Incidental Mutation 'R7754:Or9k2'
ID 597452
Institutional Source Beutler Lab
Gene Symbol Or9k2
Ensembl Gene ENSMUSG00000058084
Gene Name olfactory receptor family 9 subfamily K member 2
Synonyms GA_x6K02T2PULF-11834065-11833103, Olfr825, MOR210-1
MMRRC Submission 045810-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.370) question?
Stock # R7754 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129998231-129999193 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 129998698 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 166 (T166P)
Ref Sequence ENSEMBL: ENSMUSP00000149981 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076814] [ENSMUST00000216530]
AlphaFold Q8VFU7
Predicted Effect probably damaging
Transcript: ENSMUST00000076814
AA Change: T166P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000076091
Gene: ENSMUSG00000058084
AA Change: T166P

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 8.8e-54 PFAM
Pfam:7TM_GPCR_Srsx 38 251 9.6e-6 PFAM
Pfam:7tm_1 44 291 2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216530
AA Change: T166P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Meta Mutation Damage Score 0.6021 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik A T 4: 88,786,496 (GRCm39) W41R unknown Het
Aatf G A 11: 84,402,335 (GRCm39) S117L possibly damaging Het
Abca12 C A 1: 71,342,046 (GRCm39) V972L probably benign Het
Abcb11 T A 2: 69,117,162 (GRCm39) R495S probably damaging Het
Acss2 T A 2: 155,403,086 (GRCm39) H621Q probably benign Het
Akap9 T C 5: 4,096,736 (GRCm39) L2537P probably benign Het
Apbb1 C T 7: 105,208,509 (GRCm39) A597T probably damaging Het
Cacna1d A T 14: 29,797,809 (GRCm39) I1448N probably damaging Het
Cacna1e C T 1: 154,288,863 (GRCm39) E1841K probably damaging Het
Ccdc162 G T 10: 41,463,371 (GRCm39) P1457Q probably damaging Het
Cep70 A G 9: 99,163,145 (GRCm39) K331E probably damaging Het
Cplane1 C A 15: 8,273,310 (GRCm39) Q2534K possibly damaging Het
Cstpp1 A T 2: 91,135,188 (GRCm39) probably null Het
D430041D05Rik A T 2: 104,087,504 (GRCm39) Y491N probably benign Het
Dnah6 T C 6: 73,002,703 (GRCm39) I3898V probably benign Het
Drd2 A G 9: 49,316,277 (GRCm39) T346A probably benign Het
Efcab9 T C 11: 32,472,941 (GRCm39) T169A possibly damaging Het
Fam163a A T 1: 155,955,729 (GRCm39) I21N probably damaging Het
Fam171a2 C T 11: 102,329,389 (GRCm39) D457N probably benign Het
Fbn1 A T 2: 125,321,200 (GRCm39) probably null Het
Gpr37 A T 6: 25,689,049 (GRCm39) L16H probably damaging Het
Gtf3c2 T C 5: 31,330,175 (GRCm39) D265G probably benign Het
Idh1 G T 1: 65,198,649 (GRCm39) A407D probably benign Het
Ifna12 A G 4: 88,521,415 (GRCm39) M44T probably damaging Het
Il22ra1 A G 4: 135,461,561 (GRCm39) M109V probably benign Het
Jag2 A T 12: 112,879,089 (GRCm39) probably null Het
Lca5l T C 16: 95,960,761 (GRCm39) D572G unknown Het
Lcn11 G A 2: 25,667,830 (GRCm39) V73I probably benign Het
Lrba A G 3: 86,352,704 (GRCm39) T1951A probably damaging Het
Ltbp2 A G 12: 84,860,012 (GRCm39) probably null Het
Malrd1 G A 2: 15,802,610 (GRCm39) probably null Het
Morc2b C A 17: 33,356,218 (GRCm39) G518V probably benign Het
Muc5ac G C 7: 141,363,040 (GRCm39) G2117A unknown Het
Myo5b A T 18: 74,767,630 (GRCm39) T313S probably benign Het
Neto2 C A 8: 86,396,329 (GRCm39) L140F probably damaging Het
Nlgn1 C T 3: 25,488,467 (GRCm39) V623I probably damaging Het
Optc A G 1: 133,834,730 (GRCm39) S15P possibly damaging Het
Or1e25 C T 11: 73,494,332 (GRCm39) Q309* probably null Het
Or1l4b A G 2: 37,036,858 (GRCm39) I211M possibly damaging Het
Or52e19b C A 7: 103,032,945 (GRCm39) W88L probably damaging Het
Or7c19 T A 8: 85,957,427 (GRCm39) M101K possibly damaging Het
Otogl A G 10: 107,705,407 (GRCm39) V640A probably damaging Het
Pcdhgb2 T C 18: 37,823,023 (GRCm39) S5P probably benign Het
Pde3a A T 6: 141,404,975 (GRCm39) E400V probably benign Het
Pkhd1l1 A G 15: 44,449,804 (GRCm39) I3856V possibly damaging Het
Pld2 G A 11: 70,443,695 (GRCm39) probably null Het
Plxna4 G T 6: 32,129,807 (GRCm39) H1839N probably damaging Het
Ppp6r2 T C 15: 89,140,904 (GRCm39) V89A probably benign Het
Rapgef3 T C 15: 97,655,627 (GRCm39) D420G probably damaging Het
Rnf17 T A 14: 56,699,529 (GRCm39) probably null Het
Rps6ka2 T A 17: 7,544,848 (GRCm39) probably null Het
Rptn A T 3: 93,303,228 (GRCm39) D187V probably damaging Het
Rtn1 T C 12: 72,355,203 (GRCm39) K248E probably damaging Het
Rtn4rl1 A T 11: 75,155,871 (GRCm39) H101L probably benign Het
Septin3 A G 15: 82,174,974 (GRCm39) N305S probably benign Het
Serpina3f G T 12: 104,183,565 (GRCm39) K142N possibly damaging Het
Ssh1 C A 5: 114,104,295 (GRCm39) R116L probably benign Het
Taf4 G A 2: 179,573,822 (GRCm39) T682M probably damaging Het
Tlr6 T C 5: 65,111,693 (GRCm39) K405E possibly damaging Het
Trbv13-2 G A 6: 41,098,634 (GRCm39) A70T probably benign Het
Ttn A T 2: 76,618,540 (GRCm39) I16248N probably damaging Het
Ttn A T 2: 76,655,849 (GRCm39) probably null Het
Vldlr A T 19: 27,195,015 (GRCm39) M1L probably benign Het
Wscd1 A G 11: 71,675,191 (GRCm39) H366R probably damaging Het
Zbtb8a A G 4: 129,251,496 (GRCm39) probably null Het
Zfp827 T C 8: 79,916,958 (GRCm39) V511A Het
Other mutations in Or9k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03244:Or9k2 APN 10 129,998,269 (GRCm39) nonsense probably null
R1120:Or9k2 UTSW 10 129,998,406 (GRCm39) missense probably damaging 1.00
R1341:Or9k2 UTSW 10 129,999,185 (GRCm39) missense probably benign 0.00
R1754:Or9k2 UTSW 10 129,999,033 (GRCm39) missense probably benign 0.02
R2022:Or9k2 UTSW 10 129,999,049 (GRCm39) missense probably benign 0.00
R2027:Or9k2 UTSW 10 129,998,604 (GRCm39) missense probably benign 0.00
R3838:Or9k2 UTSW 10 129,998,275 (GRCm39) nonsense probably null
R3842:Or9k2 UTSW 10 129,998,770 (GRCm39) missense probably benign 0.00
R4737:Or9k2 UTSW 10 129,998,707 (GRCm39) missense probably benign 0.01
R5166:Or9k2 UTSW 10 129,998,430 (GRCm39) missense possibly damaging 0.60
R5744:Or9k2 UTSW 10 129,998,661 (GRCm39) missense possibly damaging 0.92
R5899:Or9k2 UTSW 10 129,998,542 (GRCm39) missense probably benign 0.00
R8098:Or9k2 UTSW 10 129,998,916 (GRCm39) missense probably benign 0.32
R9393:Or9k2 UTSW 10 129,999,016 (GRCm39) missense probably benign 0.39
X0026:Or9k2 UTSW 10 129,998,600 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGCAAGTGGAGAAGGCTTTC -3'
(R):5'- CACTGTTCATTGTGGCTGAAGG -3'

Sequencing Primer
(F):5'- CTCCACGGATCGTATCTTTAGAACAG -3'
(R):5'- GGATTTCTCCTGGCAGCCATG -3'
Posted On 2019-11-26