Incidental Mutation 'R7749:Vmn2r91'
ID |
597120 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r91
|
Ensembl Gene |
ENSMUSG00000091206 |
Gene Name |
vomeronasal 2, receptor 91 |
Synonyms |
EG665210 |
MMRRC Submission |
045805-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.065)
|
Stock # |
R7749 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 18356540 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 736
(I736V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
AlphaFold |
E9Q2U5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000172359
AA Change: I736V
PolyPhen 2
Score 0.750 (Sensitivity: 0.85; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000127465 Gene: ENSMUSG00000091206 AA Change: I736V
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
Validation Efficiency |
99% (66/67) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actr1a |
A |
T |
19: 46,368,186 (GRCm39) |
S254T |
probably benign |
Het |
Adam12 |
G |
A |
7: 133,826,542 (GRCm39) |
A22V |
unknown |
Het |
Adarb2 |
A |
G |
13: 8,619,775 (GRCm39) |
D87G |
possibly damaging |
Het |
Aldh6a1 |
A |
T |
12: 84,488,855 (GRCm39) |
I59N |
probably benign |
Het |
Ankrd50 |
C |
T |
3: 38,536,870 (GRCm39) |
C161Y |
probably damaging |
Het |
Ankrd7 |
A |
G |
6: 18,879,515 (GRCm39) |
|
probably null |
Het |
Anks1 |
T |
A |
17: 28,257,115 (GRCm39) |
I707N |
probably damaging |
Het |
Atoh1 |
A |
T |
6: 64,706,904 (GRCm39) |
M200L |
possibly damaging |
Het |
Bmp1 |
C |
T |
14: 70,730,284 (GRCm39) |
R416H |
probably damaging |
Het |
Caprin1 |
A |
G |
2: 103,602,099 (GRCm39) |
S548P |
probably benign |
Het |
Ccdc167 |
T |
A |
17: 29,924,247 (GRCm39) |
Y63F |
possibly damaging |
Het |
Cfap99 |
T |
A |
5: 34,465,284 (GRCm39) |
D174E |
probably benign |
Het |
Chil3 |
T |
G |
3: 106,056,161 (GRCm39) |
N331T |
probably benign |
Het |
Chmp5 |
T |
A |
4: 40,949,488 (GRCm39) |
I35N |
probably damaging |
Het |
Cpt1c |
A |
T |
7: 44,611,689 (GRCm39) |
S537T |
probably benign |
Het |
Dctn1 |
A |
T |
6: 83,163,123 (GRCm39) |
|
probably benign |
Het |
Dhx57 |
T |
A |
17: 80,546,287 (GRCm39) |
M1366L |
probably benign |
Het |
Dnah9 |
T |
A |
11: 65,802,656 (GRCm39) |
Y3478F |
probably damaging |
Het |
Efna3 |
A |
G |
3: 89,223,947 (GRCm39) |
Y81H |
probably damaging |
Het |
Eif4enif1 |
T |
C |
11: 3,192,608 (GRCm39) |
V812A |
probably damaging |
Het |
Erg |
A |
T |
16: 95,178,216 (GRCm39) |
I237N |
probably benign |
Het |
Fem1c |
G |
T |
18: 46,657,185 (GRCm39) |
N176K |
probably damaging |
Het |
Fgd4 |
T |
C |
16: 16,293,018 (GRCm39) |
Y233C |
probably benign |
Het |
Foxd2 |
G |
A |
4: 114,765,009 (GRCm39) |
A337V |
unknown |
Het |
Gsdma2 |
T |
C |
11: 98,548,547 (GRCm39) |
L433P |
unknown |
Het |
Hmcn2 |
C |
A |
2: 31,343,045 (GRCm39) |
|
probably null |
Het |
Hnrnpul2 |
T |
C |
19: 8,797,788 (GRCm39) |
V48A |
probably benign |
Het |
Hsf1 |
T |
A |
15: 76,383,387 (GRCm39) |
S396T |
probably benign |
Het |
Htr5b |
G |
T |
1: 121,455,487 (GRCm39) |
N144K |
probably damaging |
Het |
Igkv9-120 |
T |
C |
6: 68,027,172 (GRCm39) |
S29P |
probably damaging |
Het |
Igsf10 |
T |
A |
3: 59,236,549 (GRCm39) |
N1211Y |
possibly damaging |
Het |
Kcnh1 |
A |
C |
1: 191,959,447 (GRCm39) |
I334L |
probably benign |
Het |
Laptm4b |
T |
C |
15: 34,276,346 (GRCm39) |
I158T |
probably benign |
Het |
Mgat4f |
A |
T |
1: 134,318,250 (GRCm39) |
M341L |
probably benign |
Het |
Muc5ac |
G |
C |
7: 141,363,040 (GRCm39) |
G2117A |
unknown |
Het |
Nav3 |
T |
C |
10: 109,539,213 (GRCm39) |
T2063A |
probably damaging |
Het |
Nceh1 |
T |
A |
3: 27,261,531 (GRCm39) |
D47E |
probably benign |
Het |
Nckap5 |
A |
G |
1: 125,952,383 (GRCm39) |
S1390P |
probably damaging |
Het |
Npepps |
T |
G |
11: 97,158,454 (GRCm39) |
I104L |
probably benign |
Het |
Numb |
A |
G |
12: 83,848,051 (GRCm39) |
S229P |
not run |
Het |
Opn1sw |
T |
A |
6: 29,380,168 (GRCm39) |
I83F |
probably benign |
Het |
Or13p4 |
T |
C |
4: 118,547,425 (GRCm39) |
S75G |
probably damaging |
Het |
Or5b95 |
A |
T |
19: 12,657,576 (GRCm39) |
I35F |
probably benign |
Het |
Or5l13 |
G |
A |
2: 87,779,822 (GRCm39) |
H252Y |
probably damaging |
Het |
Pigg |
T |
G |
5: 108,484,162 (GRCm39) |
C603G |
probably benign |
Het |
Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
Pkhd1l1 |
C |
A |
15: 44,391,133 (GRCm39) |
H1504N |
probably benign |
Het |
Plcd4 |
A |
G |
1: 74,604,292 (GRCm39) |
N757D |
possibly damaging |
Het |
Ppia |
A |
G |
11: 6,369,569 (GRCm39) |
T152A |
probably benign |
Het |
Psmd8 |
G |
A |
7: 28,878,346 (GRCm39) |
|
probably null |
Het |
Pxn |
T |
A |
5: 115,686,575 (GRCm39) |
Y356N |
probably benign |
Het |
Rhoa |
G |
C |
9: 108,213,914 (GRCm39) |
C159S |
probably damaging |
Het |
Rictor |
C |
T |
15: 6,801,635 (GRCm39) |
S441L |
probably benign |
Het |
Rita1 |
C |
T |
5: 120,749,506 (GRCm39) |
C69Y |
probably benign |
Het |
Satb1 |
A |
G |
17: 52,074,961 (GRCm39) |
S512P |
possibly damaging |
Het |
Sectm1b |
A |
G |
11: 120,945,768 (GRCm39) |
I191T |
possibly damaging |
Het |
Slc22a6 |
A |
G |
19: 8,599,260 (GRCm39) |
K297R |
possibly damaging |
Het |
Snrnp48 |
T |
C |
13: 38,405,263 (GRCm39) |
Y287H |
probably benign |
Het |
Sntg2 |
A |
T |
12: 30,276,910 (GRCm39) |
C381S |
probably benign |
Het |
Syngap1 |
T |
A |
17: 27,178,938 (GRCm39) |
M649K |
probably damaging |
Het |
Taf4 |
G |
A |
2: 179,573,822 (GRCm39) |
T682M |
probably damaging |
Het |
Thap2 |
T |
C |
10: 115,212,289 (GRCm39) |
I79V |
probably damaging |
Het |
Thap7 |
T |
C |
16: 17,346,467 (GRCm39) |
N172S |
probably benign |
Het |
Ticrr |
A |
G |
7: 79,328,844 (GRCm39) |
Y661C |
possibly damaging |
Het |
Ttn |
T |
C |
2: 76,606,659 (GRCm39) |
N18084D |
probably damaging |
Het |
Usp48 |
A |
T |
4: 137,377,728 (GRCm39) |
K1020M |
probably damaging |
Het |
Vmn2r12 |
T |
C |
5: 109,233,920 (GRCm39) |
N764S |
probably damaging |
Het |
Wfdc6b |
T |
A |
2: 164,459,339 (GRCm39) |
C134S |
probably damaging |
Het |
Zcchc2 |
A |
T |
1: 105,946,003 (GRCm39) |
D481V |
probably damaging |
Het |
Zfp949 |
G |
A |
9: 88,451,923 (GRCm39) |
G498R |
probably damaging |
Het |
|
Other mutations in Vmn2r91 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
R3845:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
R7755:Vmn2r91
|
UTSW |
17 |
18,330,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R8325:Vmn2r91
|
UTSW |
17 |
18,356,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R8781:Vmn2r91
|
UTSW |
17 |
18,305,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
R9109:Vmn2r91
|
UTSW |
17 |
18,327,905 (GRCm39) |
missense |
probably damaging |
1.00 |
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCACTGTGTTGGCCAAAAC -3'
(R):5'- CCCTTTAGTGCTGTGGTAGAC -3'
Sequencing Primer
(F):5'- GTGTTGGCCAAAACTATTACAGTGG -3'
(R):5'- CAGGAAGAAAGGTGACCCAGAC -3'
|
Posted On |
2019-11-26 |