Incidental Mutation 'R7753:Vmn2r72'
| ID |
597364 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r72
|
| Ensembl Gene |
ENSMUSG00000051877 |
| Gene Name |
vomeronasal 2, receptor 72 |
| Synonyms |
EG244114, Vmn2r72-ps |
| MMRRC Submission |
045809-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
R7753 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85386992-85404189 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 85399834 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 405
(A405V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
| AlphaFold |
D3Z4N8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000063425
AA Change: A405V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: A405V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca6 |
T |
C |
11: 110,074,933 (GRCm39) |
T1377A |
probably damaging |
Het |
| AI661453 |
G |
T |
17: 47,778,439 (GRCm39) |
E722* |
probably null |
Het |
| Ap2b1 |
A |
T |
11: 83,258,733 (GRCm39) |
K735* |
probably null |
Het |
| Aqp4 |
T |
C |
18: 15,533,033 (GRCm39) |
E20G |
probably benign |
Het |
| Atp6v1b1 |
G |
T |
6: 83,729,440 (GRCm39) |
V117L |
probably benign |
Het |
| C1rb |
A |
G |
6: 124,557,390 (GRCm39) |
N509S |
probably benign |
Het |
| Cep44 |
A |
G |
8: 56,985,842 (GRCm39) |
V350A |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,234,680 (GRCm39) |
Q136R |
probably benign |
Het |
| Cntrl |
T |
C |
2: 35,001,691 (GRCm39) |
S32P |
probably damaging |
Het |
| Cyp2d12 |
A |
T |
15: 82,441,164 (GRCm39) |
E201V |
possibly damaging |
Het |
| Cyp4a14 |
G |
T |
4: 115,350,861 (GRCm39) |
Q138K |
probably damaging |
Het |
| Dapk1 |
T |
C |
13: 60,899,007 (GRCm39) |
Y826H |
possibly damaging |
Het |
| Dbh |
A |
G |
2: 27,061,448 (GRCm39) |
D294G |
probably benign |
Het |
| Ddx10 |
A |
T |
9: 53,136,904 (GRCm39) |
L336Q |
probably damaging |
Het |
| Dop1a |
A |
G |
9: 86,371,755 (GRCm39) |
T149A |
possibly damaging |
Het |
| Epg5 |
A |
G |
18: 77,991,560 (GRCm39) |
T86A |
possibly damaging |
Het |
| Fam171a1 |
A |
T |
2: 3,179,354 (GRCm39) |
Q60L |
probably damaging |
Het |
| Farsb |
T |
A |
1: 78,456,740 (GRCm39) |
E41D |
probably benign |
Het |
| Frem1 |
T |
C |
4: 82,832,217 (GRCm39) |
D1956G |
probably benign |
Het |
| Fzd4 |
T |
A |
7: 89,056,992 (GRCm39) |
Y346* |
probably null |
Het |
| Fzd7 |
A |
T |
1: 59,522,641 (GRCm39) |
S175C |
probably benign |
Het |
| Gdi2 |
A |
G |
13: 3,598,956 (GRCm39) |
T47A |
probably benign |
Het |
| Gpr155 |
A |
T |
2: 73,212,550 (GRCm39) |
H24Q |
probably benign |
Het |
| Hdac7 |
A |
T |
15: 97,698,642 (GRCm39) |
N638K |
possibly damaging |
Het |
| Hdac7 |
G |
T |
15: 97,704,369 (GRCm39) |
N515K |
probably benign |
Het |
| Hnrnpul2 |
T |
C |
19: 8,802,336 (GRCm39) |
V401A |
probably damaging |
Het |
| Ifi27l2b |
T |
A |
12: 103,417,519 (GRCm39) |
R223* |
probably null |
Het |
| Igkv4-91 |
T |
G |
6: 68,745,761 (GRCm39) |
S46R |
probably benign |
Het |
| Itk |
T |
A |
11: 46,222,722 (GRCm39) |
L582F |
probably damaging |
Het |
| Kcnab2 |
T |
C |
4: 152,481,218 (GRCm39) |
I181V |
probably benign |
Het |
| Krtap5-2 |
GCCACAGCCTCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACCACAGCCTCC |
GCCACAGCCTCC |
7: 141,729,136 (GRCm39) |
|
probably benign |
Het |
| Lce1m |
C |
A |
3: 92,925,815 (GRCm39) |
G41W |
unknown |
Het |
| Mapk10 |
T |
A |
5: 103,186,419 (GRCm39) |
K98* |
probably null |
Het |
| Mapk8ip2 |
A |
G |
15: 89,345,856 (GRCm39) |
E812G |
probably damaging |
Het |
| Mlh1 |
C |
A |
9: 111,081,931 (GRCm39) |
|
probably null |
Het |
| Mroh1 |
A |
G |
15: 76,317,475 (GRCm39) |
D784G |
possibly damaging |
Het |
| Neo1 |
A |
T |
9: 58,863,288 (GRCm39) |
D426E |
probably benign |
Het |
| Nol4 |
T |
A |
18: 23,171,659 (GRCm39) |
M1L |
probably benign |
Het |
| Nr1h3 |
A |
G |
2: 91,015,370 (GRCm39) |
F338S |
probably damaging |
Het |
| Oasl2 |
A |
G |
5: 115,043,118 (GRCm39) |
K297E |
probably benign |
Het |
| Or10ag59 |
A |
G |
2: 87,406,141 (GRCm39) |
T238A |
probably benign |
Het |
| Or10z1 |
C |
T |
1: 174,078,236 (GRCm39) |
V86I |
probably benign |
Het |
| Or4f14 |
A |
G |
2: 111,742,927 (GRCm39) |
I116T |
probably benign |
Het |
| Or56a5 |
T |
C |
7: 104,793,007 (GRCm39) |
I164M |
probably benign |
Het |
| Or5m5 |
A |
G |
2: 85,815,060 (GRCm39) |
N292S |
possibly damaging |
Het |
| Osbpl9 |
T |
C |
4: 108,990,970 (GRCm39) |
T97A |
possibly damaging |
Het |
| P3h2 |
A |
T |
16: 25,789,687 (GRCm39) |
Y527N |
probably damaging |
Het |
| Papss2 |
A |
T |
19: 32,597,579 (GRCm39) |
H9L |
probably benign |
Het |
| Pcdha4 |
C |
A |
18: 37,086,354 (GRCm39) |
S179Y |
possibly damaging |
Het |
| Ppt1 |
A |
T |
4: 122,730,131 (GRCm39) |
D28V |
possibly damaging |
Het |
| Prkcz |
T |
A |
4: 155,357,425 (GRCm39) |
Q345L |
possibly damaging |
Het |
| Prr14l |
G |
T |
5: 32,984,597 (GRCm39) |
L1633I |
probably damaging |
Het |
| Prss51 |
T |
A |
14: 64,333,376 (GRCm39) |
V13D |
possibly damaging |
Het |
| Qrich2 |
TTGCAACACACCAGGCTGAACTGGACCTTGCTG |
TTG |
11: 116,347,868 (GRCm39) |
|
probably benign |
Het |
| Rictor |
C |
T |
15: 6,801,635 (GRCm39) |
S441L |
probably benign |
Het |
| Slc2a7 |
T |
C |
4: 150,239,141 (GRCm39) |
I122T |
possibly damaging |
Het |
| Spata31e4 |
A |
T |
13: 50,855,817 (GRCm39) |
D485V |
probably damaging |
Het |
| Sprr3 |
G |
A |
3: 92,364,415 (GRCm39) |
P143L |
probably benign |
Het |
| Sugct |
A |
T |
13: 17,752,104 (GRCm39) |
S181T |
possibly damaging |
Het |
| Syne2 |
G |
A |
12: 76,085,697 (GRCm39) |
R141Q |
probably benign |
Het |
| Taok1 |
T |
C |
11: 77,428,725 (GRCm39) |
I992V |
probably benign |
Het |
| Tbc1d21 |
A |
C |
9: 58,269,306 (GRCm39) |
|
probably null |
Het |
| Thada |
T |
C |
17: 84,559,818 (GRCm39) |
D1453G |
probably damaging |
Het |
| Thoc5 |
T |
C |
11: 4,852,156 (GRCm39) |
L104S |
probably damaging |
Het |
| Tln2 |
T |
G |
9: 67,302,755 (GRCm39) |
Y72S |
probably damaging |
Het |
| Tmem98 |
A |
G |
11: 80,705,137 (GRCm39) |
E75G |
probably damaging |
Het |
| Tox3 |
A |
G |
8: 90,975,560 (GRCm39) |
L357P |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,197,603 (GRCm39) |
V4492A |
unknown |
Het |
| Ulk4 |
A |
G |
9: 121,095,578 (GRCm39) |
|
probably null |
Het |
| Ush2a |
A |
G |
1: 188,175,603 (GRCm39) |
T1234A |
probably benign |
Het |
| Usp53 |
G |
A |
3: 122,742,887 (GRCm39) |
T683I |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,837,442 (GRCm39) |
I2701F |
probably damaging |
Het |
| Vmn2r96 |
A |
T |
17: 18,806,663 (GRCm39) |
T537S |
possibly damaging |
Het |
| Vstm2a |
G |
T |
11: 16,213,040 (GRCm39) |
A142S |
probably damaging |
Het |
| Zbtb41 |
A |
G |
1: 139,374,895 (GRCm39) |
D785G |
probably benign |
Het |
| Zfp397 |
A |
T |
18: 24,090,129 (GRCm39) |
Q144H |
probably benign |
Het |
| Zfp518a |
A |
T |
19: 40,904,249 (GRCm39) |
T1393S |
possibly damaging |
Het |
|
| Other mutations in Vmn2r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00931:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01019:Vmn2r72
|
APN |
7 |
85,387,542 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01445:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02076:Vmn2r72
|
APN |
7 |
85,387,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02082:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02086:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02089:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02125:Vmn2r72
|
APN |
7 |
85,399,919 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02146:Vmn2r72
|
APN |
7 |
85,387,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02272:Vmn2r72
|
APN |
7 |
85,399,901 (GRCm39) |
missense |
probably benign |
|
|
IGL02514:Vmn2r72
|
APN |
7 |
85,387,907 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02662:Vmn2r72
|
APN |
7 |
85,387,391 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02697:Vmn2r72
|
APN |
7 |
85,387,879 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02733:Vmn2r72
|
APN |
7 |
85,401,021 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03070:Vmn2r72
|
APN |
7 |
85,401,249 (GRCm39) |
splice site |
probably benign |
|
|
IGL03150:Vmn2r72
|
APN |
7 |
85,400,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03159:Vmn2r72
|
APN |
7 |
85,404,162 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03333:Vmn2r72
|
APN |
7 |
85,400,075 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0081:Vmn2r72
|
UTSW |
7 |
85,401,044 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0090:Vmn2r72
|
UTSW |
7 |
85,404,084 (GRCm39) |
missense |
probably benign |
|
|
R0655:Vmn2r72
|
UTSW |
7 |
85,387,319 (GRCm39) |
nonsense |
probably null |
|
|
R0778:Vmn2r72
|
UTSW |
7 |
85,398,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1169:Vmn2r72
|
UTSW |
7 |
85,400,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1172:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1173:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1175:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1248:Vmn2r72
|
UTSW |
7 |
85,398,396 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1302:Vmn2r72
|
UTSW |
7 |
85,387,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1506:Vmn2r72
|
UTSW |
7 |
85,398,419 (GRCm39) |
missense |
probably benign |
|
|
R1632:Vmn2r72
|
UTSW |
7 |
85,401,000 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1775:Vmn2r72
|
UTSW |
7 |
85,387,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r72
|
UTSW |
7 |
85,398,369 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r72
|
UTSW |
7 |
85,387,444 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2290:Vmn2r72
|
UTSW |
7 |
85,387,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Vmn2r72
|
UTSW |
7 |
85,400,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2655:Vmn2r72
|
UTSW |
7 |
85,400,477 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2860:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2861:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2862:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3009:Vmn2r72
|
UTSW |
7 |
85,398,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3798:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3902:Vmn2r72
|
UTSW |
7 |
85,398,943 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R3959:Vmn2r72
|
UTSW |
7 |
85,400,339 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3974:Vmn2r72
|
UTSW |
7 |
85,399,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4399:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4421:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Vmn2r72
|
UTSW |
7 |
85,387,036 (GRCm39) |
nonsense |
probably null |
|
|
R4522:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4523:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4533:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4691:Vmn2r72
|
UTSW |
7 |
85,387,119 (GRCm39) |
nonsense |
probably null |
|
|
R4781:Vmn2r72
|
UTSW |
7 |
85,387,069 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4863:Vmn2r72
|
UTSW |
7 |
85,399,806 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4952:Vmn2r72
|
UTSW |
7 |
85,400,317 (GRCm39) |
missense |
probably benign |
|
|
R4991:Vmn2r72
|
UTSW |
7 |
85,400,338 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4995:Vmn2r72
|
UTSW |
7 |
85,387,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5095:Vmn2r72
|
UTSW |
7 |
85,387,061 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5174:Vmn2r72
|
UTSW |
7 |
85,387,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5276:Vmn2r72
|
UTSW |
7 |
85,387,462 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5395:Vmn2r72
|
UTSW |
7 |
85,400,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5560:Vmn2r72
|
UTSW |
7 |
85,401,150 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5933:Vmn2r72
|
UTSW |
7 |
85,387,058 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6354:Vmn2r72
|
UTSW |
7 |
85,399,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6362:Vmn2r72
|
UTSW |
7 |
85,400,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6594:Vmn2r72
|
UTSW |
7 |
85,398,892 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6794:Vmn2r72
|
UTSW |
7 |
85,387,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7113:Vmn2r72
|
UTSW |
7 |
85,399,011 (GRCm39) |
splice site |
probably null |
|
|
R7189:Vmn2r72
|
UTSW |
7 |
85,404,125 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7266:Vmn2r72
|
UTSW |
7 |
85,387,482 (GRCm39) |
nonsense |
probably null |
|
|
R7323:Vmn2r72
|
UTSW |
7 |
85,399,771 (GRCm39) |
missense |
probably benign |
|
|
R7426:Vmn2r72
|
UTSW |
7 |
85,400,348 (GRCm39) |
missense |
probably benign |
|
|
R7606:Vmn2r72
|
UTSW |
7 |
85,400,362 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7651:Vmn2r72
|
UTSW |
7 |
85,401,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Vmn2r72
|
UTSW |
7 |
85,404,098 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7843:Vmn2r72
|
UTSW |
7 |
85,398,838 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8157:Vmn2r72
|
UTSW |
7 |
85,400,441 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8254:Vmn2r72
|
UTSW |
7 |
85,400,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Vmn2r72
|
UTSW |
7 |
85,401,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8444:Vmn2r72
|
UTSW |
7 |
85,387,383 (GRCm39) |
missense |
probably benign |
|
|
R8989:Vmn2r72
|
UTSW |
7 |
85,404,134 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9015:Vmn2r72
|
UTSW |
7 |
85,398,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9080:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Vmn2r72
|
UTSW |
7 |
85,400,411 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9317:Vmn2r72
|
UTSW |
7 |
85,404,022 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9509:Vmn2r72
|
UTSW |
7 |
85,404,075 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,398,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCATACTAATGTCGACTGTGTC -3'
(R):5'- AGGAGATTTCATGCTATATTCCTCC -3'
Sequencing Primer
(F):5'- GATCTGTCAAGTATTCAGTAATGGAG -3'
(R):5'- ATGCTATATTCCTCCTCTGGGAC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation