Incidental Mutation 'R7745:Nedd1'
ID 596805
Institutional Source Beutler Lab
Gene Symbol Nedd1
Ensembl Gene ENSMUSG00000019988
Gene Name neural precursor cell expressed, developmentally down-regulated gene 1
Synonyms
MMRRC Submission 045801-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R7745 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 92684746-92722420 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 92714172 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 84 (D84N)
Ref Sequence ENSEMBL: ENSMUSP00000020163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020163] [ENSMUST00000216086]
AlphaFold P33215
Predicted Effect probably benign
Transcript: ENSMUST00000020163
AA Change: D84N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000020163
Gene: ENSMUSG00000019988
AA Change: D84N

DomainStartEndE-ValueType
WD40 21 63 5.97e-1 SMART
WD40 67 105 9.75e-3 SMART
WD40 108 147 6.19e-5 SMART
WD40 149 191 6.42e-1 SMART
WD40 194 235 9.1e-3 SMART
WD40 238 276 2.24e-2 SMART
low complexity region 555 568 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000216086
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (55/57)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac A C 3: 60,038,472 (GRCm38) S188R probably damaging Het
Aars T A 8: 111,041,657 (GRCm38) I220N probably damaging Het
Abca15 A G 7: 120,332,217 (GRCm38) N16S probably damaging Het
Adck1 A T 12: 88,456,800 (GRCm38) M358L probably benign Het
Adck5 A T 15: 76,594,548 (GRCm38) Q345L probably benign Het
Adgrl2 A G 3: 148,836,458 (GRCm38) F876S probably damaging Het
Aebp2 T A 6: 140,623,858 (GRCm38) L55Q unknown Het
Ampd2 C A 3: 108,080,116 (GRCm38) V134L probably benign Het
Aox3 T C 1: 58,176,517 (GRCm38) V1036A possibly damaging Het
Aox4 A G 1: 58,240,707 (GRCm38) D494G probably benign Het
Cacna1a C A 8: 84,559,394 (GRCm38) H889Q probably benign Het
Cacna1c T C 6: 119,052,626 (GRCm38) D151G Het
Car8 A G 4: 8,237,939 (GRCm38) V92A possibly damaging Het
Ccdc8 G T 7: 16,995,689 (GRCm38) A368S unknown Het
Ccng2 C G 5: 93,273,343 (GRCm38) S237R probably benign Het
Cfap57 C T 4: 118,614,931 (GRCm38) V84I probably benign Het
Cntnap5a A G 1: 116,442,283 (GRCm38) I877V probably benign Het
Copa A T 1: 172,111,942 (GRCm38) D582V probably damaging Het
Cpne2 T G 8: 94,568,684 (GRCm38) S466A probably damaging Het
Crybg2 A G 4: 134,088,845 (GRCm38) K1311R possibly damaging Het
Csmd1 A G 8: 15,932,461 (GRCm38) probably null Het
Dnah2 A T 11: 69,451,318 (GRCm38) C2947* probably null Het
Exoc1 A T 5: 76,561,512 (GRCm38) K656* probably null Het
Exoc8 T C 8: 124,895,819 (GRCm38) N603S probably benign Het
Fam171a1 T A 2: 3,225,446 (GRCm38) C539S possibly damaging Het
Fastkd5 A T 2: 130,615,068 (GRCm38) I534K probably damaging Het
Fbn1 T C 2: 125,303,195 (GRCm38) D2708G probably benign Het
Fhad1 A G 4: 141,890,939 (GRCm38) L1392P probably benign Het
Fras1 A T 5: 96,726,895 (GRCm38) T2306S probably benign Het
Gdf7 G T 12: 8,301,854 (GRCm38) A27E unknown Het
Hnrnph1 A T 11: 50,379,497 (GRCm38) I43F probably damaging Het
Igkv8-27 T A 6: 70,172,015 (GRCm38) S52C probably benign Het
Jmjd1c T C 10: 67,217,045 (GRCm38) F24L probably damaging Het
Knl1 T G 2: 119,071,556 (GRCm38) L1246R probably benign Het
Limk2 C T 11: 3,355,896 (GRCm38) S191N probably damaging Het
Mdga2 G A 12: 66,689,350 (GRCm38) A368V probably damaging Het
Mdga2 C A 12: 66,689,351 (GRCm38) A368S possibly damaging Het
Med24 A T 11: 98,704,967 (GRCm38) L966Q probably damaging Het
Mgll T C 6: 88,725,788 (GRCm38) V23A possibly damaging Het
Obscn A C 11: 59,060,855 (GRCm38) L4024R probably damaging Het
Olfr172 A T 16: 58,760,419 (GRCm38) Y252* probably null Het
Pcnx2 T C 8: 125,851,107 (GRCm38) I944V probably benign Het
Pecr T C 1: 72,266,998 (GRCm38) probably null Het
Phf3 A T 1: 30,804,224 (GRCm38) W1885R probably damaging Het
Pitpnm2 C G 5: 124,128,705 (GRCm38) A697P probably benign Het
Piwil2 T A 14: 70,394,189 (GRCm38) H602L probably benign Het
Pprc1 T C 19: 46,065,342 (GRCm38) S1104P unknown Het
Prkar1a T A 11: 109,653,847 (GRCm38) Y21* probably null Het
Prl2c3 A T 13: 12,798,297 (GRCm38) Y9* probably null Het
Rhbdl3 T A 11: 80,323,579 (GRCm38) L172Q possibly damaging Het
Rsph3a T G 17: 7,979,243 (GRCm38) L484W probably damaging Het
Sbno1 A T 5: 124,392,899 (GRCm38) S809T probably benign Het
Stmnd1 T A 13: 46,299,601 (GRCm38) V251E possibly damaging Het
Stt3a A T 9: 36,751,239 (GRCm38) C241* probably null Het
Tas2r114 A T 6: 131,689,438 (GRCm38) M209K probably damaging Het
Tchh G T 3: 93,444,777 (GRCm38) R508L unknown Het
Tgfbr3l T C 8: 4,250,622 (GRCm38) S267P possibly damaging Het
Ttn T A 2: 76,767,800 (GRCm38) I19590F probably damaging Het
Vmn1r171 A G 7: 23,632,610 (GRCm38) T87A probably benign Het
Other mutations in Nedd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00764:Nedd1 APN 10 92,694,974 (GRCm38) splice site probably benign
IGL00988:Nedd1 APN 10 92,689,686 (GRCm38) missense possibly damaging 0.71
IGL01563:Nedd1 APN 10 92,698,169 (GRCm38) critical splice donor site probably null
IGL01588:Nedd1 APN 10 92,686,262 (GRCm38) missense probably benign 0.12
IGL01988:Nedd1 APN 10 92,714,159 (GRCm38) missense probably benign 0.39
IGL02706:Nedd1 APN 10 92,686,285 (GRCm38) missense possibly damaging 0.88
IGL02938:Nedd1 APN 10 92,689,657 (GRCm38) nonsense probably null
IGL03011:Nedd1 APN 10 92,689,641 (GRCm38) missense possibly damaging 0.92
Brainless UTSW 10 92,690,773 (GRCm38) missense probably benign 0.01
R0125:Nedd1 UTSW 10 92,691,929 (GRCm38) missense possibly damaging 0.93
R0173:Nedd1 UTSW 10 92,698,883 (GRCm38) missense probably benign 0.30
R0244:Nedd1 UTSW 10 92,716,265 (GRCm38) intron probably benign
R0645:Nedd1 UTSW 10 92,691,831 (GRCm38) splice site probably null
R0791:Nedd1 UTSW 10 92,719,614 (GRCm38) missense probably damaging 1.00
R1490:Nedd1 UTSW 10 92,700,798 (GRCm38) missense probably damaging 1.00
R1522:Nedd1 UTSW 10 92,719,614 (GRCm38) missense probably damaging 1.00
R1797:Nedd1 UTSW 10 92,698,739 (GRCm38) missense possibly damaging 0.46
R1984:Nedd1 UTSW 10 92,714,160 (GRCm38) missense possibly damaging 0.63
R2474:Nedd1 UTSW 10 92,719,603 (GRCm38) missense probably damaging 0.99
R2877:Nedd1 UTSW 10 92,714,126 (GRCm38) missense possibly damaging 0.89
R2883:Nedd1 UTSW 10 92,694,998 (GRCm38) missense probably damaging 0.98
R4694:Nedd1 UTSW 10 92,719,582 (GRCm38) missense probably benign 0.00
R4798:Nedd1 UTSW 10 92,698,910 (GRCm38) missense probably benign 0.00
R4830:Nedd1 UTSW 10 92,686,258 (GRCm38) missense probably damaging 1.00
R4963:Nedd1 UTSW 10 92,695,031 (GRCm38) missense probably damaging 1.00
R5174:Nedd1 UTSW 10 92,711,212 (GRCm38) missense possibly damaging 0.77
R5329:Nedd1 UTSW 10 92,686,240 (GRCm38) missense probably damaging 1.00
R5404:Nedd1 UTSW 10 92,716,192 (GRCm38) missense probably benign 0.04
R5534:Nedd1 UTSW 10 92,695,032 (GRCm38) missense probably benign 0.01
R6045:Nedd1 UTSW 10 92,695,100 (GRCm38) nonsense probably null
R6154:Nedd1 UTSW 10 92,698,242 (GRCm38) missense possibly damaging 0.65
R6512:Nedd1 UTSW 10 92,691,875 (GRCm38) missense probably benign
R6692:Nedd1 UTSW 10 92,698,337 (GRCm38) missense possibly damaging 0.88
R6693:Nedd1 UTSW 10 92,698,337 (GRCm38) missense possibly damaging 0.88
R6943:Nedd1 UTSW 10 92,711,306 (GRCm38) missense probably damaging 1.00
R7011:Nedd1 UTSW 10 92,690,773 (GRCm38) missense probably benign 0.01
R7406:Nedd1 UTSW 10 92,711,323 (GRCm38) splice site probably null
R7455:Nedd1 UTSW 10 92,700,925 (GRCm38) missense probably benign 0.01
R7587:Nedd1 UTSW 10 92,698,730 (GRCm38) missense probably benign 0.01
R8104:Nedd1 UTSW 10 92,691,916 (GRCm38) missense probably damaging 1.00
R8209:Nedd1 UTSW 10 92,691,935 (GRCm38) missense probably benign
R8226:Nedd1 UTSW 10 92,691,935 (GRCm38) missense probably benign
R8925:Nedd1 UTSW 10 92,722,396 (GRCm38) start gained probably benign
R8927:Nedd1 UTSW 10 92,722,396 (GRCm38) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CACTTTGACGCTAAAGCATCC -3'
(R):5'- TTATACCTGTGACAGCTGGC -3'

Sequencing Primer
(F):5'- CATCCAATATCGAGGACAAGGTTTG -3'
(R):5'- CTGTGACAGCTGGCATCCAATATATC -3'
Posted On 2019-11-26