Incidental Mutation 'R7744:Trib1'
ID 596756
Institutional Source Beutler Lab
Gene Symbol Trib1
Ensembl Gene ENSMUSG00000032501
Gene Name tribbles pseudokinase 1
Synonyms A530090O15Rik, Trb1
MMRRC Submission 045800-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7744 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 59520503-59528948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 59526512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 361 (Y361N)
Ref Sequence ENSEMBL: ENSMUSP00000068834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067543] [ENSMUST00000118228]
AlphaFold Q8K4K4
Predicted Effect probably benign
Transcript: ENSMUST00000067543
AA Change: Y361N

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000068834
Gene: ENSMUSG00000032501
AA Change: Y361N

DomainStartEndE-ValueType
low complexity region 61 82 N/A INTRINSIC
Pfam:Pkinase 105 338 1.1e-33 PFAM
Pfam:Pkinase_Tyr 120 335 2.1e-15 PFAM
Pfam:Kinase-like 124 326 1.4e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118228
SMART Domains Protein: ENSMUSP00000112828
Gene: ENSMUSG00000032501

DomainStartEndE-ValueType
low complexity region 61 82 N/A INTRINSIC
Pfam:Pkinase 104 218 7.9e-12 PFAM
Meta Mutation Damage Score 0.1129 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (55/55)
MGI Phenotype PHENOTYPE: Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,240,421 (GRCm39) N761K possibly damaging Het
Abi2 A G 1: 60,476,362 (GRCm39) I145V probably benign Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Atf7ip2 T A 16: 10,059,522 (GRCm39) V354E possibly damaging Het
Bglap T C 3: 88,290,958 (GRCm39) Y91C probably damaging Het
Cacna1e A T 1: 154,341,538 (GRCm39) S1219T probably damaging Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cd177 A G 7: 24,449,800 (GRCm39) C562R probably damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Chd7 T A 4: 8,862,485 (GRCm39) probably null Het
Dyrk3 A G 1: 131,057,543 (GRCm39) V210A probably damaging Het
Eif3c C A 7: 126,158,066 (GRCm39) G297W probably damaging Het
Eml1 A G 12: 108,482,863 (GRCm39) H494R probably benign Het
Enpp2 A T 15: 54,764,629 (GRCm39) probably null Het
Fbxw21 C A 9: 108,986,720 (GRCm39) C53F possibly damaging Het
Fndc3a C A 14: 72,799,156 (GRCm39) G609V possibly damaging Het
Grid1 A G 14: 35,172,036 (GRCm39) D514G probably damaging Het
Gxylt2 T C 6: 100,760,278 (GRCm39) V271A probably damaging Het
Hes1 A G 16: 29,884,997 (GRCm39) K74R probably damaging Het
Igsf9 A G 1: 172,319,752 (GRCm39) N349S probably benign Het
Isx T A 8: 75,600,285 (GRCm39) I6N possibly damaging Het
Kcnb1 A T 2: 167,030,251 (GRCm39) F98Y probably damaging Het
Kif1b G C 4: 149,321,532 (GRCm39) T1129R possibly damaging Het
Klra10 T A 6: 130,249,724 (GRCm39) probably null Het
Mcm10 A T 2: 4,996,253 (GRCm39) L870Q probably damaging Het
Mettl16 T A 11: 74,693,829 (GRCm39) I280K probably benign Het
Mre11a G A 9: 14,721,128 (GRCm39) R349Q possibly damaging Het
Mrpl10 C T 11: 96,935,402 (GRCm39) T34I probably damaging Het
Muc16 T A 9: 18,496,392 (GRCm39) probably null Het
Myt1l T C 12: 29,877,548 (GRCm39) C400R unknown Het
Nbr1 C T 11: 101,460,210 (GRCm39) T402M probably damaging Het
Ndufs1 A G 1: 63,200,099 (GRCm39) M271T possibly damaging Het
Or10q1 A G 19: 13,727,419 (GRCm39) *316W probably null Het
Or4c29 C T 2: 88,740,003 (GRCm39) V245I possibly damaging Het
Or51f23c-ps1 G T 7: 102,431,597 (GRCm39) V305L probably benign Het
Pakap T C 4: 57,709,519 (GRCm39) S155P probably damaging Het
Pced1a C T 2: 130,263,972 (GRCm39) D227N probably damaging Het
Phf21b A G 15: 84,689,070 (GRCm39) I152T probably damaging Het
Pla2g4a A G 1: 149,736,853 (GRCm39) V430A probably benign Het
Plbd1 T C 6: 136,594,244 (GRCm39) E335G probably benign Het
Plce1 G A 19: 38,608,899 (GRCm39) V403M possibly damaging Het
Pnpla6 T A 8: 3,581,677 (GRCm39) N642K probably benign Het
Ptprb T C 10: 116,113,389 (GRCm39) I123T probably benign Het
Rab3il1 T A 19: 10,005,641 (GRCm39) probably null Het
Ranbp3 C T 17: 57,015,219 (GRCm39) T307M possibly damaging Het
Rasgrp2 T C 19: 6,455,031 (GRCm39) S254P probably damaging Het
Rgl3 T C 9: 21,898,866 (GRCm39) K191R probably benign Het
Rnf223 G A 4: 156,216,982 (GRCm39) R119H probably benign Het
Sapcd2 C T 2: 25,263,508 (GRCm39) P217S unknown Het
Setd7 C T 3: 51,434,261 (GRCm39) probably null Het
Sh3bp1 A C 15: 78,794,209 (GRCm39) T526P possibly damaging Het
Slc17a4 C A 13: 24,085,767 (GRCm39) W382L probably benign Het
Slc26a3 A T 12: 31,513,464 (GRCm39) probably null Het
Tmem129 A G 5: 33,811,732 (GRCm39) L356P probably damaging Het
Xirp1 T A 9: 119,845,912 (GRCm39) R990S possibly damaging Het
Zfp950 A C 19: 61,116,010 (GRCm39) probably null Het
Other mutations in Trib1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Trib1 APN 15 59,523,476 (GRCm39) missense probably damaging 1.00
IGL01648:Trib1 APN 15 59,526,350 (GRCm39) missense probably benign 0.38
IGL02267:Trib1 APN 15 59,523,449 (GRCm39) missense probably damaging 0.98
IGL03018:Trib1 APN 15 59,526,333 (GRCm39) missense probably damaging 1.00
Dibble UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
lawrence UTSW 15 59,521,264 (GRCm39) missense probably benign
Topcat UTSW 15 59,523,487 (GRCm39) nonsense probably null
R1994:Trib1 UTSW 15 59,521,192 (GRCm39) missense possibly damaging 0.70
R2073:Trib1 UTSW 15 59,526,189 (GRCm39) missense probably damaging 1.00
R2407:Trib1 UTSW 15 59,526,449 (GRCm39) missense probably benign 0.00
R3709:Trib1 UTSW 15 59,526,210 (GRCm39) missense probably damaging 1.00
R5759:Trib1 UTSW 15 59,526,350 (GRCm39) missense probably benign
R5986:Trib1 UTSW 15 59,526,451 (GRCm39) splice site probably null
R6083:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6084:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6086:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6112:Trib1 UTSW 15 59,523,487 (GRCm39) nonsense probably null
R6113:Trib1 UTSW 15 59,523,487 (GRCm39) nonsense probably null
R6316:Trib1 UTSW 15 59,521,264 (GRCm39) missense probably benign
R7288:Trib1 UTSW 15 59,526,471 (GRCm39) missense probably benign
R7663:Trib1 UTSW 15 59,523,562 (GRCm39) missense probably damaging 1.00
R8061:Trib1 UTSW 15 59,523,404 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGGACAGTTCTGCATTCCTG -3'
(R):5'- GTGCATGCTGGTCAAATCAAG -3'

Sequencing Primer
(F):5'- GACAGTTCTGCATTCCTGAGCAC -3'
(R):5'- TGCTGGTCAAATCAAGTCACTCAG -3'
Posted On 2019-11-26