Mutagenetix > Incidental Mutation

Incidental Mutation 'R0632:Dst'

59679

Institutional Source

Beutler Lab

Gene Symbol

Dst

Ensembl Gene

ENSMUSG00000026131

Gene Name

dystonin

Synonyms

BPAG1-n, ah, athetoid, bullous pemphigoid antigen 1, A830042E19Rik, Macf2, nmf339, Bpag1, nmf203, bullous pemphigoid antigen 1, BPAG1, Bpag, 2310001O04Rik

MMRRC Submission

038821-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.324) question?

Stock #

R0632 (G1)

Quality Score

154

Status

Validated

Chromosome

Chromosomal Location

33908225-34308661 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 34271413 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Leucine at position 4098 (R4098L)

Ref Sequence

ENSEMBL: ENSMUSP00000141127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097785] [ENSMUST00000097786] [ENSMUST00000115104] [ENSMUST00000182018] [ENSMUST00000183034] [ENSMUST00000185269] [ENSMUST00000194192]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000097785
AA Change: R6329L

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000095392
Gene: ENSMUSG00000026131
AA Change: R6329L

Domain	Start	End	E-Value	Type
CH	37	136	1.62e-28	SMART
CH	153	250	3.72e-19	SMART
PDB:2ODU\|A	261	479	1e-42	PDB
low complexity region	520	545	N/A	INTRINSIC
SPEC	602	699	8.64e-9	SMART
SPEC	702	802	2.94e-11	SMART
Blast:SPEC	809	973	4e-73	BLAST
coiled coil region	1095	1132	N/A	INTRINSIC
Blast:SPEC	1176	1285	6e-63	BLAST
SPEC	1292	1421	4.11e0	SMART
SPEC	1439	1538	4.66e0	SMART
PLEC	1537	1581	9.05e-3	SMART
PLEC	1582	1619	2.7e0	SMART
PLEC	1657	1694	2.23e0	SMART
PLEC	1695	1732	4.25e1	SMART
PLEC	1735	1770	1.39e2	SMART
PLEC	1771	1808	7.4e-8	SMART
PLEC	1811	1846	5.8e-1	SMART
PLEC	1847	1884	2.71e1	SMART
PLEC	1886	1922	4.66e0	SMART
low complexity region	2294	2307	N/A	INTRINSIC
low complexity region	2366	2381	N/A	INTRINSIC
low complexity region	2477	2491	N/A	INTRINSIC
low complexity region	2566	2593	N/A	INTRINSIC
low complexity region	2661	2675	N/A	INTRINSIC
low complexity region	2793	2799	N/A	INTRINSIC
low complexity region	2839	2847	N/A	INTRINSIC
low complexity region	3046	3057	N/A	INTRINSIC
low complexity region	3294	3314	N/A	INTRINSIC
SPEC	3321	3427	5.36e-1	SMART
low complexity region	3515	3527	N/A	INTRINSIC
low complexity region	3548	3558	N/A	INTRINSIC
SPEC	3569	3678	2.19e-1	SMART
internal_repeat_7	3771	3811	5.09e-5	PROSPERO
SPEC	3852	3971	1.75e-9	SMART
SPEC	3978	4084	3.7e-8	SMART
SPEC	4091	4190	4.56e-8	SMART
SPEC	4200	4299	3.78e0	SMART
low complexity region	4372	4388	N/A	INTRINSIC
SPEC	4447	4552	1.98e-8	SMART
SPEC	4559	4663	3.62e-11	SMART
SPEC	4673	4773	1.65e-5	SMART
SPEC	4780	4882	7.75e-11	SMART
SPEC	4889	4989	2.3e-4	SMART
SPEC	4999	5098	3.01e0	SMART
SPEC	5105	5208	2.74e-2	SMART
SPEC	5215	5319	2.46e-4	SMART
SPEC	5326	5428	1.27e-15	SMART
SPEC	5435	5537	1.54e-14	SMART
SPEC	5544	5646	8.07e-2	SMART
SPEC	5653	5755	3.67e-12	SMART
SPEC	5762	5863	1.97e-12	SMART
SPEC	5870	5976	4.19e-7	SMART
SPEC	5983	6085	2.06e-15	SMART
SPEC	6092	6195	2.89e-10	SMART
SPEC	6202	6304	2.61e-26	SMART
SPEC	6311	6413	5.31e-18	SMART
SPEC	6420	6522	1.25e-14	SMART
SPEC	6529	6632	9.1e-17	SMART
SPEC	6639	6740	9.3e-23	SMART
SPEC	6747	6849	5.43e-15	SMART
SPEC	6859	6989	1.5e-8	SMART
EFh	7023	7051	4.12e-3	SMART
EFh	7059	7087	1.25e-2	SMART
GAS2	7098	7176	3.08e-51	SMART
low complexity region	7224	7242	N/A	INTRINSIC
low complexity region	7252	7264	N/A	INTRINSIC
low complexity region	7313	7336	N/A	INTRINSIC
PDB:3GJO\|H	7364	7393	9e-10	PDB

Predicted Effect

probably damaging
Transcript: ENSMUST00000097786
AA Change: R4315L

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000095393
Gene: ENSMUSG00000026131
AA Change: R4315L

Domain	Start	End	E-Value	Type
CH	37	136	1.62e-28	SMART
CH	153	250	3.72e-19	SMART
PDB:2ODU\|A	261	479	6e-43	PDB
low complexity region	520	545	N/A	INTRINSIC
SPEC	602	699	8.64e-9	SMART
SPEC	702	802	2.94e-11	SMART
Blast:SPEC	809	973	2e-73	BLAST
coiled coil region	1095	1132	N/A	INTRINSIC
Blast:SPEC	1176	1285	2e-62	BLAST
SPEC	1292	1421	4.11e0	SMART
SPEC	1439	1538	4.66e0	SMART
SPEC	1555	1664	2.19e-1	SMART
internal_repeat_6	1757	1797	1.18e-5	PROSPERO
SPEC	1838	1957	1.75e-9	SMART
SPEC	1964	2070	3.7e-8	SMART
SPEC	2077	2176	4.56e-8	SMART
SPEC	2186	2285	3.78e0	SMART
low complexity region	2358	2374	N/A	INTRINSIC
SPEC	2433	2538	1.98e-8	SMART
SPEC	2545	2649	3.62e-11	SMART
SPEC	2659	2759	1.65e-5	SMART
SPEC	2766	2868	7.75e-11	SMART
SPEC	2875	2975	2.3e-4	SMART
SPEC	2985	3084	3.01e0	SMART
SPEC	3091	3194	2.74e-2	SMART
SPEC	3201	3305	2.46e-4	SMART
SPEC	3312	3414	1.27e-15	SMART
SPEC	3421	3523	1.54e-14	SMART
SPEC	3530	3632	8.07e-2	SMART
SPEC	3639	3741	3.67e-12	SMART
SPEC	3748	3849	1.97e-12	SMART
SPEC	3856	3962	4.19e-7	SMART
SPEC	3969	4071	2.06e-15	SMART
SPEC	4078	4181	2.89e-10	SMART
SPEC	4188	4290	2.61e-26	SMART
SPEC	4297	4399	5.31e-18	SMART
SPEC	4406	4508	1.25e-14	SMART
SPEC	4515	4618	9.1e-17	SMART
SPEC	4625	4726	9.3e-23	SMART
SPEC	4733	4835	5.43e-15	SMART
SPEC	4845	4975	1.5e-8	SMART
EFh	5009	5037	4.12e-3	SMART
EFh	5045	5073	1.25e-2	SMART
GAS2	5084	5162	3.08e-51	SMART
low complexity region	5210	5228	N/A	INTRINSIC
low complexity region	5238	5250	N/A	INTRINSIC
low complexity region	5299	5322	N/A	INTRINSIC
PDB:3GJO\|H	5350	5379	1e-9	PDB

Predicted Effect

probably damaging
Transcript: ENSMUST00000115104
AA Change: R6329L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000110756
Gene: ENSMUSG00000026131
AA Change: R6329L

Domain	Start	End	E-Value	Type
CH	37	136	1.62e-28	SMART
CH	153	250	3.72e-19	SMART
PDB:2ODU\|A	261	479	1e-42	PDB
low complexity region	520	545	N/A	INTRINSIC
SPEC	602	699	8.64e-9	SMART
SPEC	702	802	2.94e-11	SMART
Blast:SPEC	809	973	4e-73	BLAST
coiled coil region	1095	1132	N/A	INTRINSIC
Blast:SPEC	1176	1285	6e-63	BLAST
SPEC	1292	1421	4.11e0	SMART
SPEC	1439	1538	4.66e0	SMART
PLEC	1537	1581	9.05e-3	SMART
PLEC	1582	1619	2.7e0	SMART
PLEC	1657	1694	2.23e0	SMART
PLEC	1695	1732	4.25e1	SMART
PLEC	1735	1770	1.39e2	SMART
PLEC	1771	1808	7.4e-8	SMART
PLEC	1811	1846	5.8e-1	SMART
PLEC	1847	1884	2.71e1	SMART
PLEC	1886	1922	4.66e0	SMART
low complexity region	2294	2307	N/A	INTRINSIC
low complexity region	2366	2381	N/A	INTRINSIC
low complexity region	2477	2491	N/A	INTRINSIC
low complexity region	2566	2593	N/A	INTRINSIC
low complexity region	2661	2675	N/A	INTRINSIC
low complexity region	2793	2799	N/A	INTRINSIC
low complexity region	2839	2847	N/A	INTRINSIC
low complexity region	3046	3057	N/A	INTRINSIC
low complexity region	3294	3314	N/A	INTRINSIC
SPEC	3321	3427	5.36e-1	SMART
low complexity region	3515	3527	N/A	INTRINSIC
low complexity region	3548	3558	N/A	INTRINSIC
SPEC	3569	3678	2.19e-1	SMART
internal_repeat_7	3771	3811	5.08e-5	PROSPERO
SPEC	3852	3971	1.75e-9	SMART
SPEC	3978	4084	3.7e-8	SMART
SPEC	4091	4190	4.56e-8	SMART
SPEC	4200	4299	3.78e0	SMART
low complexity region	4372	4388	N/A	INTRINSIC
SPEC	4447	4552	1.98e-8	SMART
SPEC	4559	4663	3.62e-11	SMART
SPEC	4673	4773	1.65e-5	SMART
SPEC	4780	4882	7.75e-11	SMART
SPEC	4889	4989	2.3e-4	SMART
SPEC	4999	5098	3.01e0	SMART
SPEC	5105	5208	2.74e-2	SMART
SPEC	5215	5319	2.46e-4	SMART
SPEC	5326	5428	1.27e-15	SMART
SPEC	5435	5537	1.54e-14	SMART
SPEC	5544	5646	8.07e-2	SMART
SPEC	5653	5755	3.67e-12	SMART
SPEC	5762	5863	1.97e-12	SMART
SPEC	5870	5976	4.19e-7	SMART
SPEC	5983	6085	2.06e-15	SMART
SPEC	6092	6195	2.89e-10	SMART
SPEC	6202	6304	2.61e-26	SMART
SPEC	6311	6413	5.31e-18	SMART
SPEC	6420	6522	1.25e-14	SMART
SPEC	6529	6632	9.1e-17	SMART
SPEC	6639	6740	9.3e-23	SMART
SPEC	6747	6849	5.43e-15	SMART
SPEC	6859	6989	1.5e-8	SMART
EFh	7023	7051	4.12e-3	SMART
EFh	7059	7087	1.25e-2	SMART
GAS2	7098	7176	3.85e-52	SMART
low complexity region	7200	7218	N/A	INTRINSIC
low complexity region	7228	7240	N/A	INTRINSIC
low complexity region	7326	7349	N/A	INTRINSIC
PDB:3GJO\|H	7377	7406	9e-10	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000182018
AA Change: R561L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000138426
Gene: ENSMUSG00000026131
AA Change: R561L

Domain	Start	End	E-Value	Type
SPEC	1	95	3.1e-8	SMART
SPEC	102	208	2.6e-9	SMART
SPEC	215	317	1.3e-17	SMART
SPEC	324	427	1.8e-12	SMART
SPEC	434	536	1.6e-28	SMART
SPEC	543	645	3.3e-20	SMART
SPEC	652	754	7.6e-17	SMART
SPEC	761	864	5.6e-19	SMART
SPEC	871	972	5.9e-25	SMART
SPEC	979	1081	3.4e-17	SMART
SPEC	1091	1221	9.7e-11	SMART
EFh	1255	1283	2e-5	SMART
EFh	1291	1319	6e-5	SMART
GAS2	1330	1408	9.8e-56	SMART
low complexity region	1432	1450	N/A	INTRINSIC
low complexity region	1460	1472	N/A	INTRINSIC
low complexity region	1558	1581	N/A	INTRINSIC
PDB:3GJO\|H	1609	1638	2e-10	PDB

Predicted Effect

probably damaging
Transcript: ENSMUST00000183034
AA Change: R6616L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138308
Gene: ENSMUSG00000026131
AA Change: R6616L

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	82	92	N/A	INTRINSIC
low complexity region	149	163	N/A	INTRINSIC
CH	215	314	1.62e-28	SMART
CH	331	428	3.72e-19	SMART
PDB:2ODU\|A	439	657	1e-42	PDB
low complexity region	698	723	N/A	INTRINSIC
SPEC	780	877	8.64e-9	SMART
SPEC	880	980	2.94e-11	SMART
Blast:SPEC	987	1151	5e-73	BLAST
coiled coil region	1273	1310	N/A	INTRINSIC
Blast:SPEC	1354	1463	8e-63	BLAST
SPEC	1470	1599	4.11e0	SMART
SPEC	1617	1716	4.66e0	SMART
PLEC	1715	1759	9.05e-3	SMART
PLEC	1760	1797	2.7e0	SMART
PLEC	1835	1872	2.23e0	SMART
PLEC	1873	1910	4.25e1	SMART
PLEC	1913	1948	1.39e2	SMART
PLEC	1949	1986	7.4e-8	SMART
PLEC	1989	2024	5.8e-1	SMART
PLEC	2025	2062	2.71e1	SMART
PLEC	2064	2100	4.66e0	SMART
low complexity region	2472	2485	N/A	INTRINSIC
low complexity region	2544	2559	N/A	INTRINSIC
low complexity region	2655	2669	N/A	INTRINSIC
low complexity region	2744	2771	N/A	INTRINSIC
low complexity region	2839	2853	N/A	INTRINSIC
low complexity region	2971	2977	N/A	INTRINSIC
low complexity region	3017	3025	N/A	INTRINSIC
low complexity region	3224	3235	N/A	INTRINSIC
low complexity region	3472	3492	N/A	INTRINSIC
SPEC	3499	3605	5.36e-1	SMART
low complexity region	3693	3705	N/A	INTRINSIC
low complexity region	3726	3736	N/A	INTRINSIC
SPEC	3747	3856	2.19e-1	SMART
internal_repeat_12	3949	3989	5.99e-5	PROSPERO
SPEC	4030	4149	1.75e-9	SMART
SPEC	4156	4262	3.7e-8	SMART
SPEC	4269	4368	4.56e-8	SMART
SPEC	4378	4477	3.78e0	SMART
low complexity region	4550	4566	N/A	INTRINSIC
SPEC	4625	4730	1.98e-8	SMART
SPEC	4737	4841	3.62e-11	SMART
SPEC	4851	4951	1.65e-5	SMART
SPEC	4958	5060	7.75e-11	SMART
SPEC	5067	5167	2.3e-4	SMART
SPEC	5177	5276	3.01e0	SMART
SPEC	5283	5386	2.74e-2	SMART
SPEC	5393	5497	2.46e-4	SMART
SPEC	5504	5606	1.27e-15	SMART
SPEC	5613	5715	1.69e-11	SMART
SPEC	5722	5824	9.33e-5	SMART
SPEC	5831	5933	8.07e-2	SMART
SPEC	5940	6042	3.67e-12	SMART
SPEC	6049	6150	1.97e-12	SMART
SPEC	6157	6263	4.19e-7	SMART
SPEC	6270	6372	2.06e-15	SMART
SPEC	6379	6482	2.89e-10	SMART
SPEC	6489	6591	2.61e-26	SMART
SPEC	6598	6700	5.31e-18	SMART
SPEC	6707	6809	1.25e-14	SMART
SPEC	6816	6919	9.1e-17	SMART
SPEC	6926	7027	9.3e-23	SMART
SPEC	7034	7136	5.43e-15	SMART
SPEC	7146	7276	1.5e-8	SMART
EFh	7310	7338	4.12e-3	SMART
EFh	7346	7374	1.25e-2	SMART
GAS2	7385	7463	3.08e-51	SMART
low complexity region	7511	7529	N/A	INTRINSIC
low complexity region	7539	7551	N/A	INTRINSIC
low complexity region	7637	7660	N/A	INTRINSIC
PDB:3GJO\|H	7688	7717	9e-10	PDB

Predicted Effect

probably damaging
Transcript: ENSMUST00000185269
AA Change: R4098L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000141127
Gene: ENSMUSG00000026131
AA Change: R4098L

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
PDB:2ODU\|A	56	153	6e-8	PDB
low complexity region	194	219	N/A	INTRINSIC
SPEC	276	373	5.4e-11	SMART
SPEC	376	476	1.8e-13	SMART
Blast:SPEC	483	647	1e-73	BLAST
coiled coil region	769	806	N/A	INTRINSIC
Blast:SPEC	850	959	1e-62	BLAST
SPEC	966	1095	2.6e-2	SMART
SPEC	1113	1212	2.9e-2	SMART
SPEC	1229	1338	1.4e-3	SMART
internal_repeat_10	1431	1471	9.93e-6	PROSPERO
SPEC	1512	1631	1.1e-11	SMART
SPEC	1638	1744	2.3e-10	SMART
SPEC	1751	1850	2.9e-10	SMART
SPEC	1860	1959	2.4e-2	SMART
low complexity region	2032	2048	N/A	INTRINSIC
SPEC	2107	2212	1.2e-10	SMART
SPEC	2219	2323	2.3e-13	SMART
SPEC	2333	2433	1.1e-7	SMART
SPEC	2440	2542	5e-13	SMART
SPEC	2549	2649	1.4e-6	SMART
SPEC	2659	2758	1.9e-2	SMART
SPEC	2765	2868	1.8e-4	SMART
SPEC	2875	2979	1.5e-6	SMART
SPEC	2986	3088	8.2e-18	SMART
SPEC	3095	3197	1.1e-13	SMART
SPEC	3204	3306	6e-7	SMART
SPEC	3313	3415	5.1e-4	SMART
SPEC	3422	3524	2.3e-14	SMART
SPEC	3531	3632	1.3e-14	SMART
SPEC	3639	3745	2.6e-9	SMART
SPEC	3752	3854	1.3e-17	SMART
SPEC	3861	3964	1.8e-12	SMART
SPEC	3971	4073	1.6e-28	SMART
SPEC	4080	4182	3.3e-20	SMART
SPEC	4189	4291	7.6e-17	SMART
SPEC	4298	4401	5.6e-19	SMART
SPEC	4408	4509	5.9e-25	SMART
SPEC	4516	4618	3.4e-17	SMART
SPEC	4628	4758	9.7e-11	SMART
EFh	4792	4820	2e-5	SMART
EFh	4828	4856	6e-5	SMART
GAS2	4867	4945	9.8e-56	SMART
low complexity region	4969	4987	N/A	INTRINSIC
low complexity region	4997	5009	N/A	INTRINSIC
low complexity region	5095	5118	N/A	INTRINSIC
PDB:3GJO\|H	5146	5175	3e-9	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185736

Predicted Effect

probably damaging
Transcript: ENSMUST00000194192
AA Change: R1613L

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194920

Meta Mutation Damage Score

0.2788

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.8%
20x: 96.0%

Validation Efficiency

95% (81/85)

MGI Phenotype

PHENOTYPE: Mutations in this gene produce peripheral nervous system demyelination resulting in impaired muscle function and shorter lifespan. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730559C18Rik	T	C	1: 136,227,618	D83G	probably benign	Het
Acaa1a	T	A	9: 119,347,818		probably benign	Het
Adgrg7	T	A	16: 56,742,589	T462S	possibly damaging	Het
Akap6	A	T	12: 52,937,148	N825I	probably damaging	Het
Ankib1	T	A	5: 3,772,529	N59I	probably benign	Het
Anks6	T	C	4: 47,033,167	S633G	possibly damaging	Het
Ap4e1	C	A	2: 127,049,280	Y522*	probably null	Het
Art5	G	A	7: 102,097,957	T205I	probably damaging	Het
Ascc2	T	A	11: 4,649,855	L176H	probably damaging	Het
Atp13a5	T	C	16: 29,298,208	D529G	probably benign	Het
C2cd4a	T	C	9: 67,831,563	E66G	probably benign	Het
C8a	T	C	4: 104,856,492	D147G	probably damaging	Het
Ccdc109b	T	C	3: 129,918,726	M167V	probably benign	Het
Ccdc14	T	C	16: 34,721,649	V532A	possibly damaging	Het
Ccdc88a	T	A	11: 29,482,749		probably benign	Het
Cfap54	C	T	10: 92,885,096	E2543K	unknown	Het
Cldn13	C	T	5: 134,914,747	E195K	probably benign	Het
Cp	A	G	3: 19,971,082	S402G	probably null	Het
Cpa3	T	C	3: 20,225,194	T194A	probably benign	Het
Crygf	C	A	1: 65,927,997	Y93*	probably null	Het
Ctsh	A	G	9: 90,061,582	R87G	possibly damaging	Het
Cyp2t4	A	G	7: 27,158,246	D428G	possibly damaging	Het
Dnah17	C	G	11: 118,067,682		probably benign	Het
Dnah3	A	G	7: 119,967,905	V2366A	probably benign	Het
Dscaml1	A	T	9: 45,732,134	I1284F	probably benign	Het
Dsg1c	T	C	18: 20,272,346		probably benign	Het
Efhb	A	G	17: 53,413,459		probably benign	Het
Epha7	A	T	4: 28,821,104	I90F	probably damaging	Het
Fam171a2	T	A	11: 102,437,881	D684V	probably damaging	Het
Fan1	A	G	7: 64,363,199	V665A	possibly damaging	Het
Fbn2	A	G	18: 58,037,747	C2191R	probably damaging	Het
Fkbp3	G	A	12: 65,073,918	A2V	probably benign	Het
G6pd2	A	G	5: 61,810,171	N430D	probably benign	Het
Gm13119	G	A	4: 144,363,782	C464Y	probably damaging	Het
Gm13547	T	A	2: 29,761,584	D7E	possibly damaging	Het
Hdac5	A	T	11: 102,205,812	D260E	probably damaging	Het
Hist1h4i	G	T	13: 22,041,027	Y99*	probably null	Het
Hsf2bp	T	C	17: 32,013,346	E142G	probably damaging	Het
Igf1r	C	T	7: 68,165,155	T268I	probably damaging	Het
Kcne3	C	T	7: 100,184,439	R88C	probably damaging	Het
Klk1b9	G	T	7: 43,979,372	G100V	possibly damaging	Het
Kmt2d	G	A	15: 98,853,581		probably benign	Het
Lama1	C	T	17: 67,752,368		probably benign	Het
Lcp2	C	T	11: 34,082,426	P335S	possibly damaging	Het
Lrrk2	T	A	15: 91,796,028	N2047K	probably damaging	Het
Mia2	T	C	12: 59,136,143	L36P	probably damaging	Het
Mmp13	G	A	9: 7,274,032	G169R	probably damaging	Het
Mmp13	A	T	9: 7,282,077	I460F	possibly damaging	Het
Msh4	A	G	3: 153,896,895	I232T	probably damaging	Het
Msra	T	A	14: 64,210,532	M145L	probably benign	Het
Myo7a	A	T	7: 98,112,150		probably benign	Het
Nme8	A	T	13: 19,658,036	N422K	probably damaging	Het
Nol6	A	T	4: 41,121,115	F353I	probably damaging	Het
Nphp3	A	G	9: 104,018,274	K384E	probably damaging	Het
Olfr572	C	T	7: 102,928,604		probably null	Het
Olfr652	A	G	7: 104,564,337	I39V	probably benign	Het
Olfr672	A	G	7: 104,996,703	I67T	probably benign	Het
Phox2b	T	G	5: 67,096,214		probably benign	Het
Plec	A	T	15: 76,173,411	S4131T	probably damaging	Het
Pptc7	G	A	5: 122,313,591		probably benign	Het
Prpf40b	A	G	15: 99,316,289	E810G	probably benign	Het
Ptprc	C	T	1: 138,073,610	V965I	probably benign	Het
Pum1	T	A	4: 130,728,104	M180K	probably benign	Het
Ranbp3	T	C	17: 56,702,896		probably benign	Het
Rasgrf2	A	G	13: 91,972,274	S787P	probably benign	Het
Rnf19b	T	A	4: 129,073,551	N294K	probably damaging	Het
Samd3	A	T	10: 26,244,495	H156L	possibly damaging	Het
Serpinb6c	C	T	13: 33,880,031	R347Q	possibly damaging	Het
Slc36a3	A	G	11: 55,125,080	I416T	probably damaging	Het
Slc4a4	T	A	5: 89,129,641	F279Y	probably damaging	Het
Slc6a2	T	A	8: 92,992,801		probably benign	Het
Snrnp40	C	G	4: 130,378,043		probably null	Het
Tab2	A	G	10: 7,919,801	S232P	probably benign	Het
Tacc2	A	T	7: 130,625,595	K1356*	probably null	Het
Tmem87a	A	G	2: 120,359,542	S544P	probably damaging	Het
Trim52	T	A	14: 106,106,967	C20S	probably damaging	Het
Usp38	A	T	8: 81,014,150	V96E	probably benign	Het
Vmn2r59	T	C	7: 42,058,884	Y33C	probably damaging	Het
Vsig10l	T	G	7: 43,464,137	V171G	probably damaging	Het
Zfp957	T	A	14: 79,212,920	I480F	probably damaging	Het

Other mutations in Dst

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Dst	APN	1	34251839	missense	probably damaging	1.00
IGL00309:Dst	APN	1	34160652	missense	probably damaging	1.00
IGL00334:Dst	APN	1	34166292	missense	probably damaging	1.00
IGL00470:Dst	APN	1	34188962	missense	probably damaging	1.00
IGL00481:Dst	APN	1	34169329	splice site	probably benign
IGL00499:Dst	APN	1	34290423	missense	probably damaging	0.99
IGL00803:Dst	APN	1	34164124	missense	possibly damaging	0.89
IGL00850:Dst	APN	1	34306624	missense	probably damaging	1.00
IGL00957:Dst	APN	1	34228407	missense	probably benign	0.27
IGL00975:Dst	APN	1	34188312	missense	possibly damaging	0.86
IGL00984:Dst	APN	1	34256320	missense	probably damaging	1.00
IGL01284:Dst	APN	1	34163928	missense	probably damaging	1.00
IGL01393:Dst	APN	1	34167625	missense	possibly damaging	0.91
IGL01397:Dst	APN	1	34257744	missense	probably damaging	1.00
IGL01399:Dst	APN	1	34117517	missense	probably benign	0.41
IGL01412:Dst	APN	1	34242620	missense	probably benign	0.21
IGL01527:Dst	APN	1	34247653	missense	probably damaging	1.00
IGL01537:Dst	APN	1	34275320	missense	probably damaging	1.00
IGL01618:Dst	APN	1	34188909	nonsense	probably null
IGL01636:Dst	APN	1	34215569	missense	probably damaging	1.00
IGL01642:Dst	APN	1	34189389	missense	probably damaging	1.00
IGL01672:Dst	APN	1	34225693	missense	probably damaging	1.00
IGL01685:Dst	APN	1	34170452	missense	probably damaging	0.99
IGL01694:Dst	APN	1	34188160	missense	probably benign	0.13
IGL01777:Dst	APN	1	34199397	missense	probably benign	0.07
IGL01800:Dst	APN	1	34262092	missense	probably damaging	1.00
IGL01811:Dst	APN	1	34164092	missense	probably damaging	1.00
IGL01960:Dst	APN	1	34290489	missense	probably damaging	1.00
IGL02031:Dst	APN	1	34189917	missense	possibly damaging	0.95
IGL02103:Dst	APN	1	34190118	missense	possibly damaging	0.90
IGL02121:Dst	APN	1	34228657	missense	probably damaging	1.00
IGL02315:Dst	APN	1	34198665	missense	probably damaging	1.00
IGL02317:Dst	APN	1	34295163	missense	probably damaging	1.00
IGL02469:Dst	APN	1	34188828	missense	probably damaging	1.00
IGL02492:Dst	APN	1	34152193	splice site	probably benign
IGL02510:Dst	APN	1	34229251	splice site	probably null
IGL02522:Dst	APN	1	34250700	splice site	probably benign
IGL02540:Dst	APN	1	34135204	missense	probably damaging	1.00
IGL02588:Dst	APN	1	34117484	missense	probably damaging	1.00
IGL02676:Dst	APN	1	34307587	missense	probably damaging	1.00
IGL02688:Dst	APN	1	34195952	missense	probably damaging	1.00
IGL02700:Dst	APN	1	34262120	missense	probably damaging	1.00
IGL02794:Dst	APN	1	34270829	missense	probably damaging	1.00
IGL02823:Dst	APN	1	34192083	missense	possibly damaging	0.83
IGL02935:Dst	APN	1	34186845	nonsense	probably null
IGL02940:Dst	APN	1	34289587	missense	probably benign	0.36
IGL02994:Dst	APN	1	34229252	splice site	probably benign
IGL02996:Dst	APN	1	34188398	missense	possibly damaging	0.93
IGL02998:Dst	APN	1	34268275	missense	probably damaging	1.00
IGL03027:Dst	APN	1	34186025	missense	possibly damaging	0.51
IGL03033:Dst	APN	1	34169745	splice site	probably benign
IGL03099:Dst	APN	1	34275781	missense	probably damaging	1.00
IGL03119:Dst	APN	1	34161062	missense	probably damaging	1.00
IGL03121:Dst	APN	1	34217803	splice site	probably benign
IGL03132:Dst	APN	1	34256641	missense	probably benign	0.06
IGL03220:Dst	APN	1	34185995	missense	probably damaging	0.99
IGL03230:Dst	APN	1	34184052	nonsense	probably null
IGL03245:Dst	APN	1	34211148	splice site	probably null
IGL03380:Dst	APN	1	34257800	missense	probably damaging	1.00
Doodle	UTSW	1	34208558	nonsense	probably null
dyssed	UTSW	1	34256353	critical splice donor site	probably null
gobble	UTSW	1	34165155	critical splice donor site	probably null
Phelps	UTSW	1	34223795	splice site	probably null
tinsel	UTSW	1	34164167	missense	probably damaging	1.00
Wastable	UTSW	1	34295289	missense	probably damaging	1.00
E0370:Dst	UTSW	1	34249471	splice site	probably benign
FR4304:Dst	UTSW	1	34200964	missense	probably damaging	0.99
G1citation:Dst	UTSW	1	34275674	missense	probably damaging	0.99
IGL02799:Dst	UTSW	1	34179849	missense	possibly damaging	0.92
R0006:Dst	UTSW	1	34228918	missense	probably benign	0.30
R0006:Dst	UTSW	1	34228918	missense	probably benign	0.30
R0023:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0023:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0024:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0027:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0049:Dst	UTSW	1	34275781	missense	probably damaging	1.00
R0053:Dst	UTSW	1	34294550	splice site	probably null
R0053:Dst	UTSW	1	34294550	splice site	probably null
R0058:Dst	UTSW	1	34006224	missense	possibly damaging	0.93
R0066:Dst	UTSW	1	34189553	missense	possibly damaging	0.67
R0066:Dst	UTSW	1	34189553	missense	possibly damaging	0.67
R0085:Dst	UTSW	1	34229187	missense	probably damaging	1.00
R0125:Dst	UTSW	1	34270903	missense	probably damaging	1.00
R0152:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0165:Dst	UTSW	1	34154646	splice site	probably benign
R0172:Dst	UTSW	1	34270854	missense	probably damaging	1.00
R0207:Dst	UTSW	1	34186935	missense	probably benign	0.02
R0219:Dst	UTSW	1	34303478	missense	probably damaging	0.99
R0349:Dst	UTSW	1	34199553	missense	probably benign	0.12
R0386:Dst	UTSW	1	34217836	missense	probably damaging	1.00
R0389:Dst	UTSW	1	34294550	splice site	probably null
R0395:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0423:Dst	UTSW	1	34278035	missense	possibly damaging	0.95
R0443:Dst	UTSW	1	34294550	splice site	probably null
R0472:Dst	UTSW	1	34266960	critical splice donor site	probably null
R0490:Dst	UTSW	1	34307368	nonsense	probably null
R0513:Dst	UTSW	1	34219531	splice site	probably benign
R0539:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0562:Dst	UTSW	1	34227981	missense	probably damaging	1.00
R0569:Dst	UTSW	1	34293427	missense	probably damaging	1.00
R0600:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0608:Dst	UTSW	1	34290356	splice site	probably null
R0609:Dst	UTSW	1	34266960	critical splice donor site	probably null
R0630:Dst	UTSW	1	34193450	missense	probably benign	0.05
R0630:Dst	UTSW	1	34199473	missense	probably damaging	0.98
R0713:Dst	UTSW	1	34189119	missense	probably damaging	1.00
R0724:Dst	UTSW	1	34188677	missense	probably benign	0.00
R0761:Dst	UTSW	1	34182767	missense	probably benign	0.33
R0801:Dst	UTSW	1	34170389	missense	probably damaging	0.99
R0829:Dst	UTSW	1	34163220	missense	probably damaging	1.00
R0939:Dst	UTSW	1	34244383	missense	probably damaging	1.00
R0945:Dst	UTSW	1	34271419	missense	probably damaging	1.00
R0992:Dst	UTSW	1	34199536	missense	probably damaging	0.97
R1018:Dst	UTSW	1	34194093	missense	probably damaging	1.00
R1077:Dst	UTSW	1	34164167	missense	probably damaging	1.00
R1079:Dst	UTSW	1	34186863	missense	possibly damaging	0.86
R1127:Dst	UTSW	1	34275277	missense	probably damaging	1.00
R1129:Dst	UTSW	1	34199554	missense	probably benign	0.28
R1141:Dst	UTSW	1	34188696	missense	possibly damaging	0.85
R1167:Dst	UTSW	1	34223858	missense	probably damaging	1.00
R1195:Dst	UTSW	1	34211154	missense	probably damaging	1.00
R1195:Dst	UTSW	1	34211154	missense	probably damaging	1.00
R1195:Dst	UTSW	1	34211154	missense	probably damaging	1.00
R1333:Dst	UTSW	1	34228347	missense	probably damaging	1.00
R1352:Dst	UTSW	1	34229248	critical splice donor site	probably null
R1365:Dst	UTSW	1	34188194	missense	probably benign	0.02
R1382:Dst	UTSW	1	34268833	missense	probably damaging	0.99
R1389:Dst	UTSW	1	34211232	missense	probably damaging	1.00
R1394:Dst	UTSW	1	34165155	critical splice donor site	probably null
R1395:Dst	UTSW	1	34165155	critical splice donor site	probably null
R1435:Dst	UTSW	1	34113945	missense	probably damaging	1.00
R1450:Dst	UTSW	1	34188395	missense	probably damaging	1.00
R1450:Dst	UTSW	1	34212259	missense	probably damaging	0.99
R1453:Dst	UTSW	1	34189446	missense	possibly damaging	0.85
R1479:Dst	UTSW	1	34264515	splice site	probably null
R1483:Dst	UTSW	1	34252998	missense	probably damaging	1.00
R1491:Dst	UTSW	1	34154594	missense	probably damaging	0.99
R1536:Dst	UTSW	1	34260372	splice site	probably benign
R1551:Dst	UTSW	1	34192212	missense	probably benign	0.01
R1573:Dst	UTSW	1	34201231	missense	probably damaging	1.00
R1614:Dst	UTSW	1	34275263	missense	probably damaging	1.00
R1615:Dst	UTSW	1	34199371	missense	probably damaging	1.00
R1645:Dst	UTSW	1	34225722	missense	probably damaging	1.00
R1655:Dst	UTSW	1	34282576	nonsense	probably null
R1663:Dst	UTSW	1	34163385	missense	probably damaging	1.00
R1674:Dst	UTSW	1	34223795	splice site	probably null
R1702:Dst	UTSW	1	34167340	missense	probably damaging	1.00
R1707:Dst	UTSW	1	34167646	missense	probably damaging	1.00
R1747:Dst	UTSW	1	34160709	missense	probably damaging	1.00
R1760:Dst	UTSW	1	34228603	missense	probably damaging	1.00
R1773:Dst	UTSW	1	34291899	missense	probably damaging	0.99
R1793:Dst	UTSW	1	34152471	nonsense	probably null
R1842:Dst	UTSW	1	34164119	missense	probably null	0.98
R1869:Dst	UTSW	1	34252832	missense	probably damaging	0.99
R1879:Dst	UTSW	1	34188843	missense	probably benign	0.15
R1883:Dst	UTSW	1	34189308	missense	possibly damaging	0.74
R1912:Dst	UTSW	1	34291850	missense	probably damaging	1.00
R1920:Dst	UTSW	1	34161029	missense	probably damaging	0.99
R1921:Dst	UTSW	1	34161029	missense	probably damaging	0.99
R1943:Dst	UTSW	1	34228369	missense	possibly damaging	0.67
R1958:Dst	UTSW	1	34163721	missense	probably damaging	1.00
R1962:Dst	UTSW	1	34191016	missense	possibly damaging	0.47
R1991:Dst	UTSW	1	34190258	missense	probably benign	0.11
R1998:Dst	UTSW	1	34256347	missense	probably damaging	1.00
R2001:Dst	UTSW	1	34184063	missense	probably damaging	0.97
R2007:Dst	UTSW	1	34226012	splice site	probably benign
R2021:Dst	UTSW	1	34166291	missense	possibly damaging	0.70
R2022:Dst	UTSW	1	34166291	missense	possibly damaging	0.70
R2035:Dst	UTSW	1	34271413	missense	probably damaging	1.00
R2077:Dst	UTSW	1	34211170	missense	probably damaging	1.00
R2103:Dst	UTSW	1	34190258	missense	probably benign	0.11
R2111:Dst	UTSW	1	34169178	missense	probably damaging	1.00
R2112:Dst	UTSW	1	34169178	missense	probably damaging	1.00
R2113:Dst	UTSW	1	34275236	missense	probably damaging	0.97
R2201:Dst	UTSW	1	34195921	missense	possibly damaging	0.60
R2214:Dst	UTSW	1	34271401	missense	probably damaging	1.00
R2219:Dst	UTSW	1	34170433	missense	probably damaging	1.00
R2233:Dst	UTSW	1	34274262	missense	probably damaging	1.00
R2267:Dst	UTSW	1	34295466	missense	probably damaging	1.00
R2290:Dst	UTSW	1	34229200	missense	probably damaging	1.00
R2323:Dst	UTSW	1	34228437	missense	possibly damaging	0.93
R2424:Dst	UTSW	1	34167060	missense	probably damaging	1.00
R2426:Dst	UTSW	1	34192812	missense	probably benign	0.03
R2495:Dst	UTSW	1	34199373	missense	probably damaging	0.99
R2507:Dst	UTSW	1	34011909	missense	probably damaging	0.98
R2507:Dst	UTSW	1	34188417	missense	possibly damaging	0.85
R2510:Dst	UTSW	1	34212286	missense	probably benign
R2831:Dst	UTSW	1	34275292	missense	probably damaging	1.00
R2929:Dst	UTSW	1	34167062	nonsense	probably null
R3033:Dst	UTSW	1	34152285	missense	probably damaging	0.99
R3121:Dst	UTSW	1	34289648	missense	probably damaging	1.00
R3424:Dst	UTSW	1	34198505	splice site	probably benign
R3437:Dst	UTSW	1	34190222	missense	probably damaging	1.00
R3699:Dst	UTSW	1	34213074	splice site	probably benign
R3739:Dst	UTSW	1	34268894	splice site	probably benign
R3796:Dst	UTSW	1	34181915	missense	probably benign	0.15
R3847:Dst	UTSW	1	34212319	missense	probably damaging	1.00
R3848:Dst	UTSW	1	34212319	missense	probably damaging	1.00
R3849:Dst	UTSW	1	34212319	missense	probably damaging	1.00
R3850:Dst	UTSW	1	34189274	nonsense	probably null
R3850:Dst	UTSW	1	34212319	missense	probably damaging	1.00
R3873:Dst	UTSW	1	34289620	missense	probably damaging	1.00
R3875:Dst	UTSW	1	34171247	missense	probably damaging	1.00
R3973:Dst	UTSW	1	34011898	missense	probably benign	0.34
R4014:Dst	UTSW	1	34191282	nonsense	probably null
R4043:Dst	UTSW	1	34190684	missense	probably benign	0.03
R4057:Dst	UTSW	1	34186054	splice site	probably benign
R4074:Dst	UTSW	1	34192269	missense	probably benign	0.20
R4074:Dst	UTSW	1	34228461	missense	probably damaging	0.97
R4075:Dst	UTSW	1	34192269	missense	probably benign	0.20
R4076:Dst	UTSW	1	34192269	missense	probably benign	0.20
R4206:Dst	UTSW	1	34212247	missense	probably damaging	1.00
R4230:Dst	UTSW	1	34195828	missense	probably benign	0.04
R4242:Dst	UTSW	1	34006216	missense	possibly damaging	0.88
R4273:Dst	UTSW	1	34192340	missense	possibly damaging	0.72
R4366:Dst	UTSW	1	34251878	missense	probably damaging	1.00
R4370:Dst	UTSW	1	34251728	frame shift	probably null
R4379:Dst	UTSW	1	34163235	missense	probably damaging	1.00
R4379:Dst	UTSW	1	34227975	missense	probably benign	0.07
R4380:Dst	UTSW	1	34163235	missense	probably damaging	1.00
R4381:Dst	UTSW	1	34163235	missense	probably damaging	1.00
R4423:Dst	UTSW	1	34188393	missense	possibly damaging	0.76
R4427:Dst	UTSW	1	34181460	missense	probably benign	0.19
R4456:Dst	UTSW	1	34190719	missense	probably benign	0.06
R4469:Dst	UTSW	1	34191842	missense	probably benign	0.02
R4502:Dst	UTSW	1	34247691	missense	probably damaging	0.99
R4503:Dst	UTSW	1	34262253	critical splice donor site	probably null
R4545:Dst	UTSW	1	34188738	missense	probably damaging	0.99
R4610:Dst	UTSW	1	34169856	missense	probably damaging	1.00
R4633:Dst	UTSW	1	34170434	missense	probably damaging	1.00
R4675:Dst	UTSW	1	34275703	missense	possibly damaging	0.94
R4687:Dst	UTSW	1	34201123	missense	probably damaging	1.00
R4739:Dst	UTSW	1	34191147	missense	probably benign	0.01
R4751:Dst	UTSW	1	34191884	missense	probably benign	0.21
R4754:Dst	UTSW	1	34212309	missense	probably damaging	1.00
R4771:Dst	UTSW	1	34249484	missense	probably damaging	1.00
R4819:Dst	UTSW	1	33968835	missense	probably benign	0.03
R4830:Dst	UTSW	1	34198505	splice site	probably null
R4839:Dst	UTSW	1	34190862	missense	probably damaging	0.96
R4845:Dst	UTSW	1	34193127	missense	probably benign	0.02
R4904:Dst	UTSW	1	34169798	missense	probably damaging	0.99
R4932:Dst	UTSW	1	34228683	missense	possibly damaging	0.47
R4934:Dst	UTSW	1	34208588	missense	probably damaging	1.00
R4952:Dst	UTSW	1	34271422	missense	probably damaging	1.00
R4961:Dst	UTSW	1	33968823	missense	possibly damaging	0.53
R4976:Dst	UTSW	1	34195969	nonsense	probably null
R4980:Dst	UTSW	1	34256288	missense	probably damaging	1.00
R5011:Dst	UTSW	1	34250647	missense	probably damaging	1.00
R5013:Dst	UTSW	1	34250647	missense	probably damaging	1.00
R5059:Dst	UTSW	1	34163346	missense	possibly damaging	0.70
R5074:Dst	UTSW	1	34295263	missense	probably damaging	1.00
R5114:Dst	UTSW	1	34202559	missense	probably damaging	0.98
R5119:Dst	UTSW	1	34195969	nonsense	probably null
R5182:Dst	UTSW	1	34179086	missense	probably benign
R5236:Dst	UTSW	1	34164417	missense	probably damaging	1.00
R5240:Dst	UTSW	1	34208558	nonsense	probably null
R5254:Dst	UTSW	1	34177931	nonsense	probably null
R5275:Dst	UTSW	1	34180148	missense	probably benign	0.13
R5281:Dst	UTSW	1	34257782	missense	probably benign	0.29
R5299:Dst	UTSW	1	34135092	missense	probably damaging	1.00
R5316:Dst	UTSW	1	34223848	missense	probably damaging	0.97
R5319:Dst	UTSW	1	34225977	missense	possibly damaging	0.95
R5425:Dst	UTSW	1	34179750	missense	probably benign	0.00
R5443:Dst	UTSW	1	34228539	missense	probably damaging	1.00
R5522:Dst	UTSW	1	34257873	missense	possibly damaging	0.46
R5537:Dst	UTSW	1	34189878	missense	probably benign	0.25
R5548:Dst	UTSW	1	34189328	missense	probably benign
R5557:Dst	UTSW	1	34282586	missense	probably damaging	1.00
R5597:Dst	UTSW	1	34192713	missense	probably benign	0.07
R5623:Dst	UTSW	1	34190133	missense	possibly damaging	0.56
R5630:Dst	UTSW	1	34188785	frame shift	probably null
R5660:Dst	UTSW	1	34282493	missense	probably damaging	1.00
R5730:Dst	UTSW	1	34117526	splice site	probably null
R5762:Dst	UTSW	1	34179357	missense	probably damaging	0.99
R5810:Dst	UTSW	1	34183040	intron	probably benign
R5816:Dst	UTSW	1	34179234	missense	probably benign
R5846:Dst	UTSW	1	34195861	nonsense	probably null
R5874:Dst	UTSW	1	34179589	missense	probably damaging	0.98
R5899:Dst	UTSW	1	34295289	missense	probably damaging	1.00
R5923:Dst	UTSW	1	34181759	missense	probably benign	0.00
R5936:Dst	UTSW	1	34307458	missense	probably damaging	1.00
R5946:Dst	UTSW	1	34174192	missense	probably benign	0.01
R5950:Dst	UTSW	1	34262060	missense	probably damaging	1.00
R5958:Dst	UTSW	1	34186050	missense	probably damaging	0.97
R5973:Dst	UTSW	1	34156857	missense	probably damaging	1.00
R5979:Dst	UTSW	1	34160372	intron	probably benign
R5980:Dst	UTSW	1	34182891	missense	probably benign	0.34
R5984:Dst	UTSW	1	34172263	missense	probably benign	0.05
R6000:Dst	UTSW	1	34212223	missense	possibly damaging	0.92
R6014:Dst	UTSW	1	34264834	missense	probably damaging	1.00
R6042:Dst	UTSW	1	34188972	missense	probably damaging	1.00
R6064:Dst	UTSW	1	34194051	missense	probably damaging	1.00
R6126:Dst	UTSW	1	34228183	missense	probably damaging	1.00
R6157:Dst	UTSW	1	34211172	missense	probably damaging	1.00
R6162:Dst	UTSW	1	34006237	missense	probably damaging	0.99
R6185:Dst	UTSW	1	34173080	missense	probably damaging	0.99
R6226:Dst	UTSW	1	34270874	missense	probably damaging	1.00
R6227:Dst	UTSW	1	34194540	missense	probably benign	0.41
R6232:Dst	UTSW	1	34188172	missense	probably damaging	1.00
R6259:Dst	UTSW	1	34182396	missense	probably benign	0.26
R6267:Dst	UTSW	1	34228672	missense	probably damaging	1.00
R6273:Dst	UTSW	1	34275266	missense	probably damaging	1.00
R6284:Dst	UTSW	1	34229085	missense	probably damaging	1.00
R6347:Dst	UTSW	1	34179684	splice site	probably null
R6365:Dst	UTSW	1	34191927	missense	probably damaging	1.00
R6385:Dst	UTSW	1	34307468	missense	possibly damaging	0.85
R6389:Dst	UTSW	1	34193184	missense	probably damaging	0.99
R6395:Dst	UTSW	1	34182690	missense	probably benign	0.17
R6416:Dst	UTSW	1	34116128	missense	probably damaging	1.00
R6467:Dst	UTSW	1	34295196	missense	probably damaging	1.00
R6470:Dst	UTSW	1	34295237	missense	probably damaging	1.00
R6477:Dst	UTSW	1	34208728	splice site	probably null
R6485:Dst	UTSW	1	34294529	missense	probably damaging	1.00
R6491:Dst	UTSW	1	34193012	missense	probably benign	0.10
R6525:Dst	UTSW	1	34163135	missense	probably damaging	1.00
R6533:Dst	UTSW	1	34303509	missense	probably benign	0.08
R6595:Dst	UTSW	1	34250680	missense	probably damaging	1.00
R6622:Dst	UTSW	1	34179251	missense	probably benign	0.22
R6646:Dst	UTSW	1	34268807	missense	possibly damaging	0.80
R6648:Dst	UTSW	1	34262041	missense	possibly damaging	0.84
R6700:Dst	UTSW	1	34256323	missense	probably damaging	1.00
R6743:Dst	UTSW	1	34270890	missense	probably damaging	1.00
R6761:Dst	UTSW	1	34214550	missense	probably damaging	1.00
R6766:Dst	UTSW	1	34294483	missense	probably damaging	1.00
R6768:Dst	UTSW	1	34181712	missense	probably damaging	0.98
R6810:Dst	UTSW	1	34212298	missense	probably damaging	1.00
R6815:Dst	UTSW	1	34228369	missense	possibly damaging	0.67
R6820:Dst	UTSW	1	34211256	missense	probably damaging	1.00
R6822:Dst	UTSW	1	34275674	missense	probably damaging	0.99
R6831:Dst	UTSW	1	34190684	missense	probably benign	0.03
R6874:Dst	UTSW	1	34289651	missense	probably benign	0.29
R6945:Dst	UTSW	1	34190490	missense	probably damaging	1.00
R6985:Dst	UTSW	1	34190853	missense	probably benign	0.08
R6995:Dst	UTSW	1	34166234	missense	probably damaging	1.00
R7038:Dst	UTSW	1	34182798	nonsense	probably null
R7043:Dst	UTSW	1	34257911	missense	probably damaging	0.99
R7070:Dst	UTSW	1	34275302	missense	probably damaging	1.00
R7097:Dst	UTSW	1	34169260	missense	probably damaging	1.00
R7139:Dst	UTSW	1	34299807	missense	probably damaging	0.97
R7144:Dst	UTSW	1	34152243	missense	probably damaging	1.00
R7145:Dst	UTSW	1	34189882	missense	probably benign
R7158:Dst	UTSW	1	34274285	missense	probably benign
R7207:Dst	UTSW	1	34163337	missense	probably damaging	0.98
R7320:Dst	UTSW	1	34191094	missense	probably benign
R7324:Dst	UTSW	1	34006224	missense	possibly damaging	0.93
R7327:Dst	UTSW	1	34201405	missense	probably damaging	1.00
R7340:Dst	UTSW	1	34190729	missense	probably benign	0.01
R7358:Dst	UTSW	1	34191673	missense	probably benign
R7373:Dst	UTSW	1	34188391	missense	probably benign	0.02
R7376:Dst	UTSW	1	34192689	missense	probably benign
R7453:Dst	UTSW	1	34191358	missense	possibly damaging	0.95
R7467:Dst	UTSW	1	34191155	missense	probably benign	0.00
R7471:Dst	UTSW	1	34194570	missense	possibly damaging	0.49
R7472:Dst	UTSW	1	34218497	missense	probably benign	0.02
R7485:Dst	UTSW	1	34274189	missense	probably benign	0.31
R7504:Dst	UTSW	1	34201017	missense	probably damaging	1.00
R7516:Dst	UTSW	1	34170479	missense	probably benign	0.10
R7524:Dst	UTSW	1	34291893	missense	possibly damaging	0.94
R7528:Dst	UTSW	1	34294522	missense	probably damaging	1.00
R7560:Dst	UTSW	1	34182451	missense	possibly damaging	0.92
R7582:Dst	UTSW	1	34169883	missense	probably damaging	1.00
R7585:Dst	UTSW	1	34114015	missense	possibly damaging	0.50
R7594:Dst	UTSW	1	34213013	missense	probably damaging	1.00
R7600:Dst	UTSW	1	34266930	missense	probably damaging	1.00
R7619:Dst	UTSW	1	34199428	missense	probably benign	0.02
R7623:Dst	UTSW	1	34170436	missense	probably damaging	0.99
R7649:Dst	UTSW	1	34167697	missense	probably benign	0.13
R7654:Dst	UTSW	1	34228977	missense	probably damaging	1.00
R7654:Dst	UTSW	1	34228978	missense	probably damaging	1.00
R7661:Dst	UTSW	1	34256353	critical splice donor site	probably null
R7667:Dst	UTSW	1	34179035	missense	possibly damaging	0.82
R7677:Dst	UTSW	1	34169322	critical splice donor site	probably null
R7698:Dst	UTSW	1	34190387	missense	probably benign	0.02
R7765:Dst	UTSW	1	34275694	missense	probably damaging	0.97
R7772:Dst	UTSW	1	34181388	missense	possibly damaging	0.90
R7779:Dst	UTSW	1	34194597	missense	probably damaging	0.99
R7791:Dst	UTSW	1	34154592	missense	probably damaging	0.99
R7821:Dst	UTSW	1	34275362	critical splice donor site	probably null
R7834:Dst	UTSW	1	34194105	missense	probably benign	0.22
R7935:Dst	UTSW	1	34290405	missense	probably damaging	1.00
R7940:Dst	UTSW	1	34167676	missense	possibly damaging	0.94
R7951:Dst	UTSW	1	34201186	missense	probably benign
R7956:Dst	UTSW	1	34225618	missense	probably damaging	1.00
R7970:Dst	UTSW	1	34182747	missense	possibly damaging	0.80
R7982:Dst	UTSW	1	34182540	missense	possibly damaging	0.89
R8048:Dst	UTSW	1	34190636	missense	probably benign	0.00
R8052:Dst	UTSW	1	34284363	missense	probably damaging	1.00
R8094:Dst	UTSW	1	34188959	missense	possibly damaging	0.76
R8116:Dst	UTSW	1	34274180	missense	probably benign	0.27
R8127:Dst	UTSW	1	34178229	missense	probably damaging	1.00
R8139:Dst	UTSW	1	34191852	missense	probably benign
R8205:Dst	UTSW	1	34214604	missense	probably damaging	1.00
R8211:Dst	UTSW	1	34212451	missense	probably damaging	1.00
R8237:Dst	UTSW	1	34169793	missense	possibly damaging	0.96
R8265:Dst	UTSW	1	34178522	missense	probably benign	0.13
R8309:Dst	UTSW	1	34117511	missense	probably damaging	1.00
R8315:Dst	UTSW	1	34284420	critical splice donor site	probably null
R8469:Dst	UTSW	1	34229028	missense	probably damaging	1.00
R8474:Dst	UTSW	1	34169185	missense	probably damaging	1.00
R8502:Dst	UTSW	1	34167292	missense	probably damaging	1.00
R8534:Dst	UTSW	1	34190307	missense	probably benign	0.12
R8535:Dst	UTSW	1	34186001	missense	probably damaging	1.00
R8536:Dst	UTSW	1	34197246	missense	possibly damaging	0.64
R8542:Dst	UTSW	1	34192607	missense	possibly damaging	0.61
R8560:Dst	UTSW	1	34268889	missense	probably damaging	1.00
R8737:Dst	UTSW	1	34228669	missense	probably benign	0.00
R8742:Dst	UTSW	1	34212344	missense	probably benign	0.01
R8882:Dst	UTSW	1	34200924	missense	probably damaging	1.00
R8894:Dst	UTSW	1	34174133	missense	possibly damaging	0.96
R8973:Dst	UTSW	1	34228855	missense	probably damaging	1.00
R8977:Dst	UTSW	1	34247783	missense	probably damaging	0.99
R8985:Dst	UTSW	1	34249805	missense	probably benign	0.00
R9001:Dst	UTSW	1	34174211	missense	possibly damaging	0.63
R9005:Dst	UTSW	1	34228693	missense	probably damaging	0.99
R9013:Dst	UTSW	1	34178084	missense	possibly damaging	0.46
R9015:Dst	UTSW	1	34287256	missense	probably benign	0.00
R9018:Dst	UTSW	1	34196059	missense	probably damaging	0.97
R9023:Dst	UTSW	1	34114024	critical splice donor site	probably null
R9025:Dst	UTSW	1	34188504	missense	possibly damaging	0.73
R9052:Dst	UTSW	1	34166964	missense	probably damaging	1.00
R9052:Dst	UTSW	1	34197330	nonsense	probably null
R9147:Dst	UTSW	1	34189068	missense	probably damaging	0.99
R9169:Dst	UTSW	1	34264571	missense	probably damaging	1.00
R9181:Dst	UTSW	1	34192737	missense	probably benign
R9224:Dst	UTSW	1	34291798	missense	probably damaging	1.00
R9245:Dst	UTSW	1	34189862	missense	probably benign
R9267:Dst	UTSW	1	34193064	missense	probably benign
R9302:Dst	UTSW	1	34225555	missense	probably damaging	1.00
R9344:Dst	UTSW	1	34181595	missense	probably damaging	0.99
R9363:Dst	UTSW	1	34195979	missense	probably damaging	1.00
R9441:Dst	UTSW	1	34199351	missense	probably damaging	1.00
R9477:Dst	UTSW	1	34166211	missense	probably damaging	1.00
R9501:Dst	UTSW	1	34188768	missense	probably damaging	0.98
R9509:Dst	UTSW	1	33908384	missense	possibly damaging	0.72
R9572:Dst	UTSW	1	34211171	missense	probably damaging	1.00
R9598:Dst	UTSW	1	34113933	missense	possibly damaging	0.79
R9651:Dst	UTSW	1	34180377	missense	probably benign	0.39
R9652:Dst	UTSW	1	34180377	missense	probably benign	0.39
R9664:Dst	UTSW	1	34181655	missense	probably benign	0.33
R9666:Dst	UTSW	1	34179866	nonsense	probably null
R9707:Dst	UTSW	1	34189853	missense	probably benign	0.28
R9721:Dst	UTSW	1	34192785	missense	probably benign
R9727:Dst	UTSW	1	34275796	missense	probably damaging	1.00
R9781:Dst	UTSW	1	34178994	missense	probably benign
R9787:Dst	UTSW	1	34180443	missense	probably benign	0.02
RF014:Dst	UTSW	1	34247679	missense	probably benign	0.00
X0026:Dst	UTSW	1	34213055	missense	probably damaging	0.97
X0028:Dst	UTSW	1	34192199	missense	probably damaging	1.00
X0063:Dst	UTSW	1	34195895	missense	probably damaging	1.00
X0066:Dst	UTSW	1	34275703	nonsense	probably null
Z1176:Dst	UTSW	1	34165143	missense	probably benign	0.00
Z1176:Dst	UTSW	1	34188467	nonsense	probably null
Z1176:Dst	UTSW	1	34244445	missense	probably benign	0.02
Z1176:Dst	UTSW	1	34275208	missense	probably damaging	1.00
Z1177:Dst	UTSW	1	34181232	missense	probably benign	0.15
Z1177:Dst	UTSW	1	34194518	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GGCACCTGGCATTCTGATGAGATG -3'
(R):5'- TGGCCTAGCTGTGAACGGTAAAC -3'

Sequencing Primer
(F):5'- GCATTCTGATGAGATGCAGAGAC -3'
(R):5'- gagagagagagagagagagagag -3'

Posted On

2013-07-11