Mutagenetix > Incidental Mutations

Incidental Mutation 'R7749:Olfr1156'

597072

Institutional Source

Beutler Lab

Gene Symbol

Olfr1156

Ensembl Gene

ENSMUSG00000075144

Gene Name

olfactory receptor 1156

Synonyms

MOR174-3, GA_x6K02T2Q125-49433499-49432537

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R7749 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87947053-87953100 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 87949478 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 252 (H252Y)

Ref Sequence

ENSEMBL: ENSMUSP00000149665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099842] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]

AlphaFold

A2AVC3

Predicted Effect

probably damaging
Transcript: ENSMUST00000099842
AA Change: H252Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097430
Gene: ENSMUSG00000075144
AA Change: H252Y

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.2e-47	PFAM
Pfam:7tm_1	41	290	1.4e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215903

Predicted Effect

probably damaging
Transcript: ENSMUST00000216191
AA Change: H252Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000216726
AA Change: H252Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

99% (66/67)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933406M09Rik	A	T	1: 134,390,512	M341L	probably benign	Het
Actr1a	A	T	19: 46,379,747	S254T	probably benign	Het
Adam12	G	A	7: 134,224,813	A22V	unknown	Het
Adarb2	A	G	13: 8,569,739	D87G	possibly damaging	Het
Aldh6a1	A	T	12: 84,442,081	I59N	probably benign	Het
Ankrd50	C	T	3: 38,482,721	C161Y	probably damaging	Het
Ankrd7	A	G	6: 18,879,516		probably null	Het
Anks1	T	A	17: 28,038,141	I707N	probably damaging	Het
Atoh1	A	T	6: 64,729,920	M200L	possibly damaging	Het
Bmp1	C	T	14: 70,492,844	R416H	probably damaging	Het
Caprin1	A	G	2: 103,771,754	S548P	probably benign	Het
Ccdc167	T	A	17: 29,705,273	Y63F	possibly damaging	Het
Cfap99	T	A	5: 34,307,940	D174E	probably benign	Het
Chil3	T	G	3: 106,148,845	N331T	probably benign	Het
Chmp5	T	A	4: 40,949,488	I35N	probably damaging	Het
Cpt1c	A	T	7: 44,962,265	S537T	probably benign	Het
Dctn1	A	T	6: 83,186,141		probably benign	Het
Dhx57	T	A	17: 80,238,858	M1366L	probably benign	Het
Dnah9	T	A	11: 65,911,830	Y3478F	probably damaging	Het
Efna3	A	G	3: 89,316,640	Y81H	probably damaging	Het
Eif4enif1	T	C	11: 3,242,608	V812A	probably damaging	Het
Erg	A	T	16: 95,377,357	I237N	probably benign	Het
Fem1c	G	T	18: 46,524,118	N176K	probably damaging	Het
Fgd4	T	C	16: 16,475,154	Y233C	probably benign	Het
Foxd2	G	A	4: 114,907,812	A337V	unknown	Het
Gsdma2	T	C	11: 98,657,721	L433P	unknown	Het
Hmcn2	C	A	2: 31,453,033		probably null	Het
Hnrnpul2	T	C	19: 8,820,424	V48A	probably benign	Het
Hsf1	T	A	15: 76,499,187	S396T	probably benign	Het
Htr5b	G	T	1: 121,527,758	N144K	probably damaging	Het
Igkv9-120	T	C	6: 68,050,188	S29P	probably damaging	Het
Igsf10	T	A	3: 59,329,128	N1211Y	possibly damaging	Het
Kcnh1	A	C	1: 192,277,139	I334L	probably benign	Het
Laptm4b	T	C	15: 34,276,200	I158T	probably benign	Het
Muc5ac	G	C	7: 141,809,303	G2117A	unknown	Het
Nav3	T	C	10: 109,703,352	T2063A	probably damaging	Het
Nceh1	T	A	3: 27,207,382	D47E	probably benign	Het
Nckap5	A	G	1: 126,024,646	S1390P	probably damaging	Het
Npepps	T	G	11: 97,267,628	I104L	probably benign	Het
Numb	A	G	12: 83,801,277	S229P	not run	Het
Olfr1342	T	C	4: 118,690,228	S75G	probably damaging	Het
Olfr1443	A	T	19: 12,680,212	I35F	probably benign	Het
Opn1sw	T	A	6: 29,380,169	I83F	probably benign	Het
Pigg	T	G	5: 108,336,296	C603G	probably benign	Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 109,624,195		probably benign	Het
Pkhd1l1	C	A	15: 44,527,737	H1504N	probably benign	Het
Plcd4	A	G	1: 74,565,133	N757D	possibly damaging	Het
Ppia	A	G	11: 6,419,569	T152A	probably benign	Het
Psmd8	G	A	7: 29,178,921		probably null	Het
Pxn	T	A	5: 115,548,516	Y356N	probably benign	Het
Rhoa	G	C	9: 108,336,715	C159S	probably damaging	Het
Rictor	C	T	15: 6,772,154	S441L	probably benign	Het
Rita1	C	T	5: 120,611,441	C69Y	probably benign	Het
Satb1	A	G	17: 51,767,933	S512P	possibly damaging	Het
Sectm1b	A	G	11: 121,054,942	I191T	possibly damaging	Het
Slc22a6	A	G	19: 8,621,896	K297R	possibly damaging	Het
Snrnp48	T	C	13: 38,221,287	Y287H	probably benign	Het
Sntg2	A	T	12: 30,226,911	C381S	probably benign	Het
Syngap1	T	A	17: 26,959,964	M649K	probably damaging	Het
Taf4	G	A	2: 179,932,029	T682M	probably damaging	Het
Thap2	T	C	10: 115,376,384	I79V	probably damaging	Het
Thap7	T	C	16: 17,528,603	N172S	probably benign	Het
Ticrr	A	G	7: 79,679,096	Y661C	possibly damaging	Het
Ttn	T	C	2: 76,776,315	N18084D	probably damaging	Het
Usp48	A	T	4: 137,650,417	K1020M	probably damaging	Het
Vmn2r12	T	C	5: 109,086,054	N764S	probably damaging	Het
Vmn2r91	A	G	17: 18,136,278	I736V	possibly damaging	Het
Wfdc6b	T	A	2: 164,617,419	C134S	probably damaging	Het
Zcchc2	A	T	1: 106,018,273	D481V	probably damaging	Het
Zfp949	G	A	9: 88,569,870	G498R	probably damaging	Het

Other mutations in Olfr1156

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Olfr1156	APN	2	87949863	missense	probably damaging	0.99
IGL02831:Olfr1156	APN	2	87949676	splice site	probably null
IGL03214:Olfr1156	APN	2	87950071	missense	probably benign	0.16
R0285:Olfr1156	UTSW	2	87950131	missense	probably damaging	0.98
R0926:Olfr1156	UTSW	2	87949922	missense	probably damaging	1.00
R0987:Olfr1156	UTSW	2	87949547	missense	probably benign	0.12
R1422:Olfr1156	UTSW	2	87950095	missense	probably benign	0.00
R1958:Olfr1156	UTSW	2	87949465	missense	probably damaging	1.00
R2239:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R2380:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R3872:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3873:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3874:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R4526:Olfr1156	UTSW	2	87949409	missense	probably benign	0.09
R5116:Olfr1156	UTSW	2	87949529	missense	probably benign	0.03
R5985:Olfr1156	UTSW	2	87949321	missense	probably benign	0.02
R5999:Olfr1156	UTSW	2	87949801	splice site	probably null
R6127:Olfr1156	UTSW	2	87949361	missense	probably damaging	1.00
R6259:Olfr1156	UTSW	2	87949435	missense	probably benign	0.20
R6544:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6556:Olfr1156	UTSW	2	87949976	missense	probably benign	0.00
R6715:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6951:Olfr1156	UTSW	2	87949979	missense	possibly damaging	0.79
R7062:Olfr1156	UTSW	2	87950224	missense	probably benign	0.01
R7142:Olfr1156	UTSW	2	87949712	missense	probably benign	0.09
R7887:Olfr1156	UTSW	2	87949880	missense	probably damaging	1.00
R8222:Olfr1156	UTSW	2	87949444	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGGTCTTCACTATGAAACCCTAAG -3'
(R):5'- GCTTGCTCTGATGTTAGTACAAATG -3'

Sequencing Primer
(F):5'- GCATGGGAATGATCACAG -3'
(R):5'- GTACAAATGAGTTTTTCCTGTTCATC -3'

Posted On

2019-11-26