A |
G |
10: 93,816,286 (GRCm39) |
L475P |
probably damaging |
Het |
| Vmn2r115 |
C |
T |
17: 23,564,772 (GRCm39) |
Q220* |
probably null |
Het |
| Yap1 |
T |
C |
9: 7,962,379 (GRCm39) |
Q223R |
probably benign |
Het |
| Zdhhc7 |
G |
A |
8: 120,813,467 (GRCm39) |
T114M |
possibly damaging |
Het |
| Zwilch |
A |
C |
9: 64,060,217 (GRCm39) |
C374G |
probably damaging |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTACTCTCAGCTCCAGGGC -3'
(R):5'- AGCCCGGATCTAGAGAACAG -3'
Sequencing Primer
(F):5'- GCCTGTCCAAGCGCTTG -3'
(R):5'- AATTCTCCGCCCAGCCG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation