Mutagenetix > Incidental Mutation

Incidental Mutation 'R7753:Vmn2r72'

597364

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

045809-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R7753 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 85750626 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 405 (A405V)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: A405V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: A405V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,184,107	T1377A	probably damaging	Het
AI661453	G	T	17: 47,467,514	E722*	probably null	Het
Ap2b1	A	T	11: 83,367,907	K735*	probably null	Het
Aqp4	T	C	18: 15,399,976	E20G	probably benign	Het
Atp6v1b1	G	T	6: 83,752,458	V117L	probably benign	Het
C1rb	A	G	6: 124,580,431	N509S	probably benign	Het
Cep44	A	G	8: 56,532,807	V350A	probably benign	Het
Cmya5	T	C	13: 93,098,172	Q136R	probably benign	Het
Cntrl	T	C	2: 35,111,679	S32P	probably damaging	Het
Cyp2d12	A	T	15: 82,556,963	E201V	possibly damaging	Het
Cyp4a14	G	T	4: 115,493,664	Q138K	probably damaging	Het
Dapk1	T	C	13: 60,751,193	Y826H	possibly damaging	Het
Dbh	A	G	2: 27,171,436	D294G	probably benign	Het
Ddx10	A	T	9: 53,225,604	L336Q	probably damaging	Het
Dopey1	A	G	9: 86,489,702	T149A	possibly damaging	Het
Epg5	A	G	18: 77,948,345	T86A	possibly damaging	Het
Fam171a1	A	T	2: 3,178,317	Q60L	probably damaging	Het
Farsb	T	A	1: 78,480,103	E41D	probably benign	Het
Frem1	T	C	4: 82,913,980	D1956G	probably benign	Het
Fzd4	T	A	7: 89,407,784	Y346*	probably null	Het
Fzd7	A	T	1: 59,483,482	S175C	probably benign	Het
Gdi2	A	G	13: 3,548,956	T47A	probably benign	Het
Gm8765	A	T	13: 50,701,781	D485V	probably damaging	Het
Gpr155	A	T	2: 73,382,206	H24Q	probably benign	Het
Hdac7	A	T	15: 97,800,761	N638K	possibly damaging	Het
Hdac7	G	T	15: 97,806,488	N515K	probably benign	Het
Hnrnpul2	T	C	19: 8,824,972	V401A	probably damaging	Het
Ifi27l2b	T	A	12: 103,451,260	R223*	probably null	Het
Igkv4-91	T	G	6: 68,768,777	S46R	probably benign	Het
Itk	T	A	11: 46,331,895	L582F	probably damaging	Het
Kcnab2	T	C	4: 152,396,761	I181V	probably benign	Het
Krtap5-2	GCCACAGCCTCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACCACAGCCTCC	GCCACAGCCTCC	7: 142,175,399		probably benign	Het
Lce1m	C	A	3: 93,018,508	G41W	unknown	Het
Mapk10	T	A	5: 103,038,553	K98*	probably null	Het
Mapk8ip2	A	G	15: 89,461,653	E812G	probably damaging	Het
Mlh1	C	A	9: 111,252,863		probably null	Het
Mroh1	A	G	15: 76,433,275	D784G	possibly damaging	Het
Neo1	A	T	9: 58,956,005	D426E	probably benign	Het
Nol4	T	A	18: 23,038,602	M1L	probably benign	Het
Nr1h3	A	G	2: 91,185,025	F338S	probably damaging	Het
Oasl2	A	G	5: 114,905,057	K297E	probably benign	Het
Olfr1030	A	G	2: 85,984,716	N292S	possibly damaging	Het
Olfr1129	A	G	2: 87,575,797	T238A	probably benign	Het
Olfr1306	A	G	2: 111,912,582	I116T	probably benign	Het
Olfr419	C	T	1: 174,250,670	V86I	probably benign	Het
Olfr683	T	C	7: 105,143,800	I164M	probably benign	Het
Osbpl9	T	C	4: 109,133,773	T97A	possibly damaging	Het
P3h2	A	T	16: 25,970,937	Y527N	probably damaging	Het
Papss2	A	T	19: 32,620,179	H9L	probably benign	Het
Pcdha4	C	A	18: 36,953,301	S179Y	possibly damaging	Het
Ppt1	A	T	4: 122,836,338	D28V	possibly damaging	Het
Prkcz	T	A	4: 155,272,968	Q345L	possibly damaging	Het
Prr14l	G	T	5: 32,827,253	L1633I	probably damaging	Het
Prss51	T	A	14: 64,095,927	V13D	possibly damaging	Het
Qrich2	TTGCAACACACCAGGCTGAACTGGACCTTGCTG	TTG	11: 116,457,042		probably benign	Het
Rictor	C	T	15: 6,772,154	S441L	probably benign	Het
Slc2a7	T	C	4: 150,154,684	I122T	possibly damaging	Het
Sprr3	G	A	3: 92,457,108	P143L	probably benign	Het
Sugct	A	T	13: 17,577,519	S181T	possibly damaging	Het
Syne2	G	A	12: 76,038,923	R141Q	probably benign	Het
Taok1	T	C	11: 77,537,899	I992V	probably benign	Het
Tbc1d21	A	C	9: 58,362,023		probably null	Het
Thada	T	C	17: 84,252,390	D1453G	probably damaging	Het
Thoc5	T	C	11: 4,902,156	L104S	probably damaging	Het
Tln2	T	G	9: 67,395,473	Y72S	probably damaging	Het
Tmem98	A	G	11: 80,814,311	E75G	probably damaging	Het
Tox3	A	G	8: 90,248,932	L357P	probably damaging	Het
Ubr4	T	C	4: 139,470,292	V4492A	unknown	Het
Ulk4	A	G	9: 121,266,512		probably null	Het
Ush2a	A	G	1: 188,443,406	T1234A	probably benign	Het
Usp53	G	A	3: 122,949,238	T683I	probably damaging	Het
Vcan	T	A	13: 89,689,323	I2701F	probably damaging	Het
Vmn2r96	A	T	17: 18,586,401	T537S	possibly damaging	Het
Vstm2a	G	T	11: 16,263,040	A142S	probably damaging	Het
Zbtb41	A	G	1: 139,447,157	D785G	probably benign	Het
Zfp397	A	T	18: 23,957,072	Q144H	probably benign	Het
Zfp518a	A	T	19: 40,915,805	T1393S	possibly damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
R8989:Vmn2r72	UTSW	7	85754926	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85749180	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85751203	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85754814	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85754867	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGCATACTAATGTCGACTGTGTC -3'
(R):5'- AGGAGATTTCATGCTATATTCCTCC -3'

Sequencing Primer
(F):5'- GATCTGTCAAGTATTCAGTAATGGAG -3'
(R):5'- ATGCTATATTCCTCCTCTGGGAC -3'

Posted On

2019-11-26